Crat (carnitine O-acetyltransferase)

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Gene: Crat (carnitine O-acetyltransferase) Rattus norvegicus

Analyze

Symbol:

Crat

Name:

carnitine O-acetyltransferase

RGD ID:

1303031

Description:

Enables carnitine O-acetyltransferase activity. Involved in fatty acid metabolic process. Predicted to be located in mitochondrion. Predicted to be active in peroxisome. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human CRAT (carnitine O-acetyltransferase); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

carnitine acetylase; carnitine acetyltransferase; CAT; MGC94385

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CRAT (carnitine O-acetyltransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Crat (carnitine acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Crat (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CRAT (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CRAT (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Crat (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CRAT (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CRAT (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Crat (carnitine O-acetyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CHAT (choline O-acetyltransferase)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	CRAT (carnitine O-acetyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Crat (carnitine acetyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:154046	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	crata (carnitine O-acetyltransferase a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CAT2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	B0395.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5122	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5265	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CRAT	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Annotation category: suggests misassembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,675,684 - 13,689,282 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,675,684 - 13,689,255 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	16,747,217 - 16,760,812 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,332,179 - 25,345,774 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	23,578,162 - 23,591,743 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	8,967,984 - 8,981,959 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,968,417 - 8,981,362 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	14,320,758 - 14,334,741 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	9,447,585 - 9,461,180 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	9,447,886 - 9,461,480 (-)	NCBI
Celera	3	8,442,229 - 8,455,824 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Carnitine Acetyltransferase Deficiency (ISO)

genetic disease (ISO)

neurodegeneration with brain iron accumulation (ISO)

Neurodegeneration with Brain Iron Accumulation 8 (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (ISO)

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,4-benzoquinone (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-D (ISO)

2,6-dinitrotoluene (EXP)

2-(4-chloro-2-methylphenoxy)propanoic acid (ISO)

2-butoxyethanol (ISO)

3,3',5-triiodo-L-thyronine (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetyl-CoA (EXP)

aflatoxin B1 (EXP)

aristolochic acid A (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bezafibrate (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

Bisphenol B (ISO)

bisphenol F (ISO)

bromobenzene (EXP)

Butoxyacetic acid (EXP)

C60 fullerene (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

carmustine (ISO)

choline (ISO)

ciguatoxin CTX1B (ISO)

ciprofibrate (ISO)

Clinofibrate (EXP)

clofibrate (EXP,ISO)

cobalt dichloride (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

diazinon (ISO)

dichloroacetic acid (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

Ethoxyacetic acid (EXP)

fenofibrate (EXP,ISO)

finasteride (EXP)

flutamide (EXP,ISO)

folic acid (ISO)

gemfibrozil (EXP)

glafenine (EXP)

indole-3-methanol (EXP)

isotretinoin (ISO)

ivermectin (ISO)

L-methionine (ISO)

lamivudine (ISO)

leflunomide (EXP)

mecoprop (ISO)

mercury dichloride (EXP)

methoxyacetic acid (EXP)

monosodium L-glutamate (ISO)

Muraglitazar (EXP)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP,ISO)

nefazodone (EXP)

nicardipine (EXP)

nickel atom (ISO)

nimesulide (EXP)

orphenadrine (EXP)

ozone (EXP,ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

permethrin (ISO)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

potassium dichromate (ISO)

pravastatin (EXP,ISO)

rotenone (EXP)

selenium atom (ISO)

sodium fluoride (ISO)

sulforaphane (EXP)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

tetracycline (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (ISO)

Tridiphane (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

troglitazone (EXP)

tunicamycin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

zaragozic acid A (EXP,ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carnitine metabolic process, CoA-linked (IBA,IEA,ISO,ISS)

fatty acid beta-oxidation using acyl-CoA oxidase (IEA,ISO,ISS)

fatty acid metabolic process (IDA)

medium-chain fatty acid metabolic process (IEA,ISO,ISS)

short-chain fatty acid metabolic process (IEA,ISO,ISS)

Cellular Component

endoplasmic reticulum (TAS)

mitochondrial inner membrane (IEA)

mitochondrion (IEA,ISO)

mitochondrion (TAS)

peroxisome (IBA,IEA,ISO,TAS)

Molecular Function

acyl-CoA oxidase activity (IEA,ISO,ISS)

carnitine O-acetyltransferase activity (IBA,IDA,IEA,ISO)

carnitine O-octanoyltransferase activity (IEA)

