HSPA5 (heat shock protein family A (Hsp70) member 5) - Rat Genome Database
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Gene: HSPA5 (heat shock protein family A (Hsp70) member 5) Sus scrofa
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Symbol: HSPA5
Name: heat shock protein family A (Hsp70) member 5
RGD ID: 14191050
Description: ENCODES a protein that exhibits ATPase activity (ortholog); enzyme binding (ortholog); INVOLVED IN cellular response to antibiotic (ortholog); cellular response to calcium ion (ortholog); cellular response to cAMP (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); asbestosis (ortholog); Breast Neoplasms (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,4-dithiothreitol; acetylsalicylic acid; actinomycin D
Type: protein-coding
RefSeq Status: MODEL
Also known as: 78 kDa glucose-regulated protein; BIP; glucose-regulated protein, 78kDa; GRP78
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to antibiotic  (ISO)
cellular response to calcium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to drug  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to glucose starvation  (IEA)
cellular response to interleukin-4  (IEA)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to unfolded protein  (IBA)
cerebellar Purkinje cell layer development  (IEA)
cerebellum structural organization  (IEA)
chaperone cofactor-dependent protein refolding  (IBA)
endoplasmic reticulum unfolded protein response  (IBA,IEA)
ER overload response  (IEA)
IRE1-mediated unfolded protein response  (ISO)
luteolysis  (ISO)
maintenance of protein localization in endoplasmic reticulum  (IEA,ISS)
negative regulation of apoptotic process  (IEA)
negative regulation of IRE1-mediated unfolded protein response  (ISS)
negative regulation of protein-containing complex assembly  (ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (IEA)
neuron apoptotic process  (ISO)
neuron differentiation  (ISO)
positive regulation of cell migration  (IEA,ISS)
positive regulation of neuron projection development  (ISO)
positive regulation of protein ubiquitination  (IEA)
posttranslational protein targeting to membrane, translocation  (IEA,ISS)
protein refolding  (IBA)
proteolysis involved in cellular protein catabolic process  (IEA)
response to cocaine  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to methamphetamine hydrochloride  (ISO)
response to radiation  (ISO)
stress response to metal ion  (ISO)
substantia nigra development  (ISO)
toxin transport  (IEA)
ubiquitin-dependent ERAD pathway  (IBA)

Molecular Function

References
Additional References at PubMed
PMID:3360780   PMID:8104765   PMID:11683720   PMID:14681463   PMID:17145712   PMID:26907328  


Genomics

Comparative Map Data
HSPA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,930,045 - 265,934,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,754,103 - 299,758,617 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q2.10-q2.13NCBI
HSPA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9125,234,853 - 125,241,343 (-)EnsemblGRCh38hg38GRCh38
GRCh389125,234,853 - 125,241,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379127,997,127 - 128,003,666 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369127,036,953 - 127,043,430 (-)NCBINCBI36hg18NCBI36
Build 349125,076,687 - 125,083,163NCBI
Celera998,645,114 - 98,651,649 (-)NCBI
Cytogenetic Map9q33.3NCBI
HuRef997,609,713 - 97,616,253 (-)NCBIHuRef
CHM1_19128,146,874 - 128,153,413 (-)NCBICHM1_1
Hspa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39234,662,102 - 34,666,541 (+)NCBIGRCm39mm39
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl234,771,970 - 34,777,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBImm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.94NCBI
Hspa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0313,838,304 - 13,842,763 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl313,838,304 - 13,842,762 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0319,157,874 - 19,162,333 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4313,783,825 - 13,788,022 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1313,680,196 - 13,684,394 (+)NCBI
Celera312,776,654 - 12,781,113 (+)NCBICelera
Cytogenetic Map3p11NCBI
RH 3.4 Map3151.7RGD
Hspa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,055,420 - 3,062,131 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,055,420 - 3,060,208 (+)NCBIChiLan1.0ChiLan1.0
HSPA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19124,865,211 - 124,870,458 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,865,211 - 124,870,458 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0996,351,645 - 96,356,761 (-)NCBIMhudiblu_PPA_v0panPan3
HSPA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl957,850,922 - 57,855,257 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1957,850,870 - 57,855,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hspa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648713,348,465 - 13,352,717 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11212,920,705 - 12,925,888 (+)NCBI
ChlSab1.1 Ensembl1212,920,710 - 12,927,431 (+)Ensembl
Hspa5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247609,986,529 - 9,991,261 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000048425   ⟹   ENSSSCP00000055982
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1265,930,045 - 265,934,904 (-)Ensembl
RefSeq Acc Id: XM_001927795   ⟹   XP_001927830
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11265,930,044 - 265,934,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068830   ⟹   XP_020924489
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11265,930,044 - 265,934,904 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001927830 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924489 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA31006 (Get FASTA)   NCBI Sequence Viewer  
  P34935 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001927830   ⟸   XM_001927795
- Peptide Label: isoform X2
- UniProtKB: A0A287BIL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020924489   ⟸   XM_021068830
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000055982   ⟸   ENSSSCT00000048425


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070016341 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000055982 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070026836 UniProtKB/TrEMBL
  ENSSSCP00070026850 UniProtKB/TrEMBL
  ENSSSCP00070026862 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048425 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070032163 UniProtKB/TrEMBL
  ENSSSCT00070032177 UniProtKB/TrEMBL
  ENSSSCT00070032190 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIP_NBD UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:407060 UniProtKB/TrEMBL
NCBI Gene HSPA5 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HSP70_1 UniProtKB/TrEMBL
  HSP70_2 UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.1717 ENTREZGENE
UniProt A0A287BIL8 ENTREZGENE, UniProtKB/TrEMBL
  A0A480UES1_PIG UniProtKB/TrEMBL
  A0A4X1UEN5_PIG UniProtKB/TrEMBL
  A0A4X1UEP5_PIG UniProtKB/TrEMBL
  A0A4X1UFV5_PIG UniProtKB/TrEMBL
  BIP_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:103107 ENTREZGENE