Slc27a4 (solute carrier family 27 member 4)

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Gene: Slc27a4 (solute carrier family 27 member 4) Rattus norvegicus

Analyze

Symbol:

Slc27a4

Name:

solute carrier family 27 member 4

RGD ID:

1307383

Description:

Predicted to have fatty acid ligase activity and long-chain fatty acid transporter activity. Involved in response to nutrient. Predicted to localize to brush border membrane; endoplasmic reticulum membrane; and microvillus. Biomarker of fatty liver disease. Orthologous to human SLC27A4 (solute carrier family 27 member 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

Fatp4; fatty acid transport protein 4; LOC311839; long-chain fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC27A4 (solute carrier family 27 member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc27a4 (solute carrier family 27 (fatty acid transporter), member 4)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC27A1 (solute carrier family 27 member 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SLC27A4 (solute carrier family 27 member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Mus musculus (house mouse):	Slc27a4 (solute carrier family 27 (fatty acid transporter), member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	FAT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|TreeFam)
Drosophila melanogaster (fruit fly):	Fatp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Fatp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Drosophila melanogaster (fruit fly):	Fatp3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|TreeFam)
Caenorhabditis elegans (roundworm):	acs-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Caenorhabditis elegans (roundworm):	acs-22	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 1 (ISO)

fatty liver disease (IEP)

genetic disease (ISO)

Ichthyosis Prematurity Syndrome (ISO)

Insulin Resistance (ISO)

lethal restrictive dermopathy (ISS)

obesity (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-amino-2,6-dinitrotoluene (EXP)

8-Br-cAMP (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

dextran sulfate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

fenofibrate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

linalool (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotinic acid (ISO)

oleic acid (ISO)

paracetamol (ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

sulindac (EXP)

titanium dioxide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of GTPase activity (IEA,ISO)

fatty acid metabolic process (ISO)

fatty acid transport (ISO)

glucose import in response to insulin stimulus (IEA,ISO)

lipid transport across blood-brain barrier (ISO)

long-chain fatty acid import into cell (IBA,ISO)

long-chain fatty acid metabolic process (ISO)

long-chain fatty acid transport (ISO)

medium-chain fatty acid transport (IBA,ISO)

negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (ISO)

negative regulation of insulin receptor signaling pathway (IEA,ISO)

positive regulation of apoptotic process (IEA,ISO)

response to nutrient (IBA,IEP)

skin development (ISO)

very long-chain fatty acid catabolic process (IBA,ISO)

very long-chain fatty acid metabolic process (ISO)

Cellular Component

brush border membrane (ISO)

cellular_component (ND)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IBA,ISO)

integral component of membrane (IEA)

microvillus (IBA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

long-chain fatty acid transporter activity (IBA,ISO)

long-chain fatty acid-CoA ligase activity (IBA,ISO)

molecular_function (ND)

oleoyl-CoA ligase activity (IEA,ISO)

palmitoyl-CoA ligase activity (IEA,ISO)

protein binding (ISO)

very long-chain fatty acid-CoA ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

References

References - curated


1.	Feng AJ and Chen DF, Zhonghua Gan Zang Bing Za Zhi. 2005 Oct;13(10):776-9.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Gertow K, etal., Diabetologia. 2004 Jun;47(6):1118-25. Epub 2004 May 28.
4.	Habold C, etal., Pflugers Arch. 2007 Nov;455(2):323-32. Epub 2007 Jul 19.
5.	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline
7.	Pipeline to import KEGG annotations from KEGG into RGD
8.	RGD automated data pipeline
9.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	RGD automated import pipeline for gene-chemical interactions
11.	RGD comprehensive gene curation

Additional References at PubMed

PMID:10518211	PMID:11404000	PMID:12477932	PMID:12821645	PMID:14512415	PMID:15496455	PMID:15653672	PMID:16354193	PMID:17062637	PMID:17401141	PMID:17522045	PMID:18258213
PMID:18843142	PMID:19380575	PMID:19946888	PMID:21395585	PMID:22022213	PMID:23407971

