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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5affects bindingISOHSPA5 (Homo sapiens)6480464CTDHSPA5 protein binds to CopperPMID:14534351 PMID:15359738
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDCopper results in increased expression of HSPA5 proteinPMID:15836927 PMID:22692975
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD[Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in decreased expression of HSPA5 mRNA; [NSC 689534 binds to Copper] which results in increased expression of HSPA5 mRNAPMID:20971185 PMID:35809665
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