APAF1 Human (-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of APAF1 protein CTD PMID:15657356 APAF1 Human (S)-naringenin increases expression EXP 6480464 naringenin metabolite results in increased expression of APAF1 mRNA and naringenin results in increased expression of APAF1 protein CTD PMID:27838343 and PMID:36235125 APAF1 Human (S)-naringenin multiple interactions EXP 6480464 [naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA and [naringenin metabolite co-treated with bisphenol A] results in increased expression of APAF1 mRNA CTD PMID:36235125 APAF1 Human 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 o and p'-DDT analog results in decreased expression of APAF1 mRNA CTD PMID:22937105 APAF1 Human 1,1-dichloroethene increases expression ISO Apaf1 (Mus musculus) 6480464 vinylidene chloride results in increased expression of APAF1 mRNA CTD PMID:26682919 APAF1 Human 1,2-dimethylhydrazine decreases expression ISO Apaf1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in decreased expression of APAF1 mRNA CTD PMID:22206623 APAF1 Human 1,3-dinitrobenzene increases expression ISO Apaf1 (Rattus norvegicus) 6480464 3-dinitrobenzene results in increased expression of APAF1 mRNA CTD PMID:24140754 APAF1 Human 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of APAF1 mRNA CTD PMID:21826169 APAF1 Human 17beta-estradiol increases expression EXP 6480464 Estradiol analog results in increased expression of APAF1 mRNA and Estradiol analog results in increased expression of APAF1 protein CTD PMID:36460128 APAF1 Human 17beta-estradiol decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Estradiol results in decreased expression of APAF1 mRNA CTD PMID:32145629 APAF1 Human 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of APAF1 mRNA CTD PMID:23373633 and PMID:31614463 APAF1 Human 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with EGF protein] results in decreased expression of APAF1 mRNA CTD PMID:24758408 APAF1 Human 2,2',4,4'-Tetrabromodiphenyl ether affects expression EXP 6480464 2 more ... CTD PMID:27589474 APAF1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Apaf1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA CTD PMID:23864506 APAF1 Human 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Apaf1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of APAF1 mRNA CTD PMID:21570461 APAF1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA CTD PMID:19520675 and PMID:33387578 APAF1 Human 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA CTD PMID:19684285 APAF1 Human 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of APAF1 mRNA CTD PMID:19684285 APAF1 Human 2,4,6-tribromophenol increases expression EXP 6480464 2 more ... CTD PMID:31675489 APAF1 Human 2,4-D decreases expression ISO Apaf1 (Mus musculus) 6480464 2 more ... CTD PMID:33865415 APAF1 Human 2,4-D multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Lipopolysaccharides co-treated with 2 more ... CTD PMID:33865415 APAF1 Human 2,4-dinitrophenol increases expression EXP 6480464 2 and 4-Dinitrophenol results in increased expression of APAF1 mRNA alternative form CTD PMID:17064354 APAF1 Human 2,6-dinitrotoluene affects expression ISO Apaf1 (Rattus norvegicus) 6480464 2 and 6-dinitrotoluene affects the expression of APAF1 mRNA CTD PMID:21346803 APAF1 Human 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of APAF1 mRNA CTD PMID:21179406 APAF1 Human 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of APAF1 protein CTD PMID:31675489 APAF1 Human 3-chloropropane-1,2-diol multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] and Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA] CTD PMID:30107153 and PMID:33651226 APAF1 Human 3-chloropropane-1,2-diol multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]] and Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:35149085 APAF1 Human 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of APAF1 protein CTD PMID:35149085 APAF1 Human 3-chloropropane-1,2-diol increases expression ISO Apaf1 (Rattus norvegicus) 6480464 alpha-Chlorohydrin results in increased expression of APAF1 mRNA and alpha-Chlorohydrin results in increased expression of APAF1 protein CTD PMID:30107153 and PMID:33651226 APAF1 Human 3-methyladenine multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]] CTD PMID:35149085 APAF1 Human 3-methylcholanthrene increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Methylcholanthrene results in increased expression of APAF1 mRNA CTD PMID:23273579 APAF1 Human 4,4'-diaminodiphenylmethane increases expression ISO Apaf1 (Rattus norvegicus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of APAF1 mRNA CTD PMID:25380136 APAF1 Human 4-hydroxyphenyl retinamide increases expression ISO Apaf1 (Mus musculus) 6480464 Fenretinide results in increased expression of APAF1 mRNA CTD PMID:28973697 APAF1 Human 4-nitrophenol increases expression ISO Apaf1 (Mus musculus) 6480464 4-nitrophenol results in increased expression of APAF1 mRNA CTD PMID:34673133 APAF1 Human 4-nonylphenol affects expression ISO Apaf1 (Rattus norvegicus) 6480464 4-nonylphenol affects the expression of APAF1 mRNA CTD PMID:27109770 APAF1 Human 4-nonylphenol increases expression ISO Apaf1 (Rattus norvegicus) 6480464 4-nonylphenol results in increased expression of APAF1 protein CTD PMID:26804764 and PMID:27109770 APAF1 Human 4-phenylbutyric acid multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 4-phenylbutyric acid inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:33651226 APAF1 Human 4-phenylbutyric acid decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 4-phenylbutyric acid results in decreased expression of APAF1 protein CTD PMID:33651226 APAF1 Human 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of APAF1 mRNA and Decitabine results in increased expression of APAF1 protein CTD PMID:15972851 and PMID:19662370 APAF1 Human 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 TP53 protein affects the reaction [Decitabine affects the expression of APAF1 mRNA] CTD PMID:17133271 APAF1 Human 5-aza-2'-deoxycytidine affects expression EXP 6480464 Decitabine affects the expression of APAF1 mRNA CTD PMID:17133271 APAF1 Human 5-aza-2'-deoxycytidine increases expression ISO Apaf1 (Mus musculus) 6480464 Decitabine results in increased expression of APAF1 mRNA CTD PMID:27915011 