Anxa2 (annexin A2) - Rat Genome Database

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Gene: Anxa2 (annexin A2) Rattus norvegicus
Symbol: Anxa2
Name: annexin A2
RGD ID: 621170
Description: Enables bone sialoprotein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of fibroblast proliferation; protein localization to plasma membrane; and response to thyroid hormone. Located in several cellular components, including macropinosome; membrane raft; and ruffle. Part of protein-containing complex. Biomarker of hyperthyroidism; hypothyroidism; and renal cell carcinoma. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2); INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
Previously known as: annexin 2; annexin II; annexin-2; ANX2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; p36; PAP-IV; placental anticoagulant protein IV; protein I
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Anxa2-ps1  
Allele / Splice: Anxa2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8878,986,252 - 79,022,638 (+)NCBIGRCr8
mRatBN7.2870,105,268 - 70,141,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,105,253 - 70,141,658 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx875,639,429 - 75,675,821 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0873,912,396 - 73,948,787 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0871,743,865 - 71,780,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0875,687,134 - 75,723,589 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0880,014,390 - 80,050,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4873,897,618 - 73,934,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1873,916,671 - 73,953,094 (+)NCBI
Celera871,583,756 - 71,620,002 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (EXP)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
carboxin  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
daunorubicin  (ISO)
diarsenic trioxide  (ISO)
dichlorine  (EXP)
dichlorvos  (EXP)
dicrotophos  (ISO)
dihydroartemisinin  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gallic acid  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
griseofulvin  (ISO)
hexadecanoic acid  (ISO)
hyaluronic acid  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
ICI D1694  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lasalocid  (ISO)
lead(0)  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
mancozeb  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP,ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfasalazine  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells. Alvares K, etal., J Biol Chem. 2013 May 3;288(18):13036-45. doi: 10.1074/jbc.M112.389627. Epub 2013 Mar 22.
2. Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Badea L, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2016-27.
3. Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis. Baldwin C, etal., Blood. 2005 Jul 1;106(1):372-5. Epub 2005 Mar 22.
4. Annexins in human breast cancer: Possible predictors of pathological response to neoadjuvant chemotherapy. Chuthapisith S, etal., Eur J Cancer. 2009 May;45(7):1274-81. doi: 10.1016/j.ejca.2008.12.026. Epub 2009 Jan 24.
5. In vivo modulation of annexins I, II and V expression by thyroxine and methylthiouracil. el Btaouri H, etal., Eur J Biochem. 1996 Dec 15;242(3):506-11.
6. Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. Esposito I, etal., J Pathol. 2006 Apr;208(5):673-85.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Ghitescu LD, etal., Diabetes. 2001 Jul;50(7):1666-74.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Annexin A2 interactions with Rab14 in alveolar type II cells. Gou D, etal., J Biol Chem. 2008 May 9;283(19):13156-64. Epub 2008 Mar 10.
11. Annexin 2 has a dual role as regulator and effector of v-Src in cell transformation. Hayes MJ and Moss SE, J Biol Chem. 2009 Apr 10;284(15):10202-10. doi: 10.1074/jbc.M807043200. Epub 2009 Feb 4.
12. Annexin 2 binding to phosphatidylinositol 4,5-bisphosphate on endocytic vesicles is regulated by the stress response pathway. Hayes MJ, etal., J Biol Chem. 2004 Apr 2;279(14):14157-64. Epub 2004 Jan 20.
13. Recombinant annexin II modulates impaired fibrinolytic activity in vitro and in rat carotid artery. Ishii H, etal., Circ Res. 2001 Dec 7;89(12):1240-5.
14. Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage. Kirsch T, etal., Osteoarthritis Cartilage. 2000 Jul;8(4):294-302.
15. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
16. Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway. Li R, etal., J Immunol. 2015 Oct 15;195(8):3901-11. doi: 10.4049/jimmunol.1500967. Epub 2015 Sep 14.
17. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. Ling Q, etal., J Clin Invest 2004 Jan;113(1):38-48.
18. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. Liu N, etal., J Neurosci Res. 2004 Aug 1;77(3):391-401.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Pressure overload induces overexpression of annexins II and V in aortic-banded rats. Moraru II, etal., Ann N Y Acad Sci. 1998 Sep 16;853:329-32.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures. Nezi L, etal., Biol Chem 2002 Jan;383(1):167-76.
23. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
24. Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. Patel SK, etal., Mol Carcinog. 2003 Nov;38(3):141-54.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Rodrigo JP, etal., Hum Pathol. 2011 Jan;42(1):88-94. doi: 10.1016/j.humpath.2010.05.017. Epub 2010 Oct 20.
28. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
29. Molecular cloning of a novel N-terminal variant of annexin II from rat basophilic leukaemia cells. Upton AL and Moss SE, Biochem J 1994 Sep 1;302 ( Pt 2):425-8.
30. Circular RNA circ_0021093 regulates miR-432/Annexin A2 pathway to promote hepatocellular carcinoma progression. Wang Y, etal., Anticancer Drugs. 2021 Jun 1;32(5):484-495. doi: 10.1097/CAD.0000000000001053.
31. Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker. Yonglitthipagon P, etal., Int J Parasitol. 2010 May 19.
32. The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes. Zhao W, etal., Arthritis Rheumatol. 2014 Sep;66(9):2355-67. doi: 10.1002/art.38696.
Additional References at PubMed
PMID:1618851   PMID:2138016   PMID:3013422   PMID:7961821   PMID:8389036   PMID:10809787   PMID:11866539   PMID:12036597   PMID:12902340   PMID:14506282   PMID:14699089   PMID:14741744  
PMID:15001530   PMID:15078881   PMID:15166316   PMID:15226301   PMID:15489334   PMID:16731532   PMID:17575076   PMID:17690254   PMID:18504258   PMID:18767904   PMID:18799458   PMID:19056867  
PMID:19182904   PMID:19190083   PMID:19199708   PMID:19756921   PMID:19946888   PMID:20068577   PMID:20225235   PMID:20237282   PMID:20368092   PMID:20458337   PMID:21362503   PMID:21630459  
PMID:21645192   PMID:22057634   PMID:22082260   PMID:22206666   PMID:22241862   PMID:22658674   PMID:22664934   PMID:22762361   PMID:22848640   PMID:22913982   PMID:23091277   PMID:23106098  
PMID:23360953   PMID:23376485   PMID:23533145   PMID:23861394   PMID:24006456   PMID:24526686   PMID:25139904   PMID:25355205   PMID:25468996   PMID:25593157   PMID:25915724   PMID:26642807  
PMID:26644180   PMID:26812398   PMID:27068509   PMID:27559042   PMID:27836325   PMID:27974247   PMID:28259758   PMID:28450113   PMID:28705472   PMID:28729092   PMID:30332317   PMID:34494994  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8878,986,252 - 79,022,638 (+)NCBIGRCr8
mRatBN7.2870,105,268 - 70,141,663 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,105,253 - 70,141,658 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx875,639,429 - 75,675,821 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0873,912,396 - 73,948,787 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0871,743,865 - 71,780,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0875,687,134 - 75,723,589 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0880,014,390 - 80,050,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4873,897,618 - 73,934,041 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1873,916,671 - 73,953,094 (+)NCBI
Celera871,583,756 - 71,620,002 (-)NCBICelera
Cytogenetic Map8q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381560,347,151 - 60,397,986 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1560,347,134 - 60,402,883 (-)EnsemblGRCh38hg38GRCh38
GRCh371560,639,350 - 60,690,185 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361558,426,642 - 58,477,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 341558,426,642 - 58,477,477NCBI
Celera1537,527,343 - 37,578,364 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1537,461,790 - 37,512,581 (-)NCBIHuRef
CHM1_11560,757,784 - 60,809,419 (-)NCBICHM1_1
T2T-CHM13v2.01558,149,151 - 58,201,124 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39969,360,978 - 69,399,074 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl969,360,902 - 69,399,077 (+)EnsemblGRCm39 Ensembl
GRCm38969,453,683 - 69,491,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl969,453,620 - 69,491,795 (+)EnsemblGRCm38mm10GRCm38
MGSCv37969,301,490 - 69,339,592 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36969,252,847 - 69,290,949 (+)NCBIMGSCv36mm8
Celera966,675,333 - 66,713,431 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map938.58NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545014,512,381 - 14,574,696 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545014,545,586 - 14,574,161 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v21649,617,072 - 49,666,538 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11553,799,778 - 53,849,026 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01539,322,303 - 39,371,565 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11557,625,425 - 57,674,250 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1557,625,425 - 57,674,250 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13025,176,845 - 25,210,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3025,115,842 - 25,218,281 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3025,157,930 - 25,191,332 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03025,352,698 - 25,398,461 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3025,292,016 - 25,398,402 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13025,281,799 - 25,315,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03025,357,572 - 25,390,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03025,587,160 - 25,620,802 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640103,426,049 - 103,466,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647121,274,027 - 21,329,503 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647121,274,112 - 21,329,286 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1111,588,306 - 111,635,059 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11111,588,721 - 111,635,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21123,368,065 - 123,414,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12623,100,000 - 23,147,687 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2623,099,992 - 23,145,457 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048118,216,806 - 118,265,101 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462478111,781,886 - 11,821,816 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478111,781,893 - 11,820,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Anxa2
