Anxa2 (annexin A2) - Rat Genome Database

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Gene: Anxa2 (annexin A2) Rattus norvegicus
Analyze
Symbol: Anxa2
Name: annexin A2
RGD ID: 621170
Description: Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: annexin 2; annexin II; annexin-2; ANX2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; PAP-IV; placental anticoagulant protein IV; protein I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Anxa2-ps1  
Allele / Splice: Anxa2-ps1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8878,986,252 - 79,022,638 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl878,986,242 - 79,022,631 (+)EnsemblGRCr8
mRatBN7.2870,105,268 - 70,141,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,105,253 - 70,141,658 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx875,639,429 - 75,675,821 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0873,912,396 - 73,948,787 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0871,743,865 - 71,780,293 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0875,687,134 - 75,723,589 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)Ensemblrn6Rnor6.0
Rnor_5.0880,014,390 - 80,050,845 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4873,897,618 - 73,934,041 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera871,583,756 - 71,620,002 (-)NCBICelera
RGSC_v3.1873,916,671 - 73,953,094 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboxin  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dichlorvos  (EXP)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furfural  (ISO)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
ICI D1694  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lasalocid  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP,ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. Alvares K, etal., J Biol Chem. 2013 May 3;288(18):13036-45. doi: 10.1074/jbc.M112.389627. Epub 2013 Mar 22.
2. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Badea L, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2016-27.
3. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Baldwin C, etal., Blood. 2005 Jul 1;106(1):372-5. Epub 2005 Mar 22.
4. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. Chuthapisith S, etal., Eur J Cancer. 2009 May;45(7):1274-81. doi: 10.1016/j.ejca.2008.12.026. Epub 2009 Jan 24.
5. In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil. el Btaouri H, etal., Eur J Biochem. 1996 Dec 15;242(3):506-11.
6. Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. Esposito I, etal., J Pathol. 2006 Apr;208(5):673-85.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Ghitescu LD, etal., Diabetes. 2001 Jul;50(7):1666-74.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Annexin A2 interactions with Rab14 in alveolar type II cells. Gou D, etal., J Biol Chem. 2008 May 9;283(19):13156-64. Epub 2008 Mar 10.
11. Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. Hayes MJ and Moss SE, J Biol Chem. 2009 Apr 10;284(15):10202-10. doi: 10.1074/jbc.M807043200. Epub 2009 Feb 4.
12. Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway. Hayes MJ, etal., J Biol Chem. 2004 Apr 2;279(14):14157-64. Epub 2004 Jan 20.
13. Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery. Ishii H, etal., Circ Res. 2001 Dec 7;89(12):1240-5.
14. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Kirsch T, etal., Osteoarthritis Cartilage. 2000 Jul;8(4):294-302.
15. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
16. Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway. Li R, etal., J Immunol. 2015 Oct 15;195(8):3901-11. doi: 10.4049/jimmunol.1500967. Epub 2015 Sep 14.
17. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. Ling Q, etal., J Clin Invest 2004 Jan;113(1):38-48.
18. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. Liu N, etal., J Neurosci Res. 2004 Aug 1;77(3):391-401.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Moraru II, etal., Ann N Y Acad Sci. 1998 Sep 16;853:329-32.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
23. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
24. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. Patel SK, etal., Mol Carcinog. 2003 Nov;38(3):141-54.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Rodrigo JP, etal., Hum Pathol. 2011 Jan;42(1):88-94. doi: 10.1016/j.humpath.2010.05.017. Epub 2010 Oct 20.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Molecular cloning of a novel N-terminal variant of annexin II from rat basophilic leukaemia cells. Upton AL and Moss SE, Biochem J 1994 Sep 1;302 ( Pt 2):425-8.
30. Circular RNA circ_0021093 regulates miR-432/Annexin A2 pathway to promote hepatocellular carcinoma progression. Wang Y, etal., Anticancer Drugs. 2021 Jun 1;32(5):484-495. doi: 10.1097/CAD.0000000000001053.
31. Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Yonglitthipagon P, etal., Int J Parasitol. 2010 May 19.
32. The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. Zhao W, etal., Arthritis Rheumatol. 2014 Sep;66(9):2355-67. doi: 10.1002/art.38696.