APAF1 Human 5-fluorouracil increases expression EXP 6480464 Fluorouracil results in increased expression of APAF1 mRNA CTD PMID:16557594 APAF1 Human 5-fluorouracil affects expression EXP 6480464 Fluorouracil affects the expression of APAF1 mRNA CTD PMID:34151400 APAF1 Human 6-Methoxyflavone decreases expression EXP 6480464 6-methoxyflavone results in decreased expression of APAF1 mRNA CTD PMID:35400257 APAF1 Human 6-O-methylguanine multiple interactions EXP 6480464 [O(6)-benzylguanine co-treated with O-(6)-methylguanine] results in decreased expression of APAF1 mRNA CTD PMID:29666243 APAF1 Human 6-propyl-2-thiouracil increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of APAF1 mRNA CTD PMID:24780913 APAF1 Human 7,12-dimethyltetraphene multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9 more ... CTD PMID:25478867 APAF1 Human 7,12-dimethyltetraphene decreases expression ISO Apaf1 (Mus musculus) 6480464 9 more ... CTD PMID:25478867 APAF1 Human 8-Br-cAMP decreases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of APAF1 mRNA CTD PMID:22079614 APAF1 Human acetamide increases expression ISO Apaf1 (Rattus norvegicus) 6480464 acetamide results in increased expression of APAF1 mRNA CTD PMID:31881176 APAF1 Human acetylsalicylic acid increases response to substance ISO Apaf1 (Mus musculus) 6480464 APAF1 results in increased susceptibility to Aspirin CTD PMID:11228543 APAF1 Human acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of APAF1 mRNA CTD PMID:20457246 APAF1 Human acrylamide decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Acrylamide results in decreased expression of APAF1 mRNA CTD PMID:28959563 APAF1 Human acrylamide increases expression ISO Apaf1 (Mus musculus) 6480464 Acrylamide results in increased expression of APAF1 mRNA CTD PMID:21319176 APAF1 Human actinomycin D multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of APAF1 mRNA CTD PMID:38460933 APAF1 Human aflatoxin B1 increases expression ISO Apaf1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of APAF1 mRNA CTD PMID:19770486 APAF1 Human aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of APAF1 mRNA CTD PMID:22100608 and PMID:29445054 APAF1 Human aldehydo-D-glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 APAF1 Human all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of APAF1 mRNA CTD PMID:33167477 and PMID:34742744 APAF1 Human alloxan decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Alloxan results in decreased expression of APAF1 protein CTD PMID:21982801 APAF1 Human alloxan increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Alloxan results in increased expression of APAF1 protein CTD PMID:23092809 APAF1 Human alloxan multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein] CTD PMID:23092809 APAF1 Human apigenin multiple interactions EXP 6480464 [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein CTD PMID:24070738 APAF1 Human apigenin multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA] CTD PMID:30107153 APAF1 Human aristolochic acid A decreases expression EXP 6480464 aristolochic acid I results in decreased expression of APAF1 mRNA CTD PMID:33212167 APAF1 Human Aroclor 1254 increases expression ISO Apaf1 (Mus musculus) 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of APAF1 protein CTD PMID:22406624 APAF1 Human arsane increases expression EXP 6480464 Arsenic results in increased expression of APAF1 mRNA CTD PMID:19945496 APAF1 Human arsane multiple interactions EXP 6480464 Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA] CTD PMID:22293942 APAF1 Human arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of APAF1 mRNA CTD PMID:19945496 APAF1 Human arsenic atom multiple interactions EXP 6480464 Arsenic affects the reaction [GSTO1 gene alternative form results in increased expression of APAF1 mRNA] CTD PMID:22293942 APAF1 Human arsenous acid increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of APAF1 mRNA CTD PMID:19730151 APAF1 Human arsenous acid multiple interactions EXP 6480464 [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA and [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 and PMID:30012499 APAF1 Human arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of APAF1 protein CTD PMID:25258189 APAF1 Human atrazine decreases expression EXP 6480464 Atrazine results in decreased expression of APAF1 mRNA CTD PMID:34146662 APAF1 Human azadirachtin A increases expression EXP 6480464 azadirachtin results in increased expression of APAF1 protein CTD PMID:20429769 APAF1 Human bafilomycin A1 increases expression EXP 6480464 bafilomycin A1 results in increased expression of APAF1 protein CTD PMID:28483490 APAF1 Human benzene increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Benzene results in increased expression of APAF1 protein CTD PMID:17171516 APAF1 Human benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of APAF1 mRNA CTD PMID:20064835 APAF1 Human benzo[a]pyrene multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA CTD PMID:22613061 APAF1 Human benzo[a]pyrene increases expression ISO Apaf1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of APAF1 mRNA CTD PMID:19770486 and PMID:21964900 APAF1 Human benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of APAF1 mRNA and Benzo(a)pyrene results in increased expression of APAF1 protein CTD PMID:21393351 more ... APAF1 Human benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:28593498 APAF1 Human beta-lapachone decreases expression EXP 6480464 beta-lapachone results in decreased expression of APAF1 mRNA CTD PMID:38218311 APAF1 Human bifenthrin increases expression ISO Apaf1 (Mus musculus) 6480464 bifenthrin results in increased expression of APAF1 mRNA CTD PMID:26071804 and PMID:32408700 APAF1 Human bis(2-chloroethyl) sulfide increases expression ISO Apaf1 (Mus musculus) 6480464 Mustard Gas results in increased expression of APAF1 mRNA CTD PMID:15674843 and PMID:18955075 APAF1 Human bis(2-ethylhexyl) phthalate increases expression ISO Apaf1 (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of APAF1 mRNA CTD PMID:37975621 APAF1 Human bis(2-ethylhexyl) phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of APAF1 mRNA and bisphenol A results in decreased expression of APAF1 protein CTD PMID:21277958 more ... APAF1 Human bisphenol A multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human