HSPA5 (heat shock protein family A (Hsp70) member 5) - Rat Genome Database

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Gene: HSPA5 (heat shock protein family A (Hsp70) member 5) Homo sapiens
Analyze
Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
RGD ID: 736447
HGNC Page HGNC:5238
Description: Enables several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in several processes, including cellular response to glucose starvation; negative regulation of PERK-mediated unfolded protein response; and protein localization to endoplasmic reticulum. Located in several cellular components, including COP9 signalosome; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Implicated in dopamine beta-hydroxylase deficiency. Biomarker of high grade glioma; inflammatory bowel disease; and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 78 kDa glucose-regulated protein; BIP; endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; FLJ26106; glucose-regulated protein, 78-kD; glucose-regulated protein, 78kDa; GRP-78; GRP78; heat shock 70 kDa protein 5; heat shock 70kd protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; Heat-shock 70kD protein-5 (glucose-regulated protein, 78kD); HEL-S-89n; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; MIF2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AC105250.1   HSPA5P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9125,234,853 - 125,241,382 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,997,132 - 128,003,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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HSPA5HumanAcute Experimental Pancreatitis  ISOHspa5 (Rattus norvegicus)11354914protein:increased expression:neutrophil:RGD 
HSPA5HumanAcute Lung Injury treatmentISOHspa5 (Rattus norvegicus)34901874associated with Crush InjuriesRGD 
HSPA5HumanBreast Neoplasms  ISOHspa5 (Mus musculus)5686342protein:increased expressionRGD 
HSPA5HumanChronic Intermittent Hypoxia  ISOHspa5 (Rattus norvegicus)401793731mRNA:increased expression:kidney cortex more ...RGD 
HSPA5HumanContrast-Induced Nephropathy treatmentISOHspa5 (Rattus norvegicus)13782262 RGD 
HSPA5HumanDiabetic Cardiomyopathies amelioratesISOHspa5 (Mus musculus)156430337 RGD 
HSPA5HumanDiabetic Nephropathies  ISOHspa5 (Rattus norvegicus)2311449associated with Diabetes Mellitus more ...RGD 
HSPA5Humandopamine beta-hydroxylase deficiency  IAGP 5685690 RGD 
HSPA5HumanExperimental Autoimmune Myocarditis treatmentISOHspa5 (Rattus norvegicus)5685668 RGD 
HSPA5HumanExperimental Seizures  ISOHspa5 (Rattus norvegicus)11354919protein:increased expression:hippocampus:RGD 
HSPA5HumanFemale Infertility  IMP 5685640 RGD 
HSPA5Humanhigh grade glioma  IEP 5685704protein:increased expressionRGD 
HSPA5Humaninflammatory bowel disease  IEP 5685671protein:increased expressionRGD 
HSPA5Humanmetabolic dysfunction-associated steatohepatitis disease_progressionISOHspa5 (Rattus norvegicus)407420265mRNA and protein:increased expression:liver (rat)RGD 
HSPA5Humanmyeloid neoplasm  ISOHspa5 (Mus musculus)11354915 RGD 
HSPA5HumanMyocardial Reperfusion Injury treatmentISOHspa5 (Rattus norvegicus)11354962 RGD 
HSPA5HumanMyocardial Reperfusion Injury treatmentISOHspa5 (Rattus norvegicus)13782178 RGD 
HSPA5HumanNerve Degeneration  ISOHspa5 (Rattus norvegicus)5685686protein:decreased expression:spinal cordRGD 
HSPA5Humanneuronal ceroid lipofuscinosis  ISOHspa5 (Mus musculus)5686293protein:increased expression:brainRGD 
HSPA5HumanPeripheral Nerve Injuries  ISOHspa5 (Rattus norvegicus)5685664mRNA:increased expressionRGD 
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HSPA5Humanasbestosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25324550
HSPA5HumanChemical and Drug Induced Liver Injury  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
HSPA5Humanchronic myeloid leukemia  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23777986
HSPA5Humanesophagus squamous cell carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21517111
HSPA5HumanHematologic Neoplasms  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23777986
HSPA5Humanhepatocellular carcinoma  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21472284 and PMID:29698666
