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Gene: Ak1 (adenylate kinase 1) Rattus norvegicus
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Symbol: Ak1
Name: adenylate kinase 1
Description: Exhibits adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of glucose transmembrane transport. Localizes to the neuron projection; perinuclear region of cytoplasm; and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1); PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adenylate kinase isoenzyme 1; adenylate monophosphate kinase; Ak 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; MGC108678; myokinase
Orthologs:
Homo sapiens (human) : AK1 (adenylate kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Ak1 (adenylate kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ak1 (adenylate kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AK1 (adenylate kinase 1)
Canis lupus familiaris (dog) : AK1 (adenylate kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ak1 (adenylate kinase 1)
Sus scrofa (pig) : AK1 (adenylate kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0311,652,143 - 11,659,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0316,995,977 - 17,002,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,821,482 - 19,822,544 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1219,741,850 - 19,742,913 (+)NCBI
Celera310,656,923 - 10,664,139 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ak1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2076
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.