Gata4 (GATA binding protein 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gata4 (GATA binding protein 4) Rattus norvegicus
Analyze
Symbol: Gata4
Name: GATA binding protein 4
RGD ID: 2665
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Located in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4); INTERACTS WITH 17alpha-ethynylestradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA-binding protein GATA-GT2; GATA-binding factor 4; GATA-binding protein 4; transcription factor GATA-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21537,459,601 - 37,531,291 (-)NCBI
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetic acid  (ISO)
aflatoxin B1  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
carbamazepine  (ISO)
carbon monoxide  (ISO)
carvedilol  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
fluoranthene  (ISO)
fonofos  (ISO)
glyphosate  (ISO)
heparin  (EXP)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
icariin  (ISO)
irinotecan  (EXP)
isoprenaline  (EXP,ISO)
L-ascorbic acid  (ISO)
latrunculin B  (EXP)
lipopolysaccharide  (EXP)
methylmercury chloride  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (EXP)
probucol  (EXP)
progesterone  (ISO)
prostaglandin F2alpha  (EXP)
pyrogallol  (ISO)
quercetin  (EXP)
ribavirin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
tadalafil  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
warfarin  (ISO)
Y-27632  (EXP)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
atrial septum morphogenesis  (ISO)
atrial septum primum morphogenesis  (ISO)
atrial septum secundum morphogenesis  (ISO)
atrioventricular canal development  (ISO)
atrioventricular valve formation  (ISO)
atrioventricular valve morphogenesis  (ISO)
cardiac muscle cell differentiation  (IEP,ISO)
cardiac muscle hypertrophy in response to stress  (ISO)
cardiac muscle tissue development  (ISO)
cardiac muscle tissue regeneration  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cardiac septum development  (ISO)
cell fate commitment  (IBA)
cell growth involved in cardiac muscle cell development  (IDA)
cell-cell signaling  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to gonadotropin stimulus  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic foregut morphogenesis  (ISO)
embryonic heart tube anterior/posterior pattern specification  (ISO)
embryonic heart tube development  (ISO)
embryonic morphogenesis  (ISO)
endocardial cushion development  (ISO)
endoderm formation  (ISO)
epithelial cell fate commitment  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (ISO,TAS)
heart looping  (ISO)
heart morphogenesis  (ISO)
in utero embryonic development  (ISO)
intestinal epithelial cell differentiation  (ISO)
lung lobe formation  (ISO)
male gonad development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of autophagy  (IMP)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of connective tissue replacement  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of oxidative stress-induced cell death  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (IDA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardioblast differentiation  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of vascular endothelial growth factor production  (ISO)
regulation of cardiac muscle cell contraction  (IMP)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of protein kinase B signaling  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
regulation of transcription, DNA-templated  (IDA,ISO)
response to estrogen  (ISO)
response to mechanical stimulus  (IDA)
response to retinoic acid  (ISO)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (ISO)
seminiferous tubule development  (ISO)
Sertoli cell differentiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
SMAD protein signal transduction  (ISO)
spermatogenesis  (ISO)
transdifferentiation  (IMP)
tube morphogenesis  (ISO)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (ISO)
wound healing  (ISO)