bisphenol A multiple interactions EXP 6480464 [naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA more ... CTD PMID:36235125 and PMID:38421590 APAF1 Human bisphenol A increases expression ISO Apaf1 (Mus musculus) 6480464 bisphenol A results in increased expression of APAF1 mRNA CTD PMID:35598803 APAF1 Human bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APAF1 mRNA and bisphenol A results in increased expression of APAF1 protein CTD PMID:38421590 APAF1 Human bisphenol A affects expression ISO Apaf1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of APAF1 mRNA CTD PMID:32145629 APAF1 Human bisphenol A increases methylation ISO Apaf1 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of APAF1 gene CTD PMID:28505145 APAF1 Human bisphenol A decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of APAF1 mRNA CTD PMID:30816183 more ... APAF1 Human bisphenol A increases expression ISO Apaf1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of APAF1 mRNA and bisphenol A results in increased expression of APAF1 protein CTD PMID:23328667 more ... APAF1 Human bufalin increases expression EXP 6480464 bufalin results in increased expression of APAF1 protein CTD PMID:27444971 APAF1 Human butachlor decreases expression ISO Apaf1 (Mus musculus) 6480464 butachlor results in decreased expression of APAF1 mRNA CTD PMID:34351278 APAF1 Human Butylbenzyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human butyric acid multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9 more ... CTD PMID:25478867 APAF1 Human cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of APAF1 protein CTD PMID:24291162 APAF1 Human cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of APAF1 mRNA CTD PMID:38568856 APAF1 Human cadmium sulfide increases expression EXP 6480464 cadmium sulfide results in increased expression of APAF1 mRNA CTD PMID:27866839 APAF1 Human calcitriol multiple interactions EXP 6480464 Calcitriol inhibits the reaction [bisphenol A results in increased expression of APAF1 mRNA] and Calcitriol inhibits the reaction [bisphenol A results in increased expression of APAF1 protein] CTD PMID:38421590 APAF1 Human cannabidiol increases expression EXP 6480464 Cannabidiol results in increased expression of APAF1 protein CTD PMID:31349651 APAF1 Human cannabidiol multiple interactions EXP 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of APAF1 mRNA CTD PMID:30096889 APAF1 Human cannabidiol decreases expression EXP 6480464 Cannabidiol results in decreased expression of APAF1 mRNA CTD PMID:27932991 APAF1 Human capsaicin increases expression EXP 6480464 Capsaicin results in increased expression of APAF1 mRNA CTD PMID:19502594 APAF1 Human carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of APAF1 mRNA CTD PMID:24752500 APAF1 Human carbon nanotube increases expression EXP 6480464 Nanotubes and Carbon results in increased expression of APAF1 mRNA CTD PMID:15585362 APAF1 Human carnosic acid multiple interactions ISO Apaf1 (Mus musculus) 6480464 salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:29854073 APAF1 Human casticin increases expression EXP 6480464 casticin results in increased expression of APAF1 protein CTD PMID:27862857 APAF1 Human ceric oxide increases expression EXP 6480464 ceric oxide results in increased expression of APAF1 protein CTD PMID:24987704 APAF1 Human chlorpyrifos decreases expression ISO Apaf1 (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of APAF1 mRNA and Chlorpyrifos results in decreased expression of APAF1 protein CTD PMID:20350560 and PMID:34559034 APAF1 Human chlorpyrifos multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Chlorpyrifos co-treated with cypermethrin] results in decreased expression of APAF1 protein more ... CTD PMID:34559034 APAF1 Human chlorpyrifos increases expression ISO Apaf1 (Mus musculus) 6480464 Chlorpyrifos results in increased expression of APAF1 mRNA CTD PMID:27737797 APAF1 Human chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of APAF1 protein CTD PMID:26435000 APAF1 Human chlorpyrifos multiple interactions EXP 6480464 MitoTEMPO inhibits the reaction [Chlorpyrifos results in increased expression of APAF1 protein] CTD PMID:26435000 APAF1 Human cholesterol multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 6-hydroxy-2 more ... CTD PMID:19477266 APAF1 Human cholesterol increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Cholesterol analog results in increased expression of APAF1 mRNA CTD PMID:19477266 APAF1 Human choline multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene CTD PMID:20938992 APAF1 Human cimetidine increases activity EXP 6480464 Cimetidine results in increased activity of APAF1 protein CTD PMID:17273750 APAF1 Human cisplatin multiple interactions EXP 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of APAF1 mRNA and [trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin CTD PMID:20925046 and PMID:27392435 APAF1 Human cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of APAF1 mRNA CTD PMID:27392435 APAF1 Human cisplatin increases expression ISO Apaf1 (Mus musculus) 6480464 Cisplatin results in increased expression of APAF1 mRNA CTD PMID:20883750 and PMID:25270620 APAF1 Human cobalt dichloride multiple interactions ISO Apaf1 (Mus musculus) 6480464 [cobaltous chloride co-treated with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole] results in increased expression of APAF1 mRNA CTD PMID:24265542 APAF1 Human cobalt dichloride increases expression ISO Apaf1 (Mus musculus) 6480464 cobaltous chloride results in increased expression of APAF1 mRNA CTD PMID:24265542 APAF1 Human coenzyme Q10 multiple interactions ISO Apaf1 (Mus musculus) 6480464 [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 mRNA and [coenzyme Q10 co-treated with TNFSF11 protein] results in increased expression of APAF1 protein CTD PMID:33754447 APAF1 Human colistin increases expression ISO Apaf1 (Mus musculus) 6480464 Colistin results in increased expression of APAF1 mRNA and Colistin results in increased expression of APAF1 protein CTD PMID:34560125 APAF1 Human copper atom increases expression ISO Apaf1 (Mus musculus) 6480464 Copper analog results in increased expression of APAF1 protein CTD PMID:22000994 APAF1 Human copper atom increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Copper