O-acyltransferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

adrenoleukodystrophy pathway (ISO)

carnitine-acylcarnitine translocase deficiency (ISO)

fatty acid beta degradation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Redesign of carnitine acetyltransferase specificity by protein engineering.	Cordente AG, etal., J Biol Chem 2004 Aug 6;279(32):33899-908. Epub 2004 May 21.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2351134	PMID:12477932	PMID:14651853	PMID:15099582	PMID:15489334	PMID:16681386	PMID:18614015	PMID:18839069	PMID:20178365	PMID:20833797	PMID:22607230	PMID:23485643
PMID:24395925	PMID:26316108

Genomics

Comparative Map Data

Crat
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	13,675,684 - 13,689,282 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,675,684 - 13,689,255 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	16,747,217 - 16,760,812 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,332,179 - 25,345,774 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	23,578,162 - 23,591,743 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	8,967,984 - 8,981,959 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,968,417 - 8,981,362 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	14,320,758 - 14,334,741 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	9,447,585 - 9,461,180 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	9,447,886 - 9,461,480 (-)	NCBI
Celera	3	8,442,229 - 8,455,824 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

CRAT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	129,094,794 - 129,110,793 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	129,094,142 - 129,111,189 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	131,857,073 - 131,873,072 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	130,896,894 - 130,912,904 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	128,936,628 - 128,952,637	NCBI
Celera	9	102,509,370 - 102,525,353 (-)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	101,464,043 - 101,480,035 (-)	NCBI		HuRef
CHM1_1	9	132,007,896 - 132,023,887 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	141,298,255 - 141,314,238 (-)	NCBI		T2T-CHM13v2.0

Crat
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	30,290,488 - 30,306,029 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	30,290,483 - 30,305,825 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	30,400,476 - 30,416,017 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	30,400,471 - 30,415,813 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	30,255,996 - 30,271,268 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	30,222,485 - 30,237,757 (-)	NCBI		MGSCv36	mm8
Celera	2	30,105,381 - 30,120,546 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	21.69	NCBI

Crat
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	1,417,608 - 1,428,720 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955570	1,417,608 - 1,428,720 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRAT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	128,880,057 - 128,896,484 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	128,880,057 - 128,896,484 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	100,220,019 - 100,236,061 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CRAT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	54,566,708 - 54,580,301 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	54,566,407 - 54,580,025 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	53,762,362 - 53,775,887 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	55,462,309 - 55,475,915 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	55,462,359 - 55,498,279 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	54,248,963 - 54,262,568 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	54,560,854 - 54,574,458 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	54,654,564 - 54,668,171 (+)	NCBI		UU_Cfam_GSD_1.0

Crat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	196,755,044 - 196,768,721 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	16,523,571 - 16,537,248 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936487	16,523,571 - 16,537,242 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRAT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	269,386,650 - 269,401,331 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	269,387,430 - 269,401,334 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	303,403,630 - 303,417,527 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRAT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,057,365 - 9,072,692 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	9,058,824 - 9,072,813 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666096	491,149 - 506,483 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crat
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	6,002,568 - 6,013,491 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	6,002,032 - 6,013,489 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Crat
70 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	77
Interacting mature miRNAs:	83
Transcripts:	ENSRNOT00000065128
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High											5
Medium	3	43	56	40	19	40	8	11	74	35	36	11	8
Low			1	1		1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761663	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761664	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC098064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC115341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ620886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083616	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000065128 ⟹ ENSRNOP00000063089

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	13,675,684 - 13,689,255 (-)	Ensembl
Rnor_6.0 Ensembl	3	8,968,417 - 8,979,889 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000086717 ⟹ ENSRNOP00000075070

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	13,675,684 - 13,687,360 (-)	Ensembl
Rnor_6.0 Ensembl	3	8,968,616 - 8,981,362 (-)	Ensembl

RefSeq Acc Id:

NM_001004085 ⟹ NP_001004085

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	13,675,684 - 13,689,282 (-)	NCBI
Rnor_6.0	3	8,967,989 - 8,981,584 (-)	NCBI
Rnor_5.0	3	14,320,758 - 14,334,741 (-)	NCBI
RGSC_v3.4	3	9,447,585 - 9,461,180 (-)	RGD
Celera	3	8,442,229 - 8,455,824 (-)	RGD

Sequence:

