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Gene: Apaf1 (apoptotic peptidase activating factor 1) Mus musculus
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Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Description: Exhibits cysteine-type endopeptidase activator activity involved in apoptotic process and identical protein binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; nervous system development; and regulation of apoptotic process. Localizes to cytosol and nucleus. Is expressed in several structures, including heart; inner cell mass; limb interdigital region; liver; and vibrissa. Used to study Noonan syndrome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1); PARTICIPATES IN intrinsic apoptotic pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6230400I06Rik; Apaf-1; Apaf1l; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Orthologs:
Homo sapiens (human) : APAF1 (apoptotic peptidase activating factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Apaf1 (apoptotic peptidase activating factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apaf1 (apoptotic peptidase activating factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APAF1 (apoptotic peptidase activating factor 1)
Canis lupus familiaris (dog) : APAF1 (apoptotic peptidase activating factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apaf1 (apoptotic peptidase activating factor 1)
Sus scrofa (pig) : APAF1 (apoptotic peptidase activating factor 1)
Chlorocebus sabaeus (African green monkey) : APAF1 (apoptotic peptidase activating factor 1)
Heterocephalus glaber (naked mole-rat) : Apaf1 (apoptotic peptidase activating factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBImm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Apaf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733294
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.