Nek6 (NIMA-related kinase 6) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nek6 (NIMA-related kinase 6) Rattus norvegicus
Analyze
Symbol: Nek6
Name: NIMA-related kinase 6
RGD ID: 727779
Description: Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Orthologous to human NEK6 (NIMA related kinase 6); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: never in mitosis A-related kinase 6; NIMA (never in mitosis gene a)-related expressed kinase 6; NIMA (never in mitosis gene a)-related kinase 6; nimA-related protein kinase 6; serine/threonine-protein kinase Nek6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,693,994 - 42,766,026 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl342,693,971 - 42,767,773 (+)EnsemblGRCr8
mRatBN7.2322,284,269 - 22,356,302 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,284,279 - 22,395,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx325,752,489 - 25,824,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,337,482 - 34,409,485 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,149,813 - 32,221,975 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,811,927 - 22,888,598 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)Ensemblrn6Rnor6.0
Rnor_5.0328,037,221 - 28,114,175 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4318,348,698 - 18,381,895 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera320,719,448 - 20,791,246 (+)NCBICelera
RGSC_v3.1318,245,069 - 18,278,267 (+)NCBI
Cytogenetic Map3q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
cefaloridine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
lead(0)  (ISO)
leflunomide  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
tioguanine  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriolar satellite  (IEA,ISO)
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO,ISS)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
nuclear speck  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)
spindle pole  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Belham C, etal., Curr Biol. 2001 Aug 7;11(15):1155-67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Information Derived from GenBank Report RGD, Sept. 2003
Additional References at PubMed
PMID:10964517   PMID:12054534   PMID:12477932   PMID:12761501   PMID:12840024   PMID:14563848   PMID:19001501   PMID:20873783  


Genomics

Comparative Map Data
Nek6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8342,693,994 - 42,766,026 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl342,693,971 - 42,767,773 (+)EnsemblGRCr8
mRatBN7.2322,284,269 - 22,356,302 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,284,279 - 22,395,990 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx325,752,489 - 25,824,488 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,337,482 - 34,409,485 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,149,813 - 32,221,975 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,811,927 - 22,888,598 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)Ensemblrn6Rnor6.0
Rnor_5.0328,037,221 - 28,114,175 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4318,348,698 - 18,381,895 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera320,719,448 - 20,791,246 (+)NCBICelera
RGSC_v3.1318,245,069 - 18,278,267 (+)NCBI
Cytogenetic Map3q12NCBI
NEK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,257,606 - 124,353,307 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,257,606 - 124,353,307 (+)Ensemblhg38GRCh38
GRCh379127,019,885 - 127,115,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,060,070 - 126,154,542 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349124,099,802 - 124,194,271NCBI
Celera997,667,169 - 97,761,958 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,633,275 - 96,727,666 (+)NCBIHuRef
CHM1_19127,169,017 - 127,263,737 (+)NCBICHM1_1
T2T-CHM13v2.09136,455,708 - 136,551,354 (+)NCBIT2T-CHM13v2.0
Nek6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,314,052 - 38,477,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,401,655 - 38,484,618 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38238,483,863 - 38,587,490 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,511,643 - 38,594,606 (+)Ensemblmm10GRCm38
MGSCv37238,367,396 - 38,443,010 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36238,333,709 - 38,410,050 (+)NCBIMGSCv36mm8
MGSCv36238,950,290 - 39,027,048 (+)NCBIMGSCv36mm8
Celera240,274,369 - 40,309,329 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.41NCBI
Nek6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,762,643 - 3,820,979 (-)Ensembl
ChiLan1.0NW_0049554193,762,643 - 3,833,000 (-)NCBIChiLan1.0ChiLan1.0
NEK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,002,104 - 15,097,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,004,800 - 15,099,678 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,379,090 - 95,474,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,900,131 - 123,994,658 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,903,240 - 123,994,658 (+)EnsemblpanPan2panpan1.1
NEK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,594,026 - 58,677,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,594,045 - 58,674,274 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha957,790,942 - 57,874,150 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0959,513,709 - 59,597,117 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,513,709 - 59,594,207 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1958,271,493 - 58,354,450 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,588,052 - 58,671,089 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,678,689 - 58,761,888 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nek6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,837,785 - 192,864,646 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,606,312 - 12,633,285 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648712,606,312 - 12,632,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,078,435 - 265,176,903 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11265,078,407 - 265,170,960 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21298,837,214 - 298,942,112 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11213,791,431 - 13,887,713 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1213,792,903 - 13,842,307 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660792,189,264 - 2,285,578 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476010,739,235 - 10,797,238 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476010,739,235 - 10,807,744 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek6
