Gene: Ak1 (adenylate kinase 1) Rattus norvegicus
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Symbol:
Ak1
Name:
adenylate kinase 1
Description:
Exhibits adenylate kinase activity. Contributes to phosphotransferase activity, phosphate group as acceptor. Involved in several processes, including nervous system development; nucleobase-containing small molecule metabolic process; and positive regulation of glucose transmembrane transport. Localizes to the neuron projection; perinuclear region of cytoplasm; and sarcomere. Biomarker of middle cerebral artery infarction; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1); PARTICIPATES IN adefovir pharmacokinetics pathway; adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; acrylamide.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
adenylate kinase isoenzyme 1; adenylate monophosphate kinase; Ak 1; ATP-AMP transphosphorylase 1; ATP:AMP phosphotransferase; MGC108678; myokinase
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
AK1 (adenylate kinase 1) HGNC
HomoloGene, NCBI, Panther
Mus musculus (house mouse):
Ak1 (adenylate kinase 1) HGNC
NCBI, HomoloGene, Panther
Chinchilla lanigera (long-tailed chinchilla):
Ak1 (adenylate kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
AK1 (adenylate kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
AK1 (adenylate kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ak1 (adenylate kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
AK1 (adenylate kinase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Ak1 (adenylate kinase 1)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
AK1 (adenylate kinase 1)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
ak1 (adenylate kinase 1)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Adk1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
F38B2.4
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: partial on reference assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 11,652,143 - 11,659,135 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 3 16,995,977 - 17,002,969 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 19,821,482 - 19,822,544 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 19,741,850 - 19,742,913 (+) NCBI Celera 3 10,656,923 - 10,664,139 (+) NCBI Celera Cytogenetic Map 3 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
congenital disorder of glycosylation Iu ISO RGD:736701 8554872 ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1u ClinVar PMID:28492532 early infantile epileptic encephalopathy ISO RGD:736701 8554872 ClinVar Annotator: match by term: Early infantile epileptic encephalopathy ClinVar PMID:18469812 more ... Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 8554872 ClinVar Annotator: match by OMIM:612631 ClinVar PMID:12649162 Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 8554872 ClinVar Annotator: match by OMIM:612631 ClinVar PMID:10233365 Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 8554872 ClinVar Annotator: match by OMIM:612631 ClinVar PMID:9432020 Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 8554872 ClinVar Annotator: match by OMIM:612631 ClinVar PMID:2542324 Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 8554872 ClinVar Annotator: match by OMIM:612631 ClinVar PMID:15315793
Imported Annotations - CTD
mantle cell lymphoma ISO RGD:736701 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23676220 Myocardial Ischemia ISO RGD:736701 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16214533 Imported Annotations - MGI
hemolytic anemia ISS RGD:736701 13592920 OMIM:266120 , OMIM:612631MouseDO Imported Annotations - OMIM
Hemolytic Anemia due to Adenylate Kinase Deficiency ISO RGD:736701 7240710 OMIM
(S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of AK1 mRNA CTD PMID:20624997 1,1-dichloroethene decreases expression ISO RGD:10129 6480464 vinylidene chloride results in decreased expression of AK1 mRNA CTD PMID:26682919 1,10-phenanthroline decreases expression ISO RGD:736701 6480464 1, 10-phenanthroline results in decreased expression of AK1 mRNA CTD PMID:19502547 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of AK1 mRNA CTD PMID:30723492 14-Deoxy-11,12-didehydroandrographolide decreases expression ISO RGD:736701 6480464 14-deoxy-11, 12-didehydroandrographolide results in decreased expression of AK1 mRNA CTD PMID:22101062 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:10129 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:10129 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10129 6480464 Tetrachlorodibenzodioxin affects the expression of AK1 mRNA CTD PMID:21570461 2-acetamidofluorene increases expression ISO RGD:10129 6480464 2-Acetylaminofluorene results in increased expression of AK1 mRNA CTD PMID:17317680 2-methylcholine affects expression ISO RGD:736701 6480464 beta-methylcholine affects the expression of AK1 mRNA CTD PMID:21179406 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:736701 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:736701 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA CTD PMID:28628672 5-chloro-7-iodoquinolin-8-ol decreases expression ISO RGD:736701 6480464 Clioquinol results in decreased expression of AK1 mRNA CTD PMID:19502547 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of AK1 mRNA CTD PMID:28959563 aflatoxin B1 increases expression ISO RGD:736701 6480464 Aflatoxin B1 results in increased expression of AK1 mRNA CTD PMID:21632981 , PMID:21641981 aflatoxin B1 increases expression ISO RGD:10129 6480464 Aflatoxin B1 results in increased expression of AK1 mRNA CTD PMID:19770486 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of AK1 mRNA CTD PMID:16483693 amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of AK1 mRNA CTD PMID:30779732 atrazine decreases expression ISO RGD:736701 6480464 Atrazine results in decreased expression of AK1 mRNA CTD PMID:22378314 benzo[a]pyrene multiple interactions ISO RGD:10129 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to AK1 promoter] CTD PMID:19654925 benzo[a]pyrene decreases expression ISO RGD:10129 6480464 Benzo(a)pyrene results in decreased expression of AK1 mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:736701 6480464 Benzo(a)pyrene results in increased expression of AK1 mRNA CTD PMID:20106945 , PMID:21632981 benzo[a]pyrene increases expression ISO RGD:10129 6480464 Benzo(a)pyrene results in increased expression of AK1 mRNA CTD PMID:19770486 , PMID:22228805 benzo[b]fluoranthene increases expression ISO RGD:10129 6480464 benzo(b)fluoranthene results in increased expression of AK1 mRNA CTD PMID:26377693 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of AK1 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:10129 6480464 bisphenol A results in decreased expression of AK1 protein CTD PMID:28279065 butanal increases expression ISO RGD:736701 6480464 butyraldehyde results in increased expression of AK1 mRNA CTD PMID:26079696 cadmium dichloride affects expression ISO RGD:10129 6480464 Cadmium Chloride affects the expression of AK1 mRNA CTD PMID:18974090 cadmium dichloride increases expression ISO RGD:736701 6480464 Cadmium Chloride results in increased expression of AK1 protein CTD PMID:24527689 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of AK1 protein CTD PMID:21699967 carbon nanotube decreases expression ISO RGD:10129 6480464 Nanotubes, Carbon results in decreased expression of AK1 mRNA CTD PMID:25554681 choline multiple interactions ISO RGD:10129 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA CTD PMID:20938992 cisplatin increases expression ISO RGD:10129 6480464 Cisplatin results in increased expression of AK1 mRNA CTD PMID:24280081 cisplatin multiple interactions ISO RGD:736701 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of AK1 mRNA CTD PMID:27392435 cisplatin increases expression ISO RGD:736701 6480464 Cisplatin results in increased expression of AK1 mRNA CTD PMID:19561079 more ... cobalt dichloride decreases expression ISO RGD:736701 6480464 cobaltous chloride results in decreased expression of AK1 mRNA CTD PMID:19502547 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of AK1 protein CTD PMID:24386269 cobalt(2+) sulfate decreases expression ISO RGD:736701 6480464 cobalt sulfate results in decreased expression of AK1 mRNA CTD PMID:19502547 cocaine decreases expression ISO RGD:736701 6480464 Cocaine results in decreased expression of AK1 mRNA CTD PMID:15009677 copper(II) sulfate decreases expression ISO RGD:736701 6480464 Copper Sulfate results in decreased expression of AK1 mRNA CTD PMID:19549813 curcumin multiple interactions ISO RGD:736701 6480464 [ERBB2 protein results in increased susceptibility to Curcumin analog] which results in decreased phosphorylation of AK1 protein CTD PMID:25866362 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of AK1 mRNA CTD PMID:23914054 dexamethasone multiple interactions ISO RGD:736701 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA CTD PMID:28628672 diazinon increases methylation ISO RGD:736701 6480464 Diazinon results in increased methylation of AK1 gene CTD PMID:22964155 dibenz[a,h]anthracene increases expression ISO RGD:10129 6480464 1 more ... CTD PMID:26377693 dioxygen multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of AK1 mRNA CTD PMID:19915844 elemental selenium increases expression ISO RGD:736701 6480464 Selenium results in increased expression of AK1 mRNA CTD PMID:19244175 ethanol multiple interactions ISO RGD:10129 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of AK1 mRNA CTD PMID:30517762 folic acid multiple interactions ISO RGD:10129 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of AK1 mRNA CTD PMID:22079235 , PMID:27387713 genistein increases expression EXP 6480464 Genistein results in increased expression of AK1 mRNA CTD PMID:21782745 genistein multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of AK1 mRNA CTD PMID:21782745 indometacin multiple interactions ISO RGD:736701 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of AK1 mRNA CTD PMID:28628672 L-methionine multiple interactions ISO RGD:10129 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of AK1 mRNA CTD PMID:20938992 methamphetamine decreases expression EXP 6480464 Methamphetamine results in decreased expression of AK1 protein CTD PMID:19826936 methoxychlor multiple interactions EXP 6480464 [Genistein co-treated with Methoxychlor] results in increased expression of AK1 mRNA CTD PMID:21782745 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of AK1 mRNA CTD PMID:21782745 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of