HSPA5Humanmyocardial infarction  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25450231
HSPA5Humanobesity  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:26655953
HSPA5Humanrespiratory allergy  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:24211530
HSPA5Humanspinocerebellar ataxia type 17  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:24413982
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HSPA5Human(+)-pilocarpine multiple interactionsISOHspa5 (Rattus norvegicus)6480464[Pilocarpine co-treated with Lithium] results in increased expression of HSPA5 mRNA more ...CTDPMID:21429313
HSPA5Human(+)-schisandrin B multiple interactionsISOHspa5 (Rattus norvegicus)6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HSPA5 mRNA]CTDPMID:31150632
HSPA5Human(+)-Tetrandrine increases expressionEXP 6480464tetrandrine results in increased expression of HSPA5 proteinCTDPMID:26822499
HSPA5Human(-)-alpha-phellandrene decreases expressionEXP 6480464alpha phellandrene results in decreased expression of HSPA5 mRNACTDPMID:25075043
HSPA5Human(-)-anisomycin decreases expressionISOHspa5 (Mus musculus)6480464Anisomycin results in decreased expression of HSPA5 mRNA and Anisomycin results in decreased expression of HSPA5 proteinCTDPMID:25324550
HSPA5Human(-)-gambogic acid increases expressionEXP 6480464gambogic acid results in increased expression of HSPA5 proteinCTDPMID:24291039
HSPA5Human(-)-gambogic acid multiple interactionsEXP 6480464Bortezomib promotes the reaction [gambogic acid results in increased expression of HSPA5 protein] and gambogic acid promotes the reaction [Bortezomib results in increased expression of HSPA5 protein]CTDPMID:24291039
HSPA5Human(1->4)-beta-D-glucan multiple interactionsISOHspa5 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HSPA5 mRNACTDPMID:36331819
HSPA5Human(E)-thiamethoxam increases expressionISOHspa5 (Mus musculus)6480464Thiamethoxam results in increased expression of HSPA5 mRNA and Thiamethoxam results in increased expression of HSPA5 proteinCTDPMID:33533595
HSPA5Human(R)-adrenaline multiple interactionsISOHspa5 (Rattus norvegicus)6480464[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of HSPA5 proteinCTDPMID:19464573
HSPA5Human(R)-lipoic acid multiple interactionsISOHspa5 (Mus musculus)6480464Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of HSPA5 protein]CTDPMID:23892647
HSPA5Human(R)-lipoic acid multiple interactionsISOHspa5 (Rattus norvegicus)6480464Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of HSPA5 protein]CTDPMID:30605698
HSPA5Human(R)-noradrenaline increases expressionISOHspa5 (Rattus norvegicus)6480464Norepinephrine results in increased expression of HSPA5 mRNA and Norepinephrine results in increased expression of HSPA5 proteinCTDPMID:16338971
HSPA5Human(R,S)-Scoulerine multiple interactionsEXP 64804644-phenylbutyric acid inhibits the reaction [discretamine results in increased expression of HSPA5 protein] and Acetylcysteine inhibits the reaction [discretamine results in increased expression of HSPA5 protein]CTDPMID:32590070
HSPA5Human(R,S)-Scoulerine increases expressionEXP 6480464discretamine results in increased expression of HSPA5 proteinCTDPMID:32590070
HSPA5Human(S)-colchicine increases expressionEXP 6480464Colchicine results in increased expression of HSPA5 proteinCTDPMID:27358234
HSPA5Human(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of HSPA5CTDPMID:24201001
HSPA5Human(S)-nicotine multiple interactionsISOHspa5 (Mus musculus)6480464Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:28082123
HSPA5Human(S)-nicotine multiple interactionsISOHspa5 (Rattus norvegicus)6480464Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HSPA5 protein] and Nicotine inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]CTDPMID:18477628 and PMID:28082123
HSPA5Human(Z)-3-butylidenephthalide increases expressionEXP 6480464butylidenephthalide results in increased expression of HSPA5 proteinCTDPMID:23770345

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Biological Process
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HSPA5Humancellular response to antibiotic  ISOHspa5 (Rattus norvegicus)9068941tunicamycinRGDPMID:19332540 and REF_RGD_ID:7242708
HSPA5Humancellular response to calcium ion  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:9058202 and REF_RGD_ID:11354978
HSPA5Humancellular response to cAMP  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:9058202 and REF_RGD_ID:11354978
HSPA5Humancellular response to gamma radiation  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:20470193 and REF_RGD_ID:11354917
HSPA5Humancellular response to glucose starvation involved_inIDA 150520179 PMID:10085239UniProtPMID:10085239
HSPA5Humancellular response to interleukin-4 acts_upstream_of_or_withinIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humancellular response to manganese ion involved_inISOHspa5 (Rattus norvegicus)9068941PMID:23934647ParkinsonsUK-UCLPMID:23934647 and REF_RGD_ID:10047151
HSPA5Humancellular response to nerve growth factor stimulus  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:10936191 and REF_RGD_ID:11354963
HSPA5Humancellular response to xenobiotic stimulus  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:18757512 and REF_RGD_ID:11354916
HSPA5Humancerebellar Purkinje cell layer development involved_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humancerebellum structural organization involved_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanchaperone cofactor-dependent protein refolding involved_inIBAMGI:105384 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humanendoplasmic reticulum unfolded protein response involved_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanendoplasmic reticulum unfolded protein response involved_inIBAMGI:95835 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humanendoplasmic reticulum unfolded protein response involved_inTAS 150520179 PMID:19816510BHF-UCLPMID:19816510
HSPA5HumanER overload response acts_upstream_of_or_withinIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5HumanERAD pathway involved_inTAS 150520179 PMID:19816510BHF-UCLPMID:19816510
HSPA5HumanERAD pathway involved_inIBAPANTHER:PTN001834223 more ...150520179 GO_CentralGO_REF:0000033
HSPA5HumanIRE1-mediated unfolded protein response involved_inISOHspa5 (Mus musculus)9068941 PMID:24508390WBPMID:24508390
HSPA5Humanluteolysis  ISOHspa5 (Rattus norvegicus)9068941 RGDPMID:25332219 and REF_RGD_ID:13782179
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Cellular Component
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HSPA5Humancell surface located_inIEAUniProtKB-SubCell:SL-0310150520179 UniProtGO_REF:0000044
HSPA5Humancell surface located_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5HumanCOP9 signalosome located_inIDA 150520179 PMID:18850735UniProtPMID:18850735
HSPA5Humancytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
HSPA5Humancytoplasm is_active_inIBACGD:CAL0000184706 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humancytoplasm located_inIDA 150520179 PMID:22689054UniProtPMID:22689054
HSPA5Humancytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
HSPA5Humancytosol located_inIDA 150520179 PMID:22689054UniProtPMID:22689054
HSPA5Humandendritic shaft  ISOHspa5 (Rattus norvegicus)9068941MMO:0000686RGDPMID:26088419 and REF_RGD_ID:11096590
HSPA5Humanendoplasmic reticulum located_inIDA 150520179 PMID:16223484MGIPMID:16223484
HSPA5Humanendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
HSPA5Humanendoplasmic reticulum located_inIMP 150520179 PMID:11943137UniProtPMID:11943137
HSPA5Humanendoplasmic reticulum located_inTAS 150520179 PMID:16130169UniProtPMID:16130169
HSPA5Humanendoplasmic reticulum located_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanendoplasmic reticulum chaperone complex part_ofIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanendoplasmic reticulum chaperone complex part_ofIBAFB:FBgn0001218 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humanendoplasmic reticulum chaperone complex part_ofIDA 150520179 PMID:18400946UniProtPMID:18400946
HSPA5Humanendoplasmic reticulum lumen located_inIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanendoplasmic reticulum lumen is_active_inIBAMGI:95835 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humanendoplasmic reticulum lumen located_inTAS 150520179 ReactomeReactome:R-HSA-381086 more ...