results in increased expression of APAF1 protein CTD PMID:30556269 APAF1 Human copper atom multiple interactions EXP 6480464 [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] and [Chelating Agents binds to Copper] which results in increased expression of APAF1 mRNA CTD PMID:22951949 and PMID:30911355 APAF1 Human copper(0) increases expression ISO Apaf1 (Mus musculus) 6480464 Copper analog results in increased expression of APAF1 protein CTD PMID:22000994 APAF1 Human copper(0) increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Copper results in increased expression of APAF1 protein CTD PMID:30556269 APAF1 Human copper(0) multiple interactions EXP 6480464 [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] and [Chelating Agents binds to Copper] which results in increased expression of APAF1 mRNA CTD PMID:22951949 and PMID:30911355 APAF1 Human curcumin increases expression ISO Apaf1 (Mus musculus) 6480464 Curcumin results in increased expression of APAF1 protein CTD PMID:17277231 APAF1 Human curcumin multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] CTD PMID:20869986 APAF1 Human cycloheximide decreases expression EXP 6480464 Cycloheximide results in decreased expression of APAF1 mRNA CTD PMID:19684285 APAF1 Human cycloheximide multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in decreased expression of APAF1 mRNA CTD PMID:19684285 APAF1 Human cyclophosphamide decreases expression EXP 6480464 Cyclophosphamide results in decreased expression of APAF1 mRNA CTD PMID:29445054 APAF1 Human cyfluthrin increases expression EXP 6480464 cyfluthrin results in increased expression of APAF1 mRNA CTD PMID:31330490 APAF1 Human cylindrospermopsin decreases expression EXP 6480464 cylindrospermopsin results in decreased expression of APAF1 mRNA CTD PMID:23726867 APAF1 Human cypermethrin increases expression EXP 6480464 cypermethrin results in increased expression of APAF1 mRNA and cypermethrin results in increased expression of APAF1 protein CTD PMID:27704156 and PMID:36063984 APAF1 Human cypermethrin multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Chlorpyrifos co-treated with cypermethrin] results in decreased expression of APAF1 protein more ... CTD PMID:34559034 APAF1 Human cypermethrin decreases expression ISO Apaf1 (Mus musculus) 6480464 cypermethrin results in decreased expression of APAF1 mRNA and cypermethrin results in decreased expression of APAF1 protein CTD PMID:34559034 APAF1 Human D-glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 APAF1 Human DDE increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of APAF1 mRNA CTD PMID:25410718 APAF1 Human decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of APAF1 protein CTD PMID:31675489 APAF1 Human desferrioxamine B multiple interactions EXP 6480464 [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of APAF1 mRNA more ... CTD PMID:33962019 and PMID:35690295 APAF1 Human Di-n-octyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human diarsenic trioxide increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of APAF1 mRNA CTD PMID:19730151 APAF1 Human diarsenic trioxide multiple interactions EXP 6480464 [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA and [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 and PMID:30012499 APAF1 Human diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of APAF1 protein CTD PMID:25258189 APAF1 Human diazinon affects expression ISO Apaf1 (Rattus norvegicus) 6480464 Diazinon affects the expression of APAF1 mRNA CTD PMID:22546817 APAF1 Human dibutyl phthalate increases expression ISO Apaf1 (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of APAF1 protein CTD PMID:34864091 APAF1 Human dibutyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human diclofenac affects expression EXP 6480464 Diclofenac affects the expression of APAF1 mRNA CTD PMID:24752500 APAF1 Human Didecyldimethylammonium increases expression EXP 6480464 didecyldimethylammonium results in increased expression of APAF1 protein CTD PMID:32763356 APAF1 Human dieldrin affects expression ISO Apaf1 (Rattus norvegicus) 6480464 Dieldrin affects the expression of APAF1 mRNA CTD PMID:22546817 APAF1 Human diepoxybutane increases expression EXP 6480464 diepoxybutane results in increased expression of APAF1 mRNA CTD PMID:29792945 APAF1 Human diethyl maleate increases expression EXP 6480464 diethyl maleate results in increased expression of APAF1 mRNA CTD PMID:11875189 APAF1 Human diethyl phthalate increases expression ISO Apaf1 (Mus musculus) 6480464 diethyl phthalate results in increased expression of APAF1 protein CTD PMID:37942807 APAF1 Human diethyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human diethyldithiocarbamic acid multiple interactions EXP 6480464 [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] CTD PMID:22951949 APAF1 Human diethylstilbestrol decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Diethylstilbestrol results in decreased expression of APAF1 mRNA CTD PMID:37077353 APAF1 Human Diisodecyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human diisononyl phthalate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in increased expression of APAF1 mRNA CTD PMID:37364641 APAF1 Human dioscin decreases expression EXP 6480464 dioscin results in decreased expression of APAF1 mRNA CTD PMID:33359023 APAF1 Human diosgenin multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]] and Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein] CTD PMID:35149085 APAF1 Human dioxygen increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Oxygen deficiency results in increased expression of APAF1 protein CTD PMID:21468576 APAF1 Human disulfiram increases expression EXP 6480464 Disulfiram results in increased expression of APAF1 mRNA CTD PMID:34182011 APAF1 Human doxorubicin multiple interactions EXP 6480464 ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA] more ... CTD PMID:15939500 more ... APAF1 Human doxorubicin increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of APAF1 protein CTD PMID:22015447 and PMID:25169008 APAF1 Human doxorubicin multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein] CTD PMID:22015447 APAF1 Human doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of APAF1 mRNA and Doxorubicin results in increased expression of APAF1 protein CTD PMID:15939500 