Cm48 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Cm48 (Cardiac mass QTL 48) Rattus norvegicus

Symbol: Cm48
Name: Cardiac mass QTL 48
RGD ID: 1558650
Trait: heart mass   (VT:0007028)    
Measurement Type: heart weight to body weight ratio   (CMO:0000074)    
LOD Score: 4.0
P Value: 1.0E-4
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8350,766,145 - 95,766,145RGD_MAPPER_PIPELINE
mRatBN7.2310,778,823 - 30,356,773RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.036,000,866 - 34,394,121RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0311,361,817 - 39,535,971RGDRnor5.0
RGSC_v3.436,373,454 - 26,674,018RGDRGSC3.4
RGSC_v3.136,373,754 - 26,570,390RGD
Cross Type: Not Available
Strains Crossed: WKY/Tkyo SHR/Tkyo 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48RatCardiomegaly  IAGP 1554311 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48Ratcardiac hypertrophy  IAGP 1554311 RGD 
Cm48Ratincreased heart weight  IAGP 1554311 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48Ratheart weight to body weight ratio  IDA 1554311 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48Ratcontrolled sodium content diet  IDA 1554311 RGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48Ratpost excision weight measurement  IDA 1554311 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48RatSHR/Tkyo  IEA 1554311 RGD 
Cm48RatWKY/Tkyo  IEA 1554311 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cm48Ratheart mass  IDA 1554311 RGD 


#
Reference Title
Reference Citation
1. Identification of quantitative trait loci for cardiac hypertrophy in two different strains of the spontaneously hypertensive rat. Inomata H, etal., Hypertens Res 2005 Mar;28(3):273-81.

Related QTL Description Reference
Cm46 maps to same region RGD:1554311
Cm43 maps to same region RGD:1554311
Bw56 maps to same region RGD:1554311



1 to 20 of 335 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1308925Brd3bromodomain containing 331077316310829675Rat
41113215LOC120102083small nucleolar RNA SNORA2631082231010822430Rat
1305159Wdr5WD repeat domain 531083696410856682Rat
41292532Trnaa-agc47transfer RNA alanine (anticodon AGC) 4731084647710846558Rat
40972164LOC120102096U6atac minor spliceosomal RNA31085986810859993Rat
3610Rxraretinoid X receptor alpha31098983211076366Rat
70920Col5a1collagen type V alpha 1 chain31120842911356715Rat
621222Fcnbficolin B31139371311402198Rat
620320Olfm1olfactomedin 131152052211558240Rat
9339909LOC103691762microtubule-associated proteins 1A/1B light chain 3B pseudogene31164751611656307Rat
1595050Ppp1r26protein phosphatase 1, regulatory subunit 2631178150411790076Rat
1306233Pierce1piercer of microtubule wall 131179703111801568Rat
1309116Mrps2mitochondrial ribosomal protein S231180304411806341Rat
1591938Gbgt1globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)31182613111829745Rat
3533Ralgdsral guanine nucleotide dissociation stimulator31183968611880059Rat
2331Celcarboxyl ester lipase31188353211891035Rat
1305173Gtf3c5general transcription factor IIIC subunit 531189386711914187Rat
41017381Rnu6-592RNA, U6 small nuclear 59231192697611927077Rat
1311727Gfi1bgrowth factor independent 1B transcriptional repressor31194023211952989Rat
620124Tsc1TSC complex subunit 131196954712018591Rat

1 to 20 of 335 rows
1 to 20 of 424 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10260D3Rat5215631831145418311610Ratregion
10344D3Wox1212531188471211884828Ratregion
33862D3Mit924533035677330357018Ratregion
34252D3Mgh1913231922714719227279Ratregion
34347D3Mgh1611931077870410778823Ratregion
36167D3Rat5012232071409020714212Ratregion
36195D3Rat5115032146466021464822Ratregion
36354D3Mit2221031916237119162581Ratregion
37010D3Rat4915732749462127494778Ratregion
36657D3Rat5814531500542215005567Ratregion
35054D3Rat5513831493762114937759Ratregion
35609D3Rat5318031737470317374883Ratregion
35617D3Rat5416831448914514489218Ratregion
35617D3Rat5416831448914514489306Ratregion
35745D3Rat4812032946323529463355Ratregion
38506D3Rat9619231487214914872341Ratregion
38646D3Rat11719332901749029017683Ratregion
39072D3Rat12420031533793115338131Ratregion
39214D3Rat13117432143858421438758Ratregion
41476D3Rat19315731424056014240717Ratregion
1 to 20 of 424 rows

Flank 1: (D3Mit9)
Rat AssemblyChrPosition (strand)Source
GRCr8350,766,145 - 50,766,390 (+)Marker Load Pipeline
mRatBN7.2330,356,773 - 30,357,018 (+)MAPPER
Rnor_6.0334,394,121 - 34,394,365NCBI
Rnor_5.0339,535,971 - 39,536,215UniSTS
RGSC_v3.4326,674,018 - 26,674,263RGD
RGSC_v3.4326,674,019 - 26,674,263UniSTS
RGSC_v3.1326,570,390 - 26,570,635RGD
Celera328,648,833 - 28,649,077UniSTS
Cytogenetic Map3 RGD
Peak: (D3Mgh16)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,778,704 - 10,778,823 (+)MAPPER
Rnor_6.036,000,748 - 6,000,866NCBI
Rnor_5.0311,361,699 - 11,361,817UniSTS
RGSC_v3.436,373,335 - 6,373,454RGD
RGSC_v3.436,373,336 - 6,373,454UniSTS
RGSC_v3.136,373,636 - 6,373,754RGD
Celera35,573,283 - 5,573,401UniSTS
RH 3.4 Map316.9UniSTS
RH 3.4 Map316.9RGD
Cytogenetic Map3p12UniSTS
Flank 2: (D3Mgh16)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,778,704 - 10,778,823 (+)MAPPER
Rnor_6.036,000,748 - 6,000,866NCBI
Rnor_5.0311,361,699 - 11,361,817UniSTS
RGSC_v3.436,373,335 - 6,373,454RGD
RGSC_v3.436,373,336 - 6,373,454UniSTS
RGSC_v3.136,373,636 - 6,373,754RGD
Celera35,573,283 - 5,573,401UniSTS
RH 3.4 Map316.9UniSTS
RH 3.4 Map316.9RGD
Cytogenetic Map3p12UniSTS


1 to 10 of 60 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31649064819241681Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat

1 to 10 of 60 rows


Note Type Note Reference
qtl_statistics_details obtained from analysis of F2 males only 1554311
qtl_statistics_details MAPMAKER/QTL 1.1 was used for linkage analysis 1554311