Bss113 QTL Report (Rattus norvegicus) - Rat Genome Database
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QTL: Bss113 (Bone structure and strength QTL 113) Rattus norvegicus

Symbol: Bss113
Name: Bone structure and strength QTL 113
RGD ID: 11528620
Trait: femur morphology trait   (VT:0000559)    
Measurement Type: femoral neck width   (CMO:0001695)    
LOD Score: 9.75
P Value: 1.7E-10
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0312,236,221 - 15,217,668RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0317,570,016 - 20,527,281RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4312,200,198 - 14,999,876RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: NAft:HS 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
NAft:HS  (IEA)

References

References - curated
1. Alam I, etal., Bone. 2015 Dec;81:417-26. doi: 10.1016/j.bone.2015.08.013. Epub 2015 Aug 19.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
2319500Ralgps1Ral GEF with PH domain and SH3 binding motif 131218272212415081Rat
620004Angptl2angiopoietin-like 231226282212292665Rat
1596130Zbtb34zinc finger and BTB domain containing 3431245270512468487Rat
1310287Zbtb43zinc finger and BTB domain containing 4331248977412509372Rat
7578982LOC102550017uncharacterized LOC10255001731252395212526848Rat
620843Lmx1bLIM homeobox transcription factor 1 beta31260874812686937Rat
9300457LOC10369515260S ribosomal protein L39 pseudogene31271596612716198Rat
1309709Mvb12bmultivesicular body subunit 12B31278019612944542Rat
11490445LOC108350351uncharacterized LOC10835035131303114713048043Rat
11425803LOC108350352uncharacterized LOC10835035231313544413168658Rat
1307198Pbx3PBX homeobox 331324103113436084Rat
9255683LOC103691768uncharacterized LOC10369176831338788813393011Rat
11375987LOC108350353uncharacterized LOC10835035331348273013484818Rat
1305363Mapkap1MAPK associated protein 131348495213701772Rat
6490845LOC10091175340S ribosomal protein S7-like31351422113514935Rat
9360889LOC103691769uncharacterized LOC10369176931352772013528048Rat
1307479Gapvd1GTPase activating protein and VPS9 domains 131375157213825573Rat
9357370LOC103691795mitogen-activated protein kinase 7-like31382454113825332Rat
2843Hspa5heat shock protein family A (Hsp70) member 531383830413842763Rat
1310612RabepkRab9 effector protein with kelch motifs31384535213865843Rat
1310460Fbxw2F-box and WD repeat domain containing 231387151313897033Rat
11360258LOC108350354uncharacterized LOC10835035431388253313884996Rat
9424697B3galt9beta-1,3-galactosyltransferase 931390417113906523Rat
1308434Psmd5proteasome 26S subunit, non-ATPase 531391619913937031Rat
1564854RGD1564854similar to divalent cation tolerant protein CUTA31393670913955651Rat
1310390Phf19PHD finger protein 1931395713613978283Rat
7703143LOC102550940uncharacterized LOC10255094031399117213993028Rat
1596290Traf1TNF receptor-associated factor 131400334014022955Rat
2237C5complement C531404999314113931Rat
9255024LOC103691770uncharacterized LOC10369177031413533814136083Rat
7560948LOC102551296pre-B-cell leukemia transcription factor 3-like31416486214169438Rat
7586747LOC10255139840S ribosomal protein S7-like31417203514172631Rat
6488496LOC100912221target of rapamycin complex 2 subunit MAPKAP1-like31417269414203317Rat
2237C5complement C531420646614229141Rat
9094692LOC103691771uncharacterized LOC10369177131425660814258163Rat
1308742RGD1308742similar to Complement C5 precursor31427355214291401Rat
1305317Cntrlcentriolin31429944114371681Rat
620881Rab14RAB14, member RAS oncogene family31437327014395357Rat
7711368LOC102548763uncharacterized LOC10254876331441802314420298Rat
7626419LOC102554040uncharacterized LOC10255404031442032514456057Rat
1303089Gsngelsolin31445610614508922Rat
1305109Stomstomatin31451557614538199Rat
11415833LOC10835035540S ribosomal protein S29 pseudogene31452256214524447Rat
1565200Ggta1l1glycoprotein, alpha-galactosyltransferase 1-like 131455591614573016Rat
7519388LOC102548933uncharacterized LOC10254893331457314914575432Rat
6485978LOC100912604spermidine synthase-like31458881814591980Rat
1560029LOC502618ABO-family member 631459298514614011Rat
629476Ggta1glycoprotein alpha-galactosyltransferase 131461409914701185Rat
7519941LOC102549213uncharacterized LOC10254921331483112814837521Rat
1564343RGD1564343similar to 40S ribosomal protein S1631487302214873533Rat
621686Dab2ipDAB2 interacting protein31488926315060286Rat
11512228LOC108350356uncharacterized LOC10835035631491344214921584Rat
1588742Ttll11tubulin tyrosine ligase like1131508424415312312Rat
11390233LOC108350357uncharacterized LOC10835035731519737515199549Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
10260D3Rat5216631409041114090566Ratregion
34252D3Mgh1914231520312215203253Ratregion
36354D3Mit2222731513801215138221Ratregion
35609D3Rat5315831312691413127093Ratregion
42641D3Rat27821031506533915065554Ratregion
40854D3Rat19223531351825613518613Ratregion
43611D3Got1121531262220312622417Ratregion
43616D3Got913231270826112708392Ratregion
43618D3Got1012131316542313165540Ratregion
43626D3Got817731513802015138196Ratregion
66452D3Mco1819931315325713153456Ratregion
728012D3Chm1522331315938913159611Ratregion
728028D3Chm722731335260113352827Ratregion
728038D3Chm619131315846913158659Ratregion
67266D3Arb521031248101712481226Ratregion
1640270D3Got20216431242354212423705Ratregion
1640611D3Cebr731405745514057665Ratregion
7206072Srm031459110314591783Ratregion
5036213D2Wsu141e20931384248113842689Ratregion
5036233RH12584824531352110813521352Ratregion
5029085RH14346214831422479314224940Ratregion
5029389RH14460615231488057114880722Ratregion
5029963BF38826316631384382513843990Ratregion
5025340RH12794221031451494214515151Ratregion
8663472rs106373454031494918014949180Ratregion
5025578RH12886521031278028012780489Ratregion
5033671RH13968120431393299213933195Ratregion
5031149BE11638815531496047014960624Ratregion
5054949RH14351913531348568813485822Ratregion
5055813RH14401710931344786213447970Ratregion
5050284RH13396720631415961214159817Ratregion
5050284RH13396720631342621113426416Ratregion
5051326AW26036312331229334112293463Ratregion
5054251RH14311723331401702414017256Ratregion
5044398RH13058019331391628813916480Ratregion
5044176RH13045321631370047113700686Ratregion
5046024RH13151519431410514914105342Ratregion
5045798RH13138518631375284713753032Ratregion
5047750RH13250719131428011314280303Ratregion
5048318RH13283420031451566114515857Ratregion
5049802RH13369020131384538913845589Ratregion
5047286RH13224019231389008113890272Ratregion
5048408RH13288615031439862514398774Ratregion
5039598RH12779719431461429614614489Ratregion
5040392RH12825718331450870014508882Ratregion
5042774RH12963818331248986912491162Ratregion
5074284RH13792712731294181712941943Ratregion
5074562RH13808813031379968413799813Ratregion
5078406RH14032314431313102113131164Ratregion
5078404RH14032214331508465815084802Ratregion
5073382RH13740421331388087713881089Ratregion
5074364RH13797419031299529012995479Ratregion
5071264RH13498220731386967313869879Ratregion
5072444RH13685319531438116914381363Ratregion
5070099RH9447215831384251313842670Ratregion
5069148AU04669215731400077614000932Ratregion
5070434AI59152911131370142613701536Ratregion
5063762AW53510715431270103412701187Ratregion
5060500BE11023316231384416713844328Ratregion
5063956BE12031515131388531213885462Ratregion
5060330AW53147719831293091712931114Ratregion
5061842AW53384018031470097314701152Ratregion
5064570BE10812815031510172815101877Ratregion
5082151BI28002815231488057114880719Ratregion
5086201AA85861920131459172014591920Ratregion
5087797D2Wsu17e20531384245313842657Ratregion
5087905Hspa513331384246713842599Ratregion
5089789AU04936419131393000213930192Ratregion
5089717AU04932114731262430012624446Ratregion
5090291AU04966413631520313215203267Ratregion
5090517AU04979819831455919814559395Ratregion
5081104RH14196722031299362612993845Ratregion
5089061AU04893118531438353014383714Ratregion
5086743AA81918019631229341312293608Ratregion
5085722BQ20338018731430868114308868Ratregion
5504145UniSTS:25918016231383896913839502Ratregion
5504930Zik112331454355914543681Ratregion
5506131UniSTS:4984326631448395814484023Ratregion
5506539HSPA5_98879631384187913842674Ratregion
5506821G4613020231247135612471557Ratregion
5500831G0709310731324155213241658Ratregion
5502567RH12536827331384195913842231Ratregion
11528616rs10698495631329474613294746Ratregion
11528617rs10675850031223622112236221Ratregion
11528618rs10698764431521766815217668Ratregion
Position Markers

Flank 1: (rs106758500)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0312,236,221 - 12,236,221RGD
Rnor_5.0317,570,016 - 17,570,016RGD
RGSC_v3.4312,200,198 - 12,200,198RGD
Peak: (rs106984956)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0313,294,746 - 13,294,746RGD
Rnor_5.0318,622,898 - 18,622,898RGD
RGSC_v3.4313,253,530 - 13,253,530RGD
Flank 2: (rs106987644)
Rat AssemblyChrPosition (strand)Source
Rnor_6.0315,217,668 - 15,217,668RGD
Rnor_5.0320,527,281 - 20,527,281RGD
RGSC_v3.4314,999,876 - 14,999,876RGD


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)3565463925105730Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3600074834394365Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)3600074851687917Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)3600074851687917Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)3600086634394121Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)3600086634394121Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31009408193415837Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31011931879772001Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
11528620Bss113Bone structure and strength QTL 1139.750.00000000017femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31223622115217668Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31312691436600143Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31312691436600143Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31312691441510346Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31409041129084626Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31409041148562146Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31409041148562146Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31409041148562146Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31409041148562146Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31409041148562146Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31409041148562146Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31409041148562146Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 1524 HS rats (728 male, 796 female) were used. 11528619
qtl_general measurement method: Rats on a standard diet were euthanized at 17 to 20 weeks of age, and left femurs were measured using digital calipers (Mitutoyo, Aurora, IL). 11528619