more ... APAF1 Human ellagic acid decreases expression EXP 6480464 Ellagic Acid results in decreased expression of APAF1 mRNA CTD PMID:12002526 APAF1 Human ellagic acid increases expression EXP 6480464 Ellagic Acid results in increased expression of APAF1 mRNA CTD PMID:35179410 APAF1 Human endosulfan decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Endosulfan results in decreased expression of APAF1 mRNA CTD PMID:29391264 APAF1 Human endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of APAF1 protein CTD PMID:36513242 APAF1 Human endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of APAF1 mRNA CTD PMID:30090376 APAF1 Human epichlorohydrin increases expression EXP 6480464 Epichlorohydrin results in increased expression of APAF1 mRNA CTD PMID:29792945 APAF1 Human erlotinib hydrochloride multiple interactions EXP 6480464 [Erlotinib Hydrochloride co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:29274334 APAF1 Human ethanol increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Ethanol results in increased expression of APAF1 mRNA CTD PMID:23273579 APAF1 Human ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of APAF1 mRNA CTD PMID:23649840 APAF1 Human etoposide increases expression ISO Apaf1 (Mus musculus) 6480464 Etoposide results in increased expression of APAF1 mRNA CTD PMID:25270620 APAF1 Human eugenol multiple interactions ISO Apaf1 (Mus musculus) 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] CTD PMID:20434464 APAF1 Human flavone increases expression EXP 6480464 flavone results in increased expression of APAF1 protein CTD PMID:14750173 APAF1 Human flavonoids increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Flavonoids results in increased expression of APAF1 mRNA CTD PMID:18035473 APAF1 Human flutamide decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Flutamide results in decreased expression of APAF1 mRNA CTD PMID:24793618 APAF1 Human folic acid multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene CTD PMID:20938992 APAF1 Human formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of APAF1 mRNA CTD PMID:23649840 APAF1 Human fructose multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA and troxerutin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of APAF1 mRNA] CTD PMID:28916335 APAF1 Human fumonisin B1 multiple interactions ISO Apaf1 (Mus musculus) 6480464 [fumonisin B1 co-treated with ochratoxin A] results in increased expression of APAF1 protein and fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA] CTD PMID:36397609 APAF1 Human furan increases expression ISO Apaf1 (Rattus norvegicus) 6480464 furan results in increased expression of APAF1 mRNA CTD PMID:22079235 APAF1 Human furosemide affects expression ISO Apaf1 (Rattus norvegicus) 6480464 Furosemide affects the expression of APAF1 mRNA CTD PMID:17497460 APAF1 Human genistein increases expression EXP 6480464 Genistein results in increased expression of APAF1 mRNA CTD PMID:15256057 APAF1 Human genistein increases expression ISO Apaf1 (Mus musculus) 6480464 Genistein results in increased expression of APAF1 mRNA CTD PMID:24967385 APAF1 Human gentamycin increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of APAF1 mRNA CTD PMID:22061828 APAF1 Human gingerol increases expression EXP 6480464 gingerol results in increased expression of APAF1 mRNA and gingerol results in increased expression of APAF1 protein CTD PMID:19481070 APAF1 Human ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of APAF1 mRNA] CTD PMID:34783124 APAF1 Human glucaric acid multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9 more ... CTD PMID:25478867 APAF1 Human glucose multiple interactions EXP 6480464 [Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA and Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 APAF1 Human glyphosate affects methylation ISO Apaf1 (Rattus norvegicus) 6480464 Glyphosate affects the methylation of APAF1 gene CTD PMID:35440735 APAF1 Human glyphosate decreases expression EXP 6480464 Glyphosate results in decreased expression of APAF1 mRNA and Glyphosate results in decreased expression of APAF1 protein CTD PMID:24073338 and PMID:31295307 APAF1 Human glyphosate increases expression EXP 6480464 Glyphosate results in increased expression of APAF1 mRNA CTD PMID:31874349 APAF1 Human gold atom multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA and [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein CTD PMID:27470402 and PMID:28433809 APAF1 Human gold atom decreases expression EXP 6480464 Gold analog results in decreased expression of APAF1 mRNA CTD PMID:36057382 APAF1 Human gold(0) multiple interactions EXP 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA and [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein CTD PMID:27470402 and PMID:28433809 APAF1 Human gold(0) decreases expression EXP 6480464 Gold analog results in decreased expression of APAF1 mRNA CTD PMID:36057382 APAF1 Human hydroxyurea increases expression ISO Apaf1 (Mus musculus) 6480464 Hydroxyurea results in increased expression of APAF1 mRNA CTD PMID:27208086 APAF1 Human indole-3-methanol increases expression ISO Apaf1 (Mus musculus) 6480464 indole-3-carbinol results in increased expression of APAF1 protein CTD PMID:29775573 APAF1 Human isoflurane decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Isoflurane results in decreased expression of APAF1 mRNA CTD PMID:16978161 APAF1 Human isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of APAF1 mRNA CTD PMID:24286936 APAF1 Human ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of APAF1 protein CTD PMID:32959892 APAF1 Human kainic acid increases expression ISO Apaf1 (Mus musculus) 6480464 Kainic Acid results in increased expression of APAF1 mRNA CTD PMID:17997037 APAF1 Human ketoconazole decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Ketoconazole results in decreased expression of APAF1 mRNA CTD PMID:37077353 APAF1 Human L-methionine multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APAF1 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of APAF1 gene CTD PMID:20938992 APAF1 Human lead diacetate increases expression ISO Apaf1 (Mus musculus) 6480464 lead acetate results in increased expression of APAF1 mRNA CTD PMID:20542052 APAF1 Human lead diacetate increases expression ISO Apaf1 (Rattus norvegicus) 6480464 lead