MIR221 (microRNA 221) - Rat Genome Database
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Gene: MIR221 (microRNA 221) Homo sapiens
Analyze
Symbol: MIR221
Name: microRNA 221
RGD ID: 1349484
HGNC Page HGNC
Description: Predicted to be involved in several processes, including cellular response to forskolin; cellular response to tumor necrosis factor; and long-term synaptic potentiation. Predicted to localize to RISC complex and synapse. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: mir-221; MIRN221; miRNA221
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX45,746,157 - 45,746,266 (-)EnsemblGRCh38hg38GRCh38
GRCh38X45,746,157 - 45,746,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X45,605,585 - 45,605,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,490,528 - 45,490,637 (-)NCBINCBI36hg18NCBI36
CeleraX49,797,482 - 49,797,591 (-)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX43,320,976 - 43,321,084 (-)NCBIHuRef
CHM1_1X45,638,042 - 45,638,151 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)
synapse  (ISO)

References

Additional References at PubMed
PMID:12624257   PMID:15325244   PMID:16330772   PMID:16365291   PMID:16381832   PMID:17569667   PMID:17604727   PMID:17616659   PMID:17721077   PMID:17914108   PMID:18246122   PMID:18382364  
PMID:18413744   PMID:18521080   PMID:18548003   PMID:18708351   PMID:18759060   PMID:18766170   PMID:18794255   PMID:19088079   PMID:19107213   PMID:19109175   PMID:19126397   PMID:19153141  
PMID:19159078   PMID:19351599   PMID:19351832   PMID:19424584   PMID:19464057   PMID:19585579   PMID:19615744   PMID:19671867   PMID:19730150   PMID:19749093   PMID:19767219   PMID:19953484  
PMID:19962668   PMID:20012062   PMID:20018759   PMID:20110463   PMID:20146005   PMID:20158877   PMID:20167074   PMID:20198336   PMID:20203269   PMID:20299489   PMID:20305142   PMID:20388878  
PMID:20417062   PMID:20428775   PMID:20461750   PMID:20516212   PMID:20547861   PMID:20624000   PMID:20813046   PMID:20818387   PMID:20880178   PMID:20975375   PMID:21037258   PMID:21042732  
PMID:21057537   PMID:21071579   PMID:21076613   PMID:21119596   PMID:21132270   PMID:21159845   PMID:21236259   PMID:21278784   PMID:21310411   PMID:21378318   PMID:21458843   PMID:21487968  
PMID:21538272   PMID:21562054   PMID:21586237   PMID:21673316   PMID:21706050   PMID:21743492   PMID:21756067   PMID:21868360   PMID:21873159   PMID:22075712   PMID:22117988   PMID:22127852  
PMID:22156446   PMID:22267590   PMID:22272270   PMID:22275134   PMID:22294051   PMID:22396537   PMID:22466166   PMID:22562984   PMID:22572970   PMID:22613407   PMID:22660186   PMID:22681957  
PMID:22685016   PMID:22728346   PMID:22855362   PMID:22864280   PMID:23023232   PMID:23031797   PMID:23307259   PMID:23320393   PMID:23333386   PMID:23353719   PMID:23372675   PMID:23390134  
PMID:23400877   PMID:23444217   PMID:23497354   PMID:23564792   PMID:23569131   PMID:23579640   PMID:23607629   PMID:23630541   PMID:23648338   PMID:23770133   PMID:23770851   PMID:23776679  
PMID:23860376   PMID:23867206   PMID:23895238   PMID:23944957   PMID:24093444   PMID:24129242   PMID:24147037   PMID:24147153   PMID:24195082   PMID:24269686   PMID:24286315   PMID:24295494  
PMID:24319365   PMID:24324033   PMID:24409057   PMID:24412053   PMID:24475314   PMID:24607843   PMID:24643689   PMID:24667259   PMID:24674454   PMID:24718706   PMID:24736554   PMID:24760272  
PMID:24832085   PMID:24892674   PMID:24905916   PMID:24913549   PMID:24931456   PMID:24969479   PMID:24993451   PMID:25007959   PMID:25019494   PMID:25053875   PMID:25190021   PMID:25233396  
PMID:25236949   PMID:25279769   PMID:25428536   PMID:25430553   PMID:25433287   PMID:25447917   PMID:25483016   PMID:25585941   PMID:25586265   PMID:25686829   PMID:25731730   PMID:25738598  
PMID:25761682   PMID:25865302   PMID:25883224   PMID:25891943   PMID:25893733   PMID:25898773   PMID:25910754   PMID:25928257   PMID:26106610   PMID:26117405   PMID:26164758   PMID:26186233  
PMID:26191177   PMID:26191221   PMID:26197878   PMID:26209976   PMID:26249174   PMID:26253160   PMID:26325107   PMID:26364844   PMID:26397386   PMID:26422796   PMID:26464363   PMID:26482612  
PMID:26501139   PMID:26503209   PMID:26527748   PMID:26556862   PMID:26571175   PMID:26637460   PMID:26646931   PMID:26708164   PMID:26772615   PMID:26788506   PMID:26806834   PMID:26827795  
PMID:26831656   PMID:26930142   PMID:26990535   PMID:26997108   PMID:27035337   PMID:27044817   PMID:27174021   PMID:27230035   PMID:27358112   PMID:27374153   PMID:27420990   PMID:27427222  
PMID:27488105   PMID:27513632   PMID:27542224   PMID:27629767   PMID:27644883   PMID:27712596   PMID:27748571   PMID:27780851   PMID:27798914   PMID:27834806   PMID:27835701   PMID:27837435  
PMID:27940575   PMID:27983537   PMID:28003306   PMID:28057486   PMID:28061868   PMID:28111007   PMID:28191469   PMID:28236026   PMID:28366737   PMID:28392366   PMID:28431233   PMID:28434388  
PMID:28442344   PMID:28453462   PMID:28519068   PMID:28539268   PMID:28576513   PMID:28618968   PMID:28628920   PMID:28677788   PMID:28694128   PMID:28770966   PMID:28774868   PMID:28798470  
PMID:28844858   PMID:28886115   PMID:28938482   PMID:28978468   PMID:28986522   PMID:29036829   PMID:29120535   PMID:29172404   PMID:29181884   PMID:29242498   PMID:29301198   PMID:29474925  
PMID:29476051   PMID:29479893   PMID:29506516   PMID:29529124   PMID:29596155   PMID:29630521   PMID:29644894   PMID:29666964   PMID:29687843   PMID:29729889   PMID:29737876   PMID:29754884  
