Ptges2 (prostaglandin E synthase 2) - Rat Genome Database

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Gene: Ptges2 (prostaglandin E synthase 2) Rattus norvegicus
Analyze
Symbol: Ptges2
Name: prostaglandin E synthase 2
RGD ID: 1310836
Description: Predicted to enable DNA binding activity; lyase activity; and prostaglandin-E synthase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of DNA-templated transcription and secretion. Predicted to be located in Golgi membrane; cytosol; and nucleus. Predicted to be active in mitochondrion. Orthologous to human PTGES2 (prostaglandin E synthase 2); PARTICIPATES IN prostaglandin biosynthetic pathway; type II interferon signaling pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC311865
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,088,246 - 36,095,430 (+)NCBIGRCr8
mRatBN7.2315,690,501 - 15,697,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,759,325 - 18,766,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,344,320 - 27,351,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,595,176 - 25,602,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,424,195 - 11,431,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,773,065 - 16,780,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,521,214 - 11,528,395 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,418,096 - 11,424,768 (+)NCBI
Celera310,433,385 - 10,440,575 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
Golgi membrane  (ISO)
mitochondrion  (IBA,ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
3. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12050152   PMID:12804604   PMID:15358613   PMID:16217040   PMID:16804969   PMID:18614015   PMID:20833797  


Genomics

Comparative Map Data
Ptges2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,088,246 - 36,095,430 (+)NCBIGRCr8
mRatBN7.2315,690,501 - 15,697,688 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,759,325 - 18,766,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,344,320 - 27,351,561 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,595,176 - 25,602,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,424,195 - 11,431,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,773,065 - 16,780,249 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,521,214 - 11,528,395 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,418,096 - 11,424,768 (+)NCBI
Celera310,433,385 - 10,440,575 (+)NCBICelera
Cytogenetic Map3p12NCBI
PTGES2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,120,693 - 128,128,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,120,693 - 128,128,462 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,882,972 - 130,890,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,922,793 - 129,930,533 (-)NCBINCBI36Build 36hg18NCBI36
Build 349127,962,526 - 127,970,266NCBI
Celera9101,534,900 - 101,542,641 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,497,534 - 100,505,316 (-)NCBIHuRef
CHM1_19131,034,931 - 131,042,710 (-)NCBICHM1_1
T2T-CHM13v2.09140,328,727 - 140,336,488 (-)NCBIT2T-CHM13v2.0
Ptges2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,285,902 - 32,292,752 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,285,908 - 32,295,784 (+)EnsemblGRCm39 Ensembl
GRCm38232,395,890 - 32,402,740 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,395,896 - 32,405,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,251,410 - 32,258,260 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,218,267 - 32,224,748 (+)NCBIMGSCv36mm8
Celera232,101,545 - 32,108,385 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Ptges2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419608,365 - 612,479 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419608,313 - 612,813 (+)NCBIChiLan1.0ChiLan1.0
PTGES2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,224,577 - 11,232,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,227,499 - 11,234,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,241,257 - 99,249,022 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,911,911 - 127,918,367 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,912,363 - 127,918,036 (-)Ensemblpanpan1.1panPan2
PTGES2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,343,424 - 55,349,349 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,343,424 - 55,348,959 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,538,207 - 54,543,755 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,265,556 - 56,271,558 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,265,645 - 56,271,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,025,498 - 55,031,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,340,213 - 55,345,769 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,431,910 - 55,437,458 (+)NCBIUU_Cfam_GSD_1.0
Ptges2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,934,652 - 195,939,572 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,703,153 - 15,707,697 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,703,179 - 15,708,408 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGES2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,583,439 - 268,590,855 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,585,725 - 268,591,356 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,576,191 - 302,582,036 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ptges2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,501,939 - 7,507,093 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,501,902 - 7,506,221 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptges2
55 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:44
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000019184
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

Markers in Region
RH132618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,697,345 - 15,697,562 (+)MAPPERmRatBN7.2
Rnor_6.0311,431,037 - 11,431,253NCBIRnor6.0
Rnor_5.0316,779,907 - 16,780,123UniSTSRnor5.0
RGSC_v3.4311,528,053 - 11,528,269UniSTSRGSC3.4
Celera310,440,233 - 10,440,449UniSTS
RH 3.4 Map360.4UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 49 39 6 39 8 11 74 35 39 11 8
Low 8 2 13 2 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019184   ⟹   ENSRNOP00000019184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,690,501 - 15,697,688 (+)Ensembl
Rnor_6.0 Ensembl311,424,099 - 11,431,402 (+)Ensembl
RefSeq Acc Id: NM_001107832   ⟹   NP_001101302
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,088,246 - 36,095,430 (+)NCBI
mRatBN7.2315,690,501 - 15,697,688 (+)NCBI
Rnor_6.0311,424,195 - 11,431,379 (+)NCBI
Rnor_5.0316,773,065 - 16,780,249 (+)NCBI
RGSC_v3.4311,521,214 - 11,528,395 (+)RGD
Celera310,433,385 - 10,440,575 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101302 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93234 (Get FASTA)   NCBI Sequence Viewer  
  EDL93235 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019184
  ENSRNOP00000019184.4
RefSeq Acc Id: NP_001101302   ⟸   NM_001107832
- UniProtKB: D4AE56 (UniProtKB/TrEMBL),   A6JU62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019184   ⟸   ENSRNOT00000019184
Protein Domains
GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE56-F1-model_v2 AlphaFold D4AE56 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691986
Promoter ID:EPDNEW_R2511
Type:multiple initiation site
Name:Ptges2_1
Description:prostaglandin E synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,424,697 - 11,424,757EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310836 AgrOrtholog
BioCyc Gene G2FUF-50140 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000014050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019184 ENTREZGENE
  ENSRNOT00000019184.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  6.20.200.30 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  PGES2 UniProtKB/TrEMBL
  PGES2_C UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:311865 UniProtKB/TrEMBL
NCBI Gene 311865 ENTREZGENE
PANTHER MICROSOMAL PROSTAGLANDIN E SYNTHASE-2 UniProtKB/TrEMBL
  PROSTAGLANDIN E SYNTHASE 2 UniProtKB/TrEMBL
Pfam GST_N_3 UniProtKB/TrEMBL
PhenoGen Ptges2 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014050 RatGTEx
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A6JU62 ENTREZGENE, UniProtKB/TrEMBL
  D4AE56 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ptges2  prostaglandin E synthase 2   Ptges2_predicted  prostaglandin E synthase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ptges2_predicted  prostaglandin E synthase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED