Gria2 (glutamate ionotropic receptor AMPA type subunit 2) - Rat Genome Database

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Gene: Gria2 (glutamate ionotropic receptor AMPA type subunit 2) Rattus norvegicus
Analyze
Symbol: Gria2
Name: glutamate ionotropic receptor AMPA type subunit 2
RGD ID: 61862
Description: Enables several functions, including PDZ domain binding activity; enzyme binding activity; and transmitter-gated ion channel activity. Involved in several processes, including modulation of chemical synaptic transmission; response to fungicide; and response to lithium ion. Located in several cellular components, including dendrite; distal axon; and perikaryon. Is integral component of postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Biomarker of status epilepticus. Orthologous to human GRIA2 (glutamate ionotropic receptor AMPA type subunit 2); PARTICIPATES IN N-cadherin signaling pathway; amyotrophic lateral sclerosis pathway; glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-AMPA; 1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AMPA-selective glutamate receptor 2; GluA2; gluR-B; GluR-K2; GluR2; glutamate receptor 2; glutamate receptor B; glutamate receptor ionotropic AMPA2 (alpha 2); glutamate receptor, ionotropic, 2; glutamate receptor, ionotropic, AMPA 2; glutamate receptor, ionotropic, AMPA2; glutamate receptor, ionotropic, AMPA2 (alpha 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22165,949,379 - 166,069,510 (-)NCBI
Rnor_6.0 Ensembl2179,584,308 - 179,704,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02179,584,302 - 179,704,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02198,991,672 - 199,113,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42172,265,155 - 172,385,285 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12172,216,247 - 172,335,391 (-)NCBI
Celera2159,991,989 - 160,110,044 (-)NCBICelera
Cytogenetic Map2q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-AMPA  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-Naphthylacetylspermine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-nitropropanoic acid  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
arsenic acid  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Bay-K-8644  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzoates  (EXP)
bicuculline  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Butylparaben  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbofuran  (EXP)
celecoxib  (ISO)
chlorpyrifos  (EXP)
Citreoviridin  (ISO)
cocaine  (EXP,ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (EXP)
DDE  (EXP)
Diacetoxyscirpenol  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dithionite(2-)  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fenvalerate  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
glucose  (EXP)
kainic acid  (EXP,ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
linuron  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
methamphetamine  (EXP)
methoxychlor  (EXP)
miconazole  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP)
olanzapine  (EXP)
oxidopamine  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propofol  (EXP)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
sulfur dioxide  (EXP)
T-2 toxin  (ISO)
tadalafil  (ISO)
tetrodotoxin  (EXP,ISO)
thioacetamide  (ISO)
thiopental  (ISO)
tocopherol  (ISO)
toluene  (EXP)
topiramate  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:7545935   PMID:7992055   PMID:8848293   PMID:9069286   PMID:9351977   PMID:9697855   PMID:9712644   PMID:9804426   PMID:10688364   PMID:12050666   PMID:12379442   PMID:12507773  
PMID:12603280   PMID:12605900   PMID:12665613   PMID:12904794   PMID:12909632   PMID:12956708   PMID:14534256   PMID:14555717   PMID:14687553   PMID:14706873   PMID:14730302   PMID:14739560  
PMID:14976558   PMID:15071096   PMID:15260958   PMID:15331617   PMID:15351509   PMID:15458844   PMID:15601948   PMID:15750591   PMID:15784965   PMID:15858065   PMID:15883194   PMID:15924137  
PMID:15944123   PMID:16103115   PMID:16186507   PMID:16480690   PMID:16483599   PMID:16707783   PMID:16814779   PMID:16990276   PMID:17018279   PMID:17093100   PMID:17302911   PMID:17446041  
PMID:17460072   PMID:17460080   PMID:17472959   PMID:17543993   PMID:17873364   PMID:17969105   PMID:18190519   PMID:18341993   PMID:18390190   PMID:18403705   PMID:18439999   PMID:18500330  
PMID:18598260   PMID:18679721   PMID:18720514   PMID:18722513   PMID:18794522   PMID:18795801   PMID:18815255   PMID:18823129   PMID:19020286   PMID:19063943   PMID:19071197   PMID:19091980  
PMID:19105974   PMID:19110036   PMID:19176091   PMID:19185395   PMID:19200070   PMID:19222700   PMID:19330849   PMID:19439609   PMID:19508696   PMID:19534762   PMID:19558602   PMID:19563786  