PMID:29789601   PMID:29843209   PMID:29876362   PMID:29894779   PMID:30015977   PMID:30024497   PMID:30053090   PMID:30115076   PMID:30130742   PMID:30254211   PMID:30274025   PMID:30370582  
PMID:30378307   PMID:30396069   PMID:30396237   PMID:30485259   PMID:30516071   PMID:30538172   PMID:30551723   PMID:30551873   PMID:30582227   PMID:30582979   PMID:30654657   PMID:30688676  
PMID:30816673   PMID:30887564   PMID:30891072   PMID:30911942   PMID:30926320   PMID:30993566   PMID:31045265   PMID:31069760   PMID:31084400   PMID:31106423   PMID:31114989   PMID:31115025  
PMID:31173294   PMID:31180541   PMID:31211948   PMID:31214616   PMID:31221814   PMID:31238903   PMID:31307177   PMID:31341019   PMID:31416845   PMID:31422498   PMID:31470827   PMID:31486498  
PMID:31514066   PMID:31550968   PMID:31569377   PMID:31570425   PMID:31607285   PMID:31698701   PMID:31773681   PMID:31828111   PMID:31828133   PMID:31839741   PMID:31926502   PMID:32319375  
PMID:32487621   PMID:33285691  


Genomics

Comparative Map Data
MIR221
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX45,746,157 - 45,746,266 (-)EnsemblGRCh38hg38GRCh38
GRCh38X45,746,157 - 45,746,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X45,605,585 - 45,605,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X45,490,528 - 45,490,637 (-)NCBINCBI36hg18NCBI36
CeleraX49,797,482 - 49,797,591 (-)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX43,320,976 - 43,321,084 (-)NCBIHuRef
CHM1_1X45,638,042 - 45,638,151 (-)NCBICHM1_1
Mir221
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X19,012,533 - 19,012,627 (-)NCBIGRCm39mm39
GRCm38X19,146,294 - 19,146,388 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX19,146,294 - 19,146,388 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X18,723,420 - 18,723,514 (-)NCBIGRCm37mm9NCBIm37
CeleraX16,722,452 - 16,722,546 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
Mir221
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X3,684,480 - 3,684,588 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX3,684,480 - 3,684,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X4,475,295 - 4,475,403 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
CeleraX3,969,242 - 3,969,350 (+)NCBICelera
Cytogenetic MapXq11NCBI
MIR221
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX39,523,885 - 39,523,954 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X39,523,890 - 39,523,951 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MIR221
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX40,571,068 - 40,571,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X40,571,068 - 40,571,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X45,274,873 - 45,274,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Northern Functional MTI17569667
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19088079
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18155131
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19153141
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoWestern blot//Northern blotFunctional MTI19107213
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19859555
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18246122
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19150885
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18521080
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18834855
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18983236
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19749093
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18417445
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCRFunctional MTI (Weak)20012062
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI20018759
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//LucifFunctional MTI19424584
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI17721077
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI17627278
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI18708351
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoReporter assayFunctional MTI17914108
CDKN1Bhsa-miR-221-3pMirtarbaseexternal_infoReporter assayFunctional MTI18413744
BCL2L11hsa-miR-221-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
BMFhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19671867
FOXO3hsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//ChIP//Luciferase reporter assay//Western Functional MTI20388878
DICER1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21761362
KIThsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19126397
KIThsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI18417445
KIThsa-miR-221-3pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI16365291
KIThsa-miR-221-3pMirtarbaseexternal_infoReporter assay;MicroarrayFunctional MTI20018759
KIThsa-miR-221-3pMirtarbaseexternal_infoReporter assayFunctional MTI16330772
CDKN1Chsa-miR-221-3pMirtarbaseexternal_infoReporter assay//Luciferase reporter assay//qRT-PCRFunctional MTI18521080
CDKN1Chsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21278784
TMED7hsa-miR-221-3pMirtarbaseexternal_infoWestern blotFunctional MTI21226887
TMED7hsa-miR-221-3pMirtarbaseexternal_infoReporter assay;qRT-PCRFunctional MTI20018759
HMGXB4hsa-miR-221-3pMirtarbaseexternal_infoReporter assay;MicroarrayNon-Functional MTI20018759
BBC3hsa-miR-221-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//LucifFunctional MTI20813046
TBK1hsa-miR-221-3pMirtarbaseexternal_infoReporter assay;Western blot;MicroarrayFunctional MTI20018759