Cellular Component

References

References - curated
1. Charron F, etal., Mol Cell Biol. 1999 Jun;19(6):4355-65.
2. Clabby ML, etal., J Biol Chem 2003 Feb 21;278(8):5760-7.
3. Dai YS, etal., J Biol Chem 2002 Jul 5;277(27):24390-8.
4. Feng Y, etal., J Nutr Biochem. 2013 Jul;24(7):1373-80. doi: 10.1016/j.jnutbio.2012.11.005. Epub 2013 Jan 17.
5. Garg V, etal., Nature. 2003 Jul 24;424(6947):443-7. Epub 2003 Jul 6.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Guo J, etal., Circ Heart Fail. 2011 Jan 1;4(1):79-88. Epub 2010 Oct 22.
9. Kamrul Hasan M, etal., Genes Cells. 2010 May;15(5):439-54. Epub 2010 Apr 7.
10. Kerkela R, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R140-9. Epub 2010 Nov 17.
11. Kerkela R, etal., J Biol Chem 2002 Apr 19;277(16):13752-60.
12. Kobayashi S, etal., J Biol Chem. 2007 Jul 27;282(30):21945-52. Epub 2007 May 24.
13. Kobayashi S, etal., J Biol Chem. 2010 Jan 1;285(1):793-804. Epub 2009 Nov 9.
14. Ku PM, etal., Cardiovasc Diabetol. 2011 Jun 24;10:57. doi: 10.1186/1475-2840-10-57.
15. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Le K, etal., Arch Biochem Biophys. 2012 Feb 1;518(1):71-8. Epub 2011 Dec 16.
17. Liu XY, etal., Int J Mol Med. 2011 Jul;28(1):17-23. doi: 10.3892/ijmm.2011.638. Epub 2011 Mar 3.
18. Lu T, etal., Tissue Eng Part A. 2010 Oct;16(10):3111-7.
19. Mar GY, etal., Int J Cardiol. 2012 Jan 29.
20. MGD data from the GO Consortium
21. Molkentin JD, etal., Mol Cell Biol. 1994 Jul;14(7):4947-57.
22. Morimoto T, etal., J Clin Invest. 2008 Mar;118(3):868-78.
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Nemer G and Nemer M, Dev Biol. 2003 Feb 1;254(1):131-48.
25. OMIM Disease Annotation Pipeline
26. Online Mendelian Inheritance in Man, OMIM (TM).
27. Park AM, etal., Hypertension. 2010 Dec;56(6):1145-51. doi: 10.1161/HYPERTENSIONAHA.110.160515. Epub 2010 Nov 8.
28. Pikkarainen S, etal., J Biol Chem. 2003 Jun 27;278(26):23807-16. Epub 2003 Apr 17.
29. Potvin E, etal., Mol Cell Biol. 2010 Nov;30(22):5348-63. doi: 10.1128/MCB.00353-09. Epub 2010 Sep 20.
30. RGD automated data pipeline
31. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. RGD automated import pipeline for gene-chemical interactions
33. Sunagawa Y, etal., J Biol Chem. 2010 Mar 26;285(13):9556-68. doi: 10.1074/jbc.M109.070458. Epub 2010 Jan 17.
34. Tamura S, etal., Proc Natl Acad Sci U S A 1993 Nov 15;90(22):10876-80.
35. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Tremblay JJ and Viger RS, J Biol Chem 2003 Jun 13;278(24):22128-35.
37. Yanazume T, etal., J Biol Chem 2002 Mar 8;277(10):8618-25.
38. Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
Additional References at PubMed
PMID:8183957   PMID:8455608   PMID:8582296   PMID:8754853   PMID:9136932   PMID:9136933   PMID:9231805   PMID:9312027   PMID:9420335   PMID:9566909   PMID:9738004   PMID:9858576  
PMID:11297508   PMID:11810204   PMID:12530967   PMID:12606418   PMID:12801993   PMID:14978031   PMID:15051723   PMID:15059951   PMID:15082719   PMID:15220332   PMID:15310850   PMID:15464586  
PMID:15539431   PMID:15766748   PMID:15902305   PMID:16127717   PMID:16137232   PMID:16166646   PMID:16259952   PMID:16380715   PMID:16603706   PMID:16682116   PMID:16940177   PMID:17142311  
PMID:17227882   PMID:17272516   PMID:17360443   PMID:17495229   PMID:17498735   PMID:17548362   PMID:17643447   PMID:17848411   PMID:17975667   PMID:18252717   PMID:18259093   PMID:18400219  
PMID:18439490   PMID:18462699   PMID:19084512   PMID:19162035   PMID:19253817   PMID:19327894   PMID:19546173   PMID:19966502   PMID:20041118   PMID:20123909   PMID:20347099   PMID:20585342  
PMID:20691899   PMID:20705924   PMID:20708014   PMID:20833366   PMID:21029371   PMID:21146513   PMID:21172404   PMID:21179204   PMID:21220346   PMID:21330551   PMID:21379568   PMID:21571865  
PMID:21846294   PMID:22227582   PMID:22228770   PMID:22473995   PMID:22532871   PMID:22674427   PMID:23327965   PMID:23426975   PMID:23558708   PMID:23632743   PMID:24000169   PMID:24015301  
PMID:24268575   PMID:24582939   PMID:24866243   PMID:25000170   PMID:25241353   PMID:25332186   PMID:25501827   PMID:25590961   PMID:25869677   PMID:26100648   PMID:26252173   PMID:26388265  
PMID:26477491   PMID:26962868   PMID:27216460   PMID:27236543   PMID:27485101   PMID:27569279   PMID:27783597   PMID:28440427   PMID:29325903   PMID:31949236  