PMID:19644508   PMID:19673491   PMID:19774669   PMID:19776277   PMID:19908285   PMID:20110361   PMID:20110365   PMID:20155979   PMID:20179884   PMID:20403402   PMID:20408958   PMID:20417256  
PMID:20418887   PMID:20422983   PMID:20534470   PMID:20547835   PMID:20614889   PMID:20869354   PMID:21106836   PMID:21141507   PMID:21414928   PMID:21425350   PMID:21527319   PMID:21558424  
PMID:21895609   PMID:22144581   PMID:22219297   PMID:22284903   PMID:22573673   PMID:22632720   PMID:22813734   PMID:22871113   PMID:23076153   PMID:23129617   PMID:23141062   PMID:23212166  
PMID:23296627   PMID:23326329   PMID:23360709   PMID:23375774   PMID:23460828   PMID:23719929   PMID:23760273   PMID:23799014   PMID:23940029   PMID:23942984   PMID:23999288   PMID:24030012  
PMID:24098468   PMID:24244357   PMID:24264036   PMID:24381264   PMID:24442866   PMID:24487031   PMID:24599038   PMID:24599450   PMID:24625397   PMID:24753224   PMID:24831007   PMID:25109876  
PMID:25218043   PMID:25349168   PMID:25437879   PMID:25475532   PMID:25834064   PMID:26134564   PMID:26260133   PMID:26343542   PMID:26384129   PMID:26391783   PMID:26766634   PMID:27013677  
PMID:27288240   PMID:27368053   PMID:27601647   PMID:27618672   PMID:27641494   PMID:27714514   PMID:27856517   PMID:28119091   PMID:28132827   PMID:28244309   PMID:28459140   PMID:28585865  
PMID:28630296   PMID:28719803   PMID:28737760   PMID:28823560   PMID:28888867   PMID:28951554   PMID:29107806   PMID:29202853   PMID:29230056   PMID:29476059   PMID:29490264   PMID:29515177  
PMID:29588465   PMID:30328550   PMID:30590038   PMID:30872532   PMID:30914678   PMID:31283924   PMID:31784233   PMID:31794026  


Genomics

Comparative Map Data
Gria2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22165,949,379 - 166,069,510 (-)NCBI
Rnor_6.0 Ensembl2179,584,308 - 179,704,629 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02179,584,302 - 179,704,629 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02198,991,672 - 199,113,059 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42172,265,155 - 172,385,285 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12172,216,247 - 172,335,391 (-)NCBI
Celera2159,991,989 - 160,110,044 (-)NCBICelera
Cytogenetic Map2q33NCBI
GRIA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4157,204,182 - 157,366,075 (+)EnsemblGRCh38hg38GRCh38
GRCh384157,220,120 - 157,370,583 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374158,141,272 - 158,287,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364158,361,186 - 158,506,677 (+)NCBINCBI36hg18NCBI36
Build 344158,499,639 - 158,642,707NCBI
Celera4155,484,938 - 155,630,358 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4153,892,713 - 154,037,902 (+)NCBIHuRef
CHM1_14158,118,907 - 158,264,349 (+)NCBICHM1_1
Gria2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39380,588,757 - 80,711,534 (-)NCBIGRCm39mm39
GRCm39 Ensembl380,588,757 - 80,710,142 (-)Ensembl
GRCm38380,681,450 - 80,804,227 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl380,681,450 - 80,802,835 (-)EnsemblGRCm38mm10GRCm38
MGSCv37380,488,858 - 80,606,713 (-)NCBIGRCm37mm9NCBIm37
MGSCv36380,770,863 - 80,888,718 (-)NCBImm8
Celera380,695,789 - 80,807,271 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.5NCBI
Gria2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554719,970,403 - 10,108,898 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554719,970,396 - 10,108,871 (-)NCBIChiLan1.0ChiLan1.0
GRIA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14161,380,933 - 161,524,376 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4161,380,933 - 161,524,376 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04149,566,563 - 149,712,135 (+)NCBIMhudiblu_PPA_v0panPan3
GRIA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11554,634,332 - 54,710,711 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1554,634,335 - 54,708,184 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1554,899,350 - 55,051,036 (+)NCBI
ROS_Cfam_1.01555,280,110 - 55,432,031 (+)NCBI
UMICH_Zoey_3.11554,520,013 - 54,671,698 (+)NCBI
UNSW_CanFamBas_1.01554,628,421 - 54,780,188 (+)NCBI
UU_Cfam_GSD_1.01554,943,850 - 55,095,680 (+)NCBI
Gria2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530135,606,967 - 35,746,531 (-)NCBI
SpeTri2.0NW_0049365763,800,369 - 3,940,324 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl846,078,246 - 46,241,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1846,078,122 - 46,247,144 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2848,116,966 - 48,280,583 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRIA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17103,808,789 - 103,957,947 (+)NCBI
ChlSab1.1 Ensembl7103,808,797 - 103,953,040 (+)Ensembl
Vero_WHO_p1.0NW_02366603783,492,906 - 83,648,026 (+)NCBI