acetate results in increased expression of APAF1 mRNA CTD PMID:37471654 APAF1 Human lead diacetate multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA] CTD PMID:37471654 APAF1 Human lead nitrate decreases expression ISO Apaf1 (Mus musculus) 6480464 lead nitrate results in decreased expression of APAF1 protein CTD PMID:23451106 APAF1 Human lead nitrate multiple interactions ISO Apaf1 (Mus musculus) 6480464 mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] CTD PMID:23451106 APAF1 Human leptomycin B multiple interactions EXP 6480464 [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA CTD PMID:20803015 APAF1 Human linuron increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Linuron results in increased expression of APAF1 mRNA CTD PMID:28705778 APAF1 Human lipopolysaccharide multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Lipopolysaccharides co-treated with 2 more ... CTD PMID:33865415 APAF1 Human lipopolysaccharide decreases expression ISO Apaf1 (Mus musculus) 6480464 Lipopolysaccharides results in decreased expression of APAF1 mRNA and Lipopolysaccharides results in decreased expression of APAF1 protein CTD PMID:33865415 APAF1 Human mangiferin multiple interactions ISO Apaf1 (Mus musculus) 6480464 mangiferin inhibits the reaction [lead nitrate results in decreased expression of APAF1 protein] CTD PMID:23451106 APAF1 Human MeIQx increases expression EXP 6480464 2-amino-3 more ... CTD PMID:20816883 APAF1 Human melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of APAF1 mRNA] CTD PMID:33962019 APAF1 Human melittin multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Melitten inhibits the reaction [[IL6 protein co-treated with IL6R protein] results in increased expression of APAF1 protein] CTD PMID:21354845 APAF1 Human melittin multiple interactions ISO Apaf1 (Mus musculus) 6480464 Melitten affects the reaction [TGFB1 protein affects the localization of APAF1 protein] CTD PMID:21871910 APAF1 Human metformin multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA CTD PMID:29309887 APAF1 Human methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of APAF1 mRNA CTD PMID:21678067 and PMID:24449571 APAF1 Human methyl methanesulfonate affects response to substance ISO Apaf1 (Mus musculus) 6480464 APAF1 protein affects the susceptibility to Methyl Methanesulfonate CTD PMID:16019050 APAF1 Human methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of APAF1 mRNA CTD PMID:23649840 APAF1 Human methylisothiazolinone increases expression EXP 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of APAF1 protein CTD PMID:29110394 and PMID:31629900 APAF1 Human methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of APAF1 mRNA CTD PMID:28001369 APAF1 Human mitomycin C increases expression ISO Apaf1 (Mus musculus) 6480464 Mitomycin results in increased expression of APAF1 mRNA CTD PMID:25270620 APAF1 Human morin increases expression EXP 6480464 morin results in increased expression of APAF1 mRNA CTD PMID:28689916 APAF1 Human Muraglitazar decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 muraglitazar results in decreased expression of APAF1 mRNA CTD PMID:21515302 APAF1 Human N-acetyl-L-cysteine multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA] and Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein] CTD PMID:15877105 and PMID:19477266 APAF1 Human N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of APAF1 protein] CTD PMID:35396826 APAF1 Human N-methyl-N'-nitro-N-nitrosoguanidine affects response to substance ISO Apaf1 (Mus musculus) 6480464 APAF1 protein affects the susceptibility to Methylnitronitrosoguanidine CTD PMID:16019050 APAF1 Human N-methyl-N'-nitro-N-nitrosoguanidine decreases expression ISO Apaf1 (Mus musculus) 6480464 Methylnitronitrosoguanidine results in decreased expression of APAF1 protein CTD PMID:20434464 APAF1 Human N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO Apaf1 (Mus musculus) 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of APAF1 protein] CTD PMID:20434464 APAF1 Human N-methyl-N-nitrosourea increases expression ISO Apaf1 (Mus musculus) 6480464 Methylnitrosourea results in increased expression of APAF1 mRNA CTD PMID:25270620 APAF1 Human N-nitrosodiethylamine multiple interactions ISO Apaf1 (Mus musculus) 6480464 AHR protein affects the reaction [Diethylnitrosamine affects the expression of APAF1 mRNA] and AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of APAF1 mRNA] CTD PMID:19996281 APAF1 Human N-nitrosodiethylamine multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:27048571 APAF1 Human N-nitrosodiethylamine affects expression ISO Apaf1 (Mus musculus) 6480464 Diethylnitrosamine affects the expression of APAF1 mRNA CTD PMID:19996281 APAF1 Human N-nitrosodimethylamine increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Dimethylnitrosamine results in increased expression of APAF1 mRNA CTD PMID:25380136 APAF1 Human neomycin multiple interactions ISO Apaf1 (Mus musculus) 6480464 peoniflorin inhibits the reaction [Neomycin results in increased expression of APAF1 mRNA] CTD PMID:29292089 APAF1 Human neomycin increases expression ISO Apaf1 (Mus musculus) 6480464 Neomycin results in increased expression of APAF1 mRNA CTD PMID:29292089 APAF1 Human nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of APAF1 mRNA CTD PMID:23195993 APAF1 Human nicotinamide multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Butyric Acid co-treated with Niacinamide co-treated with Glucaric Acid] inhibits the reaction [9 more ... CTD PMID:25478867 APAF1 Human Nutlin-3 multiple interactions EXP 6480464 [Dactinomycin co-treated with nutlin 3] results in increased expression of APAF1 mRNA CTD PMID:38460933 APAF1 Human ochratoxin A increases expression ISO Apaf1 (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of APAF1 mRNA CTD PMID:19562491 APAF1 Human ochratoxin A increases expression ISO Apaf1 (Mus musculus) 6480464 ochratoxin A results in increased expression of APAF1 mRNA CTD PMID:36397609 APAF1 Human ochratoxin A multiple interactions ISO Apaf1 (Mus musculus) 6480464 [fumonisin B1 co-treated with ochratoxin A] results in increased expression of APAF1 protein and fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA] CTD PMID:36397609 APAF1 Human ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of APAF1 mRNA CTD PMID:17316727 APAF1 Human okadaic acid increases expression EXP 6480464 Okadaic Acid results in increased expression of APAF1 mRNA CTD PMID:31926150 APAF1 Human ouabain increases expression EXP 6480464 Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 APAF1 Human ozone multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Vehicle Emissions results in increased abundance of Ozone] which results in increased expression of APAF1 protein CTD PMID:21355040 APAF1 Human p-menthan-3-ol increases expression EXP 6480464 Menthol results in increased expression of APAF1 mRNA CTD PMID:26760959 APAF1 Human paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of APAF1 protein CTD PMID:14749477 APAF1 Human paclitaxel multiple interactions EXP 6480464 [Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA CTD PMID:29309887 APAF1 Human paclitaxel multiple interactions ISO Apaf1 (Mus musculus) 6480464 APAF1 protein affects the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:17652622 APAF1 Human paeoniflorin multiple interactions ISO Apaf1 (Mus musculus) 6480464 peoniflorin inhibits the reaction [Neomycin results in increased expression of APAF1 mRNA] CTD PMID:29292089 APAF1 Human paracetamol affects expression ISO Apaf1 (Mus musculus) 6480464 Acetaminophen affects the expression of APAF1 mRNA CTD PMID:17562736 APAF1 Human paracetamol increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Acetaminophen results in increased expression of APAF1 mRNA CTD PMID:33387578 APAF1 Human paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of APAF1 mRNA CTD PMID:22230336 APAF1 Human paracetamol increases expression ISO Apaf1 (Mus musculus) 6480464 Acetaminophen results in increased expression of APAF1 mRNA CTD PMID:11752693 APAF1 Human paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of APAF1 mRNA CTD PMID:17064354 APAF1 Human paraquat affects splicing ISO Apaf1 (Mus musculus) 6480464 Paraquat affects the splicing of APAF1 exon CTD PMID:27111068 APAF1 Human paraquat affects splicing EXP 6480464 Paraquat affects the splicing of APAF1 mRNA CTD PMID:23613995 APAF1 Human paraquat increases expression EXP 6480464 Paraquat results in increased expression of APAF1 mRNA alternative form CTD PMID:17064354 APAF1 Human pentobarbital decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Pentobarbital results in decreased expression of APAF1 mRNA CTD PMID:16978161 APAF1 Human perfluorononanoic acid decreases expression EXP 6480464 perfluoro-n-nonanoic acid results in decreased expression of APAF1 mRNA CTD PMID:32588087 APAF1 Human peroxynitrous acid multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Curcumin inhibits the reaction [Peroxynitrous Acid results in increased expression of APAF1 mRNA] CTD PMID:20869986 APAF1 Human peroxynitrous acid increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Peroxynitrous Acid results in increased expression of APAF1 mRNA CTD PMID:20869986 APAF1 Human phenethyl isothiocyanate increases expression EXP 6480464 phenethyl isothiocyanate results in increased expression of APAF1 protein CTD PMID:16054126 APAF1 Human phenobarbital affects expression ISO Apaf1 (Mus musculus) 6480464 Phenobarbital affects the expression of APAF1 mRNA CTD PMID:23091169 APAF1 Human phenobarbital multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:27048571 APAF1 Human phenobarbital increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of APAF1 mRNA CTD PMID:23273579 APAF1 Human PhIP decreases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in decreased expression of APAF1 mRNA CTD PMID:20816883 APAF1 Human phorbol 13-acetate 12-myristate affects expression EXP 6480464 Tetradecanoylphorbol Acetate affects the expression of APAF1 protein CTD PMID:11139146 APAF1 Human pifithrin-? increases expression EXP 6480464 pifithrin results in increased expression of APAF1 protein CTD PMID:28483490 APAF1 Human pirinixic acid decreases expression ISO Apaf1 (Mus musculus) 6480464 pirinixic acid results in decreased expression of APAF1 mRNA CTD PMID:17426115 APAF1 Human propofol decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Propofol results in decreased expression of APAF1 protein CTD PMID:21468576 APAF1 Human propofol multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Propofol inhibits the reaction [Doxorubicin results in increased expression of APAF1 protein] CTD PMID:22015447 APAF1 Human propylparaben increases expression EXP 6480464 propylparaben results in increased expression of APAF1 mRNA CTD PMID:24481588 APAF1 Human pyrethrins decreases expression EXP 6480464 Pyrethrins results in decreased expression of APAF1 mRNA CTD PMID:35321623 APAF1 Human quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of APAF1 mRNA CTD PMID:15309432 APAF1 Human quercetin multiple interactions EXP 6480464 [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein CTD PMID:27470402 APAF1 Human quercetin increases expression EXP 6480464 Quercetin results in increased expression of APAF1 mRNA and Quercetin results in increased expression of APAF1 protein CTD PMID:14750173 more ... APAF1 Human resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of APAF1 mRNA and resveratrol results in decreased expression of APAF1 protein CTD PMID:12002526 and PMID:14749477 APAF1 Human resveratrol increases expression EXP 6480464 resveratrol results in increased expression of APAF1 mRNA CTD PMID:12569576 APAF1 Human rotenone increases expression EXP 6480464 Rotenone results in increased expression of APAF1 mRNA alternative form CTD PMID:17064354 APAF1 Human ruxolitinib multiple interactions EXP 6480464 [ruxolitinib co-treated with Arsenic Trioxide] results in increased expression of APAF1 mRNA CTD PMID:30012499 APAF1 Human S-(1,2-dichlorovinyl)-L-cysteine increases expression EXP 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of APAF1 protein CTD PMID:15967204 APAF1 Human safrole increases expression EXP 6480464 Safrole results in increased expression of APAF1 protein CTD PMID:21591240 APAF1 Human Se-methyl-L-selenocysteine increases expression EXP 6480464 selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA CTD PMID:25321483 APAF1 Human Se-methylselenocysteine increases expression EXP 6480464 selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA CTD PMID:25321483 APAF1 Human sinapic acid multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 