Ralgds (ral guanine nucleotide dissociation stimulator) - Rat Genome Database

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Gene: Ralgds (ral guanine nucleotide dissociation stimulator) Rattus norvegicus
Analyze
Symbol: Ralgds
Name: ral guanine nucleotide dissociation stimulator
RGD ID: 3533
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to be located in brush border; cytosol; and nucleus. Predicted to be active in plasma membrane. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator); PARTICIPATES IN ceramide signaling pathway; colorectal cancer pathway; pancreatic cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC102554500; ral guanine nucleotide dissociation stimulator-like; ral guanine nucleotide exchange factor; ralGEF; Rgds
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2311,839,686 - 11,880,059 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl311,839,416 - 11,880,059 (+)Ensembl
Rnor_6.037,090,134 - 7,130,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,109,920 - 7,130,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,440,157 - 12,481,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,516,054 - 7,537,651 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.137,516,353 - 7,537,935 (+)NCBI
Celera36,640,808 - 6,660,733 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
brush border  (ISO)
cytosol  (ISO,TAS)
nucleus  (ISO)
plasma membrane  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. Albright CF, etal., EMBO J 1993 Jan;12(1):339-47.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7972015   PMID:9253406   PMID:12642511   PMID:22797597  


Genomics

Comparative Map Data
Ralgds
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2311,839,686 - 11,880,059 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl311,839,416 - 11,880,059 (+)Ensembl
Rnor_6.037,090,134 - 7,130,548 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,109,920 - 7,130,548 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,440,157 - 12,481,565 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,516,054 - 7,537,651 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.137,516,353 - 7,537,935 (+)NCBI
Celera36,640,808 - 6,660,733 (+)NCBICelera
Cytogenetic Map3p12NCBI
RALGDS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,097,722 - 133,149,210 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9133,097,720 - 133,149,334 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,973,109 - 136,024,597 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,962,928 - 135,014,409 (-)NCBINCBI36hg18NCBI36
Build 349133,002,661 - 133,026,115NCBI
Celera9106,514,832 - 106,566,263 (-)NCBI
Cytogenetic Map9q34.13-q34.2NCBI
HuRef9105,466,726 - 105,500,074 (-)NCBIHuRef
CHM1_19136,123,741 - 136,174,957 (-)NCBICHM1_1
T2T-CHM13v2.09145,311,872 - 145,363,296 (-)NCBI
Ralgds
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,403,037 - 28,443,094 (+)NCBIGRCm39mm39
GRCm39 Ensembl228,403,137 - 28,443,093 (+)Ensembl
GRCm38228,513,089 - 28,553,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,513,125 - 28,553,081 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,368,687 - 28,408,602 (+)NCBIGRCm37mm9NCBIm37
MGSCv36228,335,340 - 28,375,079 (+)NCBImm8
Celera228,217,341 - 28,257,258 (+)NCBICelera
Cytogenetic Map2A3NCBI
Ralgds
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555132,386,293 - 2,405,161 (-)NCBIChiLan1.0ChiLan1.0
RALGDS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19132,832,924 - 132,847,200 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v09104,218,338 - 104,269,322 (-)NCBIMhudiblu_PPA_v0panPan3
RALGDS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,287,252 - 51,329,997 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,550,610 - 50,592,293 (+)NCBI
ROS_Cfam_1.0952,180,564 - 52,222,391 (+)NCBI
ROS_Cfam_1.0 Ensembl952,180,324 - 52,223,270 (+)Ensembl
UMICH_Zoey_3.1950,980,284 - 51,000,916 (+)NCBI
UNSW_CanFamBas_1.0951,283,824 - 51,325,521 (+)NCBI
UU_Cfam_GSD_1.0951,363,054 - 51,404,763 (+)NCBI
Ralgds
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,706,834 - 199,732,858 (-)NCBI
SpeTri2.0NW_00493648719,475,361 - 19,501,347 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RALGDS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11272,776,844 - 272,824,179 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,700,576 - 306,713,801 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RALGDS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,993,357 - 5,042,347 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607910,611,288 - 10,660,534 (-)NCBIVero_WHO_p1.0
Ralgds
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247603,338,398 - 3,376,631 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:94
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000013809
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 3 2 12 2 74 20 33 11
Low 39 54 39 7 39 8 11 15 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013809   ⟹   ENSRNOP00000013809
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,859,428 - 11,880,059 (+)Ensembl
Rnor_6.0 Ensembl37,109,920 - 7,130,548 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084092   ⟹   ENSRNOP00000074350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,863,832 - 11,880,059 (+)Ensembl
Rnor_6.0 Ensembl37,109,920 - 7,130,532 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090398
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl34,988,097 - 4,989,205 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096803   ⟹   ENSRNOP00000087735
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,839,416 - 11,880,059 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103319   ⟹   ENSRNOP00000088988
