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Gene: Hspa5 (heat shock protein 5) Mus musculus
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Symbol: Hspa5
Name: heat shock protein 5
Description: Exhibits misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cellular response to interleukin-4; and cerebellum development. Localizes to several cellular components, including the cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to colocalize with the COP9 signalosome. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 78 kDa glucose-regulated protein; AL022860; AU019543; baffled; Bip; D2Wsu141e; D2Wsu17e; endoplasmic reticulum chaperone BiP; glucose regulated protein, 78 kDa; GRP-78; Grp78; heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock protein 70 family protein 5; heat shock protein family A member 5; Hsce70; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; mBiP; SEZ-7; Sez7; XAP-1 antigen
Orthologs:
Homo sapiens (human) : HSPA5 (heat shock protein family A (Hsp70) member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspa5 (heat shock protein family A (Hsp70) member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Canis lupus familiaris (dog) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Sus scrofa (pig) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Chlorocebus sabaeus (green monkey) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Heterocephalus glaber (naked mole-rat) : Hspa5 (heat shock protein family A (Hsp70) member 5)
more info ...
Related Pseudogenes: Gm7709  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl234,771,970 - 34,777,547 (+)Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBImm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2 BNCBI
cM Map222.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hspa5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10742
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.