Cdk9 (cyclin-dependent kinase 9) - Rat Genome Database

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Gene: Cdk9 (cyclin-dependent kinase 9) Rattus norvegicus
Analyze
Symbol: Cdk9
Name: cyclin-dependent kinase 9
RGD ID: 1359638
Description: Enables chromatin binding activity. Involved in positive regulation of cardiac muscle hypertrophy and response to xenobiotic stimulus. Predicted to be located in PML body and cytoplasmic ribonucleoprotein granule. Predicted to be part of P-TEFb complex. Predicted to be active in nucleus. Orthologous to human CDK9 (cyclin dependent kinase 9); PARTICIPATES IN RNA polymerase II transcription elongation pathway; RNA polymerase II transcription pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division protein kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); MGC95175
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,394,168 - 36,399,016 (-)NCBIGRCr8
mRatBN7.2315,996,467 - 16,001,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,996,468 - 16,002,410 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,065,041 - 19,069,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,650,044 - 27,654,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,901,304 - 25,906,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,742,269 - 11,747,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,742,266 - 11,747,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,081,164 - 17,086,012 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,672,861 - 11,677,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,569,232 - 11,574,081 (-)NCBI
Celera310,737,357 - 10,742,205 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Cdk9Ratcongestive heart failure  ISOCdk9 (Mus musculus)1556509protein:increased activity:heart:RGD 
Cdk9Ratcongestive heart failure  ISOCDK9 (Homo sapiens)1556509protein:increased activity:ventricle:RGD 
Cdk9RatExperimental Diabetes Mellitus  IEP 9698426mRNA and protein:decreased expression:liver:RGD 
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Original Reference(s)
Cdk9Ratcongenital disorder of glycosylation Iu  ISOCDK9 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23109149 and PMID:28492532
Cdk9Ratdevelopmental and epileptic encephalopathy  ISOCDK9 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:18469812 more ...
Cdk9Ratdevelopmental and epileptic encephalopathy 31A  ISOCDK9 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:18469812 more ...
Cdk9Ratdystonia  ISOCDK9 (Homo sapiens)8554872ClinVar Annotator: match by term: Dystonic disorderClinVarPMID:28492532
Cdk9Ratearly infantile epileptic encephalopathy  ISOCDK9 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:18469812 more ...
Cdk9Ratprimary coenzyme Q10 deficiency 7  ISOCDK9 (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:22368301 more ...
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Original Reference(s)
Cdk9Ratmedulloblastoma  ISOCDK9 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31594641

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Original Reference(s)
Cdk9Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOCdk9 (Mus musculus)6480464o and p'-DDT results in increased expression of CDK9 mRNACTDPMID:24096037
Cdk9Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o and p'-DDT results in increased expression of CDK9 mRNACTDPMID:24096037
Cdk9Rat1,2-dichloroethane increases expressionISOCdk9 (Mus musculus)6480464ethylene dichloride results in increased expression of CDK9 mRNACTDPMID:28960355
Cdk9Rat1,2-dimethylhydrazine multiple interactionsISOCdk9 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of CDK9 mRNA]CTDPMID:22206623
Cdk9Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOCDK9 (Homo sapiens)64804642 more ...CTDPMID:31675489
Cdk9Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCdk9 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CDK9 mRNACTDPMID:21570461
Cdk9Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CDK9 mRNACTDPMID:34747641
Cdk9Rat2,4,6-tribromophenol decreases expressionISOCDK9 (Homo sapiens)64804642 more ...CTDPMID:31675489
Cdk9Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of CDK9 mRNACTDPMID:21346803
Cdk9Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOCDK9 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of CDK9 proteinCTDPMID:31675489