Genomics

Comparative Map Data
Gata4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21537,459,601 - 37,531,291 (-)NCBI
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01546,386,703 - 46,458,679 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01550,151,497 - 50,197,708 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,472,793 - 42,519,569 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11542,488,492 - 42,535,269 (-)NCBI
Celera1537,143,928 - 37,189,874 (-)NCBICelera
RH 3.4 Map15261.71RGD
Cytogenetic Map15p12NCBI
GATA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl811,676,959 - 11,760,002 (+)EnsemblGRCh38hg38GRCh38
GRCh38811,676,935 - 11,760,002 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37811,534,444 - 11,617,511 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,599,162 - 11,654,918 (+)NCBINCBI36hg18NCBI36
Build 34811,599,161 - 11,654,918NCBI
Celera810,690,994 - 10,746,848 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef810,492,698 - 10,548,485 (+)NCBIHuRef
CHM1_1811,627,233 - 11,683,005 (+)NCBICHM1_1
Gata4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,436,363 - 63,509,161 (-)NCBIGRCm39mm39
GRCm39 Ensembl1463,436,371 - 63,509,141 (-)Ensembl
GRCm381463,198,914 - 63,271,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,198,922 - 63,271,692 (-)EnsemblGRCm38mm10GRCm38
MGSCv371463,817,752 - 63,864,097 (-)NCBIGRCm37mm9NCBIm37
MGSCv361462,153,032 - 62,199,370 (-)NCBImm8
Celera1460,962,648 - 61,008,982 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Gata4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,987,644 - 53,029,267 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540352,958,318 - 53,029,267 (+)NCBIChiLan1.0ChiLan1.0
GATA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v087,442,921 - 7,526,731 (-)NCBIMhudiblu_PPA_v0panPan3
GATA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,126,172 - 26,211,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,127,853 - 26,182,989 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,784,428 - 26,835,191 (-)NCBI
ROS_Cfam_1.02526,280,507 - 26,366,154 (-)NCBI
UMICH_Zoey_3.12526,235,249 - 26,286,037 (-)NCBI
UNSW_CanFamBas_1.02526,131,847 - 26,182,607 (-)NCBI
UU_Cfam_GSD_1.02526,283,313 - 26,334,650 (-)NCBI
Gata4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,165,238 - 5,177,602 (-)NCBI
SpeTri2.0NW_0049366753,408,549 - 3,420,828 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GATA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1414,858,159 - 14,939,941 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11414,858,470 - 14,938,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,046,527 - 16,126,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GATA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,348,145 - 7,432,574 (-)NCBI
ChlSab1.1 Ensembl87,349,660 - 7,400,562 (-)Ensembl
Vero_WHO_p1.0NW_02366605235,034,077 - 35,087,089 (+)NCBI
Gata4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475825,278,878 - 25,319,317 (+)NCBI

