Hspa1b (heat shock protein 1B) - Rat Genome Database
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Gene: Hspa1b (heat shock protein 1B) Mus musculus
Analyze
Symbol: Hspa1b
Name: heat shock protein 1B
RGD ID: 736399
MGI Page MGI
Description: Exhibits protein folding chaperone. Involved in several processes, including binding activity of sperm to zona pellucida; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and response to heat. Localizes to cell body; mitochondrion; and zona pellucida receptor complex. Predicted to colocalize with COP9 signalosome. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in several diseases, including CAKUT; brain ischemia; obesity; toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-amphetamine; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa heat shock protein; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1B; heat shock 70kDa protein 1B; heat shock protein 70.1; heat shock protein, 70 kDa 1; hsp; hsp68; Hsp70; Hsp70-1; Hsp70.1; HSP70B1
RGD Orthologs
Human
Rat
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,175,405 - 35,178,214 (-)NCBIGRCm39mm39
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,956,436 - 34,959,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBImm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxyethanol  (ISO)
2-methylcholine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (EXP)
5-fluorouracil  (ISO)
acrolein  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP)
alpha-pinene  (ISO)
AM-251  (ISO)
ammonium chloride  (ISO)
apigenin  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azetidinecarboxylic acid  (EXP)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
captan  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carnosine  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
chloroquine  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dichloroacetic acid  (EXP)
diclofenac  (EXP)
dieldrin  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP)
elesclomol  (ISO)
ethanol  (EXP,ISO)
fluoranthene  (EXP)
folpet  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glutathione  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (EXP)
ifosfamide  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
LY294002  (EXP)
maneb  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin RR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methylformamide  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
nickel dichloride  (ISO)
Niflumic acid  (EXP)
oleanolic acid  (EXP)
organoselenium compound  (ISO)
orphenadrine  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
polaprezinc  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propanil  (ISO)
propiconazole  (EXP)
quercetin  (EXP,ISO)
raloxifene  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (EXP)
sertraline  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP)
Sodium salicylate  (EXP)
Soman  (ISO)
succimer  (EXP)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (EXP)
tanespimycin  (ISO)
teprenone  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
triazines  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vanillin  (ISO)
vitamin E  (ISO)
zearalenone  (EXP,ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
binding of sperm to zona pellucida  (IDA)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (IBA,ISO)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (ISO)
defense response  (ISO)
mRNA catabolic process  (ISO)
negative regulation of apoptotic process  (IDA,ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to stress  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of vasoconstriction  (ISO)
positive regulation of endoribonuclease activity  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (IDA)
protein refolding  (IBA,ISO)
protein stabilization  (ISO)
regulation of cell death  (ISO)
regulation of mitotic spindle assembly  (IBA,ISO)
regulation of protein ubiquitination  (ISO)
response to heat  (IDA)
response to unfolded protein  (ISO)
vesicle-mediated transport  (IBA)

