Ak1 (adenylate kinase 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ak1 (adenylate kinase 1) Rattus norvegicus
Analyze
Symbol: Ak1
Name: adenylate kinase 1
RGD ID: 2076
Description: Enables adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of neuron maturation. Located in perinuclear region of cytoplasm and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1); PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate kinase isoenzyme 1; adenylate kinase isoenzyme 1-like; adenylate monophosphate kinase; Ak 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; LOC108350550; MGC108678; myokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,310,113 - 36,320,760 (+)NCBIGRCr8
mRatBN7.2315,912,431 - 15,923,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,912,485 - 15,923,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,984,611 - 18,991,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,569,617 - 27,576,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,820,734 - 25,827,945 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,652,143 - 11,659,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0316,995,977 - 17,002,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,821,482 - 19,822,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,741,850 - 19,742,913 (+)NCBI
Celera310,656,923 - 10,664,139 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dimethoxyphenol  (ISO)
2-acetamidofluorene  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
ADP  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
nickel dichloride  (EXP)
nitrites  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
permethrin  (ISO)
progesterone  (EXP)
sarin  (EXP)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia. Abrusci P, etal., Exp Hematol. 2007 Aug;35(8):1182-9.
2. A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia. Bianchi P, etal., Br J Haematol 1999 Apr;105(1):75-9.
3. Anabolic effects of a non-myotoxic dose of the beta2-adrenergic receptor agonist clenbuterol on rat plantaris muscle. Burniston JG, etal., Muscle Nerve. 2007 Feb;35(2):217-23.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A proteomic analysis of the acute effects of high-intensity exercise on skeletal muscle proteins in fasted rats. Guelfi KJ, etal., Clin Exp Pharmacol Physiol. 2006 Oct;33(10):952-7.
7. Proteome analysis of skeletal muscle from obese and morbidly obese women. Hittel DS, etal., Diabetes. 2005 May;54(5):1283-8.
8. Distribution and developmental changes of adenylate kinase isozymes in the rat brain: localization of adenylate kinase 1 in the olfactory bulb. Inouye S, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):618-22.
9. Increase of adenylate kinase isozyme 1 protein during neuronal differentiation in mouse embryonal carcinoma P19 cells and in rat brain primary cultured cells. Inouye S, etal., J Neurochem. 1998 Jul;71(1):125-33.
10. Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement. Janssen E, etal., EMBO J 2000 Dec 1;19(23):6371-81.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2. Lange S, etal., J Cell Sci. 2002 Dec 15;115(Pt 24):4925-36.
13. Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction. Lin JF, etal., Chin J Physiol. 2011 Dec 31;54(6):406-12. doi: 10.4077/CJP.2011.AMM097.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Proteomic profiling of non-obese type 2 diabetic skeletal muscle. Mullen E and Ohlendieck K, Int J Mol Med. 2010 Mar;25(3):445-58.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
18. Overexpression of NeuroD in PC12 cells alters morphology and enhances expression of the adenylate kinase isozyme 1 gene. Noma T, etal., Brain Res Mol Brain Res 1999 Apr 6;67(1):53-63.
19. Proteomic profiling reveals a severely perturbed protein expression pattern in aged skeletal muscle. O'Connell K, etal., Int J Mol Med. 2007 Aug;20(2):145-53.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Metformin activates AMP kinase through inhibition of AMP deaminase. Ouyang J, etal., J Biol Chem. 2011 Jan 7;286(1):1-11. Epub 2010 Nov 8.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Impact of testosterone and oestradiol on region specificity of skeletal muscle-ATP, creatine phosphokinase and myokinase in male and female Wistar rats. Ramamani A, etal., Acta Physiol Scand. 1999 Jun;166(2):91-7.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes. Tanabe T, etal., J Biochem. 1993 Feb;113(2):200-7.
29. Evidence of a new phosphoryl transfer system in nucleotide metabolism. Vannoni D, etal., FEBS J. 2009 Jan;276(1):271-85. Epub 2008 Nov 27.
30. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. Yoneda T, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):187-95.
31. [Comparative proteomic analysis of cerebral cortex between middle cerebral artery occlusion rats and normal controls]. Zhao XF, etal., Sheng Wu Gong Cheng Xue Bao. 2005 Nov;21(6):934-41.