Cdk9Rat3,4-methylenedioxymethamphetamine increases expressionISOCdk9 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of CDK9 mRNACTDPMID:20188158 and PMID:26251327
Cdk9Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOCDK9 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CDK9 mRNACTDPMID:28628672
Cdk9Rat4,4'-sulfonyldiphenol multiple interactionsISOCDK9 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CDK9 mRNACTDPMID:28628672
Cdk9Rat4,4'-sulfonyldiphenol affects methylationISOCdk9 (Mus musculus)6480464bisphenol S affects the methylation of CDK9 geneCTDPMID:31683443
Cdk9Rat4,4'-sulfonyldiphenol decreases methylationISOCdk9 (Mus musculus)6480464bisphenol S results in decreased methylation of CDK9 exonCTDPMID:33297965
Cdk9Rat4-hydroxynon-2-enal decreases expressionISOCDK9 (Homo sapiens)64804644-hydroxy-2-nonenal results in decreased expression of CDK9 mRNACTDPMID:12419474
Cdk9Ratafimoxifene decreases response to substanceISOCDK9 (Homo sapiens)6480464CDK9 results in decreased susceptibility to afimoxifeneCTDPMID:21233418
Cdk9Rataflatoxin B1 decreases methylationISOCDK9 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of CDK9 gene and Aflatoxin B1 results in decreased methylation of CDK9 intronCTDPMID:27153756 and PMID:30157460
Cdk9RatAflatoxin B2 alpha increases methylationISOCDK9 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of CDK9 intronCTDPMID:30157460
Cdk9Rataldehydo-D-glucose increases phosphorylationISOCdk9 (Mus musculus)6480464Glucose results in increased phosphorylation of CDK9 proteinCTDPMID:33631230

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Biological Process
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Original Reference(s)
Cdk9Ratcellular response to cytokine stimulus involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratcellular response to cytokine stimulus involved_inISOCDK9 (Homo sapiens)1624291 PMID:17956865RGDPMID:17956865
Cdk9RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9Ratnegative regulation of protein localization to chromatin involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratnegative regulation of protein localization to chromatin involved_inISOCDK9 (Homo sapiens)1624291 PMID:14701750RGDPMID:14701750
Cdk9Ratnucleus localization involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratnucleus localization involved_inISOCDK9 (Homo sapiens)1624291 PMID:12942536RGDPMID:12942536
Cdk9Ratpositive regulation by host of viral transcription involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratpositive regulation by host of viral transcription involved_inISOCDK9 (Homo sapiens)1624291 PMID:10866664RGDPMID:10866664
Cdk9Ratpositive regulation of cardiac muscle hypertrophy  IMP 9698419 RGD 
Cdk9Ratpositive regulation of protein localization to chromatin involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratpositive regulation of protein localization to chromatin involved_inISOCDK9 (Homo sapiens)1624291 PMID:29335245RGDPMID:29335245
Cdk9Ratpositive regulation of protein localization to chromatin involved_inISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
Cdk9Ratpositive regulation of transcription by RNA polymerase II involved_inISOCDK9 (Homo sapiens)1624291 PMID:29335245RGDPMID:29335245
Cdk9Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratpositive regulation of transcription by RNA polymerase II involved_inISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
Cdk9Ratpositive regulation of transcription elongation by RNA polymerase II involved_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratpositive regulation of transcription elongation by RNA polymerase II involved_inISOCDK9 (Homo sapiens)1624291 PMID:14701750 more ...RGDPMID:14701750 more ...
Cdk9Ratpositive regulation of transcription elongation by RNA polymerase II involved_inISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Original Reference(s)
Cdk9Ratcyclin/CDK positive transcription elongation factor complex part_ofISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
Cdk9Ratcyclin/CDK positive transcription elongation factor complex part_ofIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratcyclin/CDK positive transcription elongation factor complex part_ofISOCdk9 (Mus musculus)1624291 PMID:23752591RGDPMID:23752591
Cdk9Ratcyclin/CDK positive transcription elongation factor complex part_ofISOCDK9 (Homo sapiens)1624291 PMID:15905409 more ...RGDPMID:15905409 more ...