BNIP3Lhsa-miR-221-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCR;MicroarrayFunctional MTI20018759
DDIT4hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI20018759
TIMP3hsa-miR-221-3pMirtarbaseexternal_infoFlow//Immunohistochemistry//Luciferase reporter asFunctional MTI19962668
TIMP3hsa-miR-221-3pMirtarbaseexternal_infoImmunohistochemistry//In situ hybridization//qRT-PFunctional MTI22009755
TIMP3hsa-miR-221-3pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCR//WesternFunctional MTI22681957
TNFSF10hsa-miR-221-3pMirtarbaseexternal_infoWestern blotFunctional MTI18246122
ICAM1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20110463
ICAM1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI19949084
FOShsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
FOShsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23400877
NAIPhsa-miR-221-3pMirtarbaseexternal_infoWestern blotFunctional MTI18759060
ESR1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI18790736
TICAM1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI21236259
PTENhsa-miR-221-3pMirtarbaseexternal_infoFACS//Flow//Luciferase reporter assay//Northern blFunctional MTI20618998
PTENhsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23372675
TP53hsa-miR-221-3pMirtarbaseexternal_infoWestern blotNon-Functional MTI21226887
CERS2hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22393241
FMR1hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23390134
DVL2hsa-miR-221-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI21487968
POU3F2hsa-miR-221-3pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)20516212
MEOX2hsa-miR-221-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI20516212
ZEB2hsa-miR-221-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI20516212
CDKN1Bhsa-miR-221-3pTarbaseexternal_infoReporter GenePOSITIVE
CDKN1Bhsa-miR-221-3pTarbaseexternal_infoNothernblot POSITIVE
CDKN1Bhsa-miR-221-3pTarbaseexternal_infoWesternblitPOSITIVE
HOXC10hsa-miR-221-3pTarbaseexternal_infoqPCRNEGATIVE
BRAPhsa-miR-221-3pTarbaseexternal_infoReporter GeneNEGATIVE
BRAPhsa-miR-221-3pTarbaseexternal_infoMicroarrayPOSITIVE
DDIT4hsa-miR-221-3pTarbaseexternal_infoqPCRPOSITIVE
ZKSCAN8hsa-miR-221-3pTarbaseexternal_infoSequencingPOSITIVE
FOShsa-miR-221-3pOncomiRDBexternal_infoNANA23400877
TIMP3hsa-miR-221-3pOncomiRDBexternal_infoNANA22681957
GJA1hsa-miR-221-3pOncomiRDBexternal_infoNANA22294051
APAF1hsa-miR-221-3pOncomiRDBexternal_infoNANA22157681
TIMP3hsa-miR-221-3pOncomiRDBexternal_infoNANA22009755
TRPS1hsa-miR-221-3pOncomiRDBexternal_infoNANA21868360
DICER1hsa-miR-221-3pOncomiRDBexternal_infoNANA21761362
PTPRMhsa-miR-221-3pOncomiRDBexternal_infoNANA21743492
TRPS1hsa-miR-221-3pOncomiRDBexternal_infoNANA21673316
CDKN1Chsa-miR-221-3pOncomiRDBexternal_infoNANA21278784
DIRAS3hsa-miR-221-3pOncomiRDBexternal_infoNANA21071579
BBC3hsa-miR-221-3pOncomiRDBexternal_infoNANA21042732
BBC3hsa-miR-221-3pOncomiRDBexternal_infoNANA20813046
PTENhsa-miR-221-3pOncomiRDBexternal_infoNANA20618998
FOXO3hsa-miR-221-3pOncomiRDBexternal_infoNANA20388878
DDIT4hsa-miR-221-3pOncomiRDBexternal_infoNANA20018759
PTENhsa-miR-221-3pOncomiRDBexternal_infoNANA19962668
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA19749093
BMFhsa-miR-221-3pOncomiRDBexternal_infoNANA19671867
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA21475881
CDKN1Ahsa-miR-221-3pOncomiRDBexternal_infoNANA19153141
KIThsa-miR-221-3pOncomiRDBexternal_infoNANA19126397
ESR1hsa-miR-221-3pOncomiRDBexternal_infoNANA18790736
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA18708351
CDKN1Chsa-miR-221-3pOncomiRDBexternal_infoNANA18521080
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA18417445
KIThsa-miR-221-3pOncomiRDBexternal_infoNANA18246122
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA17914108
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA17721077
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA17627278
CDKN1Bhsa-miR-221-3pOncomiRDBexternal_infoNANA17569667
KIThsa-miR-221-3pOncomiRDBexternal_infoNANA16330772
SGSM1hsa-miR-221-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
KIThsa-miR-221-5pMirecordsexternal_info{unchanged}NA16330772
CDKN1Bhsa-miR-221-5pMirecordsexternal_infoNANA18155131
CDKN1Bhsa-miR-221-5pMirecordsexternal_infoNANA17721077
CDKN1Bhsa-miR-221-5pMirecordsexternal_infoNANA18413744
CDKN1Bhsa-miR-221-5pMirecordsexternal_info{unchanged}NA18417445
CDKN1Bhsa-miR-221-5pMirecordsexternal_info{changed}NA17569667
CDKN1Bhsa-miR-221-5pMirecordsexternal_info{unchanged}NA17627278
CDKN1Chsa-miR-221-5pMirecordsexternal_infoNANA18521080
ESR1hsa-miR-221-5pMirecordsexternal_info{unchanged}NA18790736
CDKN1Bhsa-miR-221-5pMirecordsexternal_info{changed}NA18708351
CDKN1Bhsa-miR-221-5pMirecordsexternal_infoNANA19107213
KIThsa-miR-221-5pMirecordsexternal_infoNANA19126397
FOShsa-miR-221-5pMirecordsexternal_infoNANA20299489
DDIT4hsa-miR-221-5pMirecordsexternal_info{changed}NA20018759
ICAM1hsa-miR-221-5pMirecordsexternal_info{unchanged}NA20110463
BMFhsa-miR-221-5pMirecordsexternal_info{unchanged}NA19671867
PIK3R1hsa-miR-221-5pMirecordsexternal_info{changed}NA20505758
PTENhsa-miR-221-5pMirecordsexternal_infoNANA20618998
CDKN1Chsa-miR-221-5pMirecordsexternal_infoNANA21226887
TIMP3hsa-miR-221-5pMirecordsexternal_info{changed}NA22009755

Predicted Targets
Summary Value
Count of predictions:42812
Count of gene targets:16481
Count of transcripts:35588
Interacting mature miRNAs:hsa-miR-221-3p, hsa-miR-221-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1