Position Markers
RH94862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,459,757 - 37,459,931 (+)MAPPER
Rnor_6.01546,386,862 - 46,387,035NCBIRnor6.0
Rnor_5.01550,151,656 - 50,151,829UniSTSRnor5.0
RGSC_v3.41542,472,950 - 42,473,123UniSTSRGSC3.4
Celera1537,144,085 - 37,144,258UniSTS
RH 3.4 Map15261.71UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,088 - 37,462,178 (+)MAPPER
Rnor_6.01546,388,193 - 46,389,282NCBIRnor6.0
Rnor_5.01550,152,987 - 50,154,076UniSTSRnor5.0
RGSC_v3.41542,474,281 - 42,475,370UniSTSRGSC3.4
Celera1537,145,416 - 37,146,505UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,463,987 - 37,465,196 (+)MAPPER
Rnor_6.01546,391,092 - 46,392,300NCBIRnor6.0
Rnor_5.01550,155,886 - 50,157,094UniSTSRnor5.0
RGSC_v3.41542,477,180 - 42,478,388UniSTSRGSC3.4
Celera1537,148,315 - 37,149,523UniSTS
Cytogenetic Map15p12UniSTS
Gata4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21537,461,101 - 37,462,231 (+)MAPPER
Rnor_6.01546,388,206 - 46,389,335NCBIRnor6.0
Rnor_5.01550,153,000 - 50,154,129UniSTSRnor5.0
RGSC_v3.41542,474,294 - 42,475,423UniSTSRGSC3.4
Celera1537,145,429 - 37,146,558UniSTS
Cytogenetic Map15p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152377896946825072Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)153948079762596410Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153974955779033707Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153974955779033707Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154106809486068094Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154275724156027084Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154309747052831189Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI19188439

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:153
Interacting mature miRNAs:188
Transcripts:ENSRNOT00000014320
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 26 26 26 35
Low 2 16 15 1 15 2 4 3 10
Below cutoff 1 14 14 7 7 26 22 3 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014320   ⟹   ENSRNOP00000014320
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1546,386,712 - 46,432,965 (-)Ensembl
RefSeq Acc Id: NM_144730   ⟹   NP_653331
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,505,636 (-)NCBI
Rnor_6.01546,386,705 - 46,432,914 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
RGSC_v3.41542,472,793 - 42,519,569 (-)RGD
Celera1537,143,928 - 37,189,874 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252189   ⟹   XP_006252251
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,505,713 (-)NCBI
Rnor_6.01546,386,703 - 46,433,144 (-)NCBI
Rnor_5.01550,151,497 - 50,197,708 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599788   ⟹   XP_017455277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21537,459,601 - 37,531,291 (-)NCBI
Rnor_6.01546,386,703 - 46,458,679 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_653331   ⟸   NM_144730
- UniProtKB: P46152 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006252251   ⟸   XM_006252189
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455277   ⟸   XM_017599788
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000014320   ⟸   ENSRNOT00000014320

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699777
Promoter ID:EPDNEW_R10299
Type:multiple initiation site
Name:Gata4_1
Description:GATA binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01546,432,946 - 46,433,006EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2665 AgrOrtholog
Ensembl Genes ENSRNOG00000010708 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000014320 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014320 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.50.10 UniProtKB/Swiss-Prot
InterPro GATA_N UniProtKB/Swiss-Prot
  TF_GATA_4/5/6 UniProtKB/Swiss-Prot
  Transcription_factor_GATA UniProtKB/Swiss-Prot
  Znf_GATA UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:54254 UniProtKB/Swiss-Prot
NCBI Gene 54254 ENTREZGENE
PANTHER PTHR10071 UniProtKB/Swiss-Prot
Pfam GATA UniProtKB/Swiss-Prot
  GATA-N UniProtKB/Swiss-Prot
PhenoGen Gata4 PhenoGen
PIRSF TF_GATA_4/5/6 UniProtKB/Swiss-Prot
PRINTS GATAZNFINGER UniProtKB/Swiss-Prot
PROSITE GATA_ZN_FINGER_1 UniProtKB/Swiss-Prot
  GATA_ZN_FINGER_2 UniProtKB/Swiss-Prot
SMART ZnF_GATA UniProtKB/Swiss-Prot
TIGR TC204221
UniProt A4K500_RAT UniProtKB/TrEMBL
  GATA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gata4  GATA-binding protein 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a DNA binding domain composed of two conserved zinc fingers 625524
gene_process may mediate hypertrophic signaling in cardiac myocytes 625524
gene_process plays a role in the cardiac muscle development during embryogenesis 625524