GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hspa5 | increases expression | EXP | | 6480464 | CTD | Acrolein results in increased expression of HSPA5 mRNA; Acrolein results in increased expression of HSPA5 protein | PMID:28119953 PMID:29414845 | Hspa5 | multiple interactions | EXP | | 6480464 | CTD | 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of HSPA5 mRNA]; 3,4-dihydroxyphenylethanol inhibits the reaction [Acrolein results in increased expression of HSPA5 protein]; [Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein; Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]; oleuropein inhibits the reaction [Acrolein results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [[Acrolein results in increased susceptibility to Isoproterenol] which results in increased expression of HSPA5 protein]; Plant Extracts inhibits the reaction [Acrolein promotes the reaction [Isoproterenol results in increased expression of HSPA5 mRNA]] | PMID:29414845 | Hspa5 | decreases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Acrolein results in decreased expression of HSPA5 mRNA | PMID:28482051 | Hspa5 | increases expression | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | Acrolein results in increased expression of HSPA5 protein | PMID:34813903 | Hspa5 | increases expression | ISO | HSPA5 (Homo sapiens) | 6480464 | CTD | Acrolein results in increased expression of HSPA5 protein | PMID:18951912 | Hspa5 | multiple interactions | ISO | Hspa5 (Mus musculus) | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Acrolein results in increased expression of HSPA5 protein]; Resveratrol inhibits the reaction [Acrolein results in increased expression of HSPA5 protein] | PMID:34813903 | | ||||||||||||||||||||||
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