Medium 57 9 82 6 92 8 91 24 38 31 142 246 4 49 13 1
Low 1418 1366 572 246 991 110 2614 769 844 216 762 935 142 719 1500 3
Below cutoff 353 564 238 65 179 54 522 501 731 32 120 84 11 134 409

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385135
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 EnsemblX45,746,157 - 45,746,266 (-)Ensembl
RefSeq Acc Id: NR_029635
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X45,746,157 - 45,746,266 (-)NCBI
GRCh37X45,605,585 - 45,605,694 (-)ENTREZGENE
HuRefX43,320,976 - 43,321,084 (-)ENTREZGENE
CHM1_1X45,638,042 - 45,638,151 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x3 copy number gain See cases [RCV000133911] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|likely pathogenic|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x3 copy number gain See cases [RCV000050810] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:3092486-155699618)x2 copy number gain See cases [RCV000050889] ChrX:3092486..155699618 [GRCh38]
ChrX:3010527..154929279 [GRCh37]
ChrX:3020527..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x1 copy number loss See cases [RCV000050811] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000050699] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss Global developmental delay [RCV000050386]|See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000050697] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-11.22(chrX:10679-52809182)x1 copy number loss See cases [RCV000051026] ChrX:10679..52809182 [GRCh38]
ChrX:60679..52838206 [GRCh37]
ChrX:679..52854931 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40704-156022362)x3 copy number gain See cases [RCV000052325] ChrX:40704..156022362 [GRCh38]
ChrX:90704..155252027 [GRCh37]
ChrX:30704..154905221 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26101-155999293)x3 copy number gain See cases [RCV000052322] ChrX:26101..155999293 [GRCh38]
ChrX:76101..155228958 [GRCh37]
ChrX:16101..154882152 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2790845-155699618)x3 copy number gain See cases [RCV000052359] ChrX:2790845..155699618 [GRCh38]
ChrX:2708886..154929279 [GRCh37]
ChrX:2718886..154582473 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:237659-156022362)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052327]|See cases [RCV000052327] ChrX:237659..156022362 [GRCh38]
ChrX:154326..155252027 [GRCh37]
ChrX:94326..154905221 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:27245-155996431)x3 copy number gain See cases [RCV000052324] ChrX:27245..155996431 [GRCh38]
ChrX:77245..155226096 [GRCh37]
ChrX:17245..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.3(chrX:675360-46016699)x3 copy number gain See cases [RCV000052328] ChrX:675360..46016699 [GRCh38]
ChrX:636095..45876134 [GRCh37]
ChrX:556095..45761078 [NCBI36]
ChrX:Xp22.33-11.3
pathogenic
GRCh38/hg38 Xp11.4-11.23(chrX:41434043-47880733)x1 copy number loss See cases [RCV000053088] ChrX:41434043..47880733 [GRCh38]
ChrX:41293296..47619970 [GRCh37]
ChrX:41178240..47625076 [NCBI36]
ChrX:Xp11.4-11.23
pathogenic
GRCh38/hg38 Xp22.33-11.23(chrX:10679-48344725)x1 copy number loss See cases [RCV000052981] ChrX:10679..48344725 [GRCh38]
ChrX:60679..48204160 [GRCh37]
ChrX:679..48089104 [NCBI36]
ChrX:Xp22.33-11.23
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss Global developmental delay [RCV000052986]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|Intellectual functioning disability [RCV000052988]|Global developmental delay [RCV000052989]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052987]|See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q22.1(chrX:675360-100368517)x1 copy number loss See cases [RCV000053005] ChrX:675360..100368517 [GRCh38]
ChrX:636095..99623515 [GRCh37]
ChrX:556095..99510171 [NCBI36]
ChrX:Xp22.33-q22.1
pathogenic
GRCh38/hg38 Xp22.33-11.21(chrX:26102-57302794)x1 copy number loss See cases [RCV000052990] ChrX:26102..57302794 [GRCh38]
ChrX:76102..57329227 [GRCh37]
ChrX:16102..57345952 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-11.21(chrX:2769041-58055036)x1 copy number loss See cases [RCV000053007] ChrX:2769041..58055036 [GRCh38]
ChrX:2687082..58081470 [GRCh37]
ChrX:2697082..58098195 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss Hypoplastic left heart [RCV000052982]|See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.1(chrX:253129-58271563)x1 copy number loss See cases [RCV000052994] ChrX:253129..58271563 [GRCh38]
ChrX:169796..58297997 [GRCh37]
ChrX:109796..58314722 [NCBI36]
ChrX:Xp22.33-11.1
pathogenic
GRCh38/hg38 Xp22.33-11.21(chrX:10679-55550898)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052971]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052971]|See cases [RCV000052971] ChrX:10679..55550898 [GRCh38]
ChrX:60679..55577331 [GRCh37]
ChrX:679..55594056 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain Global developmental delay [RCV000052984]|Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052985]|See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10479-54179172)x3 copy number gain See cases [RCV000053817] ChrX:10479..54179172 [GRCh38]
ChrX:60479..53957191 [GRCh37]
ChrX:479..54222330 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:70297-58066465)x3 copy number gain See cases [RCV000239834] ChrX:70297..58066465 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-155978689)x1 copy number loss See cases [RCV000133792] ChrX:10701..155978689 [GRCh38]