Genomics

Comparative Map Data

Slc27a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

SLC27A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	128,340,527 - 128,361,470 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	128,340,516 - 128,361,470 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	131,102,806 - 131,123,749 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	130,142,661 - 130,163,323 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	128,182,393 - 128,203,055	NCBI
Celera	9	101,753,743 - 101,774,653 (+)	NCBI
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	100,715,663 - 100,736,574 (+)	NCBI		HuRef
CHM1_1	9	131,253,875 - 131,274,787 (+)	NCBI		CHM1_1

Slc27a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	29,692,646 - 29,707,534 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	2	29,692,646 - 29,707,534 (+)	Ensembl
GRCm38	2	29,802,634 - 29,817,522 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	29,802,634 - 29,817,522 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	29,658,200 - 29,673,042 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	29,624,689 - 29,639,531 (+)	NCBI			mm8
Celera	2	29,509,747 - 29,524,590 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	20.64	NCBI

Slc27a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	853,849 - 866,383 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955570	853,856 - 866,383 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC27A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	128,133,365 - 128,151,077 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	128,133,365 - 128,151,077 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	99,463,338 - 99,483,802 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SLC27A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	9	55,164,817 - 55,177,511 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	9	55,164,106 - 55,177,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Slc27a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936487	15,877,075 - 15,905,752 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC27A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	268,756,680 - 268,788,791 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	268,773,792 - 268,788,208 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	302,768,102 - 302,778,920 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC27A4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,769,242 - 9,788,214 (-)	NCBI

Slc27a4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624760	6,529,028 - 6,542,067 (-)	NCBI

Position Markers

RH132571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	8,376,552 - 8,376,763	NCBI	Rnor6.0
Rnor_5.0	3	13,719,741 - 13,719,952	UniSTS	Rnor5.0
RGSC_v3.4	3	8,802,578 - 8,802,789	UniSTS	RGSC3.4
Celera	3	7,865,303 - 7,865,514	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

BF417583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	8,367,759 - 8,367,939	NCBI	Rnor6.0
Rnor_5.0	3	13,710,948 - 13,711,128	UniSTS	Rnor5.0
RGSC_v3.4	3	8,793,785 - 8,793,965	UniSTS	RGSC3.4
Celera	3	7,856,510 - 7,856,690	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	25786001	Rat
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	28136884	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	28500807	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	28500807	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	28500807	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	28500807	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	32972944	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	37891710	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	39773425	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	95176874	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	2631421	33477544	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	2631421	48562146	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	3285929	28136884	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	3285929	28136884	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	5654639	25105730	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	6000748	51687917	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	6000748	51687917	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	6000866	34394121	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	128
Count of miRNA genes:	90
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000019500
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	11	4	3	4			74	30	33	11
Low		17	46	37	16	37	8	11		5	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019500 ⟹ ENSRNOP00000019500

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl

RefSeq Acc Id:

NM_001100706 ⟹ NP_001094176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI

Sequence:

show sequence

AGTGGCGCGCGCAGGGCTGAAGGGGCTGGGCGGTGTCGGGCGCGCTGAGGCTGGGTTGCGCTGT
GGAACACGGGCTCAGAAGCTCGCCCTCTGCGGGGACGGCAGGGAAGGCGGTGCTGCCGGCCGGC
ACAGCCGGTGCGGGTGCGGGAGGCGGGTGGGGGTGGAGCGCGACAGAGGTACAGACCCTACAAG
GGCGAGGAGTGGGCCAGACGCGCCGAACTCGGCTGTGTGCGCCCCGGGGCGGCCGATGCCCCCA
GCGCATCGCACTCCGCTGCCGCAACCGGGCCGCATCCTGACGGGGCTCCGCGCCGCGCAGCCGC
AGCCAGGCCACAATGCTGCTTGGAGCATCTCTGGTGGGGGCGCTGCTGTTCTCCAAGCTGGTGC
TGAAGCTACCCTGGACCCAGGTGGGATTCTCCTTGTTGCTCCTGTACTTGGGGTCTGGTGGCTG
GCGTTTCATCCGGGTCTTCATCAAGACGGTCAGGAGAGATGTCTTCGGCGGCATGGTGCTCCTG
AAGGTGAAGACCAAGGTCCGACGGTACCTTCAGGAGCGGAAGACAGTGCCCTTGCTGTTTGCCT
CAGTGGTTCGGCGCCACCCCGACAAGACAGCCCTGATTTTCGAGGGCACGAATACTCACTGGAC
CTTCCGCCAGCTGGATGACTACTCCAGCAGTGTGGCCAACTTCCTGCAGGCCCGGGGCCTGGTC
TCAGGCAATGTAGTTGCTCTCTTTATGGAAAACCGTAACGAGTTTGTGGGTCTGTGGCTAGGCA
TGGCCAAGCTGGGCGTGGAGGCGGCACTCATCAACACCAACCTTAGGCGGGATGCCCTGCGCCA
CTGCCTTGACACCTCAAAGGCACGAGCCCTCATCTTTGGCAGCGAGATGGCCTCAGCTGTCTAT
GAGATCCAGGCTATCCTGGACCCCACACTCACCCTCTTCTGCTCTGGTTCCTGGGAGCCCAGCA
CCGTGCCTGCCAACACAGAGCATCTGGACCCTCTGCTGGAAGATGCCCCGAAGCACCTGCCCAG
CATCCCAGACAAGGGTTTTACAGATAAGCTCTTCTATATCTACACGTCGGGCACCACGGGGCTA
CCCAAAGCTGCCATTGTGGTGCACAGCAGGTATTACCGAATGGCTGCCCTGGTGTACTATGGAT
TCCGCATGCGGCCTGATGACATTGTCTATGACTGCCTCCCCCTCTACCACTCAGCAGGAAACAT
TGTGGGGATTGGCCAGTGCGTACTCCACGGCATGACTGTGGTGATCCGGAAGAAGTTTTCAGCC
TCCCGGTTCTGGGATGACTGTATCAAGTACAACTGCACAATTGTACAGTACATTGGTGAGCTTT
GCCGCTACCTCCTGAACCAGCCACCCCGTGAGGCTGAGTCTCGGCACAAGGTGCGCATGGCACT
GGGCAACGGTCTCCGGCAGTCCATCTGGACCGACTTCTCCAGCCGTTTCCACATTCCCCAAGTG
GCCGAGTTCTACGGGGCCACCGAGTGCAACTGTAGCTTGGGCAACTTTGACAGCCAGGTGGGGG
CCTGTGGCTTCAATAGCCGCATCCTGTCCTTTGTGTACCCCATCCGCTTGGTACGAGTCAATGA
GGATACCATGGAACTGATCCGGGGACCCGATGGCGTCTGCATTCCCTGTCAACCAGGCCAGCCA
GGCCAGCTGGTGGGTCGCATCATCCAGCAGGACCCCCTACGCCGTTTTGATGGCTACCTCAACC
AGGGTGCCAACAACAAGAAGATTGCTAGTGATGTCTTCAAGAAAGGGGACCAAGCCTACCTCAC
TGGTGACGTGCTGGTGATGGATGAGCTGGGCTACCTGTACTTCCGAGACCGCACAGGGGACACG
TTCCGCTGGAAAGGGGAGAATGTGTCTACCACTGAAGTGGAGGGCACACTCAGCCGCCTGCTTC
AGATGGCAGATGTGGCTGTTTATGGTGTTGAGGTGCCAGGAGCTGAGGGCCGAGCAGGAATGGC
TGCTGTGGCAAGCCCCACTAGCAACTGTGACCTGGAGAGCTTTGCACAGACCTTGAAAAAGGAG
CTGCCCCTGTACGCCCGCCCCATCTTCCTCCGCTTCTTGCCTGAGCTGCACAAAACAGGAACCT
TCAAGTTCCAGAAGACAGAGTTGCGGAAGGAGGGCTTTGACCCGTCTGTTGTGAAAGACCCACT
CTTCTATTTGGATGCCCGGACAGGCTGCTATGTTGCACTGGACCAAGAGGCCTATACCCGCATC
CAGGCAGGCGAGGAGAAGCTGTGATTTCCCCCACATCCCTCTGAGGGCCAGAGGATGCTGGATT
CAGAGCCCCAGCTTCCACCCCAGAGGGGTCCTGGGCAAGGCCAGACCAAAGCTAGCAGGGCCCG
CACCTCCACCCCTAGGTGCTGATCCCCCTCTCCCAAACTGCCAAGTGACTGACTCACTGCCGCT
TCCCCCACCCTCCAGAGGCTTTCTGTGAAAGTCTCATCCAAGCTGTGTCTTCTGGTCCAGGCGT
GGCCCCTGGCTCCAGGCTTACTGACAGGCACCTTTAGGATGATGTCTTGGGTCCAGCGGGCCAG
GATGTGGGAGAGGAGTCACTGAGATCCCTCCAAAAAGAAGGGAGCTTACAAATGAACCAAGACA
AAAGCCTCTCGACTCAGGAAGCTAAGTGGCCAGAGACTGAAGTGGCCAGCCATCCCGTGTCCAC
AGAGGATCTTGGTCCAAAGCTGCCAAAGTGTCACCTAGCCCTGTCTGCACCTCTGGGGAAAGGA
GGACAGCATGTGGCCAAAGTGTCACTTAGCCCTGTCTGCACCTCTGGGGAAAGGAGGACAGCAT
GTGGCCACTGGGCCCCTGTCTCAAGAAGTCGGGATCGCACACACACACACACTCCTTGTTTCTC
CAGATTCCCTTGTCCTTGTCTTAGGGAGGGAGGGGGGTGTCCTGTCTGTCTCTCAGATGCAGGC
TTCCTGCCTGTCTGTGAGTCTGTCCCTGTGTGTTGCCTTCTCCATCTGTCCTAGCCTGACTGTG
GGTGGAGAGGGCATGAGGGGAGGCTCAGGGGCTAATAAACTCTGCCTTGACTCCTCTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094176	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91430	(Get FASTA)	NCBI Sequence Viewer
	EDL93373	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001094176 ⟸ NM_001100706

