HSPA5 (heat shock protein family A (Hsp70) member 5) - Rat Genome Database

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Gene: HSPA5 (heat shock protein family A (Hsp70) member 5) Chlorocebus sabaeus
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Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
RGD ID: 18725844
Description: ENCODES a protein that exhibits unfolded protein binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); asbestosis (ortholog); FOUND IN COP9 signalosome (ortholog); dendritic shaft (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 78 kDa glucose-regulated protein; endoplasmic reticulum chaperone BiP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HSPA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HSPA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9125,234,853 - 125,241,382 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,997,132 - 128,003,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBIT2T-CHM13v2.0
Hspa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,662,102 - 34,666,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,661,982 - 34,667,559 (+)EnsemblGRCm39 Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,771,970 - 34,777,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBIMGSCv36mm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.94NCBI
Hspa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,453,016 - 38,457,475 (+)NCBIGRCr8
mRatBN7.2318,055,507 - 18,059,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,123,611 - 21,128,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,708,632 - 29,713,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0327,962,245 - 27,966,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
RH 3.4 Map3151.7RGD
Cytogenetic Map3p11NCBI
Hspa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,055,420 - 3,062,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,055,420 - 3,060,208 (+)NCBIChiLan1.0ChiLan1.0
HSPA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,121,462 - 14,127,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,124,169 - 14,129,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0996,351,645 - 96,356,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,865,211 - 124,870,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,865,211 - 124,870,458 (-)Ensemblpanpan1.1panPan2
HSPA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1957,850,870 - 57,855,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl957,850,922 - 57,855,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,050,544 - 57,055,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0958,771,363 - 58,776,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl958,771,414 - 58,776,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,529,524 - 57,534,454 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0957,846,243 - 57,851,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0957,936,913 - 57,941,842 (+)NCBIUU_Cfam_GSD_1.0
Hspa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947193,579,938 - 193,584,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648713,348,465 - 13,352,717 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648713,348,465 - 13,352,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
Hspa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247609,986,656 - 9,995,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247609,986,529 - 9,991,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008006256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCSAT00000011728   ⟹   ENSCSAP00000009792
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)Ensembl
RefSeq Acc Id: XM_008006256   ⟹   XP_008004447
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11212,920,705 - 12,925,888 (+)NCBI
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008004447 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009792
  ENSCSAP00000009792.1
RefSeq Acc Id: XP_008004447   ⟸   XM_008006256
- UniProtKB: A0A0D9RMF3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000009792   ⟸   ENSCSAT00000011728


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013633 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011728.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/TrEMBL
  3.30.420.40 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  BIP_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/TrEMBL
KEGG Report csab:103239874 UniProtKB/TrEMBL
NCBI Gene HSPA5 ENTREZGENE
PANTHER ENDOPLASMIC RETICULUM CHAPERONE BIP UniProtKB/TrEMBL
  PTHR19375 UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/TrEMBL
PRINTS HEATSHOCK70 UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/TrEMBL
  SSF100934 UniProtKB/TrEMBL
  SSF53067 UniProtKB/TrEMBL
UniProt A0A0D9RMF3 ENTREZGENE, UniProtKB/TrEMBL