ChrX:60701..155208354 [GRCh37]
ChrX:701..154861548 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10701-52857805)x1 copy number loss See cases [RCV000133817] ChrX:10701..52857805 [GRCh38]
ChrX:60701..52886834 [GRCh37]
ChrX:701..52903559 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:679..154896026 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:14245-155999293)x1 copy number loss See cases [RCV000052982] ChrX:14245..155999293 [GRCh38]
ChrX:64245..155228958 [GRCh37]
ChrX:4245..154882152 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x1 copy number loss See cases [RCV000052986] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26102-155996431)x3 copy number gain See cases [RCV000052984] ChrX:26102..155996431 [GRCh38]
ChrX:76102..155226096 [GRCh37]
ChrX:16102..154879290 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
NC_000023.10:g.(?_43479884)_(46741003_?)del deletion Kabuki syndrome 2 [RCV000172943] ChrX:43479884..46741003 [GRCh37]
ChrX:Xp11.3-11.23
likely pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022826)x4 copy number gain See cases [RCV000133654] ChrX:10679..156022826 [GRCh38]
ChrX:60679..155252491 [GRCh37]
ChrX:679..154905685 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.23(chrX:10679-50059388)x1 copy number loss See cases [RCV000133745] ChrX:10679..50059388 [GRCh38]
ChrX:60679..49824045 [GRCh37]
ChrX:679..49710785 [NCBI36]
ChrX:Xp22.33-11.23
pathogenic
GRCh38/hg38 Xp22.33-q11.1(chrX:10701-62712219)x1 copy number loss See cases [RCV000134568] ChrX:10701..62712219 [GRCh38]
ChrX:60701..61931689 [GRCh37]
ChrX:701..61848414 [NCBI36]
ChrX:Xp22.33-q11.1
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-155999253)x3 copy number gain See cases [RCV000134564] ChrX:20297..155999253 [GRCh38]
ChrX:70297..155228918 [GRCh37]
ChrX:10297..154882112 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003242)x1 copy number loss See cases [RCV000133947] ChrX:10701..156003242 [GRCh38]
ChrX:60701..155232907 [GRCh37]
ChrX:701..154886101 [NCBI36]
ChrX:Xp22.33-q28
pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-11.21(chrX:10701-58055053)x1 copy number loss See cases [RCV000134026] ChrX:10701..58055053 [GRCh38]
ChrX:60701..58081487 [GRCh37]
ChrX:701..58098212 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:37076284-156016920)x1 copy number loss See cases [RCV000135300] ChrX:37076284..156016920 [GRCh38]
ChrX:37094357..155246585 [GRCh37]
ChrX:37004278..154899779 [NCBI36]
ChrX:Xp21.1-q28
pathogenic
GRCh38/hg38 Xp22.31-11.22(chrX:8176030-53962833)x1 copy number loss See cases [RCV000135305] ChrX:8176030..53962833 [GRCh38]
ChrX:8144071..53989266 [GRCh37]
ChrX:8104071..54005991 [NCBI36]
ChrX:Xp22.31-11.22
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156026127)x1 copy number loss See cases [RCV000135321] ChrX:20297..156026127 [GRCh38]
ChrX:70297..155255792 [GRCh37]
ChrX:10297..154908986 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp11.3-11.22(chrX:43361870-50931794)x3 copy number gain See cases [RCV000134956] ChrX:43361870..50931794 [GRCh38]
ChrX:43221119..50674794 [GRCh37]
ChrX:43106063..50691534 [NCBI36]
ChrX:Xp11.3-11.22
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10679-52857805)x3 copy number gain See cases [RCV000134957] ChrX:10679..52857805 [GRCh38]
ChrX:60679..52886834 [GRCh37]
ChrX:679..52903559 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp21.1-q28(chrX:36237706-156022206)x1 copy number loss See cases [RCV000135552] ChrX:36237706..156022206 [GRCh38]
ChrX:36255823..155251871 [GRCh37]
ChrX:36165744..154905065 [NCBI36]
ChrX:Xp21.1-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:40904-155998166)x1 copy number loss See cases [RCV000136478] ChrX:40904..155998166 [GRCh38]
ChrX:90904..155227831 [GRCh37]
ChrX:30904..154881025 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x1 copy number loss See cases [RCV000136097] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q25(chrX:10701-128393708) copy number loss See cases [RCV000136094] ChrX:10701..128393708 [GRCh38]
ChrX:60701..127527686 [GRCh37]
ChrX:701..127355367 [NCBI36]
ChrX:Xp22.33-q25
pathogenic
GRCh38/hg38 Xp11.3(chrX:45555332-46436439)x2 copy number gain See cases [RCV000135948] ChrX:45555332..46436439 [GRCh38]
ChrX:45414577..46295874 [GRCh37]
ChrX:45299521..46180818 [NCBI36]
ChrX:Xp11.3
uncertain significance
GRCh38/hg38 Xp22.33-q28(chrX:10001-156030895)x1 copy number loss See cases [RCV000136005] ChrX:10001..156030895 [GRCh38]
ChrX:60001..155260560 [GRCh37]
ChrX:1..154913754 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10679-52213731)x1 copy number loss See cases [RCV000137112] ChrX:10679..52213731 [GRCh38]
ChrX:60679..51948998 [GRCh37]
ChrX:679..51973598 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic|uncertain significance
GRCh38/hg38 Xp22.33-q28(chrX:2782275-155611794)x2 copy number gain See cases [RCV000136841] ChrX:2782275..155611794 [GRCh38]
ChrX:2700316..154785891 [GRCh37]
ChrX:2710316..154494649 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2765636-155522304)x3 copy number gain See cases [RCV000136791] ChrX:2765636..155522304 [GRCh38]
ChrX:2683677..154751965 [GRCh37]
ChrX:2693677..154405159 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10701-52033734)x1 copy number loss See cases [RCV000137430] ChrX:10701..52033734 [GRCh38]
ChrX:60701..51776830 [GRCh37]
ChrX:701..51793570 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-11.21(chrX:10701-58055036)x1 copy number loss See cases [RCV000137552] ChrX:10701..58055036 [GRCh38]
