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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of HSPA5 mRNAPMID:30261314
Hspa5increases expressionEXP 6480464CTDDoxorubicin results in increased expression of HSPA5 proteinPMID:28495616 PMID:34392583 PMID:35152301
Hspa5multiple interactionsEXP 6480464CTD1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]PMID:28495616 PMID:34392583 PMID:35152301
Hspa5affects expressionISOHSPA5 (Homo sapiens)6480464CTDDoxorubicin affects the expression of HSPA5 proteinPMID:29385562
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDDoxorubicin results in increased expression of HSPA5 mRNAPMID:17680992 PMID:29803840
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTDDoxorubicin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]PMID:16298333
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