show sequence

CTGCGACCCATCAAAGCTCCGCCCCGTGAGTCCTGCCTGACCGGCAGCCCGCCGGGCCCGGTGG
CCGCGGGGCCGCCTCTACTGGCTAACGGCAGTGACTCGGCGACCTTGAACCTAGAGCCCTAACC
GCGAACCCACTGACCCCAGCACCCCAGCAGTGGCGCAGAGTTTACCCAGCGTGAGGGGCGGAGC
GGACCCAGTGTCCGCAAACAGATTGGGACAATGTTAGCTTTTGCTGCCAGAACCGTGGTGAAAC
CCCTGGGCCTCCTCAAGCCCTCCTCCTTGATGAAGGTGTCTGGTCGATTTAAGGCCCACCAGGA
TGCACTGCCACGGCTGCCTGTGCCTCCACTTCAGCAATCCCTGGACCATTACCTCAAGGCACTG
CAGCCCATCGTGAGTGAGGAAGAATGGGCTCACACCAAGCAACTGGTGGACGAGTTTCAGACCT
CAGGGGGTGTAGGGGAACGCCTGCAGAAGGGATTGGAGCGCAGGGCCAAGAAAATGGAGAACTG
GCTGTCCGAGTGGTGGCTCAAGACAGCCTATCTCCAGTTCCGCCAGCCTGTGGTCATCTACTCC
AGTCCAGGAGTGCTGCTGCCCAAGCAGGACTTCATGGATCTACAGGGTCAGCTCCGGTTTGCTG
CCAAACTCATCGAGGGTGTATTGGATTTCAAGTCCATGATTGACAACGAGACGCTGCCAGTTGA
GTTCCTGGGAGGACAGCCACTGTGCATGAACCAGTATTATCAGATCCTGTCTTCTTGCCGTGTG
CCTGGCCTCAAGCAGGACTCAGTGGTGAACTTCTTAAAGTCAAAGAAACCACCCACACATATAA
CCGTGGTGCATAACTACCAGTTCTTCGAGCTGGATGTGTACCACAGTGATGGGACACCACTCAC
CTCAGATCAGATCTTTGTGCAGCTTGAGAAAATCTGGAACTCCTCACTGCAATCCAACAAGGAG
CCTGTTGGCATCCTAACCTCCAACCACCGGAACAGCTGGGCCAAGGCCTACAGCAGCCTCATTA
AAGACAAAGTAAACCGGGAGTCGGTGAACTCCATCCAGAAGAGCATCTTCACTGTGTGCCTGGA
CAAGCAAGTGCCCAGAGTCTCAGATGATGTCTACCGCAGCCACGTAGCCGGCCAGATGCTTCAT
GGTGGTGGCAGCAAGTTCAACAGTGGCAACCGCTGGTTCGACAAGACACTGCAGTTTATTGTGG
CAGAAGATGGCTCCTGTGGGATGGTTTATGAACATGCAGCTGCAGAAGGGCCCCCCATTGTCGC
TCTTGTGGACCATGTCATGGAGTATACAAAGAAGCCTGAACTTGTGCGGTCCCCTATGGTACCC
CTGCCTATGCCCAAGAAGCTGCGGTTCAACATCACACCTGAGATCAAGAATGACATAGAGAAGG
CCAAACAGAACATCAGCATCATGATCCAGGACCTGGACATCATGATGCTGGTTTTCCATCACTT
TGGAAAGGACTTCCCCAAGTCCCAGAAGCTAAGCCCTGATGCCTTCATCCAGATAGCCCTGCAG
CTGGCATACTACAGGATCTATGGGCAGGCGTGTGCCACGTATGAAAGCGCCTCTCTGCGCATGT
TTCACCTGGGCCGCACTGACACCATCCGCTCCGCCTCCACAGACTCGCTGGCCTTTGTCAAAGG
CATGGATGACCCCAAAGTGCCGGAGCAGCAGAGGGTGGAGCTGCTTCGAAAGGCTGTGCAGGCC
CACCGAGCCTACACCGACCGCGCCATCCGAGGGGAGGCCTTTGACCGGCACTTGCTGGGTCTGA
AGCTACAGGCCATCGAGGACCTGGTGAGCATGCCTGACATCTTCATGGATACCTCCTACGCCAT
TGCCATGCACTTCAACCTTTCTACCAGCCAGGTCCCTGCCAAGACAGACTGTGTCATGTCCTTC
GGACCTGTGGTCCCAGACGGTTACGGCATCTGCTACAATCCCATGGAGGCCCATATCAACTTTT
CCGTGTCAGCCTACAACAGCTGTGCTGAGACCAACGCTGCCCGCATGGCTCACTACTTGGAGAA
AGCTCTGCTGGACATGCGCACCTTACTCCAGAACCACCCCAGGGCCAAGCTCTGAACCCAGGCC
CAGGCCTGCCCGTTCCACAGCCAAGCCCACTTTGGAATGGACTCCTGCCATGGCTCGCACTCCC
TTGGCTCCCGTGCCCTCCAGGCTGACTGAGCCAGATAAGCATTCTCTAGCAGGGCCCCGAGGTC
CAAGCCAAGTGCCTTCCAGGCCTTGTCCTCAGCACCTGCTGTAGTATGTATAGGGCTGAGCCCA
GAGGCTGAACAAGACTAAGGCCCGGGTCCCCAGCATATCATCCATCGATGTGAATCATGGGGAA
GGGAACCCGTCCAGCCCACCCCTCCTCAGCAGGAGCTGTGAAGAGTCCCTTTCCTCCGCCCTGG
CCAGTCTCTTTCATCTCCACAGCCAAGCCAGAATCTGTCTTCATGAGGAAATACCCAGGGACCA
GGAGTCAGAGGACTATCTATCGATGAGGGGCCTCAGCCTCTCCATAGTAAGGGTTAAGGGACAC
CTGAGGCCTAGCCTCCACCCTGCACCTCGAGGTGCCATCTCCCAGCTGCCACTCTCTGGTGACT
CTTGAGCCCCAGACTTCCTGCTTCCATTCAGTGTGGTTCTTGCTGCAGTCATGGTTGCATAATG
TGATTCTGCCAGGCGATCAATAAAGGGAAGAGTGCTGGTGAAAAAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004085	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83616	(Get FASTA)	NCBI Sequence Viewer
	CAF06525	(Get FASTA)	NCBI Sequence Viewer
	EDL93308	(Get FASTA)	NCBI Sequence Viewer
	EDL93309	(Get FASTA)	NCBI Sequence Viewer
	Q704S8	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001004085 ⟸ NM_001004085