sinapinic acid inhibits the reaction [lead acetate results in increased expression of APAF1 mRNA] CTD PMID:37471654 APAF1 Human sodium arsenite increases expression ISO Apaf1 (Rattus norvegicus) 6480464 sodium arsenite results in increased expression of APAF1 protein CTD PMID:20830294 APAF1 Human sodium arsenite increases expression ISO Apaf1 (Mus musculus) 6480464 sodium arsenite results in increased expression of APAF1 protein CTD PMID:29854073 APAF1 Human sodium arsenite multiple interactions ISO Apaf1 (Mus musculus) 6480464 salvin inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:29854073 APAF1 Human sodium arsenite multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Taurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:20830294 APAF1 Human sodium dichromate multiple interactions ISO Apaf1 (Mus musculus) 6480464 [Benzo(a)pyrene co-treated with sodium bichromate] results in increased expression of APAF1 mRNA CTD PMID:22613061 APAF1 Human sodium fluoride increases expression ISO Apaf1 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of APAF1 mRNA CTD PMID:30225638 APAF1 Human tanespimycin multiple interactions EXP 6480464 Scorpion Venoms results in increased susceptibility to [tanespimycin results in increased expression of APAF1 protein] CTD PMID:19913524 APAF1 Human tanespimycin increases expression EXP 6480464 tanespimycin results in increased expression of APAF1 protein CTD PMID:19913524 APAF1 Human taurine multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Taurine inhibits the reaction [Alloxan results in increased expression of APAF1 protein] and Taurine inhibits the reaction [sodium arsenite results in increased expression of APAF1 protein] CTD PMID:20830294 and PMID:23092809 APAF1 Human tauroursodeoxycholic acid affects expression ISO Apaf1 (Rattus norvegicus) 6480464 ursodoxicoltaurine affects the expression of APAF1 mRNA and ursodoxicoltaurine affects the expression of APAF1 protein CTD PMID:15885361 APAF1 Human tauroursodeoxycholic acid decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 ursodoxicoltaurine results in decreased expression of APAF1 mRNA CTD PMID:15885361 APAF1 Human tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of APAF1 protein CTD PMID:17419000 APAF1 Human tert-butyl hydroperoxide multiple interactions EXP 6480464 [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of APAF1 mRNA more ... CTD PMID:35690295 APAF1 Human tert-butyl hydroperoxide increases expression ISO Apaf1 (Rattus norvegicus) 6480464 tert-Butylhydroperoxide results in increased expression of APAF1 protein CTD PMID:15877105 APAF1 Human tert-butyl hydroperoxide multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein] CTD PMID:15877105 APAF1 Human thioacetamide increases expression ISO Apaf1 (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of APAF1 mRNA CTD PMID:34492290 APAF1 Human titanium dioxide decreases methylation ISO Apaf1 (Mus musculus) 6480464 titanium dioxide results in decreased methylation of APAF1 gene and titanium dioxide results in decreased methylation of APAF1 promoter alternative form CTD PMID:35295148 APAF1 Human topotecan multiple interactions ISO Apaf1 (Mus musculus) 6480464 APAF1 promotes the reaction [Topotecan results in increased cleavage of BID protein] more ... CTD PMID:19812371 APAF1 Human Tributyltin oxide increases expression ISO Apaf1 (Mus musculus) 6480464 bis(tri-n-butyltin)oxide results in increased expression of APAF1 mRNA CTD PMID:22434021 APAF1 Human trichloroethene increases methylation ISO Apaf1 (Rattus norvegicus) 6480464 Trichloroethylene results in increased methylation of APAF1 gene CTD PMID:27618143 APAF1 Human trichostatin A multiple interactions EXP 6480464 [trichostatin A results in increased activity of APAF1 protein] which results in increased susceptibility to Cisplatin CTD PMID:20925046 APAF1 Human trichostatin A increases activity EXP 6480464 trichostatin A results in increased activity of APAF1 protein CTD PMID:20925046 APAF1 Human Triptolide increases expression ISO Apaf1 (Mus musculus) 6480464 triptolide results in increased expression of APAF1 protein CTD PMID:25169008 and PMID:26990902 APAF1 Human Triptolide multiple interactions ISO Apaf1 (Rattus norvegicus) 6480464 NFE2L2 protein inhibits the reaction [triptolide results in increased expression of APAF1 protein] CTD PMID:25169008 APAF1 Human Triptolide increases expression ISO Apaf1 (Rattus norvegicus) 6480464 triptolide results in increased expression of APAF1 protein CTD PMID:25169008 APAF1 Human troglitazone decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 troglitazone results in decreased expression of APAF1 mRNA CTD PMID:21515302 APAF1 Human urethane increases expression EXP 6480464 Urethane results in increased expression of APAF1 mRNA CTD PMID:28818685 APAF1 Human ursodeoxycholic acid decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 Ursodeoxycholic Acid results in decreased expression of APAF1 mRNA and Ursodeoxycholic Acid results in decreased expression of APAF1 protein CTD PMID:15885361 APAF1 Human valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of APAF1 mRNA CTD PMID:24935251 APAF1 Human vemurafenib multiple interactions EXP 6480464 [(+)-JQ1 compound co-treated with vemurafenib] results in decreased expression of APAF1 mRNA CTD PMID:27169980 APAF1 Human vinclozolin decreases expression ISO Apaf1 (Rattus norvegicus) 6480464 vinclozolin results in decreased expression of APAF1 mRNA CTD PMID:23869203 APAF1 Human WIN 55212-2 decreases expression EXP 6480464 (3R)-((2 more ... CTD PMID:30776504 APAF1 Human zearalenone increases expression ISO Apaf1 (Mus musculus) 6480464 Zearalenone results in increased expression of APAF1 mRNA CTD PMID:34537261 APAF1 Human zebularine affects expression EXP 6480464 pyrimidin-2-one beta-ribofuranoside affects the expression of APAF1 mRNA CTD PMID:17133271 APAF1 Human zinc oxide multiple interactions ISO Apaf1 (Mus musculus) 6480464 Zinc Oxide affects the splicing of and results in increased expression of APAF1 mRNA CTD PMID:30500950 APAF1 Human zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of APAF1 mRNA CTD PMID:28871336 APAF1 Human zoledronic acid increases expression ISO Apaf1 (Mus musculus) 6480464 zoledronic acid results in increased expression of APAF1 mRNA CTD PMID:28871336