ChrX:60701..58081470 [GRCh37]
ChrX:701..58098195 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-11.23(chrX:10701-49071220)x1 copy number loss See cases [RCV000137413] ChrX:10701..49071220 [GRCh38]
ChrX:60701..48928877 [GRCh37]
ChrX:701..48815821 [NCBI36]
ChrX:Xp22.33-11.23
pathogenic
GRCh38/hg38 Xp22.33-11.23(chrX:10679-49157514)x1 copy number loss See cases [RCV000137166] ChrX:10679..49157514 [GRCh38]
ChrX:60679..49016667 [GRCh37]
ChrX:679..48903611 [NCBI36]
ChrX:Xp22.33-11.23
pathogenic
GRCh38/hg38 Xp11.3-11.23(chrX:44765664-49343053)x3 copy number gain See cases [RCV000137271] ChrX:44765664..49343053 [GRCh38]
ChrX:44624910..49218180 [GRCh37]
ChrX:44509854..49105124 [NCBI36]
ChrX:Xp11.3-11.23
likely pathogenic
GRCh38/hg38 Xp22.33-q13.3(chrX:10679-76420505)x3 copy number gain See cases [RCV000137137] ChrX:10679..76420505 [GRCh38]
ChrX:60679..75640898 [GRCh37]
ChrX:679..75557302 [NCBI36]
ChrX:Xp22.33-q13.3
pathogenic|likely benign
GRCh38/hg38 Xp22.33-q22.3(chrX:10701-106113403)x1 copy number loss See cases [RCV000137886] ChrX:10701..106113403 [GRCh38]
ChrX:60701..105357395 [GRCh37]
ChrX:701..105244051 [NCBI36]
ChrX:Xp22.33-q22.3
pathogenic
GRCh38/hg38 Xp22.2-q27.3(chrX:13020141-143473520)x1 copy number loss See cases [RCV000138678] ChrX:13020141..143473520 [GRCh38]
ChrX:13038260..142561303 [GRCh37]
ChrX:12948181..142388969 [NCBI36]
ChrX:Xp22.2-q27.3
pathogenic
GRCh38/hg38 Xp22.33-q21.31(chrX:10701-88318651)x1 copy number loss See cases [RCV000139352] ChrX:10701..88318651 [GRCh38]
ChrX:60701..87573652 [GRCh37]
ChrX:701..87460308 [NCBI36]
ChrX:Xp22.33-q21.31
pathogenic
GRCh38/hg38 Xp22.33-11.1(chrX:10701-58517661)x1 copy number loss See cases [RCV000139343] ChrX:10701..58517661 [GRCh38]
ChrX:60701..58544094 [GRCh37]
ChrX:701..58560819 [NCBI36]
ChrX:Xp22.33-11.1
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:1085618-155699644)x1 copy number loss See cases [RCV000139278] ChrX:1085618..155699644 [GRCh38]
ChrX:1118268..154929305 [GRCh37]
ChrX:1038268..154582499 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004181)x3 copy number gain See cases [RCV000139888] ChrX:251880..156004181 [GRCh38]
ChrX:168547..155233846 [GRCh37]
ChrX:108547..154887040 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2299223-155992188)x3 copy number gain See cases [RCV000141400] ChrX:2299223..155992188 [GRCh38]
ChrX:2217264..155221853 [GRCh37]
ChrX:2227264..154875047 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20297-156016920)x3 copy number gain See cases [RCV000141401] ChrX:20297..156016920 [GRCh38]
ChrX:70297..155246585 [GRCh37]
ChrX:10297..154899779 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x4 copy number gain See cases [RCV000140786] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10701-53750424)x1 copy number loss See cases [RCV000140711] ChrX:10701..53750424 [GRCh38]
ChrX:60701..53776922 [GRCh37]
ChrX:701..53793647 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x1 copy number loss See cases [RCV000140787] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic|conflicting data from submitters
GRCh38/hg38 Xp22.33-11.22(chrX:251879-50289363)x1 copy number loss See cases [RCV000141741] ChrX:251879..50289363 [GRCh38]
ChrX:168546..50032363 [GRCh37]
ChrX:108546..50049103 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-q12(chrX:251880-66445845)x1 copy number loss See cases [RCV000142334] ChrX:251880..66445845 [GRCh38]
ChrX:168547..65665687 [GRCh37]
ChrX:108547..65582412 [NCBI36]
ChrX:Xp22.33-q12
pathogenic
GRCh38/hg38 Xp22.33-q24(chrX:251879-118847157)x3 copy number gain See cases [RCV000142134] ChrX:251879..118847157 [GRCh38]
ChrX:168546..117981120 [GRCh37]
ChrX:108546..117865148 [NCBI36]
ChrX:Xp22.33-q24
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:251880-51643625)x1 copy number loss See cases [RCV000142035] ChrX:251880..51643625 [GRCh38]
ChrX:168547..51386559 [GRCh37]
ChrX:108547..51403299 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp11.3-11.23(chrX:44632305-47607180)x2 copy number gain See cases [RCV000143089] ChrX:44632305..47607180 [GRCh38]
ChrX:44491551..47466579 [GRCh37]
ChrX:44376495..47351523 [NCBI36]
ChrX:Xp11.3-11.23
likely pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10701-156003229)x3 copy number gain See cases [RCV000142625] ChrX:10701..156003229 [GRCh38]
ChrX:60701..155232894 [GRCh37]
ChrX:701..154886088 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.22(chrX:10701-53131191)x1 copy number loss See cases [RCV000143348] ChrX:10701..53131191 [GRCh38]
ChrX:60701..53047381 [GRCh37]
ChrX:701..53177098 [NCBI36]
ChrX:Xp22.33-11.22
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x1 copy number loss See cases [RCV000143441] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:108546..154886925 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251879-156004066)x3 copy number gain See cases [RCV000143433] ChrX:251879..156004066 [GRCh38]
ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-11.21(chrX:251879-56428859)x1 copy number loss See cases [RCV000143130] ChrX:251879..56428859 [GRCh38]
ChrX:168546..56455292 [GRCh37]
ChrX:108546..56472017 [NCBI36]
ChrX:Xp22.33-11.21
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:251880-156004066)x3 copy number gain See cases [RCV000143219] ChrX:251880..156004066 [GRCh38]
ChrX:168547..155233731 [GRCh37]
