RGD Reference Report - Prostanoids as regulators of innate and adaptive immunity. - Rat Genome Database

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Prostanoids as regulators of innate and adaptive immunity.

Authors: Hirata, T  Narumiya, S 
Citation: Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
RGD ID: 8552701
Pubmed: PMID:23063076   (View Abstract at PubMed)
DOI: DOI:10.1016/B978-0-12-394300-2.00005-3   (Journal Full-text)

Potent, oxygenated lipid molecules called prostanoids regulate a wide variety of physiological responses and pathological processes. Prostanoids are produced by various cell types and act on target cells through specific G protein-coupled receptors. Although prostanoids have historically been considered acute inflammation mediators, studies using specific receptor knockout mice indicate that prostanoids, in fact, regulate various aspects of both innate and adaptive immunity. Each prostanoid, depending on which receptor it acts on, exerts specific effects on immune cells such as macrophages, dendritic cells, and T and B lymphocytes, often in concert with microbial ligands and cytokines, to affect the strength, quality, and duration of immune responses. Prostanoids are also relevant to immunopathology, from inflammation to autoimmunity and cancer. Here, we review the role of prostanoids in regulating immunity, their involvement in immunopathology, and areas of insight that may lead to new therapeutic opportunities.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGS1Humancyclooxygenase mediated pathway of arachidonic acid metabolism   TAS  RGD 
PTGS2Humancyclooxygenase mediated pathway of arachidonic acid metabolism   TAS  RGD 
Ptgs1Ratcyclooxygenase mediated pathway of arachidonic acid metabolism   ISOPTGS1 (Homo sapiens) RGD 
Ptgs1Mousecyclooxygenase mediated pathway of arachidonic acid metabolism   ISOPTGS1 (Homo sapiens) RGD 
Ptgs2Ratcyclooxygenase mediated pathway of arachidonic acid metabolism   ISOPTGS2 (Homo sapiens) RGD 
Ptgs2Mousecyclooxygenase mediated pathway of arachidonic acid metabolism   ISOPTGS2 (Homo sapiens) RGD 
HPGDSHumanprostaglandin biosynthetic pathway  TAS  RGD 
HpgdsRatprostaglandin biosynthetic pathway  ISOHPGDS (Homo sapiens) RGD 
HpgdsMouseprostaglandin biosynthetic pathway  ISOHPGDS (Homo sapiens) RGD 
PTGDSHumanprostaglandin biosynthetic pathway  TAS  RGD 
PTGESHumanprostaglandin biosynthetic pathway  TAS  RGD 
PTGES2Humanprostaglandin biosynthetic pathway  TAS  RGD 
PTGES3Humanprostaglandin biosynthetic pathway  TAS  RGD 
PtgdsRatprostaglandin biosynthetic pathway  ISOPTGDS (Homo sapiens) RGD 
PtgdsMouseprostaglandin biosynthetic pathway  ISOPTGDS (Homo sapiens) RGD 
PtgesRatprostaglandin biosynthetic pathway  ISOPTGES (Homo sapiens) RGD 
PtgesMouseprostaglandin biosynthetic pathway  ISOPTGES (Homo sapiens) RGD 
Ptges2Ratprostaglandin biosynthetic pathway  ISOPTGES2 (Homo sapiens) RGD 
Ptges2Mouseprostaglandin biosynthetic pathway  ISOPTGES2 (Homo sapiens) RGD 
Ptges3Ratprostaglandin biosynthetic pathway  ISOPTGES3 (Homo sapiens) RGD 
Ptges3Mouseprostaglandin biosynthetic pathway  ISOPTGES3 (Homo sapiens) RGD 
PTGS1Humanprostanoid biosynthetic pathway   TAS  RGD 
PTGS2Humanprostanoid biosynthetic pathway   TAS  RGD 
Ptgs1Ratprostanoid biosynthetic pathway   ISOPTGS1 (Homo sapiens) RGD 
Ptgs1Mouseprostanoid biosynthetic pathway   ISOPTGS1 (Homo sapiens) RGD 
Ptgs2Ratprostanoid biosynthetic pathway   ISOPTGS2 (Homo sapiens) RGD 
Ptgs2Mouseprostanoid biosynthetic pathway   ISOPTGS2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Hpgds  (hematopoietic prostaglandin D synthase)
Ptgds  (prostaglandin D2 synthase)
Ptges  (prostaglandin E synthase)
Ptges2  (prostaglandin E synthase 2)
Ptges3  (prostaglandin E synthase 3)
Ptgs1  (prostaglandin-endoperoxide synthase 1)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Hpgds  (hematopoietic prostaglandin D synthase)
Ptgds  (prostaglandin D2 synthase (brain))
Ptges  (prostaglandin E synthase)
Ptges2  (prostaglandin E synthase 2)
Ptges3  (prostaglandin E synthase 3)
Ptgs1  (prostaglandin-endoperoxide synthase 1)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
HPGDS  (hematopoietic prostaglandin D synthase)
PTGDS  (prostaglandin D2 synthase)
PTGES  (prostaglandin E synthase)
PTGES2  (prostaglandin E synthase 2)
PTGES3  (prostaglandin E synthase 3)
PTGS1  (prostaglandin-endoperoxide synthase 1)
PTGS2  (prostaglandin-endoperoxide synthase 2)


Additional Information