Slc27a4 (solute carrier family 27 member 4)

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Gene: Slc27a4 (solute carrier family 27 member 4) Rattus norvegicus

Analyze

Symbol:

Slc27a4

Name:

solute carrier family 27 member 4

RGD ID:

1307383

Description:

Predicted to enable fatty acid ligase activity and long-chain fatty acid transporter activity. Involved in response to nutrient. Predicted to be located in brush border membrane and endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane; microvillus; and plasma membrane. Biomarker of fatty liver disease. Orthologous to human SLC27A4 (solute carrier family 27 member 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fatp4; fatty acid transport protein 4; LOC311839; long-chain fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC27A4 (solute carrier family 27 member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc27a4 (solute carrier family 27 (fatty acid transporter), member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC27A4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc27a4 (solute carrier family 27 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC27A1 (solute carrier family 27 member 1)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SLC27A4 (solute carrier family 27 member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc27a4 (solute carrier family 27 (fatty acid transporter), member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc27a4 (solute carrier family 27 member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	FAT1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Fatp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Fatp3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	acs-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acs-22	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	16,149,797 - 16,162,720 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	24,734,758 - 24,747,681 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	22,985,916 - 22,998,946 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive congenital ichthyosis (ISO)

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

fatty liver disease (IEP)

genetic disease (ISO)

Ichthyosis Prematurity Syndrome (ISO)

Insulin Resistance (ISO)

lethal restrictive dermopathy (ISS)

obesity (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-amino-2,6-dinitrotoluene (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

dextran sulfate (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

ivermectin (ISO)

linalool (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotinic acid (ISO)

oleic acid (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

sulindac (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of GTPase activity (ISO)

establishment of localization in cell (ISO)

fatty acid metabolic process (ISO)

fatty acid transport (ISO)

glucose import in response to insulin stimulus (ISO)

lipid transport across blood-brain barrier (ISO)

long-chain fatty acid import into cell (IBA,ISO)

long-chain fatty acid metabolic process (ISO)

long-chain fatty acid transport (ISO)

medium-chain fatty acid transport (IBA,ISO)

negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (ISO)

negative regulation of insulin receptor signaling pathway (ISO)

positive regulation of apoptotic process (ISO)

response to nutrient (IBA,IEP)

skin development (ISO)

very long-chain fatty acid catabolic process (IBA,ISO)

very long-chain fatty acid metabolic process (ISO)

Cellular Component

brush border membrane (ISO)

cellular_component (ND)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (IBA,ISO)

microvillus (IBA,ISO)

plasma membrane (IBA,ISO)

Molecular Function

long-chain fatty acid transporter activity (IBA,ISO)

long-chain fatty acid-CoA ligase activity (IBA,ISO)

molecular_function (ND)

oleoyl-CoA ligase activity (ISO)

palmitoyl-CoA ligase activity (ISO)

protein binding (ISO)

very long-chain fatty acid-CoA ligase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]	Feng AJ and Chen DF, Zhonghua Gan Zang Bing Za Zhi. 2005 Oct;13(10):776-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.	Gertow K, etal., Diabetologia. 2004 Jun;47(6):1118-25. Epub 2004 May 28.
4.	Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding.	Habold C, etal., Pflugers Arch. 2007 Nov;455(2):323-32. Epub 2007 Jul 19.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:10518211	PMID:11404000	PMID:12477932	PMID:12821645	PMID:14512415	PMID:15496455	PMID:15653672	PMID:16354193	PMID:17062637	PMID:17401141	PMID:17522045	PMID:18258213
PMID:18843142	PMID:19380575	PMID:19946888	PMID:21395585	PMID:22022213	PMID:23407971	PMID:36360622

Genomics

Comparative Map Data

Slc27a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	16,149,797 - 16,162,720 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	24,734,758 - 24,747,681 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	22,985,916 - 22,998,946 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

SLC27A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	128,340,527 - 128,361,470 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	128,340,527 - 128,361,470 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	131,102,806 - 131,123,749 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	130,142,661 - 130,163,323 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	128,182,393 - 128,203,055	NCBI
Celera	9	101,753,743 - 101,774,653 (+)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	100,715,663 - 100,736,574 (+)	NCBI		HuRef
CHM1_1	9	131,253,875 - 131,274,787 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	140,547,629 - 140,568,573 (+)	NCBI		T2T-CHM13v2.0

