Crb2 (crumbs cell polarity complex component 2)

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Gene: Crb2 (crumbs cell polarity complex component 2) Rattus norvegicus

Analyze

Symbol:

Crb2

Name:

crumbs cell polarity complex component 2

RGD ID:

1309368

Description:

Predicted to enable aspartic-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including embryonic morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and maintenance of epithelial cell apical/basal polarity. Predicted to be located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and cell junction. Predicted to be part of subapical complex. Predicted to be active in apical part of cell and plasma membrane. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; furan.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs homolog 2 (Drosophila); LOC366031; RGD1309368; similar to 5930402A21 protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	21,542,138 - 21,564,876 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	21,542,221 - 21,563,294 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	25,010,380 - 25,030,705 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	33,595,339 - 33,615,663 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	31,407,370 - 31,427,643 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	17,436,230 - 17,456,001 (+)	NCBI
Celera	3	19,976,389 - 19,996,310 (+)	NCBI		Celera
Cytogenetic Map	3	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal segmental glomerulosclerosis (ISO)

focal segmental glomerulosclerosis 9 (ISO)

genetic disease (ISO)

Leber congenital amaurosis (ISO)

nephrotic syndrome type 2 (ISO)

retinitis pigmentosa (ISO,ISS)

ventriculomegaly - cystic kidney disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clobetasol (ISO)

dorsomorphin (ISO)

ethanol (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

isoflurane (ISO)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (EXP)

potassium dichromate (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sevoflurane (ISO)

sunitinib (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

circulatory system development (ISO,ISS)

establishment of cell polarity (ISO)

establishment or maintenance of epithelial cell apical/basal polarity (IBA)

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (IBA)

ingression involved in gastrulation with mouth forming second (ISO)

maintenance of epithelial cell apical/basal polarity (ISO,ISS)

mesoderm formation (ISO,ISS)

negative regulation of endopeptidase activity (ISO)

notochord formation (ISO,ISS)

photoreceptor cell maintenance (ISO)

positive regulation of BMP signaling pathway (ISO,ISS)

positive regulation of epithelial to mesenchymal transition (ISO,ISS)

regulation of gastrulation (ISO)

retina homeostasis (ISO)

retinal cone cell development (ISO)

somitogenesis (ISO,ISS)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (ISO)

apicolateral plasma membrane (ISO)

cell junction (ISO)

cytoplasm (ISO)

plasma membrane (IBA)

protein-containing complex (IBA,ISO)

subapical complex (ISO)

Molecular Function

aspartic-type endopeptidase inhibitor activity (ISO)

calcium ion binding (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.	Alves CH, etal., Hum Mol Genet. 2014 Feb 18.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.	Pellissier LP, etal., PLoS Genet. 2013 Dec;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19056867	PMID:20299451	PMID:22072575	PMID:23376485	PMID:23533145	PMID:25636444	PMID:26496195	PMID:27870829

Genomics

Comparative Map Data

Crb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	21,542,138 - 21,564,876 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	21,542,221 - 21,563,294 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	25,010,380 - 25,030,705 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	33,595,339 - 33,615,663 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	31,407,370 - 31,427,643 (+)	NCBI	Rnor_WKY
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	17,436,230 - 17,456,001 (+)	NCBI
Celera	3	19,976,389 - 19,996,310 (+)	NCBI		Celera
Cytogenetic Map	3	q11	NCBI

CRB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	123,354,065 - 123,380,326 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	9	123,356,170 - 123,380,324 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	126,118,476 - 126,142,605 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	125,158,269 - 125,180,853 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	123,198,002 - 123,215,932	NCBI
Celera	9	96,766,676 - 96,789,262 (+)	NCBI		Celera
Cytogenetic Map	9	q33.3	NCBI
HuRef	9	95,733,274 - 95,755,982 (+)	NCBI		HuRef
CHM1_1	9	126,267,137 - 126,289,699 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	135,553,898 - 135,578,059 (+)	NCBI		T2T-CHM13v2.0

Crb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	37,666,238 - 37,689,115 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	37,666,261 - 37,689,115 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	37,776,225 - 37,799,103 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	37,776,249 - 37,799,103 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	37,631,769 - 37,654,623 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
Celera	2	37,461,524 - 37,484,418 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI

Crb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	4,607,507 - 4,626,608 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	4,604,883 - 4,626,675 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	123,011,887 - 123,034,544 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	123,011,968 - 123,032,855 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	94,473,423 - 94,511,285 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CRB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	59,427,661 - 59,450,436 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	59,427,569 - 59,450,434 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	58,621,652 - 58,645,938 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	60,346,151 - 60,370,373 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	60,346,149 - 60,370,391 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	59,104,766 - 59,129,041 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	59,420,335 - 59,444,621 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	59,512,745 - 59,536,914 (-)	NCBI		UU_Cfam_GSD_1.0

