RGD Reference Report - Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. - Rat Genome Database
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Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.

Authors: Zhang, Shuai  Qi, Yan  Xu, Youwei  Han, Xu  Peng, Jinyong  Liu, Kexin  Sun, C K 
Citation: Zhang S, etal., Neurochem Int. 2013 Nov;63(5):522-32. doi: 10.1016/j.neuint.2013.08.008. Epub 2013 Sep 4.
RGD ID: 13703113
Pubmed: (View Article at PubMed) PMID:24012531
DOI: Full-text: DOI:10.1016/j.neuint.2013.08.008

The neuroprotective effect and mechanism of the flavonoid-rich extract (FRE) from Rosa laevigata Michx fruit on cerebral ischemia-reperfusion (I/R) injury were investigated. The contents of flavonoids, saponins and tannin were determined, and ten chemicals including chlorogenic acid, 4-hydroxy-3-methoxybenzoic acid, apigenin, luteolin, kaempferol, querce-tin, kaempferide-3-O-glucoside, quercetin-3-rhamnoside, rutin and isorhamnetin-3-O-ß-rutinoside from the crude extract were separated. Oral administration of FRE obviously improved the survival rate and prevented I/R-induced disability and histological damage. Further works showed that the natural product had excellent antioxidant activity, significantly decreased DNA fragmentation, up-regulated the expression of Bcl-2, and down-regulated the expressions of p53, Apaf1, Fas, FasL, Bax, Bid, cytochrome C and active Caspase-3, -9 and -8. Moreover, the FRE decreased the expressions of NF-κB, iNOS, MMP-9, COX-2, TNF-α, IL-1ß, IL-4, IL-6, and down-regulated the levels of p-JNK, p-ERK and p-p38 in MAPK pathways. Therefore, the flavonoid-rich extract from R. laevigata Michx fruit has the potential actions for treatment of ischemic stroke due to its anti-oxidant, anti-apoptosis and anti-inflammatory properties.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Apaf1  (apoptotic peptidase activating factor 1)

Genes (Mus musculus)
Apaf1  (apoptotic peptidase activating factor 1)

Genes (Homo sapiens)
APAF1  (apoptotic peptidase activating factor 1)


Additional Information