415 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:53
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000014630
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
RH144381  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,329,649 - 22,330,836 (+)MAPPERmRatBN7.2
Rnor_6.0322,862,284 - 22,863,469NCBIRnor6.0
Rnor_5.0328,087,920 - 28,089,105UniSTSRnor5.0
RGSC_v3.4318,356,307 - 18,357,492UniSTSRGSC3.4
Celera320,764,773 - 20,765,958UniSTS
RH 3.4 Map3212.91UniSTS
Cytogenetic Map3q11UniSTS
RH141371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,355,925 - 22,356,143 (+)MAPPERmRatBN7.2
Rnor_6.0322,888,222 - 22,888,439NCBIRnor6.0
Rnor_5.0328,113,799 - 28,114,016UniSTSRnor5.0
RGSC_v3.4318,382,347 - 18,382,564UniSTSRGSC3.4
Celera320,790,870 - 20,791,087UniSTS
RH 3.4 Map3217.0UniSTS
Cytogenetic Map3q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014630   ⟹   ENSRNOP00000014631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl342,738,875 - 42,765,198 (+)Ensembl
mRatBN7.2 Ensembl322,329,151 - 22,395,990 (+)Ensembl
Rnor_6.0 Ensembl322,854,768 - 22,887,770 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082561   ⟹   ENSRNOP00000069868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,321,948 - 22,395,990 (+)Ensembl
Rnor_6.0 Ensembl322,829,817 - 22,888,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086147   ⟹   ENSRNOP00000069207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl342,699,409 - 42,764,915 (+)Ensembl
mRatBN7.2 Ensembl322,284,279 - 22,356,261 (+)Ensembl
Rnor_6.0 Ensembl322,811,927 - 22,888,598 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116855   ⟹   ENSRNOP00000083098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl342,693,971 - 42,767,773 (+)Ensembl
mRatBN7.2 Ensembl322,284,299 - 22,357,196 (+)Ensembl
RefSeq Acc Id: NM_001277232   ⟹   NP_001264161
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,706,644 - 42,766,026 (+)NCBI
mRatBN7.2322,296,919 - 22,356,302 (+)NCBI
Rnor_6.0322,829,817 - 22,888,598 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
Celera320,732,051 - 20,791,246 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182953   ⟹   NP_891998
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,693,994 - 42,766,026 (+)NCBI
mRatBN7.2322,284,269 - 22,356,302 (+)NCBI
Rnor_6.0322,811,927 - 22,888,598 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
RGSC_v3.4318,348,698 - 18,381,895 (+)RGD
Celera320,719,448 - 20,791,246 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234100   ⟹   XP_006234162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,097 - 42,765,985 (+)NCBI
mRatBN7.2322,284,367 - 22,356,294 (+)NCBI
Rnor_6.0322,812,020 - 22,888,557 (+)NCBI
Rnor_5.0328,037,221 - 28,114,175 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591866   ⟹   XP_017447355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,368 - 42,765,985 (+)NCBI
mRatBN7.2322,284,643 - 22,356,294 (+)NCBI
Rnor_6.0322,812,215 - 22,888,557 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105334   ⟹   XP_038961262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,697,285 - 42,765,985 (+)NCBI
mRatBN7.2322,287,555 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105335   ⟹   XP_038961263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,177 - 42,765,985 (+)NCBI
mRatBN7.2322,284,476 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105336   ⟹   XP_038961264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,177 - 42,765,985 (+)NCBI
mRatBN7.2322,284,547 - 22,356,294 (+)NCBI
RefSeq Acc Id: XM_039105337   ⟹   XP_038961265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8342,694,519 - 42,765,985 (+)NCBI
mRatBN7.2322,284,794 - 22,356,294 (+)NCBI
RefSeq Acc Id: NP_891998   ⟸   NM_182953
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001264161   ⟸   NM_001277232
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234162   ⟸   XM_006234100
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447355   ⟸   XM_017591866
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069868   ⟸   ENSRNOT00000082561
Ensembl Acc Id: ENSRNOP00000014631   ⟸   ENSRNOT00000014630
Ensembl Acc Id: ENSRNOP00000069207   ⟸   ENSRNOT00000086147
RefSeq Acc Id: XP_038961263   ⟸   XM_039105335
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961264   ⟸   XM_039105336
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961265   ⟸   XM_039105337
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961262   ⟸   XM_039105334
- Peptide Label: isoform X1
- UniProtKB: P59895 (UniProtKB/Swiss-Prot),   B1H218 (UniProtKB/TrEMBL),   A0A8L2R1R0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000083098   ⟸   ENSRNOT00000116855
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59895-F1-model_v2 AlphaFold P59895 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692052
Promoter ID:EPDNEW_R2575
Type:initiation region
Name:Nek6_1
Description:NIMA-related kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0322,811,951 - 22,812,011EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727779 AgrOrtholog
BioCyc Gene G2FUF-49910 BioCyc
Ensembl Genes ENSRNOG00000010897 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000086147 ENTREZGENE
  ENSRNOT00000116855 ENTREZGENE
  ENSRNOT00000116855.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7459041 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:360161 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187307 IMAGE-MGC_LOAD
NCBI Gene 360161 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Nek6 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010897 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2Q7T9_RAT UniProtKB/TrEMBL
  A0A8L2R0L5_RAT UniProtKB/TrEMBL
  A0A8L2R1R0 ENTREZGENE, UniProtKB/TrEMBL
  A6JEU5_RAT UniProtKB/TrEMBL
  B1H218 ENTREZGENE, UniProtKB/TrEMBL
  NEK6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-11-21 Nek6  NIMA-related kinase 6  Nek6  NIMA (never in mitosis gene a)-related kinase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Nek6  NIMA (never in mitosis gene a)-related kinase 6  Nek6  NIMA (never in mitosis gene a)-related expressed kinase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Nek6  NIMA (never in mitosis gene a)-related expressed kinase 6      Symbol and Name status set to approved 1299863 APPROVED