Slc27a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	29,692,646 - 29,707,534 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	29,692,646 - 29,707,534 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	29,802,634 - 29,817,522 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	29,802,634 - 29,817,522 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	29,658,200 - 29,673,042 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	29,624,689 - 29,639,531 (+)	NCBI		MGSCv36	mm8
Celera	2	29,509,747 - 29,524,590 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	20.64	NCBI

Slc27a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	853,849 - 866,383 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955570	853,856 - 866,383 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC27A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	128,133,365 - 128,151,077 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	128,133,365 - 128,151,077 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	99,463,338 - 99,483,802 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SLC27A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	55,164,106 - 55,177,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	55,164,817 - 55,177,511 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	54,357,436 - 54,372,577 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	56,084,580 - 56,099,730 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	56,086,220 - 56,099,724 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	54,844,157 - 54,859,298 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	55,158,426 - 55,173,562 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	55,250,305 - 55,265,445 (-)	NCBI		UU_Cfam_GSD_1.0

Slc27a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	196,108,549 - 196,137,225 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	15,876,606 - 15,891,160 (+)	Ensembl	SpeTri2.0
SpeTri2.0 Ensembl	NW_004936487	15,876,606 - 15,906,003 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936487	15,877,075 - 15,905,752 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC27A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	268,773,806 - 268,788,731 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	268,773,792 - 268,788,208 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	302,768,102 - 302,778,920 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC27A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,769,242 - 9,788,214 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666079	6,439,879 - 6,467,278 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc27a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	6,529,027 - 6,542,149 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	6,529,028 - 6,542,067 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc27a4
33 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	128
Count of miRNA genes:	90
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000019500
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat

Markers in Region

RH132571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	13,087,636 - 13,087,848 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	8,376,552 - 8,376,763	NCBI	Rnor6.0
Rnor_5.0	3	13,719,741 - 13,719,952	UniSTS	Rnor5.0
RGSC_v3.4	3	8,802,578 - 8,802,789	UniSTS	RGSC3.4
Celera	3	7,865,303 - 7,865,514	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

BF417583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	13,078,843 - 13,079,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	8,367,759 - 8,367,939	NCBI	Rnor6.0
Rnor_5.0	3	13,710,948 - 13,711,128	UniSTS	Rnor5.0
RGSC_v3.4	3	8,793,785 - 8,793,965	UniSTS	RGSC3.4
Celera	3	7,856,510 - 7,856,690	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	11	4	3	4			74	30	33	11
Low		17	46	37	16	37	8	11		5	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000019500 ⟹ ENSRNOP00000019500

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl

RefSeq Acc Id:

NM_001100706 ⟹ NP_001094176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI

Sequence:

show sequence

AGTGGCGCGCGCAGGGCTGAAGGGGCTGGGCGGTGTCGGGCGCGCTGAGGCTGGGTTGCGCTGT
GGAACACGGGCTCAGAAGCTCGCCCTCTGCGGGGACGGCAGGGAAGGCGGTGCTGCCGGCCGGC
ACAGCCGGTGCGGGTGCGGGAGGCGGGTGGGGGTGGAGCGCGACAGAGGTACAGACCCTACAAG
GGCGAGGAGTGGGCCAGACGCGCCGAACTCGGCTGTGTGCGCCCCGGGGCGGCCGATGCCCCCA
GCGCATCGCACTCCGCTGCCGCAACCGGGCCGCATCCTGACGGGGCTCCGCGCCGCGCAGCCGC
AGCCAGGCCACAATGCTGCTTGGAGCATCTCTGGTGGGGGCGCTGCTGTTCTCCAAGCTGGTGC
TGAAGCTACCCTGGACCCAGGTGGGATTCTCCTTGTTGCTCCTGTACTTGGGGTCTGGTGGCTG
GCGTTTCATCCGGGTCTTCATCAAGACGGTCAGGAGAGATGTCTTCGGCGGCATGGTGCTCCTG
AAGGTGAAGACCAAGGTCCGACGGTACCTTCAGGAGCGGAAGACAGTGCCCTTGCTGTTTGCCT
CAGTGGTTCGGCGCCACCCCGACAAGACAGCCCTGATTTTCGAGGGCACGAATACTCACTGGAC
CTTCCGCCAGCTGGATGACTACTCCAGCAGTGTGGCCAACTTCCTGCAGGCCCGGGGCCTGGTC
TCAGGCAATGTAGTTGCTCTCTTTATGGAAAACCGTAACGAGTTTGTGGGTCTGTGGCTAGGCA
TGGCCAAGCTGGGCGTGGAGGCGGCACTCATCAACACCAACCTTAGGCGGGATGCCCTGCGCCA
CTGCCTTGACACCTCAAAGGCACGAGCCCTCATCTTTGGCAGCGAGATGGCCTCAGCTGTCTAT
GAGATCCAGGCTATCCTGGACCCCACACTCACCCTCTTCTGCTCTGGTTCCTGGGAGCCCAGCA
CCGTGCCTGCCAACACAGAGCATCTGGACCCTCTGCTGGAAGATGCCCCGAAGCACCTGCCCAG
CATCCCAGACAAGGGTTTTACAGATAAGCTCTTCTATATCTACACGTCGGGCACCACGGGGCTA
CCCAAAGCTGCCATTGTGGTGCACAGCAGGTATTACCGAATGGCTGCCCTGGTGTACTATGGAT
TCCGCATGCGGCCTGATGACATTGTCTATGACTGCCTCCCCCTCTACCACTCAGCAGGAAACAT
TGTGGGGATTGGCCAGTGCGTACTCCACGGCATGACTGTGGTGATCCGGAAGAAGTTTTCAGCC
TCCCGGTTCTGGGATGACTGTATCAAGTACAACTGCACAATTGTACAGTACATTGGTGAGCTTT
GCCGCTACCTCCTGAACCAGCCACCCCGTGAGGCTGAGTCTCGGCACAAGGTGCGCATGGCACT
GGGCAACGGTCTCCGGCAGTCCATCTGGACCGACTTCTCCAGCCGTTTCCACATTCCCCAAGTG
GCCGAGTTCTACGGGGCCACCGAGTGCAACTGTAGCTTGGGCAACTTTGACAGCCAGGTGGGGG
CCTGTGGCTTCAATAGCCGCATCCTGTCCTTTGTGTACCCCATCCGCTTGGTACGAGTCAATGA
GGATACCATGGAACTGATCCGGGGACCCGATGGCGTCTGCATTCCCTGTCAACCAGGCCAGCCA
GGCCAGCTGGTGGGTCGCATCATCCAGCAGGACCCCCTACGCCGTTTTGATGGCTACCTCAACC
AGGGTGCCAACAACAAGAAGATTGCTAGTGATGTCTTCAAGAAAGGGGACCAAGCCTACCTCAC
TGGTGACGTGCTGGTGATGGATGAGCTGGGCTACCTGTACTTCCGAGACCGCACAGGGGACACG
TTCCGCTGGAAAGGGGAGAATGTGTCTACCACTGAAGTGGAGGGCACACTCAGCCGCCTGCTTC
AGATGGCAGATGTGGCTGTTTATGGTGTTGAGGTGCCAGGAGCTGAGGGCCGAGCAGGAATGGC
TGCTGTGGCAAGCCCCACTAGCAACTGTGACCTGGAGAGCTTTGCACAGACCTTGAAAAAGGAG
CTGCCCCTGTACGCCCGCCCCATCTTCCTCCGCTTCTTGCCTGAGCTGCACAAAACAGGAACCT
TCAAGTTCCAGAAGACAGAGTTGCGGAAGGAGGGCTTTGACCCGTCTGTTGTGAAAGACCCACT
CTTCTATTTGGATGCCCGGACAGGCTGCTATGTTGCACTGGACCAAGAGGCCTATACCCGCATC
CAGGCAGGCGAGGAGAAGCTGTGATTTCCCCCACATCCCTCTGAGGGCCAGAGGATGCTGGATT
CAGAGCCCCAGCTTCCACCCCAGAGGGGTCCTGGGCAAGGCCAGACCAAAGCTAGCAGGGCCCG
CACCTCCACCCCTAGGTGCTGATCCCCCTCTCCCAAACTGCCAAGTGACTGACTCACTGCCGCT
TCCCCCACCCTCCAGAGGCTTTCTGTGAAAGTCTCATCCAAGCTGTGTCTTCTGGTCCAGGCGT
GGCCCCTGGCTCCAGGCTTACTGACAGGCACCTTTAGGATGATGTCTTGGGTCCAGCGGGCCAG
GATGTGGGAGAGGAGTCACTGAGATCCCTCCAAAAAGAAGGGAGCTTACAAATGAACCAAGACA
AAAGCCTCTCGACTCAGGAAGCTAAGTGGCCAGAGACTGAAGTGGCCAGCCATCCCGTGTCCAC
AGAGGATCTTGGTCCAAAGCTGCCAAAGTGTCACCTAGCCCTGTCTGCACCTCTGGGGAAAGGA
GGACAGCATGTGGCCAAAGTGTCACTTAGCCCTGTCTGCACCTCTGGGGAAAGGAGGACAGCAT
GTGGCCACTGGGCCCCTGTCTCAAGAAGTCGGGATCGCACACACACACACACTCCTTGTTTCTC
CAGATTCCCTTGTCCTTGTCTTAGGGAGGGAGGGGGGTGTCCTGTCTGTCTCTCAGATGCAGGC
TTCCTGCCTGTCTGTGAGTCTGTCCCTGTGTGTTGCCTTCTCCATCTGTCCTAGCCTGACTGTG
GGTGGAGAGGGCATGAGGGGAGGCTCAGGGGCTAATAAACTCTGCCTTGACTCCTCTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094176	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91430	(Get FASTA)	NCBI Sequence Viewer
	EDL93373	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001094176 ⟸ NM_001100706

