Gpr21 (G protein-coupled receptor 21) - Rat Genome Database

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Gene: Gpr21 (G protein-coupled receptor 21) Rattus norvegicus
Analyze
Symbol: Gpr21
Name: G protein-coupled receptor 21
RGD ID: 1586383
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within glucose homeostasis; negative regulation of insulin receptor signaling pathway; and regulation of growth. Predicted to be located in plasma membrane. Orthologous to human GPR21 (G protein-coupled receptor 21); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; bromobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC689917; probable G-protein coupled receptor 21; similar to G protein-coupled receptor 21
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,685,072 - 41,688,791 (+)NCBIGRCr8
mRatBN7.2321,275,289 - 21,279,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl321,275,007 - 21,277,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx324,743,702 - 24,747,405 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0333,328,660 - 33,332,363 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,139,420 - 31,143,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0321,764,377 - 21,767,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl321,764,377 - 21,767,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,001,363 - 27,006,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,271,893 - 17,274,816 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera319,710,554 - 19,713,477 (+)NCBICelera
Cytogenetic Map3q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22155242   PMID:22653059   PMID:32583711  


Genomics

Comparative Map Data
Gpr21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,685,072 - 41,688,791 (+)NCBIGRCr8
mRatBN7.2321,275,289 - 21,279,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl321,275,007 - 21,277,930 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx324,743,702 - 24,747,405 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0333,328,660 - 33,332,363 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,139,420 - 31,143,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0321,764,377 - 21,767,300 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl321,764,377 - 21,767,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,001,363 - 27,006,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,271,893 - 17,274,816 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera319,710,554 - 19,713,477 (+)NCBICelera
Cytogenetic Map3q11NCBI
GPR21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389123,033,667 - 123,049,103 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9123,033,667 - 123,035,665 (+)EnsemblGRCh38hg38GRCh38
GRCh379125,795,946 - 125,797,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,836,667 - 124,837,716 (+)NCBINCBI36Build 36hg18NCBI36
Build 349122,876,399 - 122,877,449NCBI
Celera996,445,158 - 96,446,207 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef995,410,867 - 95,412,889 (+)NCBIHuRef
CHM1_19125,944,301 - 125,946,323 (+)NCBICHM1_1
T2T-CHM13v2.09135,230,916 - 135,239,991 (+)NCBIT2T-CHM13v2.0
Gpr21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,406,638 - 37,409,293 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl237,406,344 - 37,410,615 (+)EnsemblGRCm39 Ensembl
GRCm38237,516,626 - 37,519,281 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,516,332 - 37,520,603 (+)EnsemblGRCm38mm10GRCm38
MGSCv37237,372,146 - 37,374,801 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36237,338,635 - 37,341,292 (+)NCBIMGSCv36mm8
Celera237,201,974 - 37,204,629 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
Gpr21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554194,934,587 - 4,937,370 (-)NCBIChiLan1.0ChiLan1.0
GPR21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,295,427 - 16,315,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,313,787 - 16,317,880 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0994,161,345 - 94,166,811 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19122,495,164 - 122,496,881 (+)NCBIpanpan1.1PanPan1.1panPan2
GPR21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1959,760,384 - 59,764,309 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha958,953,380 - 58,959,611 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0960,678,678 - 60,684,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl960,678,753 - 60,684,894 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,436,534 - 59,442,763 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0959,751,526 - 59,757,756 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0959,844,442 - 59,850,686 (-)NCBIUU_Cfam_GSD_1.0
Gpr21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947191,738,241 - 191,741,010 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648711,506,803 - 11,508,764 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648711,507,244 - 11,508,846 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11263,953,495 - 263,961,284 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21297,399,909 - 297,403,225 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11215,093,969 - 15,101,088 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666079969,582 - 977,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476011,890,091 - 11,892,822 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr21
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:345
Count of miRNA genes:212
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000063938
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 13 24 8 19 8 8 8 66 10 12 11 8
Below cutoff 1 30 13 13 13 3 8 25 27

Sequence


RefSeq Acc Id: ENSRNOT00000063938   ⟹   ENSRNOP00000062017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl321,275,007 - 21,277,930 (+)Ensembl
Rnor_6.0 Ensembl321,764,377 - 21,767,300 (+)Ensembl
RefSeq Acc Id: NM_001396821   ⟹   NP_001383750
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8341,685,072 - 41,688,791 (+)NCBI
mRatBN7.2321,275,289 - 21,279,008 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001383750 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00525 (Get FASTA)   NCBI Sequence Viewer  
  EDM00526 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062017
  ENSRNOP00000062017.1
RefSeq Acc Id: ENSRNOP00000062017   ⟸   ENSRNOT00000063938
RefSeq Acc Id: NP_001383750   ⟸   NM_001396821
- UniProtKB: D3ZA59 (UniProtKB/TrEMBL),   A6JET6 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA59-F1-model_v2 AlphaFold D3ZA59 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586383 AgrOrtholog
BioCyc Gene G2FUF-49929 BioCyc
Ensembl Genes ENSRNOG00000042269 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063938 ENTREZGENE
  ENSRNOT00000063938.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:689917 UniProtKB/TrEMBL
NCBI Gene 689917 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR 21-RELATED UniProtKB/TrEMBL
  HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Gpr21 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042269 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6JET6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZA59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Gpr21  G protein-coupled receptor 21  LOC689917  similar to G protein-coupled receptor 21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689917  similar to G protein-coupled receptor 21  LOC681885  similar to G protein-coupled receptor 21  Data merged from RGD:1590481 1643240 APPROVED
2006-11-20 LOC681885  similar to G protein-coupled receptor 21      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689917  similar to G protein-coupled receptor 21      Symbol and Name status set to provisional 70820 PROVISIONAL