Cdk9Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cdk9Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9Ratcytoplasmic ribonucleoprotein granule located_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratcytoplasmic ribonucleoprotein granule located_inISOCDK9 (Homo sapiens) and UniProtKB:P50750-11624291 RGDGO_REF:0000052
Cdk9Ratnucleoplasm located_inISOCDK9 (Homo sapiens) and UniProtKB:P50750-11624291 RGDGO_REF:0000052
Cdk9Ratnucleoplasm located_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratnucleus is_active_inISOCDK9 (Homo sapiens)1624291 PMID:14701750 and PMID:29849146RGDPMID:14701750 and PMID:29849146
Cdk9Ratnucleus is_active_inIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratnucleus located_inISOCdk9 (Mus musculus)1624291 PMID:16109376 and PMID:22767893RGDPMID:16109376 and PMID:22767893
Cdk9Ratnucleus located_inISOCDK9 (Homo sapiens)1624291 PMID:16109376 and PMID:9499409RGDPMID:16109376 and PMID:9499409
Cdk9Ratnucleus is_active_inIBAFB:FBgn0015618 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk9Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Cdk9RatP-TEFb complex part_ofIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9RatP-TEFb complex part_ofISOCDK9 (Homo sapiens)1624291 PMID:18483487 and PMID:30134174RGDPMID:18483487 and PMID:30134174
Cdk9RatP-TEFb complex part_ofISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Original Reference(s)
Cdk9Rat7SK snRNA binding enablesISSUniProtKB:P507501600115GO_REF:0000024UniProtGO_REF:0000024
Cdk9Rat7SK snRNA binding enablesISOCDK9 (Homo sapiens)1624291 PMID:11713533RGDPMID:11713533
Cdk9Rat7SK snRNA binding enablesIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Cdk9RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Cdk9Ratchromatin binding  IDA 9698419 RGD 
Cdk9Ratchromatin binding enablesISOCdk9 (Mus musculus)1624291 PMID:16245309 and PMID:23154982RGDPMID:16245309 and PMID:23154982
Cdk9Ratcyclin-dependent protein serine/threonine kinase activity enablesIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratcyclin-dependent protein serine/threonine kinase activity enablesIEAEC:2.7.11.221600115GO_REF:0000003UniProtGO_REF:0000003
Cdk9Ratcyclin-dependent protein serine/threonine kinase activity enablesIBAFB:FBgn0019949 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdk9Ratcyclin-dependent protein serine/threonine kinase activity enablesISOCDK9 (Homo sapiens)1624291 PMID:12037670 and PMID:14701750RGDPMID:12037670 and PMID:14701750
Cdk9RatDNA binding enablesISOCDK9 (Homo sapiens)1624291 PMID:16109376RGDPMID:16109376
Cdk9RatDNA binding enablesIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratkinase activity enablesIEAUniProtKB:P50750 and ensembl:ENSP000003623611600115GO_REF:0000107EnsemblGO_REF:0000107
Cdk9Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9Ratkinase activity enablesISOCDK9 (Homo sapiens)1624291 PMID:22959624RGDPMID:22959624
Cdk9Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Cdk9Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Cdk9Ratprotein binding enablesISOCDK9 (Homo sapiens)1624291UniProtKB:O60563 more ...RGDPMID:12832472 more ...
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RGD Manual Annotations


  
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Original Reference(s)
Cdk9RatRNA polymerase II transcription elongation pathway  ISOCDK9 (Homo sapiens)9681735 RGD 
Cdk9RatRNA polymerase II transcription pathway   ISOCDK9 (Homo sapiens)9681737pol II carboxyl-terminal domain (CTD)RGD 
Cdk9RatRNA polymerase II transcription pathway   ISOCDK9 (Homo sapiens)9681738pol II carboxyl-terminal domain (CTD)RGD 

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Reference Title
Reference Citation
1. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, etal., Trends Genet. 2012 Jul;28(7):333-41. doi: 10.1016/j.tig.2012.03.007. Epub 2012 May 21.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, etal., Chem Rev. 2013 Nov 13;113(11):8491-522. doi: 10.1021/cr4001397. Epub 2013 Jul 10.