- UniProtKB:

G3V7V3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDVFGGMVLLKVKT
KVRRYLQERKTVPLLFASVVRRHPDKTALIFEGTNTHWTFRQLDDYSSSVANFLQARGLVSGNV
VALFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAVYEIQA
ILDPTLTLFCSGSWEPSTVPANTEHLDPLLEDAPKHLPSIPDKGFTDKLFYIYTSGTTGLPKAA
IVVHSRYYRMAALVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCVLHGMTVVIRKKFSASRFW
DDCIKYNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFY
GATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLV
GRIIQQDPLRRFDGYLNQGANNKKIASDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWK
GENVSTTEVEGTLSRLLQMADVAVYGVEVPGAEGRAGMAAVASPTSNCDLESFAQTLKKELPLY
ARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARTGCYVALDQEAYTRIQAGE
EKL

hide sequence

RefSeq Acc Id:

ENSRNOP00000019500 ⟸ ENSRNOT00000019500

Protein Domains

AMP-binding AMP-binding_C

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691943

Promoter ID:

EPDNEW_R2468

Type:

initiation region

Name:

Slc27a4_1

Description:

solute carrier family 27 member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	8,363,937 - 8,363,997	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	13716169	13716170	G	A	snv	SS/Jr (KNAW)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	8372980	8372981	G	A	snv	SS/Jr (RGD)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307383	AgrOrtholog
Ensembl Genes	ENSRNOG00000014369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019500	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019500	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.12780	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7367192	IMAGE-MGC_LOAD
InterPro	AMP-bd_C	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/TrEMBL
	FATP4	UniProtKB/TrEMBL
	Lipocalin_CS	UniProtKB/TrEMBL
KEGG Report	rno:311839	UniProtKB/TrEMBL
MGC_CLONE	MGC:109622	IMAGE-MGC_LOAD
NCBI Gene	311839	ENTREZGENE
PANTHER	PTHR43107:SF11	UniProtKB/TrEMBL
Pfam	AMP-binding	UniProtKB/TrEMBL
	AMP-binding_C	UniProtKB/TrEMBL
PhenoGen	Slc27a4	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
	LIPOCALIN	UniProtKB/TrEMBL
UniProt	G3V7V3	ENTREZGENE, UniProtKB/TrEMBL
	Q5BJL7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc27a4	solute carrier family 27 member 4	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)