- UniProtKB:

G3V7V3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDVFGGMVLLKVKT
KVRRYLQERKTVPLLFASVVRRHPDKTALIFEGTNTHWTFRQLDDYSSSVANFLQARGLVSGNV
VALFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAVYEIQA
ILDPTLTLFCSGSWEPSTVPANTEHLDPLLEDAPKHLPSIPDKGFTDKLFYIYTSGTTGLPKAA
IVVHSRYYRMAALVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCVLHGMTVVIRKKFSASRFW
DDCIKYNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFY
GATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLV
GRIIQQDPLRRFDGYLNQGANNKKIASDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWK
GENVSTTEVEGTLSRLLQMADVAVYGVEVPGAEGRAGMAAVASPTSNCDLESFAQTLKKELPLY
ARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARTGCYVALDQEAYTRIQAGE
EKL

hide sequence

RefSeq Acc Id:

ENSRNOP00000019500 ⟸ ENSRNOT00000019500

Protein Domains

AMP-binding AMP-binding_C

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7V3-F1-model_v2	AlphaFold	G3V7V3	1-643	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691943

Promoter ID:

EPDNEW_R2468

Type:

initiation region

Name:

Slc27a4_1

Description:

solute carrier family 27 member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	8,363,937 - 8,363,997	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307383	AgrOrtholog
BioCyc Gene	G2FUF-50253	BioCyc
BioCyc Pathway	PWY-8042 [acylceramide biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000014369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000019500	ENTREZGENE
	ENSRNOP00000019500.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019500	ENTREZGENE
	ENSRNOT00000019500.7	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7367192	IMAGE-MGC_LOAD
InterPro	AMP-bd_C	UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/TrEMBL
	FATP4	UniProtKB/TrEMBL
	Lipocalin_CS	UniProtKB/TrEMBL
KEGG Report	rno:311839	UniProtKB/TrEMBL
MGC_CLONE	MGC:109622	IMAGE-MGC_LOAD
NCBI Gene	311839	ENTREZGENE
PANTHER	PTHR43107:SF11	UniProtKB/TrEMBL
Pfam	AMP-binding	UniProtKB/TrEMBL
	AMP-binding_C	UniProtKB/TrEMBL
PhenoGen	Slc27a4	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
	LIPOCALIN	UniProtKB/TrEMBL
UniProt	G3V7V3	ENTREZGENE, UniProtKB/TrEMBL
	Q5BJL7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc27a4	solute carrier family 27 member 4	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)