Gria2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248481,132,939 - 1,261,110 (-)NCBI

Position Markers
Gria2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22166,069,260 - 166,069,506 (+)MAPPER
Rnor_6.02179,704,380 - 179,704,625NCBIRnor6.0
Rnor_5.02199,112,810 - 199,113,055UniSTSRnor5.0
Rnor_5.02199,112,595 - 199,113,055UniSTSRnor5.0
RGSC_v3.42172,385,036 - 172,385,281UniSTSRGSC3.4
Celera2160,109,795 - 160,110,040UniSTS
Cytogenetic Map2q33UniSTS
L32372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22165,952,542 - 165,952,694 (+)MAPPER
Rnor_6.02179,587,466 - 179,587,617NCBIRnor6.0
Rnor_5.02198,994,836 - 198,994,987UniSTSRnor5.0
RGSC_v3.42172,268,319 - 172,268,470UniSTSRGSC3.4
Celera2159,995,153 - 159,995,304UniSTS
Cytogenetic Map2q33UniSTS
PMC283538P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22165,972,008 - 165,972,589 (+)MAPPER
Rnor_6.02179,607,132 - 179,607,712NCBIRnor6.0
Rnor_5.02199,014,502 - 199,015,082UniSTSRnor5.0
RGSC_v3.42172,287,787 - 172,288,367UniSTSRGSC3.4
Celera2160,014,631 - 160,015,211UniSTS
Cytogenetic Map2q33UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242776916195645082Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)2157914311204022555Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2140566078217498545Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2140566078217498545Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2147522550217498710Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246537589217498710Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243133606217498545Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243133606217498545Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2149114878225501939Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256244671217498710Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141583337217498710Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828049217498710Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242776916217498710Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147122993240020001Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2147122993240020001Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2142053350204585731Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2157914409217498545Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2116075644228737869Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2153799203181987474Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2169852800217498545Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557254121739Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2155965557237742948Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2161745602206745602Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2172795683189857032Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2116075644228737869Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2175403337239166203Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2118446646227707979Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2138901276217498710Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243149788198704485Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)275687495221880419Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2158159186217498710Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283819608239166203Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266828236243550655Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283819608243901375Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2158159186217498710Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2142053350228984665Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2118446793228582621Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2177680772243901375Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)223837491218957222Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2118446646200453484Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2118446646200453484Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2169852670207612467Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278321410217498710Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2159585731204585731Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2149614623198704357Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143447078188447078Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2174160958219160958Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2177339806222339806Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2169852670243026643Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283754907237610852Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2149614466205573168Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