ChrX:108547..154886925 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000148135] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000148141] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155246643)x3 copy number gain See cases [RCV000240122] ChrX:71267..155246643 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155250222)x3 copy number gain See cases [RCV000239843] ChrX:176426..155250222 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:70297-58066465)x1 copy number loss See cases [RCV000239814] ChrX:70297..58066465 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255839)x1 copy number loss See cases [RCV000239832] ChrX:71267..155255839 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.2-q28(chrX:13147668-155250222)x3 copy number gain See cases [RCV000239798] ChrX:13147668..155250222 [GRCh37]
ChrX:Xp22.2-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255839)x3 copy number gain See cases [RCV000239934] ChrX:70297..155255839 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x2 copy number gain See cases [RCV000240106] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246271)x3 copy number gain See cases [RCV000239989] ChrX:60701..155246271 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:553069-155233731)x1 copy number loss See cases [RCV000446026] ChrX:553069..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155224766)x1 copy number loss See cases [RCV000239902] ChrX:71267..155224766 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155234036)x2 copy number gain See cases [RCV000239874] ChrX:71267..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp11.3-q21.1(chrX:44734936-79676121)x3 copy number gain See cases [RCV000240019] ChrX:44734936..79676121 [GRCh37]
ChrX:Xp11.3-q21.1
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:176426-155236656)x3 copy number gain See cases [RCV000240552] ChrX:176426..155236656 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:225816-155234036)x2 copy number gain See cases [RCV000240464] ChrX:225816..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:150002-155234036)x3 copy number gain See cases [RCV000240314] ChrX:150002..155234036 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2707626-155250222)x2 copy number gain See cases [RCV000240541] ChrX:2707626..155250222 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.2-q25(chrX:11692290-121187337)x2 copy number gain not provided [RCV000488046] ChrX:11692290..121187337 [GRCh37]
ChrX:Xp22.2-q25
uncertain significance
Single allele duplication Syndromic X-linked intellectual disability Lubs type [RCV000768455] ChrX:15323210..153542100 [GRCh37]
ChrX:Xp22.2-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-154930047)x3 copy number gain See cases [RCV000449437] ChrX:168546..154930047 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x3 copy number gain See cases [RCV000449330] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792) copy number loss See cases [RCV000449461] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-55529093)x1 copy number loss See cases [RCV000446584] ChrX:168546..55529093 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-56684082)x1 copy number loss See cases [RCV000447092] ChrX:168546..56684082 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60701-155246225)x3 copy number gain See cases [RCV000446270] ChrX:60701..155246225 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:2703632-155233731)x1 copy number loss See cases [RCV000446712] ChrX:2703632..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.22(chrX:168546-52573789)x1 copy number loss See cases [RCV000447470] ChrX:168546..52573789 [GRCh37]
ChrX:Xp22.33-11.22
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:71267-155255792)x1 copy number loss See cases [RCV000446197] ChrX:71267..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:318707-155224707)x1 copy number loss See cases [RCV000446667] ChrX:318707..155224707 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain See cases [RCV000446932] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155196888)x3 copy number gain See cases [RCV000446310] ChrX:168546..155196888 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155081533)x3 copy number gain See cases [RCV000447253] ChrX:168546..155081533 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168566-155233731)x1 copy number loss See cases [RCV000445720] ChrX:168566..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss See cases [RCV000448393] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155255792)x4 copy number gain See cases [RCV000448034] ChrX:70297..155255792 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.1(chrX:168546-58140271)x1 copy number loss See cases [RCV000447773] ChrX:168546..58140271 [GRCh37]
ChrX:Xp22.33-11.1
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:70297-155246585)x1 copy number loss See cases [RCV000448652] ChrX:70297..155246585 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-55240087)x1 copy number loss See cases [RCV000512136] ChrX:168546..55240087 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168547-151304063)x1 copy number loss See cases [RCV000510382] ChrX:168547..151304063 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q23(chrX:168547-112474026)x1 copy number loss See cases [RCV000510419] ChrX:168547..112474026 [GRCh37]
ChrX:Xp22.33-q23
pathogenic
GRCh37/hg19 Xp22.33-11.1(chrX:168546-58527164)x1 copy number loss See cases [RCV000510437] ChrX:168546..58527164 [GRCh37]
ChrX:Xp22.33-11.1