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:31
Interacting mature miRNAs:33
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85423764485365202Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85423764485365202Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)854259986100382532Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)85404374498968765Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)85423764499103503Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)85396876598968765Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,141,455 - 70,141,636 (+)MAPPERmRatBN7.2
Rnor_6.0875,723,391 - 75,723,571NCBIRnor6.0
Rnor_5.0880,050,647 - 80,050,827UniSTSRnor5.0
RGSC_v3.4873,933,843 - 73,934,023UniSTSRGSC3.4
Celera871,583,774 - 71,583,954UniSTS
RH 3.4 Map8872.09UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21539,788,330 - 39,789,035 (+)MAPPERmRatBN7.2
Rnor_6.01548,976,592 - 48,977,296NCBIRnor6.0
Rnor_5.01552,715,706 - 52,716,410UniSTSRnor5.0
RGSC_v3.41544,992,338 - 44,993,042UniSTSRGSC3.4
Celera1539,461,917 - 39,462,621UniSTS
RH 3.4 Map15307.4UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,111,808 - 70,111,975 (+)MAPPERmRatBN7.2
Rnor_6.0875,693,675 - 75,693,841NCBIRnor6.0
Rnor_5.0880,020,931 - 80,021,097UniSTSRnor5.0
RGSC_v3.4873,904,159 - 73,904,325UniSTSRGSC3.4
Celera871,613,295 - 71,613,461UniSTS
RH 3.4 Map8872.89UniSTS
Cytogenetic Map8q24UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2870,125,159 - 70,125,256 (+)MAPPERmRatBN7.2
Rnor_6.0875,707,026 - 75,707,122NCBIRnor6.0
Rnor_5.0880,034,282 - 80,034,378UniSTSRnor5.0
RGSC_v3.4873,917,510 - 73,917,606UniSTSRGSC3.4
Celera871,600,014 - 71,600,110UniSTS
Cytogenetic Map8q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 52 36 19 36 8 11 74 35 41 11 8
Low 5 5 5
Below cutoff


RefSeq Acc Id: ENSRNOT00000038677   ⟹   ENSRNOP00000038428
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,253 - 70,141,655 (+)Ensembl
Rnor_6.0 Ensembl875,687,100 - 75,723,594 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096961   ⟹   ENSRNOP00000094972
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,532 - 70,141,652 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111591   ⟹   ENSRNOP00000080266
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,532 - 70,141,647 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114456   ⟹   ENSRNOP00000084769
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl870,105,548 - 70,141,658 (+)Ensembl
RefSeq Acc Id: NM_019905   ⟹   NP_063970
Rat AssemblyChrPosition (strand)Source
GRCr8878,986,252 - 79,022,634 (+)NCBI
mRatBN7.2870,105,268 - 70,141,654 (+)NCBI
Rnor_6.0875,687,134 - 75,723,589 (+)NCBI
Rnor_5.0880,014,390 - 80,050,845 (+)NCBI
RGSC_v3.4873,897,618 - 73,934,041 (+)RGD
Celera871,583,756 - 71,620,002 (-)RGD
RefSeq Acc Id: XM_039082021   ⟹   XP_038937949
Rat AssemblyChrPosition (strand)Source
GRCr8878,986,556 - 79,022,638 (+)NCBI
mRatBN7.2870,105,612 - 70,141,663 (+)NCBI
RefSeq Acc Id: NP_063970   ⟸   NM_019905
- UniProtKB: Q07936 (UniProtKB/Swiss-Prot),   A6KEW0 (UniProtKB/TrEMBL),   A0A8I6A0U3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038428   ⟸   ENSRNOT00000038677
RefSeq Acc Id: XP_038937949   ⟸   XM_039082021
- Peptide Label: isoform X1
- UniProtKB: Q07936 (UniProtKB/Swiss-Prot),   A6KEW0 (UniProtKB/TrEMBL),   A0A8I6A0U3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094972   ⟸   ENSRNOT00000096961
RefSeq Acc Id: ENSRNOP00000084769   ⟸   ENSRNOT00000114456
RefSeq Acc Id: ENSRNOP00000080266   ⟸   ENSRNOT00000111591

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q07936-F1-model_v2 AlphaFold Q07936 1-339 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696099
Promoter ID:EPDNEW_R6624
Type:single initiation site
Description:annexin A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0875,687,119 - 75,687,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621170 AgrOrtholog
BioCyc Gene G2FUF-29963 BioCyc
Ensembl Genes ENSRNOG00000010362 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055006716 UniProtKB/Swiss-Prot
  ENSRNOG00060015561 UniProtKB/Swiss-Prot
  ENSRNOG00065015941 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000038677.6 UniProtKB/TrEMBL
  ENSRNOT00000096961.1 UniProtKB/TrEMBL
  ENSRNOT00000111591.1 UniProtKB/TrEMBL
  ENSRNOT00000114456.1 UniProtKB/TrEMBL
  ENSRNOT00055010993 UniProtKB/Swiss-Prot
  ENSRNOT00060026708 UniProtKB/Swiss-Prot
  ENSRNOT00065026540 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Annexin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56611 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10502:SF18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Annexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Anxa2 PhenoGen
  ANNEXINII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010362 RatGTEx
  ENSRNOG00055006716 RatGTEx
  ENSRNOG00060015561 RatGTEx
  ENSRNOG00065015941 RatGTEx
SMART ANX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Anxa2  annexin A2    calpactin I heavy chain  Name updated 1299863 APPROVED
2002-08-07 Anxa2  calpactin I heavy chain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. it binds two calcium ions with high affinity 724707