References

References - curated
1. Akcetin Z, etal., Urol Int. 2000;65(1):32-9.
2. Akcetin Z, etal., Urol Res. 1999 Oct;27(5):306-11.
3. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
4. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
5. Chouchane L, etal., Int J Obes Relat Metab Disord. 2001 Apr;25(4):462-6.
6. Clarimon J, etal., J Geriatr Psychiatry Neurol. 2003 Sep;16(3):146-50.
7. Giacconi R, etal., Mech Ageing Dev. 2005 Aug;126(8):866-73. Epub 2005 Apr 18.
8. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
9. Konings A, etal., Eur J Hum Genet. 2009 Mar;17(3):329-35. doi: 10.1038/ejhg.2008.172. Epub 2008 Sep 24.
10. Lisowska K, etal., Biochim Biophys Acta 1994 Sep 13;1219(1):64-72.
11. Lund T, etal., Diabetologia 1993 Aug;36(8):727-33.
12. MGD and Homologene mouse data transfer
13. MGD data from the GO Consortium
14. MGD IEA
15. Mir KA, etal., Br J Surg. 2009 Oct;96(10):1205-9. doi: 10.1002/bjs.6689.
16. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
17. Pipeline to import KEGG annotations from KEGG into RGD
18. RGD automated import pipeline
19. RGD automated import pipeline for gene-chemical interactions
20. Rusai K, etal., Transplant Proc. 2010 Jul-Aug;42(6):2309-11. doi: 10.1016/j.transproceed.2010.05.010.
21. Waterer GW, etal., Crit Care Med. 2003 May;31(5):1367-72.
22. Zaffanello M, etal., J Biomed Biotechnol. 2010;2010:321082. doi: 10.1155/2010/321082. Epub 2010 Mar 30.
23. Zhang Y, etal., Cell Stress Chaperones. 2013 Nov;18(6):703-9. doi: 10.1007/s12192-013-0420-4. Epub 2013 May 11.
24. Zouari Bouassida K, etal., Diabetes Metab. 2004 Apr;30(2):175-80.
Additional References at PubMed
PMID:1351875   PMID:1537426   PMID:1612651   PMID:1618738   PMID:1673964   PMID:1684177   PMID:1700760   PMID:1978715   PMID:2010034   PMID:2251119   PMID:2302214   PMID:2332169  
PMID:2351441   PMID:2377456   PMID:2557196   PMID:2868009   PMID:3201244   PMID:3405224   PMID:6201852   PMID:6413838   PMID:7512619   PMID:7560085   PMID:7588075   PMID:7631901  
PMID:7806281   PMID:7813466   PMID:7867493   PMID:7988673   PMID:7988674   PMID:7993390   PMID:8007971   PMID:8076831   PMID:8097912   PMID:8157642   PMID:8199408   PMID:8262211  
PMID:8449501   PMID:8454632   PMID:8486356   PMID:8562047   PMID:8586457   PMID:8601336   PMID:8624724   PMID:8650181   PMID:8672132   PMID:8726224   PMID:8844684   PMID:8974842  
PMID:9001232   PMID:9060426   PMID:9110944   PMID:9118005   PMID:9118006   PMID:9118007   PMID:9122205   PMID:9305631   PMID:9431456   PMID:9463375   PMID:9466981   PMID:9551980  
PMID:9712876   PMID:9820195   PMID:9857057   PMID:9880236   PMID:10349636   PMID:10452866   PMID:10545106   PMID:10689300   PMID:10723724   PMID:10748209   PMID:10783129   PMID:10862698  
PMID:10871872   PMID:10942430   PMID:11032181   PMID:11042159   PMID:11076861   PMID:11116152   PMID:11217851   PMID:11438701   PMID:11448943   PMID:11527400   PMID:11584023   PMID:11713291  
PMID:11739994   PMID:11811585   PMID:11879190   PMID:11884472   PMID:11937580   PMID:12049720   PMID:12114509   PMID:12189176   PMID:12231209   PMID:12379476   PMID:12380683   PMID:12466296  
PMID:12466851   PMID:12477932   PMID:12588994   PMID:12714332   PMID:12748967   PMID:12843283   PMID:12882502   PMID:12944486   PMID:14532117   PMID:14555980   PMID:14656967   PMID:14701760  