Crb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	192,024,531 - 192,047,256 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	11,793,005 - 11,812,934 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936487	11,793,078 - 11,813,803 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	264,276,987 - 264,301,713 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	264,277,549 - 264,301,731 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	297,886,591 - 297,910,766 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	14,756,897 - 14,782,131 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	14,758,618 - 14,779,514 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666079	1,290,401 - 1,312,970 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Crb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	11,579,163 - 11,598,287 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	11,576,683 - 11,598,354 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Crb2
83 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	75
Count of miRNA genes:	65
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000037257
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	16954708	61954708	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	17374703	35528639	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	17374703	35528639	Rat
2325840	Bp345	Blood pressure QTL 345		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	18311454	28441896	Rat
731172	Bp151	Blood pressure QTL 151		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	18311454	47233430	Rat
12879849	Bw180	Body weight QTL 180		0.037	body mass (VT:0001259)	body weight (CMO:0000012)	3	18311454	47233430	Rat
12879850	Cm91	Cardiac mass QTL 91		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	18311454	47233430	Rat
12879851	Cm92	Cardiac mass QTL 92		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	18311454	47233430	Rat
12879852	Cm93	Cardiac mass QTL 93		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	18311454	47233430	Rat
12879853	Am5	Aortic mass QTL 5		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	18311454	47233430	Rat
12879854	Kidm63	Kidney mass QTL 63		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	18311454	47233430	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	20714090	65714090	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		6	2	2		2			22	8	6
Low		16	10	8		8			41	27	25	8
Below cutoff	1	17	35	22	18	22	2	2	11		9	3	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000115	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000037257 ⟹ ENSRNOP00000035420

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	21,542,221 - 21,563,294 (+)	Ensembl
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl

RefSeq Acc Id:

NM_001135761 ⟹ NP_001129233

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	21,542,221 - 21,562,500 (+)	NCBI
Rnor_6.0	3	22,038,357 - 22,058,871 (+)	NCBI
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	RGD
Celera	3	19,976,389 - 19,996,310 (+)	RGD

Sequence:

show sequence

ATGGCGCTGTTGGGGCCTGTGATCTGGGGCTTTAGACGAGATGTCTACCTCCTGTTGCTGCTAC
TGCTGCTGTTGCTGCCGCCCTGGGTCCCGGCTGGGCTGGTTCCTTCAGAGACCCCGAATGTCTG
TGCCTCAGACCCATGTGCTCCAGGGACCAGGTGCCAGGCTACAGAAAGTGGTGGCTTTACCTGT
GAGCCCTTAGAGCTTGGAGGCTGTGCTGCTCAACCGTGCCACCATGGTGCACTGTGTGTGCCCC
AGGGCCCAGATCCTAACGGCTTCCGTTGCTACTGTGTGCCTGGATTCCAGGGACCCCACTGTGA
GCTGGACATCGATGAGTGTGCCTCCCGGCCTTGCCACCATGGGGGCACCTGCCGAAATCTGGCA
GATCACTACGAGTGCCACTGCCCCCTCGGCTATGCAGGCGTGACCTGTGAGGCGGAGGTGGACG
AGTGCTCATCAGCGCCCTGCCTGCACGGAGGCTCGTGCCTGGACGGTGTGGGCTCCTACCGCTG
TGTGTGCGCACCTGGATACGCCGGCGCGAGCTGTCAGCTGGACGTGGACGAGTGCCAGAGCCAG
CCGTGCGAGCACGGTGGCGTGTGTCACGACCTGGTCAACGGTTTCCGGTGCGACTGTGCGGACA
CGGGTTACGAAGGCGCGCGCTGTGAGCAGGAGGTGCTGGAGTGCGCCTCTGCGCCCTGCGTGCA
CAACGCATCCTGCCTCGACGGCTTCCGGAGCTTCCGCTGCCTCTGCTGGCCAGGCTTCAGTGGA
GAGCGGTGCGAAGTGGATGAGGATGAGTGTGCATCGGATCCCTGTCATAATGGGGGCCGGTGCT
CGCAGCGCTCTGACCCGACCTTGTATGGGGGTGTTCAGGCCATCTTCCCCGGAGCCTTCAGCTT
CAGCCAAGCCGCTGGCTTCCTTTGCAGCTGTCCTCCGGGCTTTGCTGGGGATGACTGCAGCGTG
GACGTGAATGAGTGTGCCTCAGAGCCATGTCTCAACGGAGGTAGCTGCCAGGACCTGCCCAATG
GTTTCCAGTGCTACTGTCAGGATGGATACACAGGACTGACATGTCAGGAGGATACGGACGAGTG
CCAGTCGGAACCATGCCTGCACGGTGGGACCTGCAGCGACACTGTAGCAGGCTACATCTGCCAG
TGCCCCGAGGCCTGGGGTGGACATGACTGTTCTGTGCAGCTCACAGGCTGCCAGGGCCACGCCT
GCCCACTGGCTGCCACCTGCATCCCCACCTTCAAGTCTGGTTTCCACAGTTATATCTGCCGTTG
CCTGCCTGGGACCTATGGGTCTTTCTGTGACCAGAATACCACTTTCTCGGTTGTGTCTGGGAGT
TCCGTGTGGGGATTGGTGCCAGCTGGTGCCTCCCTGGCTTTTGCACTGAGATTTCGTACCACCC
TGCTTGCTGGAGCCCTGGCTACTCTTAAGGACTCACGGGACAGCTTGGAGCTGGTTCTGGTGGG
GGCCATGCTCCAAGCCACACTCTGGAGACGTGGCACTGCTGACCTTGTCCTTACACTGCCAGAC
CTAGCCTTAAATGACGGGCATTGGCATCAGGTGGAAGTGACACTCCGCCTGGGAACCCTGGAGC
TGCGGCTCTGGCATGAGGGCTGCCCTGGCCAGCTCTGTGTGGTCTCTGGCACTGTGGCTACAGA
TCCTACAGCCTCGGTGGCTTCTGGGTCTCCGGAGCCCTACTCCATCCATTTGGGCGGCAGGGCC
TTTGCAGGCTGCTTCCAGGATGTGCGTGTGGAAGGGCACCTTCTGCTGCCTGAGGAGCTCAAGG
GAAGTGTGCTCCTGGGTTGTGAGCGCACAGAGCCTTGCCAACCTCTGCCCTGTGCCAATGGAGG
GGCCTGTGTGGACCTGTGGACTGACTTCCGCTGCGACTGCCCGAGACCTTACCATGGGTCCAAG
