Gata4 (GATA binding protein 4) - Rat Genome Database

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Gene: Gata4 (GATA binding protein 4) Rattus norvegicus
Symbol: Gata4
Name: GATA binding protein 4
RGD ID: 2665
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Predicted to be located in nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex and chromatin. Predicted to be active in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4); INTERACTS WITH 17alpha-ethynylestradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Previously known as: DNA-binding protein GATA-GT2; GATA-binding factor 4; GATA-binding protein 4; transcription factor GATA-4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21537,459,601 - 37,531,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,312,354 - 39,358,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,463,161 - 40,509,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,920,232 - 38,966,261 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethyl-4-tridecylmorpholine  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-hydroxytryptophan  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arecoline  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
cadmium atom  (ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carvedilol  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
fluoranthene  (ISO)
flusilazole  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
glyphosate  (ISO)
heparin  (EXP)
homocysteine  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
L-ascorbic acid  (ISO)
latrunculin B  (EXP)
lipopolysaccharide  (EXP)
malathion  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
mithramycin  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
potassium cyanide  (ISO)
probucol  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
pyrethrins  (EXP)
pyrogallol  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
remdesivir  (ISO)
ribavirin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (ISO)
Y-27632  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrial septum secundum morphogenesis  (ISO)
atrioventricular canal development  (ISO)
atrioventricular valve formation  (ISO)
atrioventricular valve morphogenesis  (ISO)
cardiac muscle cell differentiation  (IEP,ISO)
cardiac muscle cell proliferation  (ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue regeneration  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum development  (ISO)
cell fate commitment  (IBA)
cell growth involved in cardiac muscle cell development  (IDA)
cell-cell signaling  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
embryonic heart tube development  (ISO)
embryonic morphogenesis  (ISO)
endocardial cushion development  (ISO)
endoderm formation  (ISO)
epithelial cell fate commitment  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (ISO,TAS)
heart looping  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell differentiation  (ISO)
lung lobe formation  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of connective tissue replacement  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (IBA)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of cardiac muscle cell contraction  (IMP)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of DNA-templated transcription  (IDA,ISO)
regulation of gene expression  (ISO)
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to estrogen  (ISO)
response to mechanical stimulus  (IDA)
response to retinoic acid  (ISO)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (ISO)
seminiferous tubule development  (ISO)
Sertoli cell differentiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein signal transduction  (ISO)
spermatogenesis  (ISO)
transdifferentiation  (IMP)
tube morphogenesis  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (ISO)
wound healing  (ISO)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression. Charron F, etal., Mol Cell Biol. 1999 Jun;19(6):4355-65.
2. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. Clabby ML, etal., J Biol Chem 2003 Feb 21;278(8):5760-7.
3. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. Dai YS, etal., J Biol Chem 2002 Jul 5;277(27):24390-8.
4. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
5. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Garg V, etal., Nature. 2003 Jul 24;424(6947):443-7. Epub 2003 Jul 6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation. Guo J, etal., Circ Heart Fail. 2011 Jan 1;4(1):79-88. Epub 2010 Oct 22.
9. Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter. Kamrul Hasan M, etal., Genes Cells. 2010 May;15(5):439-54. Epub 2010 Apr 7.
10. Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response. Kerkela R, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R140-9. Epub 2010 Nov 17.
11. Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.PG - 13752-60 Kerkela R, etal., J Biol Chem 2002 Apr 19;277(16):13752-60.
12. Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury. Kobayashi S, etal., J Biol Chem. 2007 Jul 27;282(30):21945-52. Epub 2007 May 24.
13. Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death. Kobayashi S, etal., J Biol Chem. 2010 Jan 1;285(1):793-804. Epub 2009 Nov 9.
14. Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Ku PM, etal., Cardiovasc Diabetol. 2011 Jun 24;10:57. doi: 10.1186/1475-2840-10-57.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease. LaHaye S, etal., Circ Cardiovasc Genet. 2016 Aug;9(4):320-9. doi: 10.1161/CIRCGENETICS.115.001324. Epub 2016 Jul 14.
17. PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
18. Involvement of a novel GATA4 mutation in atrial septal defects. Liu XY, etal., Int J Mol Med. 2011 Jul;28(1):17-23. doi: 10.3892/ijmm.2011.638. Epub 2011 Mar 3.
19. Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression. Lu T, etal., Tissue Eng Part A. 2010 Oct;16(10):3111-7.
20. Increase in cardiac M(2)-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats. Mar GY, etal., Int J Cardiol. 2012 Jan 29.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Molkentin JD, etal., Mol Cell Biol. 1994 Jul;14(7):4947-57.
23. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. Morimoto T, etal., J Clin Invest. 2008 Mar;118(3):868-78.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Nemer G and Nemer M, Dev Biol. 2003 Feb 1;254(1):131-48.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
28. Pulmonary hypertension-induced GATA4 activation in the right ventricle. Park AM, etal., Hypertension. 2010 Dec;56(6):1145-51. doi: 10.1161/HYPERTENSIONAHA.110.160515. Epub 2010 Nov 8.
29. GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program. Pikkarainen S, etal., J Biol Chem. 2003 Jun 27;278(26):23807-16. Epub 2003 Apr 17.
30. Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3. Potvin E, etal., Mol Cell Biol. 2010 Nov;30(22):5348-63. doi: 10.1128/MCB.00353-09. Epub 2010 Sep 20.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes. Sunagawa Y, etal., J Biol Chem. 2010 Mar 26;285(13):9556-68. doi: 10.1074/jbc.M109.070458. Epub 2010 Jan 17.
35. Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. Tamura S, etal., Proc Natl Acad Sci U S A 1993 Nov 15;90(22):10876-80.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. Tremblay JJ and Viger RS, J Biol Chem 2003 Jun 13;278(24):22128-35.
38. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. Yanazume T, etal., J Biol Chem 2002 Mar 8;277(10):8618-25.
39. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
Additional References at PubMed
PMID:8183957   PMID:8455608   PMID:8582296   PMID:8754853   PMID:9136932   PMID:9136933   PMID:9231805   PMID:9312027   PMID:9420335   PMID:9566909   PMID:9738004   PMID:9858576  
PMID:11297508   PMID:11810204   PMID:12530967   PMID:12606418   PMID:12801993   PMID:14978031   PMID:15051723   PMID:15059951   PMID:15082719   PMID:15220332   PMID:15310850   PMID:15464586  
PMID:15539431   PMID:15766748   PMID:15902305   PMID:16127717   PMID:16137232   PMID:16166646   PMID:16259952   PMID:16380715   PMID:16603706   PMID:16682116   PMID:16940177   PMID:17142311  
PMID:17227882   PMID:17272516   PMID:17360443   PMID:17495229   PMID:17498735   PMID:17548362   PMID:17643447   PMID:17848411   PMID:17975667   PMID:18252717   PMID:18259093   PMID:18400219  
PMID:18439490   PMID:18462699   PMID:19084512   PMID:19162035   PMID:19253817   PMID:19327894   PMID:19546173   PMID:19966502   PMID:20041118   PMID:20123909   PMID:20347099   PMID:20585342  
PMID:20691899   PMID:20705924   PMID:20708014   PMID:20833366   PMID:21029371   PMID:21146513   PMID:21172404   PMID:21179204   PMID:21220346   PMID:21330551   PMID:21379568   PMID:21571865  
PMID:21846294   PMID:22227582   PMID:22228770   PMID:22473995   PMID:22532871   PMID:22674427   PMID:23327965   PMID:23426975   PMID:23558708   PMID:23632743   PMID:24000169   PMID:24015301  
PMID:24268575   PMID:24582939   PMID:24866243   PMID:25000170   PMID:25241353   PMID:25332186   PMID:25501827   PMID:25590961   PMID:25869677   PMID:26100648   PMID:26252173   PMID:26388265  
PMID:26477491   PMID:26962868   PMID:27216460   PMID:27485101   PMID:27569279   PMID:27783597   PMID:28440427   PMID:29325903   PMID:31949236   PMID:34545275   PMID:34773653   PMID:35217336  
PMID:35286985   PMID:35659652   PMID:36694058   PMID:36814152  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21537,459,601 - 37,531,291 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,312,354 - 39,358,379 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,463,161 - 40,509,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,920,232 - 38,966,261 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38811,676,935 - 11,760,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,676,959 - 11,760,002 (+)EnsemblGRCh38hg38GRCh38
GRCh37811,534,444 - 11,617,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,599,162 - 11,654,918 (+)NCBINCBI36Build 36hg18NCBI36
Build 34811,599,161 - 11,654,918NCBI
Celera810,690,994 - 10,746,848 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,492,698 - 10,548,485 (+)NCBIHuRef
CHM1_1811,627,233 - 11,683,005 (+)NCBICHM1_1
T2T-CHM13v2.087,980,285 - 8,063,322 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391463,436,363 - 63,509,161 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,436,371 - 63,509,141 (-)EnsemblGRCm39 Ensembl
GRCm381463,198,914 - 63,271,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,198,922 - 63,271,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,817,752 - 63,864,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361462,153,032 - 62,199,370 (-)NCBIMGSCv36mm8
Celera1460,962,648 - 61,008,982 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495540352,987,644 - 53,029,267 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540352,958,318 - 53,029,267 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan184,197,937 - 4,253,651 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,442,921 - 7,526,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12526,126,172 - 26,211,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,127,853 - 26,182,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,784,428 - 26,835,191 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,280,507 - 26,366,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,280,510 - 26,337,654 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,235,249 - 26,286,037 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,131,847 - 26,182,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,283,313 - 26,334,650 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_0244049435,165,238 - 5,177,602 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366753,408,549 - 3,420,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1414,884,662 - 14,939,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,046,527 - 16,126,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.187,348,145 - 7,432,574 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,349,660 - 7,400,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605235,034,077 - 35,087,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462475825,278,874 - 25,319,318 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475825,278,878 - 25,319,317 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gata4
229 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI19188439

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:153
Interacting mature miRNAs:188
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,459,757 - 37,459,931 (+)MAPPERmRatBN7.2
Rnor_6.01546,386,862 - 46,387,035NCBIRnor6.0
Rnor_5.01550,151,656 - 50,151,829UniSTSRnor5.0
RGSC_v3.41542,472,950 - 42,473,123UniSTSRGSC3.4
Celera1537,144,085 - 37,144,258UniSTS
RH 3.4 Map15261.71UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,088 - 37,462,178 (+)MAPPERmRatBN7.2
Rnor_6.01546,388,193 - 46,389,282NCBIRnor6.0
Rnor_5.01550,152,987 - 50,154,076UniSTSRnor5.0
RGSC_v3.41542,474,281 - 42,475,370UniSTSRGSC3.4
Celera1537,145,416 - 37,146,505UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,463,987 - 37,465,196 (+)MAPPERmRatBN7.2
Rnor_6.01546,391,092 - 46,392,300NCBIRnor6.0
Rnor_5.01550,155,886 - 50,157,094UniSTSRnor5.0
RGSC_v3.41542,477,180 - 42,478,388UniSTSRGSC3.4
Celera1537,148,315 - 37,149,523UniSTS
Cytogenetic Map15p12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,101 - 37,462,231 (+)MAPPERmRatBN7.2
Rnor_6.01546,388,206 - 46,389,335NCBIRnor6.0
Rnor_5.01550,153,000 - 50,154,129UniSTSRnor5.0
RGSC_v3.41542,474,294 - 42,475,423UniSTSRGSC3.4
Celera1537,145,429 - 37,146,558UniSTS
Cytogenetic Map15p12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 41 26 26 26 35
Low 2 16 15 1 15 2 4 3 10
Below cutoff 1 14 14 7 7 26 22 3 1 7


RefSeq Acc Id: ENSRNOT00000014320   ⟹   ENSRNOP00000014320
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1537,459,601 - 37,505,636 (-)Ensembl
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)Ensembl
RefSeq Acc Id: NM_144730   ⟹   NP_653331
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,505,636 (-)NCBI
Rnor_6.01546,386,705 - 46,432,914 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
RGSC_v3.41542,472,793 - 42,519,569 (-)RGD
Celera1537,143,928 - 37,189,874 (-)RGD
RefSeq Acc Id: XM_006252189   ⟹   XP_006252251
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,505,713 (-)NCBI
Rnor_6.01546,386,703 - 46,433,144 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
RefSeq Acc Id: XM_017599788   ⟹   XP_017455277
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,531,291 (-)NCBI
Rnor_6.01546,386,703 - 46,458,679 (-)NCBI
RefSeq Acc Id: NP_653331   ⟸   NM_144730
- UniProtKB: P46152 (UniProtKB/Swiss-Prot),   A6K6F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252251   ⟸   XM_006252189
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455277   ⟸   XM_017599788
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000014320   ⟸   ENSRNOT00000014320
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P46152-F1-model_v2 AlphaFold P46152 1-440 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2665 AgrOrtholog
BioCyc Gene G2FUF-13435 BioCyc
Ensembl Genes ENSRNOG00000010708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014320 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014320 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GATA_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_GATA_4/5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transcription_factor_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54254 UniProtKB/Swiss-Prot
PANTHER PTHR10071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA-N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gata4 PhenoGen
PIRSF TF_GATA_4/5/6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204221
UniProt A4K500_RAT UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gata4  GATA-binding protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a DNA binding domain composed of two conserved zinc fingers 625524
gene_process may mediate hypertrophic signaling in cardiac myocytes 625524
gene_process plays a role in the cardiac muscle development during embryogenesis 625524