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Gene: Hspa5 (heat shock protein family A (Hsp70) member 5) Rattus norvegicus
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Description: Exhibits misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to metal ion; and generation of neurons. Localizes to membrane; mitochondrion; and smooth endoplasmic reticulum. Predicted to colocalize with COP9 signalosome. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 78 kDa glucose-regulated protein; BIP; endoplasmic reticulum chaperone BiP; GRP 78; GRP-78; GRP78; heat shock 70 kDa protein 5; Heat shock 70kD protein 5; heat shock 70kDa protein 5 (glucose-regulated protein); heat shock protein 5; heat shock protein 70 family protein 5; heat shock protein family A member 5; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; steroidogenesis-activator polypeptide
Homo sapiens (human) : HSPA5 (heat shock protein family A (Hsp70) member 5)  HGNC  Alliance
Mus musculus (house mouse) : Hspa5 (heat shock protein 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Canis lupus familiaris (dog) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Sus scrofa (pig) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Chlorocebus sabaeus (African green monkey) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Heterocephalus glaber (naked mole-rat) : Hspa5 (heat shock protein family A (Hsp70) member 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
Cytogenetic Map3p11NCBI
RH 3.4 Map3151.7RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hspa5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2843
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.