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-57504183)x1 copy number loss See cases [RCV000511615] ChrX:168546..57504183 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-57683964)x1 copy number loss See cases [RCV000512022] ChrX:168546..57683964 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp21.1-q22.1(chrX:37521774-98488534)x1 copy number loss See cases [RCV000512026] ChrX:37521774..98488534 [GRCh37]
ChrX:Xp21.1-q22.1
pathogenic
GRCh37/hg19 Xp11.4-11.23(chrX:41150139-46528262)x1 copy number loss See cases [RCV000511364] ChrX:41150139..46528262 [GRCh37]
ChrX:Xp11.4-11.23
pathogenic
GRCh37/hg19 Xp21.2-q28(chrX:31088082-155233731)x1 copy number loss See cases [RCV000511413] ChrX:31088082..155233731 [GRCh37]
ChrX:Xp21.2-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168547-155233731) copy number gain See cases [RCV000512020] ChrX:168547..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168546-54996659)x1 copy number loss See cases [RCV000510822] ChrX:168546..54996659 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp11.3-11.23(chrX:43507300-48929622) copy number gain not provided [RCV000767648] ChrX:43507300..48929622 [GRCh37]
ChrX:Xp11.3-11.23
pathogenic
GRCh37/hg19 Xp22.33-q13.3(chrX:168546-74549686) copy number loss See cases [RCV000512142] ChrX:168546..74549686 [GRCh37]
ChrX:Xp22.33-q13.3
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:168564-57413442)x1 copy number loss See cases [RCV000512339] ChrX:168564..57413442 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.31-q21.31(chrX:7841947-90815333)x1,2 copy number gain not provided [RCV000684261] ChrX:7841947..90815333 [GRCh37]
ChrX:Xp22.31-q21.31
pathogenic
GRCh37/hg19 Xp22.33-11.23(chrX:168546-46908284)x1 copy number loss not provided [RCV000684185] ChrX:168546..46908284 [GRCh37]
ChrX:Xp22.33-11.23
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:60814-55476165)x1 copy number loss not provided [RCV000753275] ChrX:60814..55476165 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-11.22(chrX:60814-51821765)x1 copy number loss not provided [RCV000753274] ChrX:60814..51821765 [GRCh37]
ChrX:Xp22.33-11.22
pathogenic
GRCh37/hg19 Xp11.3(chrX:45179191-45726868)x3 copy number gain not provided [RCV000753526] ChrX:45179191..45726868 [GRCh37]
ChrX:Xp11.3
benign
GRCh37/hg19 Xp22.33-11.23(chrX:60814-48317386)x1 copy number loss not provided [RCV000753273] ChrX:60814..48317386 [GRCh37]
ChrX:Xp22.33-11.23
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155254881)x2 copy number gain not provided [RCV000753277] ChrX:60814..155254881 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x1 copy number loss not provided [RCV000753271] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:181779-155171702)x1 copy number loss not provided [RCV000753278] ChrX:181779..155171702 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
NC_000023.11:g.(?_44209146)_(46109507_?)del deletion Autistic disorder of childhood onset [RCV000754372] ChrX:44209146..46109507 [GRCh38]
ChrX:Xp11.3
likely pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60262-155245765)x3 copy number gain not provided [RCV000753272] ChrX:60262..155245765 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
Single allele duplication Autistic disorder of childhood onset [RCV000754365] ChrX:1..156040895 [GRCh38]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:60814-155236712)x2 copy number gain not provided [RCV000753276] ChrX:60814..155236712 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
NC_000023.10:g.36649710_136649711del100000002insG indel Heterotaxy, visceral, 1, X-linked [RCV000754886] ChrX:36649710..136649711 [GRCh37]
ChrX:Xp21.1-q26.3
pathogenic
GRCh37/hg19 Xp22.33-11.22(chrX:60814-50519984)x1 copy number loss See cases [RCV000790583] ChrX:60814..50519984 [GRCh37]
ChrX:Xp22.33-11.22
pathogenic
46,Y,inv(X)(p21.1q13.3) inversion Elevated serum creatine phosphokinase [RCV000856573] ChrX:32196272..75245806 [GRCh37]
ChrX:Xp21.1-q13.3
likely pathogenic
NC_000023.10:g.(?_45605561)_(46952346_?)del deletion not provided [RCV001031576] ChrX:45605561..46952346 [GRCh37]
ChrX:Xp11.3-11.23
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787440] ChrX:1..47140860 [GRCh37]
ChrX:Xp22.33-11.23
pathogenic
GRCh37/hg19 Xp11.4-q21.32(chrX:40572613-92796528)x1 copy number loss not provided [RCV000845670] ChrX:40572613..92796528 [GRCh37]
ChrX:Xp11.4-q21.32
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x4 copy number gain not provided [RCV000846039] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q28(chrX:168546-155233731)x1 copy number loss not provided [RCV000848828] ChrX:168546..155233731 [GRCh37]
ChrX:Xp22.33-q28
pathogenic
GRCh37/hg19 Xp22.33-q11.1(chrX:168546-61877279)x1 copy number loss not provided [RCV000846273] ChrX:168546..61877279 [GRCh37]
ChrX:Xp22.33-q11.1
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:539722-55509385)x1 copy number loss not provided [RCV001007224] ChrX:539722..55509385 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic
GRCh37/hg19 Xp22.33-11.21(chrX:219609-55466476)x1 copy number loss See cases [RCV001263061] ChrX:219609..55466476 [GRCh37]
ChrX:Xp22.33-11.21
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31601 AgrOrtholog
COSMIC MIR221 COSMIC
Ensembl Genes ENSG00000207870 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385135 ENTREZGENE
GTEx ENSG00000207870 GTEx
HGNC ID HGNC:31601 ENTREZGENE
Human Proteome Map MIR221 Human Proteome Map
miRBase MI0000298 ENTREZGENE
NCBI Gene 407006 ENTREZGENE
OMIM 300568 OMIM
PharmGKB PA164722609 PharmGKB
RNAcentral URS0000170CF4 RNACentral
  URS0000245997 RNACentral
  URS0000593537 RNACentral