PMID:14766729   PMID:14962978   PMID:15135218   PMID:15189447   PMID:15243143   PMID:15327774   PMID:15456882   PMID:15483628   PMID:15590690   PMID:15639784   PMID:15715955   PMID:15735755  
PMID:15802640   PMID:15826944   PMID:15864309   PMID:15936758   PMID:15959878   PMID:15988927   PMID:16008572   PMID:16081837   PMID:16116448   PMID:16136780   PMID:16141072   PMID:16141073  
PMID:16260608   PMID:16263790   PMID:16298734   PMID:16361353   PMID:16407317   PMID:16424188   PMID:16554822   PMID:16563356   PMID:16571921   PMID:16624816   PMID:16697380   PMID:16705022  
PMID:16727733   PMID:16735677   PMID:16798735   PMID:16880526   PMID:16912653   PMID:16931512   PMID:17014532   PMID:17018872   PMID:17046822   PMID:17069463   PMID:17185630   PMID:17208201  
PMID:17234954   PMID:17274640   PMID:17334227   PMID:17376863   PMID:17427954   PMID:17540008   PMID:17556362   PMID:17661394   PMID:17671199   PMID:17914183   PMID:17980153   PMID:18056375  
PMID:18073525   PMID:18218636   PMID:18337834   PMID:18348256   PMID:18385140   PMID:18392951   PMID:18434628   PMID:18495661   PMID:18511309   PMID:18512096   PMID:18580041   PMID:18581325  
PMID:18703412   PMID:18755693   PMID:18841484   PMID:18849323   PMID:18940912   PMID:18945899   PMID:18959120   PMID:19005184   PMID:19036738   PMID:19072255   PMID:19109201   PMID:19116445  
PMID:19136968   PMID:19171884   PMID:19269368   PMID:19299493   PMID:19299581   PMID:19336471   PMID:19338779   PMID:19357808   PMID:19439408   PMID:19549684   PMID:19581287   PMID:19581626  
PMID:19605647   PMID:19615333   PMID:19639652   PMID:19725048   PMID:19745103   PMID:19776393   PMID:19816249   PMID:19841136   PMID:19888987   PMID:20110459   PMID:20159978   PMID:20516211  
PMID:20566634   PMID:20679486   PMID:21053113   PMID:21087969   PMID:21114495   PMID:21135124   PMID:21183741   PMID:21187371   PMID:21246580   PMID:21270764   PMID:21296977   PMID:21356360  
PMID:21439970   PMID:21536655   PMID:21749827   PMID:21775628   PMID:21782904   PMID:21817814   PMID:21873635   PMID:21880732   PMID:21960124   PMID:21978301   PMID:22275297   PMID:22327294  
PMID:22396390   PMID:22461698   PMID:22590864   PMID:22617454   PMID:22647551   PMID:22896903   PMID:22900316   PMID:23023377   PMID:23096703   PMID:23135720   PMID:23178238   PMID:23240583  
PMID:23247210   PMID:23251530   PMID:23419754   PMID:23569248   PMID:23626847   PMID:23679814   PMID:23780557   PMID:23808579   PMID:23816752   PMID:23817427   PMID:23847051   PMID:23863716  
PMID:23872636   PMID:23973223   PMID:23980576   PMID:24173532   PMID:24219791   PMID:24251647   PMID:24357103   PMID:24376495   PMID:24421334   PMID:24510904   PMID:24586549   PMID:24651434  
PMID:24662819   PMID:24726381   PMID:24909693   PMID:25153885   PMID:25167838   PMID:25329411   PMID:25330109   PMID:25485480   PMID:25603952   PMID:25792827   PMID:25840912   PMID:26197988  
PMID:26215736   PMID:26398934   PMID:26799792   PMID:26976620   PMID:27021371   PMID:27477512   PMID:27496612   PMID:27498116   PMID:27889896   PMID:27925208   PMID:28116619   PMID:28152512  
PMID:28317868   PMID:28737513   PMID:28837204   PMID:28928431   PMID:29179216   PMID:29459677   PMID:29572180   PMID:29631603   PMID:29715263   PMID:29733819   PMID:29749430   PMID:30409884  
PMID:30543447   PMID:30596969   PMID:30632067   PMID:30874540   PMID:31102152   PMID:31320473   PMID:31756487   PMID:32169844  


