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Gene: Apaf1 (apoptotic peptidase activating factor 1) Mus musculus
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Description: Exhibits cysteine-type endopeptidase activator activity involved in apoptotic process and identical protein binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; nervous system development; and regulation of apoptotic process. Localizes to cytosol and nucleus. Is expressed in several structures, including heart; inner cell mass; limb interdigital region; liver; and vibrissa. Used to study Noonan syndrome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1); PARTICIPATES IN intrinsic apoptotic pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6230400I06Rik; Apaf-1; Apaf1l; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Homo sapiens (human) : APAF1 (apoptotic peptidase activating factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Apaf1 (apoptotic peptidase activating factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apaf1 (apoptotic peptidase activating factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APAF1 (apoptotic peptidase activating factor 1)
Canis lupus familiaris (dog) : APAF1 (apoptotic peptidase activating factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apaf1 (apoptotic peptidase activating factor 1)
Sus scrofa (pig) : APAF1 (apoptotic peptidase activating factor 1)
Chlorocebus sabaeus (African green monkey) : APAF1 (apoptotic peptidase activating factor 1)
Heterocephalus glaber (naked mole-rat) : Apaf1 (apoptotic peptidase activating factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1090,989,311 - 91,082,770 (-)EnsemblGRCm38mm10GRCm38
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBImm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Apaf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733294
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.