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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa5
Name: heat shock protein family A (Hsp70) member 5
Acc ID: CHEBI:22977
Term: cadmium atom
Definition: A zinc group element atom that has formula Cd.
Chemical ID: MESH:D002104
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa5increases expressionISOHSPA5 (Homo sapiens)6480464CTDCadmium results in increased expression of HSPA5 mRNA; Cadmium results in increased expression of HSPA5 proteinPMID:16020198 PMID:20600546 PMID:21694771
Hspa5multiple interactionsISOHspa5 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 proteinPMID:37261864
Hspa5multiple interactionsISOHSPA5 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Cadmium] results in increased expression of HSPA5 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA5 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HSPA5 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of HSPA5 protein]PMID:33040242 PMID:34516972 PMID:34687772 PMID:37300854
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