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Gene: Hspa5 (heat shock protein 5) Mus musculus
Symbol: Hspa5
Name: heat shock protein 5
Description: Exhibits misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cellular response to interleukin-4; and cerebellum development. Localizes to several cellular components, including the cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Predicted to colocalize with the COP9 signalosome. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH (-)-anisomycin; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 78 kDa glucose-regulated protein; AL022860; AU019543; baffled; Bip; D2Wsu141e; D2Wsu17e; endoplasmic reticulum chaperone BiP; glucose regulated protein, 78 kDa; GRP-78; Grp78; heat shock 70 kDa protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock protein 70 family protein 5; heat shock protein family A member 5; Hsce70; HSP70 family protein 5; immunoglobulin heavy chain-binding protein; mBiP; SEZ-7; Sez7; XAP-1 antigen
Homo sapiens (human) : HSPA5 (heat shock protein family A (Hsp70) member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hspa5 (heat shock protein family A (Hsp70) member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Canis lupus familiaris (dog) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa5 (heat shock protein family A (Hsp70) member 5)
Sus scrofa (pig) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Chlorocebus sabaeus (green monkey) : HSPA5 (heat shock protein family A (Hsp70) member 5)
Heterocephalus glaber (naked mole-rat) : Hspa5 (heat shock protein family A (Hsp70) member 5)
more info ...
Related Pseudogenes: Gm7709  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl234,771,970 - 34,777,547 (+)Ensembl
GRCm38234,772,090 - 34,776,529 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37234,627,610 - 34,632,049 (+)NCBIGRCm37mm9NCBIm37
MGSCv36234,594,104 - 34,598,466 (+)NCBImm8
Celera234,472,567 - 34,477,006 (+)NCBICelera
Cytogenetic Map2 BNCBI
cM Map222.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hspa5
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10742
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.