TGCACTGATGAGGTTCCTGCTGCCACCTTTGGCTTGGGCGGTGTCATGAGCTCAGCCACCTTCC
TGCTCCACCAGATGCTAGGCCCGAACCTCACCGTGTCGTTTTTCCTCCGCACTCGTGAGCCCGC
CAGCCTGTTGCTCCAGTTTGCCAATGATTCAGTTGCTAGCCTAACTGTGTCCCTGAGTGAGGGC
CAGATCCGGGCAGAGGTGCTGGGTCATCCTGCTGTGATCCTCCCTGGGCGCCGGGATGATGGAC
TCCGTCACTTGGTGGTGCTCAGCTTTGGGCCTGACCAGCTCCAGGACCTGGGCCAGTGGCTGTA
TGTGGGTGGGAGGCTCTACCCTGATGATACCCAGCCCTGGGGTGGGCCCTTCCGAGGCTGTCTC
CAGGACCTACAACTCAACGGCATCCACCTCCCCTTCTTCTCTTCTCCCATGGAGAACTCAAGTT
GGCCCAGTGAACTGGAAGCTGGTCAGTCCTCCAACCTCACCCAGGGCTGTGTCTCTGAGGACAC
GTGCAATCCCAATCCCTGTTTCAATGGTGGAACATGCCACATCACCTGGAATGACTTCTACTGC
ACTTGCCCTGACAACTTCACGGGGCCCACCTGTGCCCAGCAGCGATGGTGCCCCAGGCAGCCAT
GCCTGCCGCCTGCCACCTGTGAGGAGGTTCCAGATGGCTTTGTGTGTGTGGCCGAAGCCACGTT
CCGCGAGGGCCCTCCTGCTGTGTTCACAGGCCACAACGTGTCCTCATCGCGCGCGCTCAGCAGG
GTCACCCTGGCCTTCCGCACACGCGACCTGGAGGCTGGGCTGCTGCGCGCTGCCTCTGCCGCGG
GTGCCCACTCCAATATCTGGCTGGCGGTGCGCAATGGCTTGCTGGCAGTAGATGTGGCGGGCTC
GGTGCTGCCGGCGCCCGGGCCGCGCGTGGCTGACGGTGCCTGGCATCGCGTGCGCCTAGCCCGG
GAGTTTCCACAGGCCGCCGCCTCACGCTGGCTGCTGTGGCTGGACGGCGCGGCGACACCCGTGG
CTTTGCACGGCTTGGGCGGCGACCTGGGTTTCCTTCAGGGCCCGGGTGCCGTGCCTCTGCTACT
GGCCGAGAACTTCACGGGCTGCCTGGGCCGGGTGGCGCTCGGCGACCTCCCCTTACCCTTGGCG
CCACCGCGGTCCGGCGCGATGTCTGGGGCACGCGAGCACTTCATGGCTTGGCCTGGGTCTCCGC
CGGCAGTGAGCCTAGGCTGCCGGGGCGGGCCAGTATGCACGCCCTCGCCCTGCCTGCACGGCGG
TGCCTGCCTCGACCTCTTCGACGTCTTTGCTTGTTCCTGCGGCCCCGCCTGGGAAGGACCCCGC
TGCGAGATCCACGCTGATCCATGTCGCTCATCGCCCTGTGTCCGGGGCCAATGCAACACGCGCC
CGGACGGCCGCTTCGAGTGTCGGTGCCCTCCGGGTTTCTCCGGCCCGCGCTGCAGGTTGCCTAC
CTTGCCTCAGGGGTGTAGCCTCAACTCCACCTGCAAGGATGGTGCCCCTTGTGGGGGTGGCCCC
TTAGGCACTAACTGCAGTTGCCAGGAAGGCCTTGCTGGCCTCAGATGTCAGAGTCTTGACCAAC
CCTGTGAAGCCAGTCCTTGCTTGAATGGGGGCACCTGCCGGGTGACCAGTGGCATATTTGAATG
TACTTGCAGTGCAGGATTCTCTGGCCAGTTCTGTGAAGTGGTGAAAACCCTGCCTCTGCCTCTG
CCATTCCCACTGCTGGAGGTAGCAGTGCCTGCAGCCTGTGCCTGCCTCCTCCTCCTCCTCCTGG
GCCTCCTCTCAGGAATTCTGGCTGCCAGAAAGCGCCGCCAGTCTGAGGGCACTTACAGCCCAAG
TCAGCAGGAGGTAGCTGGGGCTCGTCTGGAGATGGACAGTGTCCTCAAGGTGCCACCAGAGGAG
AGACTTATCTAG

hide sequence

RefSeq Acc Id:

XM_006234103 ⟹ XP_006234165

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	21,542,138 - 21,564,876 (+)	NCBI
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI

Sequence:

show sequence

ACCTTACTGATAGCCTCAAGGACAGGATCTGTGTGGTAGGGTGGGACCCAGGAGGGCAGCAGGG
ACAGGAACCCCTGTGAGAGGAGGGGAGGGGCCTTGATATCTCAGGTGTGGAAGGAGCAGGTTAA
GTAAGGACAGATGGGAGCGCTGAACTAGGAGCACCGAACTGAGGCCAGGCGGGAGGACCAAGGC
CTGAAACTGCCGGGTAGCTGAGCTCTTGCGGGAAATCGGACTAGCCCCAGGCATCCTGGCCCGC
CCCATGGACCGGACTGCCTGGCAAGAGGGCTTGTGCACTGAGACCCAGGGTCAGGCCCAGGGCC
TTGTCTGGAGCTGAGGCCTCCGAAGGGGCTGGAGTCTGTGAAGTGCGGTGGGTCAGACCCTCCG
CGAGGATCCTGCTCCGGGAGGAGCAGTGGGAGGCGGGGCGGAGGGGGAGGGCTGGAGGAGGGGC
CGGGCCTCTGTCCACCTCGTCAGTGCTGGTTGGAGGGACGAAGGGGCGCGGAGCCCGCCGAGCA
GAGGGTTCCCATAGGCAAGCAGAGCCGGCTGCCATGGCGCTGTTGGGGCCTGTGATCTGGGGCT
TTAGACGAGATGTCTACCTCCTGTTGCTGCTACTGCTGCTGTTGCTGCCGCCCTGGGTCCCGGC
TGGGCTGGTTCCTTCAGAGACCCCGAATGTCTGTGCCTCAGACCCATGTGCTCCAGGGACCAGG
TGCCAGGCTACAGAAAGTGGTGGCTTTACCTGTGAGCCCTTAGAGCTTGGAGGCTGTGCTGCTC
AACCGTGCCACCATGGTGCACTGTGTGTGCCCCAGGGCCCAGATCCTAACGGCTTCCGTTGCTA
CTGTGTGCCTGGATTCCAGGGACCCCACTGTGAGCTGGACATCGATGAGTGTGCCTCCCGGCCT
TGCCACCATGGGGGCACCTGCCGAAATCTGGCAGATCACTACGAGTGCCACTGCCCCCTCGGCT
ATGCAGGCGTGACCTGTGAGGCGGAGGTGGACGAGTGCTCATCAGCGCCCTGCCTGCACGGAGG
CTCGTGCCTGGACGGTGTGGGCTCCTACCGCTGTGTGTGCGCACCTGGATACGCCGGCGCGAGC
TGTCAGCTGGACGTGGACGAGTGCCAGAGCCAGCCGTGCGAGCACGGTGGCGTGTGTCACGACC
TGGTCAACGGTTTCCGGTGCGACTGTGCGGACACGGGTTACGAAGGCGCGCGCTGTGAGCAGGA
GGTGCTGGAGTGCGCCTCTGCGCCCTGCGTGCACAACGCATCCTGCCTCGACGGCTTCCGGAGC
TTCCGCTGCCTCTGCTGGCCAGGCTTCAGTGGAGAGCGGTGCGAAGTGGATGAGGATGAGTGTG
CATCGGATCCCTGTCATAATGGGGGCCGGTGCTCGCAGCGCTCTGACCCGACCTTGTATGGGGG
TGTTCAGGCCATCTTCCCCGGAGCCTTCAGCTTCAGCCAAGCCGCTGGCTTCCTTTGCAGCTGT
CCTCCGGGCTTTGCTGGACTGACATGTCAGGAGGATACGGACGAGTGCCAGTCGGAACCATGCC
TGCACGGTGGGACCTGCAGCGACACTGTAGCAGGCTACATCTGCCAGTGCCCCGAGGCCTGGGG
TGGACATGACTGTTCTGTGCAGCTCACAGGCTGCCAGGGCCACGCCTGCCCACTGGCTGCCACC
TGCATCCCCACCTTCAAGTCTGGTTTCCACAGTTATATCTGCCGTTGCCTGCCTGGGACCTATG
GGTCTTTCTGTGACCAGAATACCACTTTCTCGGTTGTGTCTGGGAGTTCCGTGTGGGGATTGGT
GCCAGCTGGTGCCTCCCTGGCTTTTGCACTGAGATTTCGTACCACCCTGCTTGCTGGAGCCCTG
GCTACTCTTAAGGACTCACGGGACAGCTTGGAGCTGGTTCTGGTGGGGGCCATGCTCCAAGCCA
CACTCTGGAGACGTGGCACTGCTGACCTTGTCCTTACACTGCCAGACCTAGCCTTAAATGACGG
GCATTGGCATCAGGTGGAAGTGACACTCCGCCTGGGAACCCTGGAGCTGCGGCTCTGGCATGAG
GGCTGCCCTGGCCAGCTCTGTGTGGTCTCTGGCACTGTGGCTACAGATCCTACAGCCTCGGTGG
CTTCTGGGTCTCCGGAGCCCTACTCCATCCATTTGGGCGGCAGGGCCTTTGCAGGCTGCTTCCA
GGATGTGCGTGTGGAAGGGCACCTTCTGCTGCCTGAGGAGCTCAAGGGAAGTGTGCTCCTGGGT
TGTGAGCGCACAGAGCCTTGCCAACCTCTGCCCTGTGCCAATGGAGGGGCCTGTGTGGACCTGT
GGACTGACTTCCGCTGCGACTGCCCGAGACCTTACCATGGGTCCAAGTGCACTGATGAGGTTCC
TGCTGCCACCTTTGGCTTGGGCGGTGTCATGAGCTCAGCCACCTTCCTGCTCCACCAGATGCTA
GGCCCGAACCTCACCGTGTCGTTTTTCCTCCGCACTCGTGAGCCCGCCAGCCTGTTGCTCCAGT
TTGCCAATGATTCAGTTGCTAGCCTAACTGTGTCCCTGAGTGAGGGCCAGATCCGGGCAGAGGT
GCTGGGTCATCCTGCTGTGATCCTCCCTGGGCGCCGGGATGATGGACTCCGTCACTTGGTGGTG
