Dmp1 (dentin matrix acidic phosphoprotein 1) - Rat Genome Database

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Gene: Dmp1 (dentin matrix acidic phosphoprotein 1) Rattus norvegicus
Analyze
Symbol: Dmp1
Name: dentin matrix acidic phosphoprotein 1
RGD ID: 2508
Description: Enables Hsp70 protein binding activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within positive regulation of cell-substrate adhesion and regulation of enamel mineralization. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular matrix. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AG1; dentin matrix protein 1; DENTMAT; DMP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,833,111 - 5,867,154 (-)NCBIGRCr8
mRatBN7.2145,528,441 - 5,542,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,528,431 - 5,539,323 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,490,829 - 5,497,861 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,791,044 - 6,798,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,486,067 - 5,493,061 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,889,851 - 6,923,961 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,889,856 - 6,900,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,878,104 - 6,889,061 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,637,127 - 6,644,100 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,637,127 - 6,648,005 (-)NCBI
Celera145,667,320 - 5,674,293 (-)NCBICelera
RH 3.4 Map1488.8RGD
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
extracellular matrix  (IBA,IEA,ISO)
extracellular region  (IEA)
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. George A, etal., J Biol Chem 1993 Jun 15;268(17):12624-30.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Endoplasmic reticulum chaperone protein GRP-78 mediates endocytosis of dentin matrix protein 1. Ravindran S, etal., J Biol Chem. 2008 Oct 31;283(44):29658-70. doi: 10.1074/jbc.M800786200. Epub 2008 Aug 28.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10744713   PMID:11697797   PMID:12005026   PMID:12369786   PMID:12477932   PMID:12647294   PMID:12813042   PMID:14699165   PMID:14751569   PMID:15193538   PMID:15533758   PMID:16014627  
PMID:17950631   PMID:18215377   PMID:18698129   PMID:18757743   PMID:18854597   PMID:19001636   PMID:19908197   PMID:20200415   PMID:24076023   PMID:24085820   PMID:25158192   PMID:25158195  
PMID:27039006   PMID:27614627   PMID:30238933  


Genomics

Comparative Map Data
Dmp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,833,111 - 5,867,154 (-)NCBIGRCr8
mRatBN7.2145,528,441 - 5,542,078 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,528,431 - 5,539,323 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx145,490,829 - 5,497,861 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,791,044 - 6,798,076 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,486,067 - 5,493,061 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,889,851 - 6,923,961 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,889,856 - 6,900,733 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0146,878,104 - 6,889,061 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4146,637,127 - 6,644,100 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1146,637,127 - 6,648,005 (-)NCBI
Celera145,667,320 - 5,674,293 (-)NCBICelera
RH 3.4 Map1488.8RGD
Cytogenetic Map14p22NCBI
DMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,650,280 - 87,664,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,650,280 - 87,664,361 (+)EnsemblGRCh38hg38GRCh38
GRCh37488,571,432 - 88,585,509 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,790,483 - 88,804,534 (+)NCBINCBI36Build 36hg18NCBI36
Build 34488,928,637 - 88,942,686NCBI
Celera485,859,845 - 85,873,897 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,317,316 - 84,331,369 (+)NCBIHuRef
CHM1_1488,548,218 - 88,562,278 (+)NCBICHM1_1
T2T-CHM13v2.0490,976,706 - 90,990,757 (+)NCBIT2T-CHM13v2.0
Dmp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,345,441 - 104,361,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,350,479 - 104,361,968 (+)EnsemblGRCm39 Ensembl
GRCm385104,197,575 - 104,214,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,202,613 - 104,214,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv375104,631,636 - 104,643,121 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365104,442,930 - 104,454,375 (+)NCBIMGSCv36mm8
Celera5101,517,275 - 101,528,747 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.61NCBI
Dmp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554742,188,090 - 2,200,284 (-)NCBIChiLan1.0ChiLan1.0
DMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,653,451 - 85,671,285 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1485,915,798 - 85,933,632 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0479,943,709 - 79,957,430 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,669,649 - 90,683,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,675,812 - 90,682,314 (+)Ensemblpanpan1.1panPan2
DMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,022,900 - 11,053,900 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,045,508 - 11,053,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3230,900,611 - 30,931,380 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,076,073 - 11,106,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,093,408 - 11,106,325 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,159,225 - 11,189,280 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03210,984,877 - 11,015,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,939,356 - 28,952,608 (-)NCBIUU_Cfam_GSD_1.0
Dmp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052851,999,568 - 2,012,641 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936905420,354 - 427,324 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936905419,478 - 427,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,285,330 - 131,313,130 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18131,285,238 - 131,319,398 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,501,459 - 140,531,081 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,032,320 - 36,046,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,039,432 - 36,046,278 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603714,740,470 - 14,754,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248724,177,624 - 4,183,234 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248724,169,052 - 4,184,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dmp1
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:140
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000061224
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat

Markers in Region
RH94681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,530,599 - 5,530,848 (+)MAPPERmRatBN7.2
Rnor_6.0146,892,010 - 6,892,258NCBIRnor6.0
Rnor_5.0146,880,263 - 6,880,511UniSTSRnor5.0
RGSC_v3.4146,639,286 - 6,639,534UniSTSRGSC3.4
Celera145,669,479 - 5,669,727UniSTS
RH 3.4 Map1488.8UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 11 32 108 45 41 13 18 13 6 143 73 88 45 52 28

Sequence


Ensembl Acc Id: ENSRNOT00000061224   ⟹   ENSRNOP00000057936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,528,446 - 5,539,323 (-)Ensembl
Rnor_6.0 Ensembl146,889,856 - 6,900,733 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116244   ⟹   ENSRNOP00000095386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl145,528,431 - 5,539,323 (-)Ensembl
RefSeq Acc Id: NM_203493   ⟹   NP_987089
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,833,111 - 5,840,084 (-)NCBI
mRatBN7.2145,528,441 - 5,535,414 (-)NCBI
Rnor_6.0146,889,851 - 6,896,824 (-)NCBI
Rnor_5.0146,878,104 - 6,889,061 (-)NCBI
RGSC_v3.4146,637,127 - 6,644,100 (-)RGD
Celera145,667,320 - 5,674,293 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250622   ⟹   XP_006250684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,833,111 - 5,846,893 (-)NCBI
mRatBN7.2145,528,441 - 5,542,077 (-)NCBI
Rnor_6.0146,889,851 - 6,923,961 (-)NCBI
Rnor_5.0146,878,104 - 6,889,061 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272869   ⟹   XP_063128939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,833,111 - 5,867,154 (-)NCBI
RefSeq Acc Id: NP_987089   ⟸   NM_203493
- Peptide Label: precursor
- UniProtKB: P98193 (UniProtKB/Swiss-Prot),   A2VD06 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250684   ⟸   XM_006250622
- Peptide Label: isoform X1
- UniProtKB: P98193 (UniProtKB/Swiss-Prot),   A0A8I6GLL4 (UniProtKB/TrEMBL),   A6K5S9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057936   ⟸   ENSRNOT00000061224
Ensembl Acc Id: ENSRNOP00000095386   ⟸   ENSRNOT00000116244
RefSeq Acc Id: XP_063128939   ⟸   XM_063272869
- Peptide Label: isoform X1
- UniProtKB: P98193 (UniProtKB/Swiss-Prot),   A0A8I6GLL4 (UniProtKB/TrEMBL),   A6K5S9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P98193-F1-model_v2 AlphaFold P98193 1-489 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699174
Promoter ID:EPDNEW_R9699
Type:single initiation site
Name:Dmp1_1
Description:dentin matrix acidic phosphoprotein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,900,729 - 6,900,789EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2508 AgrOrtholog
BioCyc Gene G2FUF-16503 BioCyc
Ensembl Genes ENSRNOG00000002167 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061224.4 UniProtKB/TrEMBL
  ENSRNOT00000116244.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8365946 IMAGE-MGC_LOAD
InterPro DMP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25312 UniProtKB/TrEMBL
MGC_CLONE MGC:156551 IMAGE-MGC_LOAD
NCBI Gene 25312 ENTREZGENE
PANTHER DENTIN MATRIX ACIDIC PHOSPHOPROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DMP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dmp1 PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002167 RatGTEx
UniProt A0A8I6GLL4 ENTREZGENE, UniProtKB/TrEMBL
  A2VD06 ENTREZGENE, UniProtKB/TrEMBL
  A6K5S9 ENTREZGENE, UniProtKB/TrEMBL
  DMP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-17 Dmp1  dentin matrix acidic phosphoprotein 1  Dmp1  dentin matrix protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Dmp1  dentin matrix protein 1    Dentin matrix acidic phosphoprotein 1  Symbol and Name updated 625702 APPROVED
2002-06-10 Dmp1  Dentin matrix acidic phosphoprotein 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains acidic consensus sites for phosphorylation by casein kinases I and II, and single RGD integrin binding and N-glycosylation sequences 728616
gene_expression protein is found in phosphorylated form in the dentin matrix 728616
gene_protein predicted protein contains 473 aa residues 728616