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Molecular Function
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HSPA5HumanATP binding enablesIDA 150520179 PMID:26655470UniProtPMID:26655470
HSPA5HumanATP binding enablesIEAInterPro:IPR013126150520179 InterProGO_REF:0000002
HSPA5HumanATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
HSPA5HumanATP hydrolysis activity enablesIDA 150520179 PMID:20335166 and PMID:23975754CACAOPMID:20335166 and PMID:23975754
HSPA5HumanATP hydrolysis activity enablesIBAFB:FBgn0001218 more ...150520179 GO_CentralGO_REF:0000033
HSPA5HumanATP hydrolysis activity enablesISSUniProtKB:P07823150520179 UniProtGO_REF:0000024
HSPA5HumanATP hydrolysis activity enablesIEARHEA:13065150520179 RHEAGO_REF:0000116
HSPA5HumanATP-dependent protein folding chaperone enablesIEAInterPro:IPR013126150520179 InterProGO_REF:0000002
HSPA5Humancadherin binding enablesHDA 150520179 PMID:25468996BHF-UCLPMID:25468996
HSPA5Humancalcium ion binding enablesTAS 150520179 PMID:16130169UniProtPMID:16130169
HSPA5Humanenzyme binding enablesIPIUniProtKB:Q8WXB1150520179 PMID:23921388BHF-UCLPMID:23921388
HSPA5Humanheat shock protein binding enablesIBAPANTHER:PTN000452648 more ...150520179 GO_CentralGO_REF:0000033
HSPA5Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
HSPA5Humanmisfolded protein binding enablesIEAUniProtKB:P20029 and ensembl:ENSMUSP00000028222150520179 EnsemblGO_REF:0000107
HSPA5Humanmisfolded protein binding enablesIDA 150520179 PMID:18400946UniProtPMID:18400946
HSPA5Humannucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
HSPA5Humanprotein binding enablesIPIUniProtKB:Q91YW3150520179 PMID:18923430IntActPMID:18923430
HSPA5Humanprotein binding enablesIPIUniProtKB:P0DTC2 and UniProtKB:Q9BYF1150520179 PMID:33965375 and PMID:34615619IntActPMID:33965375 and PMID:34615619
HSPA5Humanprotein binding enablesIPIUniProtKB:Q9H173150520179 PMID:12356756 more ...IntActPMID:12356756 more ...
HSPA5Humanprotein binding enablesIPIUniProtKB:O95994150520179 PMID:23220234UniProtPMID:23220234
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Imported Annotations - SMPDB

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Imported Annotations - KEGG (archival)

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HSPA5Humanantigen processing and presentation pathway  IEA 6907045 KEGGhsa:04612
HSPA5HumanEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGhsa:04141
HSPA5Humanprion disease pathway  IEA 6907045 KEGGhsa:05020

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#
Reference Title
Reference Citation
1. The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Blass S, etal., Arthritis Rheum. 2001 Apr;44(4):761-71.
2. [Effect of electroacupuncture pretreatment on apoptotic neurons and expression of GRP 78 and GADD 153 in the hippocampus in rats with global cerebral ischemia/reperfusion injury]. Chen HL, etal., Zhen Ci Yan Jiu. 2014 Dec;39(6):431-6.
3. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
4. Proteomic and PROTEOMEX profiling of mammary cancer progression in a HER-2/neu oncogene-driven animal model system. Croci S, etal., Proteomics. 2010 Nov;10(21):3835-53.
5. Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding. Deuring JJ, etal., Biochem J. 2012 Jan 1;441(1):87-93.
6. [Protective effect of adenosine preconditioning against spinal cord ischemia-reperfusion injury in rats]. Fu Q, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2014 Jan;34(1):92-5.
7. Different early ER-stress responses in the CLN8(mnd) mouse model of neuronal ceroid lipofuscinosis. Galizzi G, etal., Neurosci Lett. 2011 Jan 25;488(3):258-62. Epub 2010 Nov 19.
8. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
9. Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase. Kim CH, etal., J Biol Chem. 2011 Mar 18;286(11):9196-204. Epub 2011 Jan 5.
10. Atorvastatin reduces alcohol-induced endoplasmic reticulum stress in AC16 cardiomyocytes. Li N, etal., Scand Cardiovasc J. 2019 Feb;53(1):42-47. doi: 10.1080/14017431.2018.1516891.
11. Ginsenoside-Rg1 inhibits endoplasmic reticulum stress-induced apoptosis after unilateral ureteral obstruction in rats. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
12. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
13. Immunization with Ovarian Autoantigens leads to Reduced Fertility in Mice following Follicular dysfunction. Mande PV, etal., Reproduction. 2011 Dec 5.
14. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. Mantuano E, etal., J Neurosci. 2011 Sep 21;31(38):13376-85.
15. Naltrexone changes the expression of lipid metabolism-related proteins in the endoplasmic reticulum stress induced hepatic steatosis in mice. Moslehi A, etal., Clin Exp Pharmacol Physiol. 2017 Feb;44(2):207-212. doi: 10.1111/1440-1681.12695.