- UniProtKB:

Q704S8 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLAFAARTVVKPLGLLKPSSLMKVSGRFKAHQDALPRLPVPPLQQSLDHYLKALQPIVSEEEWA
HTKQLVDEFQTSGGVGERLQKGLERRAKKMENWLSEWWLKTAYLQFRQPVVIYSSPGVLLPKQD
FMDLQGQLRFAAKLIEGVLDFKSMIDNETLPVEFLGGQPLCMNQYYQILSSCRVPGLKQDSVVN
FLKSKKPPTHITVVHNYQFFELDVYHSDGTPLTSDQIFVQLEKIWNSSLQSNKEPVGILTSNHR
NSWAKAYSSLIKDKVNRESVNSIQKSIFTVCLDKQVPRVSDDVYRSHVAGQMLHGGGSKFNSGN
RWFDKTLQFIVAEDGSCGMVYEHAAAEGPPIVALVDHVMEYTKKPELVRSPMVPLPMPKKLRFN
ITPEIKNDIEKAKQNISIMIQDLDIMMLVFHHFGKDFPKSQKLSPDAFIQIALQLAYYRIYGQA
CATYESASLRMFHLGRTDTIRSASTDSLAFVKGMDDPKVPEQQRVELLRKAVQAHRAYTDRAIR
GEAFDRHLLGLKLQAIEDLVSMPDIFMDTSYAIAMHFNLSTSQVPAKTDCVMSFGPVVPDGYGI
CYNPMEAHINFSVSAYNSCAETNAARMAHYLEKALLDMRTLLQNHPRAKL

hide sequence

RefSeq Acc Id:

ENSRNOP00000063089 ⟸ ENSRNOT00000065128

RefSeq Acc Id:

ENSRNOP00000075070 ⟸ ENSRNOT00000086717

Protein Domains

Choline/carnitine acyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q704S8-F1-model_v2	AlphaFold	Q704S8	1-626	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691959

Promoter ID:

EPDNEW_R2484

Type:

initiation region

Name:

Crat_1

Description:

carnitine O-acetyltransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	8,981,323 - 8,981,383	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303031	AgrOrtholog
BioCyc Gene	G2FUF-50212	BioCyc
Ensembl Genes	ENSRNOG00000018145	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000063089	ENTREZGENE
	ENSRNOP00000063089.3	UniProtKB/TrEMBL
	ENSRNOP00000075070.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000065128	ENTREZGENE
	ENSRNOT00000065128.3	UniProtKB/TrEMBL
	ENSRNOT00000086717.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.559.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.559.70	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7133847	IMAGE-MGC_LOAD
InterPro	Carn_acyl_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CAT-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cho/carn_acyl_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Cho/carn_acyl_trans_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:311849	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94385	IMAGE-MGC_LOAD
NCBI Gene	311849	ENTREZGENE
PANTHER	CARNITINE O-ACETYLTRANSFERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR22589	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Carn_acyltransf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Crat	PhenoGen
PROSITE	ACYLTRANSF_C_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ACYLTRANSF_C_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	CoA-dependent acyltransferases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UI21_RAT	UniProtKB/TrEMBL
	A0A8L2RAJ5_RAT	UniProtKB/TrEMBL
	CACP_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Crat	carnitine O-acetyltransferase	Crat	carnitine acetyltransferase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Crat	carnitine acetyltransferase			Symbol and Name status set to approved	1299863	APPROVED
2005-02-14	Crat	carnitine acetyltransferase			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB