Mir181a2 (microRNA 181a-2) - Rat Genome Database

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Gene: Mir181a2 (microRNA 181a-2) Rattus norvegicus
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Symbol: Mir181a2
Name: microRNA 181a-2
RGD ID: 2325335
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of gene expression; positive regulation of nitric oxide biosynthetic process; and positive regulation of p38MAPK cascade. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; cellular response to lipopolysaccharide; and long-term synaptic potentiation. Predicted to be located in apical part of cell and extracellular space. Orthologous to human MIR181A2 (microRNA 181a-2); INTERACTS WITH atrazine; bis(2-ethylhexyl) phthalate; hesperidin.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-181a-2; Mir181a-2; rno-mir-181a-2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2322,615,845 - 22,615,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,615,845 - 22,615,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx326,084,562 - 26,084,678 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0334,669,555 - 34,669,671 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0332,482,101 - 32,482,217 (+)NCBIRnor_WKY
Rnor_6.0323,150,352 - 23,150,468 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl323,150,352 - 23,150,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,374,769 - 28,374,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera321,049,302 - 21,049,418 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:16381832   PMID:17604727   PMID:17805466   PMID:18762567   PMID:20403161   PMID:20439489   PMID:22144581   PMID:23273104   PMID:23646144   PMID:25858512   PMID:31364134  
PMID:32290769   PMID:33052248   PMID:33820869   PMID:35472240  


Genomics

Comparative Map Data
Mir181a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2322,615,845 - 22,615,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,615,845 - 22,615,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx326,084,562 - 26,084,678 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0334,669,555 - 34,669,671 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0332,482,101 - 32,482,217 (+)NCBIRnor_WKY
Rnor_6.0323,150,352 - 23,150,468 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl323,150,352 - 23,150,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,374,769 - 28,374,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera321,049,302 - 21,049,418 (+)NCBICelera
Cytogenetic Map3q12NCBI
MIR181A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,692,442 - 124,692,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9124,692,442 - 124,692,551 (+)EnsemblGRCh38hg38GRCh38
GRCh379127,454,721 - 127,454,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,494,541 - 126,494,650 (+)NCBINCBI36Build 36hg18NCBI36
Celera998,102,607 - 98,102,716 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,067,445 - 97,067,554 (+)NCBIHuRef
CHM1_19127,603,590 - 127,603,699 (+)NCBICHM1_1
T2T-CHM13v2.09136,890,690 - 136,890,799 (+)NCBIT2T-CHM13v2.0
Mir181a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,742,747 - 38,742,822 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,742,747 - 38,742,822 (+)EnsemblGRCm39 Ensembl
GRCm38238,852,735 - 38,852,810 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,852,735 - 38,852,810 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,708,255 - 38,708,330 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera240,576,847 - 40,576,922 (+)NCBICelera
Cytogenetic Map2BNCBI
MIR181A-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,302,547 - 58,302,606 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,302,547 - 58,302,606 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,501,180 - 57,501,239 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0959,222,881 - 59,222,940 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,222,881 - 59,222,940 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,981,720 - 57,981,779 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,298,088 - 58,298,147 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,388,572 - 58,388,631 (-)NCBIUU_Cfam_GSD_1.0
MIR181A-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,497,249 - 265,497,328 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,497,249 - 265,497,328 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,322,152 - 299,322,231 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Gria2rno-miR-181a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//NFunctional MTI22144581

Predicted Targets
Summary Value
Count of predictions:1670
Count of gene targets:1315
Count of transcripts:1429
Interacting mature miRNAs:rno-miR-181a-2-3p, rno-miR-181a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1
Low 1 16 27 11 16 11 6 6 43 16 25 9 6
Below cutoff 10 6 6 6 1 1 7 10 5 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053753
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,615,845 - 22,615,961 (+)Ensembl
Rnor_6.0 Ensembl323,150,352 - 23,150,468 (+)Ensembl
RefSeq Acc Id: NR_031898
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2322,615,845 - 22,615,961 (+)NCBI
Rnor_6.0323,150,352 - 23,150,468 (+)NCBI
Rnor_5.0328,374,769 - 28,374,885 (+)NCBI
Celera321,049,302 - 21,049,418 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325335 AgrOrtholog
BioCyc Gene G2FUF-49898 BioCyc
Ensembl Genes ENSRNOG00000035630 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053753 ENTREZGENE
miRBase MI0000925 ENTREZGENE
NCBI Gene 100314292 ENTREZGENE
PhenoGen Mir181a2 PhenoGen
RNAcentral URS00003DA300 RNACentral
  URS000075B5CF RNACentral
  URS000075F12A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir181a2  microRNA 181a-2  Mir181a-2  microRNA mir-181a-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir181a-2  microRNA mir-181a-2      Symbol and Name status set to provisional 70820 PROVISIONAL