16. Deletion of the Pro-Apoptotic Endoplasmic Reticulum Stress Response Effector CHOP Does Not Result in Improved Locomotor Function after Severe Contusive Spinal Cord Injury. Ohri SS, etal., J Neurotrauma. 2011 Nov 21.
17. Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons. Penas C, etal., Cell Death Differ. 2011 Oct;18(10):1617-27. doi: 10.1038/cdd.2011.24. Epub 2011 Mar 25.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
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PMID:1480470   PMID:1602151   PMID:1649196   PMID:1900540   PMID:2294010   PMID:2840249   PMID:3087629   PMID:3122216   PMID:7724523   PMID:7878056   PMID:7906708   PMID:7957306  
PMID:8020977   PMID:8666824   PMID:9006956   PMID:9150946   PMID:9150948   PMID:9305856   PMID:9409741   PMID:9492298   PMID:9885241   PMID:10049727   PMID:10085239   PMID:10197448  
PMID:10397760   PMID:10461883   PMID:10514465   PMID:10588643   PMID:10617616   PMID:10708769   PMID:10760948   PMID:10777498   PMID:10887119   PMID:10906332   PMID:10964507   PMID:10964928  
PMID:10970892   PMID:11013075   PMID:11160188   PMID:11162507   PMID:11162551   PMID:11181571   PMID:11294872   PMID:11476899   PMID:11719466   PMID:11751874   PMID:11752154   PMID:11765911  
PMID:11790298   PMID:11907036   PMID:11932435   PMID:11943137   PMID:12076252   PMID:12097557   PMID:12194978   PMID:12356756   PMID:12359150   PMID:12383251   PMID:12397072   PMID:12411443  
PMID:12471035   PMID:12475965   PMID:12477932   PMID:12480769   PMID:12493773   PMID:12514190   PMID:12516782   PMID:12552023   PMID:12577067   PMID:12621026   PMID:12637535   PMID:12643545  
PMID:12665508   PMID:12713871   PMID:12832005   PMID:12840015   PMID:14685163   PMID:14744259   PMID:15009096   PMID:15077298   PMID:15146195   PMID:15150263   PMID:15166316   PMID:15280358  
PMID:15308636   PMID:15324660   PMID:15456888   PMID:15489334   PMID:15514946   PMID:15525676   PMID:15618547   PMID:15635413   PMID:15657421   PMID:15664986   PMID:15778089   PMID:15817150  
PMID:15899857   PMID:15908432   PMID:15949590   PMID:15952740   PMID:16027165   PMID:16049007   PMID:16051665   PMID:16130169   PMID:16168956   PMID:16169070   PMID:16182273   PMID:16212417  
PMID:16223484   PMID:16236267   PMID:16257961   PMID:16282978   PMID:16329989   PMID:16344560   PMID:16400691   PMID:16428306   PMID:16472112   PMID:16488447   PMID:16497268   PMID:16522924  
1 to 10 of 95 rows



HSPA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9125,234,853 - 125,241,382 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,997,132 - 128,003,622 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBIT2T-CHM13v2.0
Hspa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,662,102 - 34,666,541 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl234,661,982 - 34,667,559 (+)EnsemblGRCm39 Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,771,970 - 34,777,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBIMGSCv36mm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.94NCBI
Hspa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8338,453,016 - 38,457,475 (+)NCBIGRCr8
mRatBN7.2318,055,507 - 18,059,969 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,055,405 - 18,059,891 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,123,611 - 21,128,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0329,708,632 - 29,713,088 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0327,962,245 - 27,966,702 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
RH 3.4 Map3151.7RGD
Cytogenetic Map3p11NCBI
Hspa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,055,420 - 3,062,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,055,420 - 3,060,208 (+)NCBIChiLan1.0ChiLan1.0
HSPA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,121,462 - 14,127,266 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,124,169 - 14,129,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0996,351,645 - 96,356,761 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,865,211 - 124,870,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,865,211 - 124,870,458 (-)Ensemblpanpan1.1panPan2
HSPA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1957,850,870 - 57,855,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl957,850,922 - 57,855,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,050,544 - 57,055,478 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0958,771,363 - 58,776,290 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl958,771,414 - 58,776,279 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,529,524 - 57,534,454 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0957,846,243 - 57,851,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0957,936,913 - 57,941,842 (+)NCBIUU_Cfam_GSD_1.0