CTCAGCTTTGGGCCTGACCAGCTCCAGGACCTGGGCCAGTGGCTGTATGTGGGTGGGAGGCTCT
ACCCTGATGATACCCAGCCCTGGGGTGGGCCCTTCCGAGGCTGTCTCCAGGACCTACAACTCAA
CGGCATCCACCTCCCCTTCTTCTCTTCTCCCATGGAGAACTCAAGTTGGCCCAGTGAACTGGAA
GCTGGTCAGTCCTCCAACCTCACCCAGGGCTGTGTCTCTGAGGACACGTGCAATCCCAATCCCT
GTTTCAATGGTGGAACATGCCACATCACCTGGAATGACTTCTACTGCACTTGCCCTGACAACTT
CACGGGGCCCACCTGTGCCCAGCAGCGATGGTGCCCCAGGCAGCCATGCCTGCCGCCTGCCACC
TGTGAGGAGGTTCCAGATGGCTTTGTGTGTGTGGCCGAAGCCACGTTCCGCGAGGGCCCTCCTG
CTGTGTTCACAGGCCACAACGTGTCCTCATCGCGCGCGCTCAGCAGGGTCACCCTGGCCTTCCG
CACACGCGACCTGGAGGCTGGGCTGCTGCGCGCTGCCTCTGCCGCGGGTGCCCACTCCAATATC
TGGCTGGCGGTGCGCAATGGCTTGCTGGCAGTAGATGTGGCGGGCTCGGTGCTGCCGGCGCCCG
GGCCGCGCGTGGCTGACGGTGCCTGGCATCGCGTGCGCCTAGCCCGGGAGTTTCCACAGGCCGC
CGCCTCACGCTGGCTGCTGTGGCTGGACGGCGCGGCGACACCCGTGGCTTTGCACGGCTTGGGC
GGCGACCTGGGTTTCCTTCAGGGCCCGGGTGCCGTGCCTCTGCTACTGGCCGAGAACTTCACGG
GCTGCCTGGGCCGGGTGGCGCTCGGCGACCTCCCCTTACCCTTGGCGCCACCGCGGTCCGGCGC
GATGTCTGGGGCACGCGAGCACTTCATGGCTTGGCCTGGGTCTCCGCCGGCAGTGAGCCTAGGC
TGCCGGGGCGGGCCAGTATGCACGCCCTCGCCCTGCCTGCACGGCGGTGCCTGCCTCGACCTCT
TCGACGTCTTTGCTTGTTCCTGCGGCCCCGCCTGGGAAGGACCCCGCTGCGAGATCCACGCTGA
TCCATGTCGCTCATCGCCCTGTGTCCGGGGCCAATGCAACACGCGCCCGGACGGCCGCTTCGAG
TGTCGGTGCCCTCCGGGTTTCTCCGGCCCGCGCTGCAGGTTGCCTACCTTGCCTCAGGGGTGTA
GCCTCAACTCCACCTGCAAGGATGGTGCCCCTTGTGGGGGTGGCCCCTTAGGCACTAACTGCAG
TTGCCAGGAAGGCCTTGCTGGCCTCAGATGTCAGAGTCTTGACCAACCCTGTGAAGCCAGTCCT
TGCTTGAATGGGGGCACCTGCCGGGTGACCAGTGGCATATTTGAATGTACTTGCAGTGCAGGAT
TCTCTGGCCAGTTCTGTGAAGTGGTGAAAACCCTGCCTCTGCCTCTGCCATTCCCACTGCTGGA
GGTAGCAGTGCCTGCAGCCTGTGCCTGCCTCCTCCTCCTCCTCCTGGGCCTCCTCTCAGGAATT
CTGGCTGCCAGAAAGCGCCGCCAGTCTGAGGGCACTTACAGCCCAAGTCAGCAGGAGGTAGCTG
GGGCTCGTCTGGAGATGGACAGTGTCCTCAAGGTGCCACCAGAGGAGAGACTTATCTAGGCTTG
GCTGGCTGCTATGTCCTGAAGGCCCCACAGGGTCACCACAGAACTTCTACCTGGAGACCCAAGG
AGACTGTTTCCAGAGATGGGACATCCACAGGATGTGCCCCGGTGGCTGGCAGCCCTTGCCCTGT
CCATCCATGGACTCAGGAAGTGGGAAACGACTCAGGGAAGCAGAGAAGGCTGTGAGGGAATGCA
CCTCTCTGACCTGCTGGGCTGTATACAGGGCACACGTGGGTGTCCATGGTATGACAGGGTGTGT
GCGTGTGTGTTTGTGTGCATCTTTCTGTTTGGGGAAGAAAGGAGAGGAAGAAAGAGAATATACA
TGGGGATGTGTTGGTCAGCAGATTGTAATGTGTTATGACTGTGGTAAGAGCTTCATGTCTGGGG
ACAACCCAGATGGATACCTCTGAGACAGGGGCAGCCCAAGGCTGCACGTTCTCTCACACTGAAC
TGGCCACAGCTTACCCAAGCACCTAGACTTTGGTCTTGACATCTTGTTCTCCAAGGACAGCCCT
TATCCTGGGGAAGCTGGGAAATAGAGGAGTATCCTTGGTTTCCAGAACAAAAGCCCTTTGGGGT
AGATCTGACTTGACAGTGCTATGGCCATGGCTGTAGGGCAGGTCTGCAGGAACCATGGAGCAGC
TGCCCTGGGCTGTCCTGCCTGCTGTGGGCACTTGCTGGAGTGGAGCAACCTGTCTGCCTACCTC
ACGAGGGAGGCTATTCTGAGGATCCGAGAGACAAACAGGCAGAAAACTTCAGAAGTCATTAAAA
TTCCATTCTGATGGAAAGAACTGGTGCCCTTTTGGGTGTTGGAAAGTGGCTCACCTGCCTAGAG
TTGAAAGGACTTCTTGGGACCTTGGAAAGGAGGCAGAAGGATGGAGATGTCTTTCTCCCCTGTC
CCTGGCCCCTGCAGACTCACCATCTTGTGGTTCTCCAGCGCAGGCTACCCCTTTGCCTGCAGTT
CTGTTGCCAAGGAAGACCTCTGTTGTGTGCCAAACAGCAGTACCCGGCAGATGGACCGCAGGCA
GCTTCTGCACTGGTGCTCGTCCTGTGACTACTCAGTGTGCTTGACTTCTGATACCCCCTGCCCC
AAGCACTGGCCTGCAGGTTTAGCCTCCCTGAAACCTCCCAGAGCCCTCTGACTTGGAGAGGTGT
CCTTTGTCTTCCTTGTTTACCAGGAGTTTCCACGTGCAAATGCCAAGTGACTTTTACACATGGA