4. Control of transcriptional elongation. Kwak H and Lis JT, Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure. Sano M, etal., EMBO J 2004 Sep 1;23(17):3559-69. Epub 2004 Aug 5.
9. Activation of MyoD-dependent transcription by cdk9/cyclin T2. Simone C, etal., Oncogene 2002 Jun 13;21(26):4137-48.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. Sunagawa Y, etal., J Biol Chem. 2010 Mar 26;285(13):9556-68. doi: 10.1074/jbc.M109.070458. Epub 2010 Jan 17.
12. Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver. Zhou JY and Zhou SW, Fitoterapia. 2011 Mar;82(2):184-9. doi: 10.1016/j.fitote.2010.08.019. Epub 2010 Sep 7.
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PMID:9499409   PMID:11713533   PMID:12037672   PMID:12721286   PMID:15489334   PMID:15905409   PMID:16109376   PMID:16245309   PMID:17700062   PMID:17956865   PMID:18250157   PMID:19575011  
PMID:19844166   PMID:19946888   PMID:20493174   PMID:20570862   PMID:20930849   PMID:21245044   PMID:22195968   PMID:22509028   PMID:22547058   PMID:22767893   PMID:23154982   PMID:23752591  
PMID:28426094   PMID:32341082   PMID:38167752  



Cdk9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,394,168 - 36,399,016 (-)NCBIGRCr8
mRatBN7.2315,996,467 - 16,001,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,996,468 - 16,002,410 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,065,041 - 19,069,877 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,650,044 - 27,654,880 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,901,304 - 25,906,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,742,269 - 11,747,117 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,742,266 - 11,747,113 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,081,164 - 17,086,012 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,672,861 - 11,677,709 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1311,569,232 - 11,574,081 (-)NCBI
Celera310,737,357 - 10,742,205 (-)NCBICelera
Cytogenetic Map3p11NCBI
CDK9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,786,034 - 127,790,792 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,785,679 - 127,790,792 (+)EnsemblGRCh38hg38GRCh38
GRCh379130,548,313 - 130,553,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,588,152 - 129,592,184 (+)NCBINCBI36Build 36hg18NCBI36
Build 349127,627,890 - 127,631,917NCBI
Celera9101,199,168 - 101,203,915 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,164,574 - 100,169,598 (+)NCBIHuRef
CHM1_19130,699,854 - 130,704,602 (+)NCBICHM1_1
T2T-CHM13v2.09139,993,485 - 139,998,243 (+)NCBIT2T-CHM13v2.0
Cdk9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,595,794 - 32,608,098 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,595,796 - 32,603,088 (-)EnsemblGRCm39 Ensembl
GRCm38232,705,782 - 32,712,784 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,705,784 - 32,713,076 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,561,302 - 32,568,304 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,529,447 - 32,534,794 (-)NCBIMGSCv36mm8
Celera232,412,389 - 32,419,391 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Cdk9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419873,289 - 883,160 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955419874,959 - 883,160 (-)NCBIChiLan1.0ChiLan1.0
CDK9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,558,761 - 11,569,295 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,561,106 - 11,571,580 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,905,468 - 98,909,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,580,862 - 127,584,936 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,580,862 - 127,584,935 (+)Ensemblpanpan1.1panPan2
CDK9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,615,271 - 55,619,493 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,615,827 - 55,620,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,808,829 - 54,812,940 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,536,951 - 56,541,065 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,536,954 - 56,541,348 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,296,987 - 55,301,098 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,611,719 - 55,615,827 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,703,144 - 55,707,256 (-)NCBIUU_Cfam_GSD_1.0
Cdk9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,678,357 - 195,682,223 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,446,858 - 15,452,796 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,446,864 - 15,450,750 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,276,841 - 268,281,052 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,277,083 - 268,280,493 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,142,973 - 302,146,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,342,240 - 10,346,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,342,801 - 10,346,502 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,874,123 - 5,879,334 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247607,760,474 - 7,765,711 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cdk9
18 total Variants

Predicted Target Of
Summary Value
Count of predictions:376
Count of miRNA genes:220
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000032893
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 25 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat

1 to 10 of 25 rows
RH129246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,996,557 - 15,996,773 (+)MAPPERmRatBN7.2
Rnor_6.0311,742,360 - 11,742,575NCBIRnor6.0
Rnor_5.0317,081,255 - 17,081,470UniSTSRnor5.0
RGSC_v3.4311,672,952 - 11,673,167UniSTSRGSC3.4
Celera310,737,448 - 10,737,663UniSTS
RH 3.4 Map370.3UniSTS
Cytogenetic Map3p11UniSTS
Cdk9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,996,503 - 15,998,178 (+)MAPPERmRatBN7.2
Rnor_6.0311,742,306 - 11,743,980NCBIRnor6.0
Rnor_5.0317,081,201 - 17,082,875UniSTSRnor5.0
RGSC_v3.4311,672,898 - 11,674,572UniSTSRGSC3.4
Celera310,737,394 - 10,739,068UniSTS
Cytogenetic Map3p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000032893   ⟹   ENSRNOP00000037778
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,996,468 - 16,002,410 (-)Ensembl
Rnor_6.0 Ensembl311,742,266 - 11,747,113 (-)Ensembl
RefSeq Acc Id: NM_001007743   ⟹   NP_001007744
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,394,168 - 36,399,016 (-)NCBI
mRatBN7.2315,996,467 - 16,001,315 (-)NCBI
Rnor_6.0311,742,269 - 11,747,117 (-)NCBI
Rnor_5.0317,081,164 - 17,086,012 (-)NCBI
RGSC_v3.4311,672,861 - 11,677,709 (-)RGD
Celera310,737,357 - 10,742,205 (-)RGD
Sequence:
Protein RefSeqs NP_001007744 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH82037 (Get FASTA)   NCBI Sequence Viewer  
  EDL93216 (Get FASTA)   NCBI Sequence Viewer  
  EDL93217 (Get FASTA)   NCBI Sequence Viewer  
  EDL93218 (Get FASTA)   NCBI Sequence Viewer  
  Q641Z4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007744   ⟸   NM_001007743
- UniProtKB: Q641Z4 (UniProtKB/Swiss-Prot),   A6JU80 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037778   ⟸   ENSRNOT00000032893
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q641Z4-F1-model_v2 AlphaFold Q641Z4 1-372 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691991
Promoter ID:EPDNEW_R2516
Type:initiation region
Name:Cdk9_1
Description:cyclin-dependent kinase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,747,183 - 11,747,243EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50126 BioCyc
Ensembl Genes ENSRNOG00000022586 Ensembl
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130973 IMAGE-MGC_LOAD
InterPro CDK UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:362110 UniProtKB/Swiss-Prot
MGC_CLONE MGC:95175 IMAGE-MGC_LOAD
NCBI Gene 362110 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot
  CYCLIN-DEPENDENT KINASE 9 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Cdk9 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000022586 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2QJI9_RAT UniProtKB/TrEMBL
  A6JU79_RAT UniProtKB/TrEMBL
  A6JU80 ENTREZGENE, UniProtKB/TrEMBL
  A6JU81_RAT UniProtKB/TrEMBL
  CDK9_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Cdk9  cyclin-dependent kinase 9  Cdk9  cyclin-dependent kinase 9 (CDC2-related kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cdk9  cyclin-dependent kinase 9 (CDC2-related kinase)    cyclin-dependent kinase 9  Name updated 1299863 APPROVED
2005-07-29 Cdk9  cyclin-dependent kinase 9      Symbol and Name status set to provisional 70820 PROVISIONAL