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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620575
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Apaf1affects splicingISOAPAF1 (Homo sapiens)6480464CTDParaquat affects the splicing of APAF1 mRNAPMID:23613995
Apaf1affects splicingISOApaf1 (Mus musculus)6480464CTDParaquat affects the splicing of APAF1 exonPMID:27111068
Apaf1decreases expressionISOAPAF1 (Homo sapiens)6480464CTDParaquat results in decreased expression of APAF1 mRNAPMID:17064354
Apaf1increases expressionISOAPAF1 (Homo sapiens)6480464CTDParaquat results in increased expression of APAF1 mRNA alternative formPMID:17064354
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