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,854,184 - 11,879,149 (+)Ensembl
RefSeq Acc Id: NM_019250   ⟹   NP_062123
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,859,428 - 11,880,059 (+)NCBI
Rnor_6.037,109,920 - 7,130,548 (+)NCBI
Rnor_5.0312,440,157 - 12,481,565 (+)NCBI
RGSC_v3.437,516,054 - 7,537,651 (+)RGD
Celera36,640,808 - 6,660,733 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233750   ⟹   XP_006233812
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,859,509 - 11,880,050 (+)NCBI
Rnor_6.037,109,420 - 7,130,539 (+)NCBI
Rnor_5.0312,440,157 - 12,481,565 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233751   ⟹   XP_006233813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,848,760 - 11,880,050 (+)NCBI
Rnor_6.037,096,774 - 7,130,539 (+)NCBI
Rnor_5.0312,440,157 - 12,481,565 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233752   ⟹   XP_006233814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,839,686 - 11,880,050 (+)NCBI
Rnor_6.037,090,134 - 7,130,539 (+)NCBI
Rnor_5.0312,440,157 - 12,481,565 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233753   ⟹   XP_006233815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,839,686 - 11,880,050 (+)NCBI
Rnor_6.037,090,134 - 7,130,539 (+)NCBI
Rnor_5.0312,440,157 - 12,481,565 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591589   ⟹   XP_017447078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2311,849,200 - 11,880,050 (+)NCBI
Rnor_6.037,099,610 - 7,130,539 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062123   ⟸   NM_019250
- UniProtKB: Q03386 (UniProtKB/Swiss-Prot),   F1LN84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233814   ⟸   XM_006233752
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006233815   ⟸   XM_006233753
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006233813   ⟸   XM_006233751
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006233812   ⟸   XM_006233750
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447078   ⟸   XM_017591589
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000074350   ⟸   ENSRNOT00000084092
RefSeq Acc Id: ENSRNOP00000013809   ⟸   ENSRNOT00000013809
RefSeq Acc Id: ENSRNOP00000088988   ⟸   ENSRNOT00000103319
RefSeq Acc Id: ENSRNOP00000087735   ⟸   ENSRNOT00000096803
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03386-F1-model_v2 AlphaFold Q03386 1-895 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691933
Promoter ID:EPDNEW_R2458
Type:single initiation site
Name:Ralgds_1
Description:ral guanine nucleotide dissociation stimulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.037,110,022 - 7,110,082EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 7117985 7117986 C T snv COP/CrCrl (MCW & UW), WN/N (2020), SBN/Ygl (MCW), F344/NRrrc (MCW), WN/N (MCW), F344/NCrl (RGD), MNS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FXLE18/Stm (2020), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LEXF10A/StmMcwi (2020), SBH/Ygl (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 12468087 12468088 C T snv COP/CrCrl (MCW & UW), KFRS3B/Kyo (KyushuU), SBN/Ygl (MCW), WN/N (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), MNS/Gib (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), F344/NSlc (KyushuU), F344/Stm (KyushuU), F344/Jcl (KyushuU), SBH/Ygl (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 7524119 7524120 C T snv F344/NRrrc (KNAW), WN/N (KNAW), COP/CrCrl (MCW & UW), F344/NCrl (ICL), MNS/Gib (ICL), F344/NHsd (ICAHN), SBN/Ygl (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), SBH/Ygl (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 11867495 11867496 C T snv F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), WN/N (2020), LEXF2B/Stm (2019), LEXF3/Stm (2020), LEXF4/Stm (2020), LEXF10A/StmMcwi (2020), FXLE18/Stm (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3533 AgrOrtholog
BioCyc Gene G2FUF-50279 BioCyc
Ensembl Genes ENSRNOG00000010219 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000053371 Ensembl
Ensembl Protein ENSRNOP00000013809 ENTREZGENE
  ENSRNOP00000013809.7 UniProtKB/TrEMBL
  ENSRNOP00000074350 ENTREZGENE
  ENSRNOP00000074350.2 UniProtKB/TrEMBL
  ENSRNOP00000087735 ENTREZGENE
  ENSRNOP00000087735.1 UniProtKB/TrEMBL
  ENSRNOP00000088988.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013809 ENTREZGENE
  ENSRNOT00000013809.8 UniProtKB/TrEMBL
  ENSRNOT00000084092 ENTREZGENE
  ENSRNOT00000084092.2 UniProtKB/TrEMBL
  ENSRNOT00000096803 ENTREZGENE
  ENSRNOT00000096803.1 UniProtKB/TrEMBL
  ENSRNOT00000103319.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro RA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RalGDS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29622 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29622 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23113:SF35 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ralgds PhenoGen
PROSITE PS50200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00314 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217563
UniProt A0A0G2K7U4_RAT UniProtKB/TrEMBL
  A0A8I6A7N2_RAT UniProtKB/TrEMBL
  A0A8I6A8C4_RAT UniProtKB/TrEMBL
  F1LN84 ENTREZGENE, UniProtKB/TrEMBL
  GNDS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ralgds  ral guanine nucleotide dissociation stimulator  LOC102554500  ral guanine nucleotide dissociation stimulator-like  Data Merged 737654 PROVISIONAL
2013-12-18 LOC102554500  ral guanine nucleotide dissociation stimulator-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ralgds  ral guanine nucleotide dissociation stimulator      Name updated 70584 APPROVED