AK1 mRNA CTD PMID:22546817 nitrites multiple interactions EXP 6480464 [Nitrites co-treated with Oxygen deficiency] results in increased activity of AK1 protein CTD PMID:22892143 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of AK1 mRNA CTD PMID:18417182 paracetamol increases expression ISO RGD:736701 6480464 Acetaminophen results in increased expression of AK1 mRNA CTD PMID:22230336 paracetamol increases expression ISO RGD:10129 6480464 Acetaminophen results in increased expression of AK1 mRNA CTD PMID:11752693 paraquat increases expression ISO RGD:10129 6480464 Paraquat results in increased expression of AK1 mRNA CTD PMID:21371552 permethrin increases activity ISO RGD:736701 6480464 Permethrin results in increased activity of AK1 protein CTD PMID:19326768 progesterone increases expression EXP 6480464 Progesterone results in increased expression of AK1 mRNA CTD PMID:20726854 sarin decreases expression EXP 6480464 Sarin results in decreased expression of AK1 protein CTD PMID:28973502 selenium atom increases expression ISO RGD:736701 6480464 Selenium results in increased expression of AK1 mRNA CTD PMID:19244175 silver atom increases expression ISO RGD:10129 6480464 Silver results in increased expression of AK1 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:10129 6480464 Silver results in increased expression of AK1 mRNA CTD PMID:27131904 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of AK1 protein CTD PMID:29459688 sodium fluoride increases expression ISO RGD:10129 6480464 Sodium Fluoride results in increased expression of AK1 protein CTD PMID:28918527 tetrachloromethane multiple interactions ISO RGD:10129 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of AK1 mRNA CTD PMID:30517762 titanium dioxide affects expression ISO RGD:10129 6480464 titanium dioxide affects the expression of AK1 mRNA CTD PMID:23557971 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of AK1 gene CTD PMID:27618143 valproic acid affects expression ISO RGD:736701 6480464 Valproic Acid affects the expression of AK1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:736701 6480464 Valproic Acid results in increased expression of AK1 mRNA CTD PMID:23179753 , PMID:27188386 valproic acid increases expression ISO RGD:10129 6480464 Valproic Acid results in increased expression of AK1 mRNA CTD PMID:19136453 vincaleukoblastine decreases expression EXP 6480464 Vinblastine results in decreased expression of AK1 mRNA CTD PMID:20624997 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of AK1 mRNA CTD PMID:19015723 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of AK1 mRNA CTD PMID:20624997 vitamin E increases expression ISO RGD:736701 6480464 Vitamin E results in increased expression of AK1 mRNA CTD PMID:19244175
Biological Process adenine metabolic process NAS 5490217 RGD ADP biosynthetic process IDA 5134369 RGD AMP metabolic process IDA 5134369 RGD ATP metabolic process IEA UniRule:UR000166136 1600115 GO_REF:0000104 UniProt GO_REF:0000104 cell cycle arrest ISO RGD:10129 1624291 (MGI:MGI:1928244, PMID:10557075) RGD MGI:MGI:1928244 , PMID:10557075 cerebellum development IEP 632499 RGD inosine biosynthetic process IDA 5134369 RGD muscle organ development IEP 5490217 RGD neuron differentiation IEP 727267 RGD nucleoside diphosphate phosphorylation ISO RGD:736701 1624291 (PMID:23416111) RGD PMID:23416111 nucleoside diphosphate phosphorylation ISS UniProtKB:P00568 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleoside monophosphate phosphorylation IEA GO:0004017 1600115 GO_REF:0000108 GOC GO_REF:0000108 nucleoside triphosphate biosynthetic process ISO RGD:736701 1624291 (PMID:23416111) RGD PMID:23416111 nucleoside triphosphate biosynthetic process ISS UniProtKB:P00568 1600115 GO_REF:0000024 UniProt GO_REF:0000024 olfactory bulb development IEP 632499 RGD positive regulation of glucose transmembrane transport IMP 5134355 RGD positive regulation of neuron maturation IEP 632499 RGD response to activity IEP 5490161 RGD response to drug IEP 2301763 clenbuterol RGD response to estradiol IEP 5490212 RGD response to testosterone IEP 5490212 RGD Cellular Component cytoplasm ISO RGD:10129 1624291 (MGI:MGI:1928244, PMID:10557075) RGD MGI:MGI:1928244 , PMID:10557075 cytosol ISO RGD:736701 1624291 RGD GO_REF:0000052 neuron projection IDA 1599010 RGD outer dense fiber ISO RGD:10129 1624291 (MGI:MGI:3686560, PMID:16790685) RGD MGI:MGI:3686560 , PMID:16790685 perinuclear region of cytoplasm IDA 1599010 RGD plasma membrane ISO RGD:10129 1624291 (MGI:MGI:1928244, PMID:10557075) RGD MGI:MGI:1928244 , PMID:10557075 sarcomere IDA 5490518 RGD sperm flagellum ISO RGD:10129 1624291 (MGI:MGI:3686560, PMID:16790685) RGD MGI:MGI:3686560 , PMID:16790685 Molecular Function adenylate kinase activity IDA 5490217 RGD adenylate kinase activity ISO RGD:10129 1624291 (MGI:MGI:54349 more ... RGD MGI:MGI:54349 more ... ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000037 UniProt GO_REF:0000037 nucleoside diphosphate kinase activity ISO RGD:736701 1624291 (PMID:23416111) RGD PMID:23416111 nucleoside diphosphate kinase activity ISS UniProtKB:P00568 1600115 GO_REF:0000024 UniProt GO_REF:0000024 phosphotransferase activity, phosphate group as acceptor contributes_to IDA 5134369 AMP:AMP phosphotransferase RGD
Gene-Chemical Interaction Annotations