AGCTGGCTGTTTCAAGGTTTCAGCCGGCTCAGAAGGCAGACGTGGGCTTTGATATGAGACCCTG
GATGCTAAGCTAGGAGGCCTGCTTGGTTCTTACCCTGTAGTGGTGGGACCACTTCGCCATCAGC
TGTCTCCATGTCCCTTGGGAGAGGGAAGAGGAAACAGGCTCCTGTGTGAACTGTTGCAGTTGCC
AGCTCCCAAGATGTTTCCTGTGGAATGCCAACTCGATGAAACATTCCAGTTCCACGTCAGTGTC
ACCAATGTGGCCTACACAAGTACTCACTTGGGGTAGATGCTGTTCTTGCTGAGATATGGCGGAG
GGGTGGAACTTGTTCGTTCGTATAGTCCTGCCCCCTGCTCATCTATAATCCCTCACTGGGAGGG
ATGGTGGCTCAGAGCCTCAGGTATGCATAGGCTGGAGTGCAGTGGCCTCTACTTCTGCAGGATG
GCTGGTGGAGATGAGTACCTGCTCAGGCTCCCCATGCCCAGAGCTCCTTGAAGGACTCGGGACT
ACAGTCCTCTGCCCAGTTTCAGTGACCACATCTAGAGTTCATCATTGGGACTGCAGCTTCTACC
CGGTGAGATGGACAGGTGACAACAAACATGTGCAGTGGGCCACAGGTGTCTGCTGCTTCCTAGG
CTGCCCCACACCTCGTCACCCTACTGCCCACTGCTTCATCTTGTGTGGAGCCCAGAGTTTGCTG
GGGTGGAGGAAGTGGAGCTGAGACCTGTCCTGAAACACCAGGATGCCAGGAGGCTTTCCATGAC
CCAGGAGAGACTGCTGTCTAGTGGCTGAGCACACCAAGACAGAGCCCTGGGCGGGATGGGGGGG
CTCTGGCCTAGGCCTCAGGGACCCATAAACCTCTCAGACACAGAGAGGGTCCCTAAAGTGATAG
GGACCTCTGATGACTCCACCCCCGTGTTCCCAACCCCCAGAAACCCTGGGGTTGGCTGTCTGAC
CATTTACACATAGGAAATGAGAAATCAGGTCAAATGTGCACAATTTCCTGCATGTCTCTGTGGA
TGTTTTCTTAAATGGTTAGTCTGTGTTTTACCTTGGTTTATTGAAAGGAATCAATTTTCAAGAT
TCATCAAATCAATAAGGTAAAAAGGAAAAGCAAGATCAAAGAAACAATAACAAACATTTCATTA
TAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001129233	(Get FASTA)	NCBI Sequence Viewer
	XP_006234165	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00520	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001129233 ⟸ NM_001135761
- Peptide Label:	precursor
- UniProtKB:	D4A3W2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALLGPVIWGFRRDVYLLLLLLLLLLPPWVPAGLVPSETPNVCASDPCAPGTRCQATESGGFTC EPLELGGCAAQPCHHGALCVPQGPDPNGFRCYCVPGFQGPHCELDIDECASRPCHHGGTCRNLA DHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGASCQLDVDECQSQ PCEHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCVHNASCLDGFRSFRCLCWPGFSG ERCEVDEDECASDPCHNGGRCSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPGFAGDDCSV DVNECASEPCLNGGSCQDLPNGFQCYCQDGYTGLTCQEDTDECQSEPCLHGGTCSDTVAGYICQ CPEAWGGHDCSVQLTGCQGHACPLAATCIPTFKSGFHSYICRCLPGTYGSFCDQNTTFSVVSGS SVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLELVLVGAMLQATLWRRGTADLVLTLPD LALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSGTVATDPTASVASGSPEPYSIHLGGRA FAGCFQDVRVEGHLLLPEELKGSVLLGCERTEPCQPLPCANGGACVDLWTDFRCDCPRPYHGSK CTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLRTREPASLLLQFANDSVASLTVSLSEG QIRAEVLGHPAVILPGRRDDGLRHLVVLSFGPDQLQDLGQWLYVGGRLYPDDTQPWGGPFRGCL QDLQLNGIHLPFFSSPMENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCHITWNDFYC TCPDNFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSRALSR VTLAFRTRDLEAGLLRAASAAGAHSNIWLAVRNGLLAVDVAGSVLPAPGPRVADGAWHRVRLAR EFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDLPLPLA PPRSGAMSGAREHFMAWPGSPPAVSLGCRGGPVCTPSPCLHGGACLDLFDVFACSCGPAWEGPR CEIHADPCRSSPCVRGQCNTRPDGRFECRCPPGFSGPRCRLPTLPQGCSLNSTCKDGAPCGGGP LGTNCSCQEGLAGLRCQSLDQPCEASPCLNGGTCRVTSGIFECTCSAGFSGQFCEVVKTLPLPL PFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEE RLI hide sequence

RefSeq Acc Id:

XP_006234165 ⟸ XM_006234103

- Peptide Label:

isoform X1

- Sequence:

show sequence

MALLGPVIWGFRRDVYLLLLLLLLLLPPWVPAGLVPSETPNVCASDPCAPGTRCQATESGGFTC
EPLELGGCAAQPCHHGALCVPQGPDPNGFRCYCVPGFQGPHCELDIDECASRPCHHGGTCRNLA
DHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGASCQLDVDECQSQ
PCEHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCVHNASCLDGFRSFRCLCWPGFSG
ERCEVDEDECASDPCHNGGRCSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPGFAGLTCQE
DTDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHACPLAATCIPTFKSGFHS
YICRCLPGTYGSFCDQNTTFSVVSGSSVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLE
LVLVGAMLQATLWRRGTADLVLTLPDLALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSG
TVATDPTASVASGSPEPYSIHLGGRAFAGCFQDVRVEGHLLLPEELKGSVLLGCERTEPCQPLP
CANGGACVDLWTDFRCDCPRPYHGSKCTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLR
TREPASLLLQFANDSVASLTVSLSEGQIRAEVLGHPAVILPGRRDDGLRHLVVLSFGPDQLQDL
GQWLYVGGRLYPDDTQPWGGPFRGCLQDLQLNGIHLPFFSSPMENSSWPSELEAGQSSNLTQGC
VSEDTCNPNPCFNGGTCHITWNDFYCTCPDNFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCV
AEATFREGPPAVFTGHNVSSSRALSRVTLAFRTRDLEAGLLRAASAAGAHSNIWLAVRNGLLAV
DVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGA
VPLLLAENFTGCLGRVALGDLPLPLAPPRSGAMSGAREHFMAWPGSPPAVSLGCRGGPVCTPSP
CLHGGACLDLFDVFACSCGPAWEGPRCEIHADPCRSSPCVRGQCNTRPDGRFECRCPPGFSGPR
CRLPTLPQGCSLNSTCKDGAPCGGGPLGTNCSCQEGLAGLRCQSLDQPCEASPCLNGGTCRVTS
GIFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEG
TYSPSQQEVAGARLEMDSVLKVPPEERLI

hide sequence

RefSeq Acc Id:

ENSRNOP00000035420 ⟸ ENSRNOT00000037257

Protein Domains

EGF-like Laminin G

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A3W2-F1-model_v2	AlphaFold	D4A3W2	1-1283	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309368	AgrOrtholog
BioCyc Gene	G2FUF-49921	BioCyc
Ensembl Genes	ENSRNOG00000025498	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000035420	ENTREZGENE
	ENSRNOP00000035420.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037257	ENTREZGENE
	ENSRNOT00000037257.4	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_subgrp	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Laminin_G	UniProtKB/TrEMBL
KEGG Report	rno:366031	UniProtKB/TrEMBL
NCBI Gene	366031	ENTREZGENE
PANTHER	CRUMBS FAMILY MEMBER	UniProtKB/TrEMBL
	PROTEIN CRUMBS HOMOLOG 2	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/TrEMBL
PhenoGen	Crb2	PhenoGen
PRINTS	EGFBLOOD	UniProtKB/TrEMBL
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LamG	UniProtKB/TrEMBL
Superfamily-SCOP	ConA_like_lec_gl	UniProtKB/TrEMBL
	EGF/Laminin	UniProtKB/TrEMBL
UniProt	D4A3W2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Crb2	crumbs cell polarity complex component 2	Crb2	crumbs 2, cell polarity complex component	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-01	Crb2	crumbs 2, cell polarity complex component	Crb2	crumbs family member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-02-13	Crb2	crumbs family member 2	Crb2	crumbs homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-01	Crb2	crumbs homolog 2 (Drosophila)	RGD1309368	similar to 5930402A21 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309368	similar to 5930402A21 protein	RGD1309368_predicted	similar to 5930402A21 protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309368_predicted	similar to 5930402A21 protein (predicted)	LOC366031_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC366031_predicted	similar to 5930402A21 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

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