Hspa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947193,579,938 - 193,584,190 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648713,348,465 - 13,352,717 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648713,348,465 - 13,352,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,894 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
HSPA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660793,184,743 - 3,190,031 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hspa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247609,986,656 - 9,995,252 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247609,986,529 - 9,991,261 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in HSPA5
26 total Variants

1 to 10 of 61 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
NM_005347.4(HSPA5):c.1525C>T (p.Leu509Phe) single nucleotide variant Malignant melanoma [RCV000061893] Chr9:125237032 [GRCh38]
Chr9:127999311 [GRCh37]
Chr9:127039132 [NCBI36]
Chr9:9q33.3		 not provided
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
1 to 10 of 61 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR181A2hsa-miR-181a-5pOncomiRDBexternal_infoNANA23085757
MIR122hsa-miR-122-5pTarbaseexternal_infoOtherPOSITIVE
MIR199A1hsa-miR-199a-5pOncomiRDBexternal_infoNANA23085757
MIR181A1hsa-miR-181a-5pOncomiRDBexternal_infoNANA23085757
MIR30Dhsa-miR-30d-5pOncomiRDBexternal_infoNANA23085757

Predicted Target Of
Summary Value
Count of predictions:674
Count of miRNA genes:482
Interacting mature miRNAs:537
Transcripts:ENST00000324460
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

RH102504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,997,180 - 127,997,357UniSTSGRCh37
Build 369127,037,001 - 127,037,178RGDNCBI36
Celera998,645,167 - 98,645,344RGD
Cytogenetic Map9q33.3UniSTS
HuRef997,609,766 - 97,609,943UniSTS
GeneMap99-GB4 RH Map9383.29UniSTS
D2Wsu17e  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37139,176,669 - 39,176,879UniSTSGRCh37
GRCh379127,998,557 - 127,998,766UniSTSGRCh37
Build 36138,949,256 - 38,949,466RGDNCBI36
Celera998,646,545 - 98,646,754UniSTS
Celera137,455,287 - 37,455,497RGD
HuRef997,611,144 - 97,611,353UniSTS
HuRef137,295,242 - 37,295,452UniSTS
PMC108893P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379128,003,406 - 128,003,627UniSTSGRCh37
Build 369127,043,227 - 127,043,448RGDNCBI36
Celera998,651,394 - 98,651,615RGD
Cytogenetic Map9q33.3UniSTS
HuRef997,615,993 - 97,616,214UniSTS
HSPA5_988  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,998,540 - 127,999,338UniSTSGRCh37
Build 369127,038,361 - 127,039,159RGDNCBI36
Celera998,646,528 - 98,647,326RGD
HuRef997,611,127 - 97,611,925UniSTS
D9S1138  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,998,566 - 127,998,740UniSTSGRCh37
GRCh37139,176,695 - 39,176,870UniSTSGRCh37
Build 36138,949,282 - 38,949,457RGDNCBI36
Celera137,455,313 - 37,455,488RGD
Celera998,646,554 - 98,646,728UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map9q33.3UniSTS
HuRef137,295,268 - 37,295,443UniSTS
HuRef997,611,153 - 97,611,327UniSTS
GeneMap99-GB4 RH Map9389.68UniSTS
Whitehead-RH Map9462.6UniSTS
Whitehead-YAC Contig Map9 UniSTS
RH94472  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,998,544 - 127,998,705UniSTSGRCh37
Celera998,646,532 - 98,646,693UniSTS
HuRef997,611,131 - 97,611,292UniSTS
D10S275  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map13q12.13UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map14q24UniSTS
Cytogenetic Map14q22-q24UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map10p11UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map3p25UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q22UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map20pter-q11.23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map3q13.31UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map1q24-q25.3UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map2q32.1UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12q24.32UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map13q12-q14UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11p14.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4q13UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map2p25.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map7p14.2UniSTS
Cytogenetic Map6q24.3UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map6q12-q13UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 19 of 19 rows
RefSeq Transcripts NG_027761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA433933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF188611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF216292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ271729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL354710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS288575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA549454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ385847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M19645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X87949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENST00000324460   ⟹   ENSP00000324173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,853 - 125,241,343 (-)Ensembl
