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Gene: Hspa1b (heat shock protein 1B) Mus musculus
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Symbol: Hspa1b
Name: heat shock protein 1B
Description: Exhibits protein folding chaperone. Involved in several processes, including binding activity of sperm to zona pellucida; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and response to heat. Localizes to the cell body; mitochondrion; and zona pellucida receptor complex. Predicted to colocalize with the COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; senile cataract; toxic shock syndrome; and type 2 diabetes mellitus. Is expressed in early conceptus and embryo. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa heat shock protein; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1B; heat shock 70kDa protein 1B; heat shock protein 70.1; heat shock protein, 70 kDa 1; hsp68; Hsp70; Hsp70-1; Hsp70.1; HSP70B1
Orthologs:
Homo sapiens (human) : HSPA1B (heat shock protein family A (Hsp70) member 1B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspa1b (heat shock protein family A (Hsp70) member 1B)  Alliance
Canis lupus familiaris (dog) : HSP70 (heat shock protein 70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1b (heat shock protein family A (Hsp70) member 1B)
Chlorocebus sabaeus (African green monkey) : HSPA1B (heat shock protein family A (Hsp70) member 1B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1734,956,436 - 34,959,238 (-)Ensembl
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBImm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hspa1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736399
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.