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Gene: Lrrc8a (leucine rich repeat containing 8 VRAC subunit A) Rattus norvegicus
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Symbol: Lrrc8a
Name: leucine rich repeat containing 8 VRAC subunit A
Description: Exhibits volume-sensitive anion channel activity. Predicted to contribute to anion channel activity. Involved in aspartate transmembrane transport; response to osmotic stress; and taurine transport. Localizes to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: leucine rich repeat containing 8 family, member A; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; LOC311846; Lrrc8; volume-regulated anion channel subunit LRRC8A
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.038,801,544 - 8,829,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,802,852 - 8,828,533 (+)Ensembl
Rnor_5.0314,155,802 - 14,182,455 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.439,280,625 - 9,306,317 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.139,280,924 - 9,306,606 (+)NCBI
Celera38,277,157 - 8,302,778 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lrrc8a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311690
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.