Ensembl Acc Id: ENST00000679355
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000679475
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,344 (-)Ensembl
Ensembl Acc Id: ENST00000680032   ⟹   ENSP00000506285
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,236,489 - 125,241,382 (-)Ensembl
Ensembl Acc Id: ENST00000680234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,236,578 - 125,241,382 (-)Ensembl
Ensembl Acc Id: ENST00000680257
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,382 (-)Ensembl
Ensembl Acc Id: ENST00000680272   ⟹   ENSP00000506097
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000680494
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,344 (-)Ensembl
Ensembl Acc Id: ENST00000680640
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,342 (-)Ensembl
Ensembl Acc Id: ENST00000681045
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000681424
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000681540
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,236,562 - 125,241,382 (-)Ensembl
Ensembl Acc Id: ENST00000681544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000681675
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,368 (-)Ensembl
Ensembl Acc Id: ENST00000681774
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9125,234,860 - 125,241,344 (-)Ensembl
RefSeq Acc Id: NM_005347   ⟹   NP_005338
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389125,234,853 - 125,241,343 (-)NCBI
GRCh379127,997,127 - 128,003,666 (-)ENTREZGENE
Build 369127,036,953 - 127,043,430 (-)NCBI Archive
HuRef997,609,713 - 97,616,253 (-)ENTREZGENE
CHM1_19128,146,874 - 128,153,413 (-)NCBI
T2T-CHM13v2.09137,433,170 - 137,439,661 (-)NCBI
Sequence:
RefSeq Acc Id: NP_005338   ⟸   NM_005347
- Peptide Label: precursor
- UniProtKB: Q9NPF1 (UniProtKB/Swiss-Prot),   Q2EF78 (UniProtKB/Swiss-Prot),   B0QZ61 (UniProtKB/Swiss-Prot),   Q9UK02 (UniProtKB/Swiss-Prot),   P11021 (UniProtKB/Swiss-Prot),   V9HWB4 (UniProtKB/TrEMBL),   A0A7P0TB36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000324173   ⟸   ENST00000324460
Ensembl Acc Id: ENSP00000506097   ⟸   ENST00000680272
Ensembl Acc Id: ENSP00000506285   ⟸   ENST00000680032

Name Modeler Protein Id AA Range Protein Structure
AF-P11021-F1-model_v2 AlphaFold P11021 1-654 view protein structure

RGD ID:7216135
Promoter ID:EPDNEW_H13814
Type:initiation region
Name:HSPA5_1
Description:heat shock protein family A member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389125,241,343 - 125,241,403EPDNEW
RGD ID:6813642
Promoter ID:HG_ACW:82390
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid
Transcripts:HSPA5.CAPR07,   HSPA5.DAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 369127,041,321 - 127,041,822 (-)MPROMDB
RGD ID:6807776
Promoter ID:HG_KWN:64931
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005347
Position:
Human AssemblyChrPosition (strand)Source
Build 369127,043,351 - 127,044,057 (-)MPROMDB
RGD ID:6853286
Promoter ID:EP74464
Type:initiation region
Name:HS_HSPA5
Description:Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 369127,043,443 - 127,043,503EPD


1 to 40 of 43 rows
Database
Acc Id
Source(s)
COSMIC HSPA5 COSMIC
Ensembl Genes ENSG00000044574 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000324460 ENTREZGENE
  ENST00000324460.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  3.30.420.40 UniProtKB/Swiss-Prot
  Actin, Chain A, domain 4 UniProtKB/Swiss-Prot
  Substrate Binding Domain Of DNAk, Chain A, domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000044574 GTEx
HGNC ID HGNC:5238 ENTREZGENE
Human Proteome Map HSPA5 Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  BIP_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report hsa:3309 UniProtKB/Swiss-Prot
NCBI Gene 3309 ENTREZGENE
OMIM 138120 OMIM
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PharmGKB PA29504 PharmGKB
PRINTS HEATSHOCK70 UniProtKB/Swiss-Prot
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt A0A7P0TAI0_HUMAN UniProtKB/TrEMBL
  A0A7P0TB36 ENTREZGENE, UniProtKB/TrEMBL
  B0QZ61 ENTREZGENE
  BIP_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q2EF78 ENTREZGENE
  Q9NPF1 ENTREZGENE
  Q9UK02 ENTREZGENE
  V9HWB4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B0QZ61 UniProtKB/Swiss-Prot
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA5  heat shock protein family A (Hsp70) member 5    heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)  Symbol and/or name change 5135510 APPROVED