Hspa1a (heat shock protein 1A) - Rat Genome Database
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Gene: Hspa1a (heat shock protein 1A) Mus musculus
Analyze
Symbol: Hspa1a
Name: heat shock protein 1A
RGD ID: 1558069
MGI Page MGI
Description: Exhibits protein folding chaperone. Involved in several processes, including DNA metabolic process; lysosomal transport; and response to heat. Localizes to cytoplasm. Predicted to colocalize with COP9 signalosome. Is expressed in several structures, including adrenal gland; early conceptus; genitourinary system; and vibrissa. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-amphetamine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa heat shock protein; heat shock 70 kDa protein 1A; heat shock 70 kDa protein 3; heat shock 70kDa protein 1A; heat shock protein, 70 kDa 3; Hsp; hsp68; Hsp7; Hsp70; Hsp70-3; Hsp70.3; hsp70A1; Hsp72; inducible heat shock protein 70; MGC189852
RGD Orthologs
Human
Rat
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39mm39
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBImm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-amphetamine  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dichloroindophenol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-dihydrocoumarin  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
aminoglutethimide  (ISO)
ammonia  (EXP)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
aniline  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Aurin  (ISO)
azadiradione  (ISO)
azetidinecarboxylic acid  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (ISO)
carboplatin  (ISO)
carrageenan  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
cerium trichloride  (ISO)
chelerythrine  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chrysene  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
Dimethyl adipate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (ISO)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
famotidine  (ISO)
fenbuconazole  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
flavone  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
formetanate  (ISO)
gadolinium trichloride  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GYKI 52466  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indometacin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methomyl  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
morphine  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naloxone  (ISO)
naphthalene  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nitrobenzenes  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
orphenadrine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (EXP)
pirimicarb  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
polaprezinc  (ISO)
poly(I:C)  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propiconazole  (EXP)
Protolichesterinic acid  (ISO)
pyrene  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
styrene  (ISO)
sulfasalazine  (EXP)
tamoxifen  (EXP)
tanespimycin  (ISO)
temozolomide  (ISO)
teprenone  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetraphene  (EXP)
thimerosal  (EXP,ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triazines  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (IBA,ISO)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (ISO)
DNA repair  (IMP)
lysosomal transport  (IMP)
mRNA catabolic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to stress  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron differentiation  (ISO)
positive regulation of endoribonuclease activity  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (IDA)
protein refolding  (IBA,ISO)
protein stabilization  (ISO)
regulation of cell death  (ISO)
regulation of mitotic spindle assembly  (IBA,ISO)
regulation of protein ubiquitination  (ISO)
response to ethanol  (ISO)
response to heat  (IDA,IMP)
response to ischemia  (ISO)
response to mechanical stimulus  (ISO)
response to radiation  (ISO)
response to unfolded protein  (ISO)
telomere maintenance  (IMP)
vesicle-mediated transport  (IBA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
2. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
3. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
4. Dong Z, etal., Mol Ther. 2005 Jan;11(1):80-8.
5. Dulin E, etal., Cell Stress Chaperones. 2010 Nov;15(6):929-37. Epub 2010 May 20.
6. Dulin E, etal., Cell Stress Chaperones. 2012 Jul;17(4):507-16. doi: 10.1007/s12192-012-0328-4. Epub 2012 Feb 11.
7. Fung HC, etal., Dement Geriatr Cogn Disord. 2005;20(1):1-7. Epub 2005 Apr 12.
8. Furnrohr BG, etal., Ann Rheum Dis. 2010 Nov;69(11):1983-9. Epub 2010 May 24.
9. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
10. Grossin L, etal., FASEB J. 2006 Jan;20(1):65-75.
11. He M, etal., PLoS One. 2009;4(3):e4851. doi: 10.1371/journal.pone.0004851. Epub 2009 Mar 31.
12. Hua F, etal., J Neuroinflammation. 2011 May 8;8:42.
13. Jenei ZM, etal., Cell Stress Chaperones. 2013 Apr 7.
14. Jenei ZM, etal., Cell Stress Chaperones. 2013 Jul;18(4):447-54. doi: 10.1007/s12192-012-0399-2. Epub 2013 Jan 16.
15. Kawaguchi S, etal., Acta Otolaryngol. 2008 Nov;128(11):1173-7. doi: 10.1080/00016480801901675.
16. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
17. Kowalczyk M, etal., Cell Stress Chaperones. 2013 Jul 28.
18. Lonati C, etal., Anesthesiology. 2012 Mar;116(3):692-700. doi: 10.1097/ALN.0b013e318246ea68.
19. Maggioli E, etal., Int J Immunogenet. 2014 Feb;41(1):44-53. doi: 10.1111/iji.12077. Epub 2013 Jul 22.
20. MGD data from the GO Consortium
21. MGD IEA
22. Mosenson JA, etal., Sci Transl Med. 2013 Feb 27;5(174):174ra28. doi: 10.1126/scitranslmed.3005127.
23. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
24. Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
25. Pipeline to import KEGG annotations from KEGG into RGD
26. Rejdak K, etal., Epilepsia. 2012 May;53(5):922-7. doi: 10.1111/j.1528-1167.2012.03459.x. Epub 2012 Apr 17.
27. RGD automated import pipeline
28. RGD automated import pipeline for gene-chemical interactions
29. Wilhide ME, etal., J Mol Cell Cardiol. 2011 Jul;51(1):82-9. doi: 10.1016/j.yjmcc.2011.03.011. Epub 2011 Mar 23.
30. Yang M, etal., Cell Stress Chaperones. 2006 Autumn;11(3):233-9.
31. Zhang HN, etal., Neurol Sci. 2013 Apr;34(4):471-7. doi: 10.1007/s10072-012-1063-4. Epub 2012 Apr 18.
32. Zhang X, etal., Cardiology. 2011;119(1):57-64. doi: 10.1159/000329917. Epub 2011 Aug 17.
Additional References at PubMed
PMID:2868009   PMID:3582732   PMID:7806281   PMID:7916002   PMID:7988674   PMID:7993390   PMID:8076831   PMID:8199408   PMID:8449501   PMID:8486356   PMID:9122205   PMID:9551980  
PMID:9685725   PMID:9820195   PMID:10349636   PMID:10783129   PMID:11032181   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11568360   PMID:11713291   PMID:12466851   PMID:12477932  
PMID:12714332   PMID:12834871   PMID:14656967   PMID:14672969   PMID:14701760   PMID:14766729   PMID:15129916   PMID:15155620   PMID:15371421   PMID:15498567   PMID:15719414   PMID:15988927  
PMID:16002707   PMID:16100242   PMID:16141072   PMID:16141073   PMID:16306130   PMID:16361353   PMID:16397188   PMID:16482515   PMID:16602821   PMID:16651615   PMID:16679378   PMID:16705022  
PMID:16735677   PMID:16906134   PMID:16971451   PMID:17126904   PMID:17234954   PMID:17244351   PMID:17482577   PMID:17513788   PMID:17617616   PMID:17661394   PMID:17947709   PMID:18056375  
PMID:18379898   PMID:18385140   PMID:18755693   PMID:18927263   PMID:19005184   PMID:19052621   PMID:19157555   PMID:19269368   PMID:19299581   PMID:19581626   PMID:19605647   PMID:19639652  
PMID:20018843   PMID:20093776   PMID:20235222   PMID:20368414   PMID:20430459   PMID:20643136   PMID:20679486   PMID:20849898   PMID:20926391   PMID:21094186   PMID:21108992   PMID:21135124  
PMID:21266579   PMID:21267068   PMID:21270764   PMID:21296977   PMID:21297664   PMID:21757701   PMID:21873635   PMID:22461698   PMID:22495301   PMID:22673618   PMID:22792201   PMID:22940431  
PMID:22956628   PMID:23212905   PMID:23271055   PMID:23352621   PMID:23704948   PMID:23816752   PMID:23817427   PMID:23847051   PMID:23980576   PMID:24142690   PMID:24347059   PMID:24379352  
PMID:24430435   PMID:24667831   PMID:24726381   PMID:25446099   PMID:25555205   PMID:25618331   PMID:25638293   PMID:25727182   PMID:26197988   PMID:26311113   PMID:26370502   PMID:26476215  
PMID:26851345   PMID:26923070   PMID:26976620   PMID:27113764   PMID:27317670   PMID:27496612   PMID:27789271   PMID:28025138   PMID:28378742   PMID:28837204   PMID:29964156   PMID:30068389  
PMID:30333137   PMID:30457570   PMID:30532989   PMID:30704515   PMID:30713523   PMID:31102152   PMID:31320473   PMID:32169844   PMID:32325033   PMID:32758484  


