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Gene: Hspa1b (heat shock protein 1B) Mus musculus
Symbol: Hspa1b
Name: heat shock protein 1B
Description: Exhibits protein folding chaperone. Involved in several processes, including binding activity of sperm to zona pellucida; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; and response to heat. Localizes to the cell body; mitochondrion; and zona pellucida receptor complex. Predicted to colocalize with the COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including brain ischemia; obesity; senile cataract; toxic shock syndrome; and type 2 diabetes mellitus. Is expressed in early conceptus and embryo. Orthologous to human HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa heat shock protein; heat shock 70 kDa protein 1; heat shock 70 kDa protein 1B; heat shock 70kDa protein 1B; heat shock protein 70.1; heat shock protein, 70 kDa 1; hsp68; Hsp70; Hsp70-1; Hsp70.1; HSP70B1
Homo sapiens (human) : HSPA1B (heat shock protein family A (Hsp70) member 1B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspa1b (heat shock protein family A (Hsp70) member 1B)  Alliance
Canis lupus familiaris (dog) : HSP70 (heat shock protein 70)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1b (heat shock protein family A (Hsp70) member 1B)
Chlorocebus sabaeus (African green monkey) : HSPA1B (heat shock protein family A (Hsp70) member 1B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1734,956,436 - 34,959,238 (-)Ensembl
GRCm381734,956,429 - 34,959,238 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371735,093,374 - 35,096,183 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,564,485 - 34,567,642 (-)NCBImm8
Celera1738,052,658 - 38,055,467 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspa1b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736399
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.