Genomics

Comparative Map Data
Hspa1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,175,405 - 35,178,214 (-)NCBIGRCm39mm39
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,956,436 - 34,959,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBImm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
HSPA1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,827,738 - 31,830,254 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,827,738 - 31,830,254 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,795,515 - 31,798,031 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37631,789,964 - 31,798,032 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,903,503 - 31,906,010 (+)NCBINCBI36hg18NCBI36
Build 34631,903,502 - 31,906,010NCBI
Celera633,393,763 - 33,396,281 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,582,004 - 31,584,555 (+)NCBIHuRef
CHM1_1631,797,655 - 31,800,174 (+)NCBICHM1_1
Hspa1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,855,104 - 3,859,148 (+)NCBI
Rnor_6.0 Ensembl202,699,712 - 2,701,815 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,877,638 - 4,880,112 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,029,038 - 7,033,025 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,802,576 - 4,804,849 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,955,274 - 3,957,748 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,167,705 - 4,171,749 (-)NCBICelera
RH 3.4 Map20 RGD
Cytogenetic Map20p12NCBI
HSP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,285,282 - 1,287,670 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hspa1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367271,718,952 - 1,721,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103221743
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,191,695 - 40,194,459 (-)NCBI
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)Ensembl

Position Markers
D17Mit83.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,990 - 34,957,099UniSTSGRCm38
MGSCv371735,093,935 - 35,094,044UniSTSGRCm37
Celera1738,053,219 - 38,053,328UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.9UniSTS
cM Map17 UniSTS
Whitehead_YAC17 UniSTS
Hspa1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,726 - 34,957,020UniSTSGRCm38
MGSCv371735,093,671 - 35,093,965UniSTSGRCm37
Celera1738,052,955 - 38,053,249UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.9UniSTS
D17Mit83  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,841 - 34,956,961UniSTSGRCm38
MGSCv371735,093,786 - 35,093,906UniSTSGRCm37
Celera1738,053,070 - 38,053,190UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.9UniSTS
Whitehead Genetic178.7UniSTS
PMC117401P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,971,100 - 34,971,579UniSTSGRCm38
GRCm381734,958,182 - 34,958,661UniSTSGRCm38
MGSCv371735,095,127 - 35,095,606UniSTSGRCm37
MGSCv371735,108,045 - 35,108,524UniSTSGRCm37
Celera1738,054,411 - 38,054,890UniSTS
Celera1738,067,324 - 38,067,803UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.95UniSTS
cM Map1718.9UniSTS
cM Map1718.95UniSTS
PMC314357P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,971,069 - 34,971,557UniSTSGRCm38
GRCm381734,958,151 - 34,958,639UniSTSGRCm38
MGSCv371735,095,096 - 35,095,584UniSTSGRCm37
MGSCv371735,108,014 - 35,108,502UniSTSGRCm37
Celera1738,054,380 - 38,054,868UniSTS
Celera1738,067,293 - 38,067,781UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.95UniSTS
cM Map1718.9UniSTS
cM Map1718.95UniSTS
D17Mit1011  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,656 - 34,956,838UniSTSGRCm38
MGSCv371735,093,601 - 35,093,783UniSTSGRCm37
Celera1738,052,885 - 38,053,067UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.9UniSTS
cM Map17 UniSTS
D17Nds2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,842 - 34,956,943UniSTSGRCm38
MGSCv371735,093,787 - 35,093,888UniSTSGRCm37
Celera1738,053,071 - 38,053,172UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.94UniSTS
cM Map1718.9UniSTS
Hspa1b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,956,828 - 34,957,393UniSTSGRCm38
MGSCv371735,093,773 - 35,094,338UniSTSGRCm37
Celera1738,053,057 - 38,053,622UniSTS
Cytogenetic Map17B1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173184267837333884Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173244145235301060Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173360074735939288Mouse
1301759Sles1_msystemic lupus erythmatosus suppressor 1 (mouse)Not determined173400091634956961Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173495684169858931Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1a-1mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17715156
Mir1a-2mmu-miR-1a-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17715156

Predicted Target Of
Summary Value
Count of predictions:1144
Count of miRNA genes:561
Interacting mature miRNAs:661
Transcripts:ENSMUST00000165202, ENSMUST00000172753
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000172753   ⟹   ENSMUSP00000133815
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1734,956,436 - 34,959,238 (-)Ensembl
RefSeq Acc Id: NM_010478   ⟹   NP_034608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,175,405 - 35,178,214 (-)NCBI
GRCm381734,956,429 - 34,959,238 (-)ENTREZGENE
MGSCv371735,093,374 - 35,096,183 (-)RGD
Celera1738,052,658 - 38,055,467 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034608   ⟸   NM_010478
- UniProtKB: P17879 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000133815   ⟸   ENSMUST00000172753

Promoters
RGD ID:13675766
Promoter ID:EPDNEW_M22032
Type:multiple initiation site
Name:Hspa1b_1
Description:Mus musculus heat shock protein 1B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,959,235 - 34,959,295EPDNEW
RGD ID:6828252
Promoter ID:MM_KWN:23250
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_010478
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361735,095,026 - 35,096,962 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99517 AgrOrtholog
Ensembl Genes ENSMUSG00000090877 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000133815 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000172753 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  2.60.34.10 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report mmu:15511 UniProtKB/Swiss-Prot
MGD MGI:99517 ENTREZGENE
NCBI Gene 15511 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa1b PhenoGen
PROSITE HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt HS71B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q61689 UniProtKB/Swiss-Prot
  Q925V6 UniProtKB/Swiss-Prot