Genomics

Comparative Map Data
Hspa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39mm39
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBImm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
HSPA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37631,782,952 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
Hspa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,875,834 - 4,881,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,363,499 - 32,366,005 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0panPan3
Hspa1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367271,732,323 - 1,735,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103221745
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,203,647 - 40,206,028 (-)NCBI
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)Ensembl

Position Markers
M12572  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,969,717 - 34,969,907UniSTSGRCm38
MGSCv371735,106,662 - 35,106,852UniSTSGRCm37
Celera1738,065,941 - 38,066,131UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.95UniSTS
Whitehead_YAC17 UniSTS
Hspa1a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,969,732 - 34,969,962UniSTSGRCm38
MGSCv371735,106,677 - 35,106,907UniSTSGRCm37
Celera1738,065,956 - 38,066,186UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.945UniSTS
PMC117401P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,971,100 - 34,971,579UniSTSGRCm38
GRCm381734,958,182 - 34,958,661UniSTSGRCm38
MGSCv371735,095,127 - 35,095,606UniSTSGRCm37
MGSCv371735,108,045 - 35,108,524UniSTSGRCm37
Celera1738,054,411 - 38,054,890UniSTS
Celera1738,067,324 - 38,067,803UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.95UniSTS
cM Map1718.9UniSTS
cM Map1718.95UniSTS
PMC314357P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,971,069 - 34,971,557UniSTSGRCm38
GRCm381734,958,151 - 34,958,639UniSTSGRCm38
MGSCv371735,095,096 - 35,095,584UniSTSGRCm37
MGSCv371735,108,014 - 35,108,502UniSTSGRCm37
Celera1738,054,380 - 38,054,868UniSTS
Celera1738,067,293 - 38,067,781UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.95UniSTS
cM Map1718.9UniSTS
cM Map1718.95UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173184267837333884Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173244145235301060Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173360074735939288Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:546
Count of miRNA genes:422
Interacting mature miRNAs:464
Transcripts:ENSMUST00000087328, ENSMUST00000179128
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC054782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC157921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU406961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU463845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF100780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M76613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000087328   ⟹   ENSMUSP00000084586
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)Ensembl
RefSeq Acc Id: NM_010479   ⟹   NP_034609
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,188,335 - 35,191,132 (-)NCBI
GRCm381734,969,359 - 34,972,156 (-)ENTREZGENE
MGSCv371735,106,304 - 35,109,101 (-)RGD
Celera1738,065,583 - 38,068,380 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034609   ⟸   NM_010479
- UniProtKB: Q61696 (UniProtKB/Swiss-Prot),   Q3TU85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000084586   ⟸   ENSMUST00000087328

Promoters
RGD ID:13675768
Promoter ID:EPDNEW_M22033
Type:multiple initiation site
Name:Hspa1a_1
Description:Mus musculus heat shock protein 1A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,972,153 - 34,972,213EPDNEW
RGD ID:6828249
Promoter ID:MM_KWN:23252
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:NM_010479
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361735,106,951 - 35,108,997 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96244 AgrOrtholog
Ensembl Genes ENSMUSG00000091971 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000084586 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000087328 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:193740 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96244 ENTREZGENE
NCBI Gene 193740 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hspa1a PhenoGen
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt HS71A_MOUSE UniProtKB/Swiss-Prot
  Q3TU85 ENTREZGENE, UniProtKB/TrEMBL
  Q61696 ENTREZGENE
UniProt Secondary Q61697 UniProtKB/Swiss-Prot
  Q7TQD8 UniProtKB/Swiss-Prot
  Q9QWJ5 UniProtKB/Swiss-Prot