2149614466205573168Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2172795683189857032Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2172795683199696953Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)216679272245624402Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2172795683199696953Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2172795683189857032Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2172795683199696953Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2172795683199696953Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2172795683189857032Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2172795683189857032Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2172795683199696953Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2172795683189857032Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir181a2rno-miR-181a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//NFunctional MTI22144581

Predicted Target Of
Summary Value
Count of predictions:972
Count of miRNA genes:253
Interacting mature miRNAs:344
Transcripts:ENSRNOT00000039587, ENSRNOT00000067113
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 68 1
Low 3 46 31 18 31 7 7 6 16 36 8 7
Below cutoff 37 11 10 1 10 1 4 16 4 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000077941   ⟹   ENSRNOP00000069094
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2179,584,308 - 179,704,629 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083361   ⟹   ENSRNOP00000072906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2179,584,308 - 179,704,629 (-)Ensembl
RefSeq Acc Id: NM_001083811   ⟹   NP_001077280
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22165,949,379 - 166,069,510 (-)NCBI
Rnor_6.02179,584,302 - 179,704,629 (-)NCBI
Rnor_5.02198,991,672 - 199,113,059 (-)NCBI
RGSC_v3.42172,265,155 - 172,385,285 (-)RGD
Celera2159,991,989 - 160,110,044 (-)RGD
Sequence:
RefSeq Acc Id: NM_017261   ⟹   NP_058957
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22165,949,379 - 166,069,510 (-)NCBI
Rnor_6.02179,584,302 - 179,704,629 (-)NCBI
Rnor_5.02198,991,672 - 199,113,059 (-)NCBI
RGSC_v3.42172,265,155 - 172,385,285 (-)RGD
Celera2159,991,989 - 160,110,044 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058957   ⟸   NM_017261
- Peptide Label: isoform 1 precursor
- UniProtKB: P19491 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001077280   ⟸   NM_001083811
- Peptide Label: isoform 2 precursor
- UniProtKB: P19491 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069094   ⟸   ENSRNOT00000077941
RefSeq Acc Id: ENSRNOP00000072906   ⟸   ENSRNOT00000083361
Protein Domains
Lig_chan-Glu_bd   PBPe

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61862 AgrOrtholog
Ensembl Genes ENSRNOG00000054204 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000069094 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072906 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000077941 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000083361 ENTREZGENE, UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glu/Gly-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iono_rcpt_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Iontro_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29627 UniProtKB/Swiss-Prot
NCBI Gene 29627 ENTREZGENE
Pfam ANF_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gria2 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBPe UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204985
UniProt F1LNE4_RAT UniProtKB/TrEMBL
  G3V914_RAT UniProtKB/TrEMBL
  GRIA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9R174 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Gria2  glutamate ionotropic receptor AMPA type subunit 2  Gria2  glutamate receptor, ionotropic, AMPA 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-11 Gria2  glutamate receptor, ionotropic, AMPA 2  Gria2  glutamate receptor, ionotropic, AMPA 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-10 Gria2  glutamate receptor, ionotropic, AMPA 2  Gria2  glutamate receptor, ionotropic, AMPA2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gria2  glutamate receptor, ionotropic, AMPA2    glutamate receptor, ionotropic, 2  Name updated 1299863 APPROVED
2002-06-10 Gria2  glutamate receptor, ionotropic, 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deacetylation of promoter-bound histones also occurs after transient global ischemia 628432
gene_process may play a role in seizure-induced pathological events in the hippocampus 628432
gene_regulation histones (e.g. H4) associated with the promoters in hippocampal CA3 neurons after seizures, are rapidly deacetylated, and a histone deacetylase inhibitor, trichostatin A, inhibits and quickly reverses deacetylation 628432