Additional References at PubMed
PMID:198184   PMID:211388   PMID:2542324   PMID:7323947   PMID:7444718   PMID:10557075   PMID:12477932   PMID:15489334   PMID:16790685   PMID:18050275   PMID:19056867   PMID:19437111  
PMID:20426806   PMID:23376485   PMID:23416111   PMID:23620342   PMID:29476059   PMID:32357304   PMID:34192805  


Genomics

Comparative Map Data
Ak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,310,113 - 36,320,760 (+)NCBIGRCr8
mRatBN7.2315,912,431 - 15,923,045 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,912,485 - 15,923,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,984,611 - 18,991,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,569,617 - 27,576,860 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,820,734 - 25,827,945 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,652,143 - 11,659,135 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0316,995,977 - 17,002,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4219,821,482 - 19,822,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1219,741,850 - 19,742,913 (+)NCBI
Celera310,656,923 - 10,664,139 (+)NCBICelera
Cytogenetic Map3p11NCBI
AK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,866,480 - 127,879,621 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,866,486 - 127,877,675 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,628,759 - 130,641,900 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,668,580 - 129,679,843 (-)NCBINCBI36Build 36hg18NCBI36
Build 349127,708,222 - 127,719,495NCBI
Celera9101,279,601 - 101,290,850 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,246,223 - 100,257,472 (-)NCBIHuRef
CHM1_19130,780,691 - 130,791,941 (-)NCBICHM1_1
T2T-CHM13v2.09140,073,895 - 140,087,021 (-)NCBIT2T-CHM13v2.0
Ak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,511,770 - 32,525,070 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,511,770 - 32,525,070 (+)EnsemblGRCm39 Ensembl
GRCm38232,621,758 - 32,635,058 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,621,758 - 32,635,058 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,485,024 - 32,490,572 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,451,513 - 32,457,061 (+)NCBIMGSCv36mm8
Celera232,336,146 - 32,341,694 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Ak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419799,410 - 811,029 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419799,415 - 807,138 (+)NCBIChiLan1.0ChiLan1.0
AK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,476,471 - 11,486,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,478,853 - 11,488,753 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,987,348 - 98,997,252 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,657,338 - 127,678,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,657,338 - 127,678,245 (-)Ensemblpanpan1.1panPan2
AK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,539,179 - 55,548,132 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,539,260 - 55,548,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,737,172 - 54,742,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,461,156 - 56,477,699 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,461,226 - 56,470,095 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,225,113 - 55,230,060 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,539,847 - 55,544,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,631,318 - 55,636,272 (+)NCBIUU_Cfam_GSD_1.0
Ak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,739,140 - 195,748,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,507,498 - 15,517,469 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,507,663 - 15,517,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,355,033 - 268,365,598 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,355,032 - 268,365,659 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,278,352 - 302,287,965 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,251,793 - 10,261,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,256,054 - 10,261,465 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,960,893 - 5,972,066 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,684,109 - 7,693,405 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,684,098 - 7,693,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ak1
74 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:118
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000073840
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
AI073285  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,921,645 - 15,921,815 (+)MAPPERmRatBN7.2
Rnor_6.0311,657,732 - 11,657,901NCBIRnor6.0
Rnor_5.0317,001,566 - 17,001,735UniSTSRnor5.0
Celera310,662,743 - 10,662,912UniSTS
RH 3.4 Map360.7UniSTS
Cytogenetic Map2q12UniSTS
RH137043  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0317,002,727 - 17,002,923UniSTSRnor5.0
Rnor_5.0218,472,832 - 18,473,028UniSTSRnor5.0
RGSC_v3.4219,822,309 - 19,822,505UniSTSRGSC3.4
Celera310,663,904 - 10,664,100UniSTS
Celera217,011,877 - 17,012,073UniSTS