Additional References at PubMed
PMID:1618851   PMID:2138016   PMID:3013422   PMID:7961821   PMID:8389036   PMID:10809787   PMID:11866539   PMID:12036597   PMID:12902340   PMID:14506282   PMID:14699089   PMID:14741744  
PMID:15001530   PMID:15078881   PMID:15166316   PMID:15226301   PMID:15489334   PMID:16731532   PMID:17575076   PMID:17690254   PMID:18504258   PMID:18767904   PMID:18799458   PMID:19056867  
PMID:19182904   PMID:19190083   PMID:19199708   PMID:19756921   PMID:19946888   PMID:20068577   PMID:20225235   PMID:20237282   PMID:20368092   PMID:20458337   PMID:21362503   PMID:21630459  
PMID:21645192   PMID:22057634   PMID:22082260   PMID:22206666   PMID:22241862   PMID:22658674   PMID:22664934   PMID:22762361   PMID:22848640   PMID:22913982   PMID:23091277   PMID:23106098  
PMID:23360953   PMID:23376485   PMID:23533145   PMID:23861394   PMID:24006456   PMID:24526686   PMID:25139904   PMID:25355205   PMID:25468996   PMID:25593157   PMID:25915724   PMID:26642807  
PMID:26644180   PMID:26812398   PMID:27068509   PMID:27559042   PMID:27836325   PMID:27974247   PMID:28259758   PMID:28450113   PMID:28705472   PMID:28729092   PMID:30332317   PMID:34494994  
PMID:37249328  


Genomics

Comparative Map Data
Anxa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8878,986,252 - 79,022,638 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl878,986,242 - 79,022,631 (+)EnsemblGRCr8
mRatBN7.2870,105,268 - 70,141,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,105,253 - 70,141,658 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx875,639,429 - 75,675,821 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0873,912,396 - 73,948,787 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0871,743,865 - 71,780,293 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0875,687,134 - 75,723,589 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)Ensemblrn6Rnor6.0
Rnor_5.0880,014,390 - 80,050,845 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4873,897,618 - 73,934,041 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera871,583,756 - 71,620,002 (-)NCBICelera
RGSC_v3.1873,916,671 - 73,953,094 (+)NCBI
Cytogenetic Map8q24NCBI
ANXA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381560,347,151 - 60,397,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1560,347,134 - 60,402,883 (-)Ensemblhg38GRCh38
GRCh371560,639,350 - 60,690,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361558,426,642 - 58,477,477 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341558,426,642 - 58,477,477NCBI
Celera1537,527,343 - 37,578,364 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1537,461,790 - 37,512,581 (-)NCBIHuRef
CHM1_11560,757,784 - 60,809,419 (-)NCBICHM1_1
T2T-CHM13v2.01558,149,151 - 58,201,124 (-)NCBIT2T-CHM13v2.0
Anxa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39969,360,978 - 69,399,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl969,360,902 - 69,399,077 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38969,453,683 - 69,491,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl969,453,620 - 69,491,795 (+)Ensemblmm10GRCm38
MGSCv37969,301,490 - 69,339,592 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36969,252,847 - 69,290,949 (+)NCBIMGSCv36mm8
Celera966,675,333 - 66,713,431 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map938.58NCBI
Anxa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545014,512,381 - 14,574,696 (+)Ensembl
ChiLan1.0NW_00495545014,545,586 - 14,574,161 (+)NCBIChiLan1.0ChiLan1.0
ANXA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21649,617,072 - 49,666,538 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11553,799,778 - 53,849,026 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01539,322,303 - 39,371,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11557,625,425 - 57,674,250 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1557,625,425 - 57,674,250 (-)EnsemblpanPan2panpan1.1
ANXA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13025,176,845 - 25,210,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3025,115,842 - 25,218,281 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3025,157,930 - 25,191,332 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03025,352,698 - 25,398,461 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3025,292,016 - 25,398,402 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13025,281,799 - 25,315,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03025,357,572 - 25,390,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03025,587,160 - 25,620,802 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Anxa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640103,426,049 - 103,466,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647121,274,027 - 21,329,503 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647121,274,112 - 21,329,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1111,588,306 - 111,635,059 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11111,588,721 - 111,635,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21123,368,065 - 123,414,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12623,100,000 - 23,147,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2623,099,992 - 23,145,457 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048118,216,806 - 118,265,101 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Anxa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478111,781,886 - 11,821,816 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478111,781,893 - 11,820,440 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Anxa2
234 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000038677
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
RH128604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,141,455 - 70,141,636 (+)MAPPERmRatBN7.2
Rnor_6.0875,723,391 - 75,723,571NCBIRnor6.0
Rnor_5.0880,050,647 - 80,050,827UniSTSRnor5.0
RGSC_v3.4873,933,843 - 73,934,023UniSTSRGSC3.4
Celera871,583,774 - 71,583,954UniSTS
RH 3.4 Map8872.09UniSTS
Cytogenetic Map8q24UniSTS
RH129518  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,788,330 - 39,789,035 (+)MAPPERmRatBN7.2
Rnor_6.01548,976,592 - 48,977,296NCBIRnor6.0
Rnor_5.01552,715,706 - 52,716,410UniSTSRnor5.0
RGSC_v3.41544,992,338 - 44,993,042UniSTSRGSC3.4
Celera1539,461,917 - 39,462,621UniSTS
RH 3.4 Map15307.4UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map15p12UniSTS
RH143050  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,111,808 - 70,111,975 (+)MAPPERmRatBN7.2
Rnor_6.0875,693,675 - 75,693,841NCBIRnor6.0
Rnor_5.0880,020,931 - 80,021,097UniSTSRnor5.0
RGSC_v3.4873,904,159 - 73,904,325UniSTSRGSC3.4
Celera871,613,295 - 71,613,461UniSTS
RH 3.4 Map8872.89UniSTS
Cytogenetic Map8q24UniSTS
BF406531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,125,159 - 70,125,256 (+)MAPPERmRatBN7.2
Rnor_6.0875,707,026 - 75,707,122NCBIRnor6.0
Rnor_5.0880,034,282 - 80,034,378UniSTSRnor5.0
RGSC_v3.4873,917,510 - 73,917,606UniSTSRGSC3.4
Celera871,600,014 - 71,600,110UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000038677   ⟹   ENSRNOP00000038428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,253 - 70,141,655 (+)Ensembl
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096961   ⟹   ENSRNOP00000094972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl878,986,242 - 79,022,631 (+)Ensembl
mRatBN7.2 Ensembl870,105,532 - 70,141,652 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111591   ⟹   ENSRNOP00000080266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,532 - 70,141,647 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114456   ⟹   ENSRNOP00000084769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,548 - 70,141,658 (+)Ensembl
RefSeq Acc Id: NM_019905   ⟹   NP_063970
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8878,986,252 - 79,022,634 (+)NCBI
mRatBN7.2870,105,268 - 70,141,654 (+)NCBI
Rnor_6.0875,687,134 - 75,723,589 (+)NCBI
Rnor_5.0880,014,390 - 80,050,845 (+)NCBI
RGSC_v3.4873,897,618 - 73,934,041 (+)RGD
Celera871,583,756 - 71,620,002 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082021   ⟹   XP_038937949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8878,986,556 - 79,022,638 (+)NCBI
mRatBN7.2870,105,612 - 70,141,663 (+)NCBI
RefSeq Acc Id: NP_063970   ⟸   NM_019905
- UniProtKB: Q07936 (UniProtKB/Swiss-Prot),   A6KEW0 (UniProtKB/TrEMBL),   A0A8I6A0U3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000038428   ⟸   ENSRNOT00000038677
RefSeq Acc Id: XP_038937949   ⟸   XM_039082021
- Peptide Label: isoform X1
- UniProtKB: Q07936 (UniProtKB/Swiss-Prot),   A6KEW0 (UniProtKB/TrEMBL),   A0A8I6A0U3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094972   ⟸   ENSRNOT00000096961
Ensembl Acc Id: ENSRNOP00000084769   ⟸   ENSRNOT00000114456
Ensembl Acc Id: ENSRNOP00000080266   ⟸   ENSRNOT00000111591

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07936-F1-model_v2 AlphaFold Q07936 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696099
Promoter ID:EPDNEW_R6624
Type:single initiation site
Name:Anxa2_1
Description:annexin A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0875,687,119 - 75,687,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621170 AgrOrtholog
BioCyc Gene G2FUF-29963 BioCyc
Ensembl Genes ENSRNOG00000010362 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000096961 ENTREZGENE
Gene3D-CATH 1.10.220.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920034 IMAGE-MGC_LOAD
InterPro Annexin UniProtKB/Swiss-Prot
  Annexin_repeat UniProtKB/Swiss-Prot
  Annexin_repeat_CS UniProtKB/Swiss-Prot
  Annexin_sf UniProtKB/Swiss-Prot
  ANX2 UniProtKB/Swiss-Prot
KEGG Report rno:56611 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72849 IMAGE-MGC_LOAD
NCBI Gene 56611 ENTREZGENE
PANTHER ANNEXIN UniProtKB/Swiss-Prot
  PTHR10502:SF18 UniProtKB/Swiss-Prot
Pfam Annexin UniProtKB/Swiss-Prot
PhenoGen Anxa2 PhenoGen
PRINTS ANNEXIN UniProtKB/Swiss-Prot
  ANNEXINII UniProtKB/Swiss-Prot
PROSITE ANNEXIN UniProtKB/Swiss-Prot
  ANNEXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010362 RatGTEx
SMART ANX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPN9_RAT UniProtKB/TrEMBL
  A0A8I6A0U3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ANV9_RAT UniProtKB/TrEMBL
  A0A8L2QJ26_RAT UniProtKB/TrEMBL
  A6KEV9_RAT UniProtKB/TrEMBL
  A6KEW0 ENTREZGENE, UniProtKB/TrEMBL
  ANXA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa2  annexin A2    calpactin I heavy chain  Name updated 1299863 APPROVED
2002-08-07 Anxa2  calpactin I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity 724707