RH 3.4 Map371.5UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000073840   ⟹   ENSRNOP00000067175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,916,831 - 15,923,041 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091048   ⟹   ENSRNOP00000074303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,912,485 - 15,923,037 (+)Ensembl
RefSeq Acc Id: NM_024349   ⟹   NP_077325
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,313,533 - 36,320,757 (+)NCBI
mRatBN7.2315,915,818 - 15,923,042 (+)NCBI
Rnor_6.0311,652,143 - 11,659,135 (+)NCBI
Rnor_5.0316,995,977 - 17,002,969 (+)NCBI
RGSC_v3.4219,821,482 - 19,822,544 (+)RGD
Celera310,656,923 - 10,664,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104231   ⟹   XP_038960159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,314,511 - 36,320,760 (+)NCBI
mRatBN7.2315,916,864 - 15,923,045 (+)NCBI
RefSeq Acc Id: XM_039104232   ⟹   XP_038960160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,310,113 - 36,320,760 (+)NCBI
mRatBN7.2315,912,431 - 15,923,045 (+)NCBI
RefSeq Acc Id: XM_039104233   ⟹   XP_038960161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,310,164 - 36,320,760 (+)NCBI
mRatBN7.2315,912,483 - 15,923,045 (+)NCBI
RefSeq Acc Id: XM_039104234   ⟹   XP_038960162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,310,164 - 36,320,760 (+)NCBI
mRatBN7.2315,912,482 - 15,923,045 (+)NCBI
RefSeq Acc Id: XM_039104235   ⟹   XP_038960163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,313,281 - 36,320,760 (+)NCBI
mRatBN7.2315,915,650 - 15,923,045 (+)NCBI
RefSeq Acc Id: XM_063283073   ⟹   XP_063139143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,310,253 - 36,320,760 (+)NCBI
RefSeq Acc Id: NP_077325   ⟸   NM_024349
- UniProtKB: P39069 (UniProtKB/Swiss-Prot),   Q5EBC5 (UniProtKB/Swiss-Prot),   Q9JJN3 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038960160   ⟸   XM_039104232
- Peptide Label: isoform X2
- UniProtKB: Q5EBC5 (UniProtKB/Swiss-Prot),   P39069 (UniProtKB/Swiss-Prot),   Q9JJN3 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960162   ⟸   XM_039104234
- Peptide Label: isoform X2
- UniProtKB: Q5EBC5 (UniProtKB/Swiss-Prot),   P39069 (UniProtKB/Swiss-Prot),   Q9JJN3 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960161   ⟸   XM_039104233
- Peptide Label: isoform X2
- UniProtKB: Q5EBC5 (UniProtKB/Swiss-Prot),   P39069 (UniProtKB/Swiss-Prot),   Q9JJN3 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960163   ⟸   XM_039104235
- Peptide Label: isoform X2
- UniProtKB: Q5EBC5 (UniProtKB/Swiss-Prot),   P39069 (UniProtKB/Swiss-Prot),   Q9JJN3 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960159   ⟸   XM_039104231
- Peptide Label: isoform X1
- UniProtKB: M0RC66 (UniProtKB/TrEMBL),   A6JU74 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000074303   ⟸   ENSRNOT00000091048
Ensembl Acc Id: ENSRNOP00000067175   ⟸   ENSRNOT00000073840
RefSeq Acc Id: XP_063139143   ⟸   XM_063283073
- Peptide Label: isoform X2
- UniProtKB: Q9JJN3 (UniProtKB/Swiss-Prot),   Q5EBC5 (UniProtKB/Swiss-Prot),   P39069 (UniProtKB/Swiss-Prot),   A6JU73 (UniProtKB/TrEMBL),   A6JU72 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39069-F1-model_v2 AlphaFold P39069 1-194 view protein structure
AF-A0A0G2K7Q6-F1-model_v2 AlphaFold A0A0G2K7Q6 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2076 AgrOrtholog
BioCyc Gene G2FUF-50129 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000049056 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073840.3 UniProtKB/TrEMBL
  ENSRNOT00000091048 UniProtKB/TrEMBL
  ENSRNOT00000091048.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130672 IMAGE-MGC_LOAD
InterPro Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AK1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AK1/5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24183 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108678 IMAGE-MGC_LOAD
NCBI Gene 24183 ENTREZGENE
PANTHER PTHR23359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ak1 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049056 RatGTEx
  ENSRNOG00055006133 RatGTEx
  ENSRNOG00060032927 RatGTEx
  ENSRNOG00065024512 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K7Q6_RAT UniProtKB/TrEMBL
  A6JU72 ENTREZGENE, UniProtKB/TrEMBL
  A6JU73 ENTREZGENE, UniProtKB/TrEMBL
  A6JU74 ENTREZGENE, UniProtKB/TrEMBL
  A6JU75_RAT UniProtKB/TrEMBL
  KAD1_RAT UniProtKB/Swiss-Prot
  M0RC66 ENTREZGENE, UniProtKB/TrEMBL
  P39069 ENTREZGENE
  Q5EBC5 ENTREZGENE
  Q9JJN3 ENTREZGENE
UniProt Secondary Q5EBC5 UniProtKB/Swiss-Prot
  Q9JJN3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ak1  adenylate kinase 1  LOC108350550  adenylate kinase isoenzyme 1-like  Data merged from RGD:11499875 737654 PROVISIONAL
2016-08-02 LOC108350550  adenylate kinase isoenzyme 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ak1  Adenylate kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in skeletal muscle 631735
gene_function catalyzes the conversion of ATP and AMP to ADP and ADP 631735
gene_process plays a role in adenine nucleotide metabolism and homeostasis 631735
gene_product member of a family of adenylate kinase isozymes 631735
gene_regulation tissue expression levels are inversly correlated with expression levels of the Ak2 isozyme 631735