Crb2 (crumbs cell polarity complex component 2)

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Gene: Crb2 (crumbs cell polarity complex component 2) Rattus norvegicus

Analyze

Symbol:

Crb2

Name:

crumbs cell polarity complex component 2

RGD ID:

1309368

Description:

Predicted to have aspartic-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including embryonic morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and maintenance of epithelial cell apical/basal polarity. Predicted to localize to apical plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2); INTERACTS WITH bisphenol A; furan; 1,2-dichloroethane (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2; crumbs homolog 2 (Drosophila); LOC366031; RGD1309368; similar to 5930402A21 protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	17,436,230 - 17,456,001 (+)	NCBI
Celera	3	19,976,389 - 19,996,310 (+)	NCBI		Celera
Cytogenetic Map	3	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal segmental glomerulosclerosis (ISO)

focal segmental glomerulosclerosis 9 (ISO)

Leber congenital amaurosis (ISO)

nephrotic syndrome type 2 (ISO)

retinitis pigmentosa (ISO,ISS)

ventriculomegaly - cystic kidney disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

cisplatin (ISO)

clobetasol (ISO)

dorsomorphin (ISO)

ethanol (ISO)

formaldehyde (ISO)

furan (EXP)

genistein (ISO)

N-methyl-4-phenylpyridinium (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

sunitinib (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

circulatory system development (ISO,ISS)

establishment of cell polarity (IEA,ISO)

establishment or maintenance of epithelial cell apical/basal polarity (IBA)

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (IBA)

ingression involved in gastrulation with mouth forming second (ISO)

maintenance of epithelial cell apical/basal polarity (ISO,ISS)

mesoderm formation (ISO,ISS)

negative regulation of endopeptidase activity (ISO)

notochord formation (ISO,ISS)

photoreceptor cell maintenance (IEA,ISO)

positive regulation of BMP signaling pathway (ISO,ISS)

positive regulation of epithelial to mesenchymal transition (ISO,ISS)

regulation of gastrulation (ISO)

retina homeostasis (ISO)

retinal cone cell development (IEA,ISO)

somitogenesis (ISO,ISS)

Cellular Component

apical part of cell (ISO)

apical plasma membrane (ISO)

apicolateral plasma membrane (IEA,ISO)

cell junction (IEA,ISO)

cytoplasm (IEA,ISO)

integral component of membrane (IEA)

plasma membrane (IBA)

protein-containing complex (IBA,ISO)

Molecular Function

aspartic-type endopeptidase inhibitor activity (ISO)

calcium ion binding (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

References

References - curated


1.	Alves CH, etal., Hum Mol Genet. 2014 Feb 18.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Pellissier LP, etal., PLoS Genet. 2013 Dec;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.
4.	RGD automated data pipeline
5.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:19056867	PMID:20299451	PMID:22072575	PMID:23376485	PMID:23533145	PMID:25636444	PMID:26496195	PMID:27870829

Genomics

Comparative Map Data

Crb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	17,436,230 - 17,456,001 (+)	NCBI
Celera	3	19,976,389 - 19,996,310 (+)	NCBI		Celera
Cytogenetic Map	3	q11	NCBI

CRB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	123,356,170 - 123,380,324 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	123,354,065 - 123,380,326 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	126,118,448 - 126,141,034 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	125,158,269 - 125,180,853 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	123,198,002 - 123,215,932	NCBI
Celera	9	96,766,676 - 96,789,262 (+)	NCBI
Cytogenetic Map	9	q33.3	NCBI
HuRef	9	95,733,274 - 95,755,982 (+)	NCBI		HuRef
CHM1_1	9	126,267,135 - 126,291,277 (+)	NCBI		CHM1_1

Crb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	37,666,238 - 37,689,115 (+)	NCBI	GRCm39		mm39
GRCm38	2	37,776,225 - 37,799,103 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	37,776,249 - 37,799,103 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	37,631,769 - 37,654,623 (+)	NCBI	GRCm37		mm9	NCBIm37
Celera	2	37,461,524 - 37,484,418 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI

Crb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955419	4,607,507 - 4,626,608 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955419	4,604,883 - 4,626,675 (-)	NCBI	ChiLan1.0	ChiLan1.0

CRB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	123,011,887 - 123,034,544 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	123,011,968 - 123,032,855 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	94,473,423 - 94,511,285 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CRB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	9	59,427,569 - 59,450,434 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	9	59,427,661 - 59,450,436 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Crb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936487	11,793,078 - 11,813,803 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CRB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	264,276,572 - 264,301,725 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	264,277,549 - 264,301,731 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	297,886,591 - 297,910,766 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CRB2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	14,756,897 - 14,782,131 (-)	NCBI
ChlSab1.1 Ensembl	12	14,758,618 - 14,779,514 (-)	Ensembl

Crb2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624760	11,576,683 - 11,598,354 (-)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	6000748	51687917	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	6000748	51687917	Rat
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	28136884	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	3285929	28136884	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	10119318	79772001	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	28500807	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	28500807	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	28500807	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	41510346	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	18023664	63023664	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	25786001	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	39773425	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	2631421	33477544	Rat
2325840	Bp345	Blood pressure QTL 345		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14090411	29084626	Rat
731172	Bp151	Blood pressure QTL 151		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14090411	48562146	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	28500807	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	32972944	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	13126914	36600143	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	6000866	34394121	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	95176874	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10094081	93415837	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	3285929	28136884	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	37891710	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	5654639	25105730	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	2631421	48562146	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	13126914	36600143	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
12879851	Cm92	Cardiac mass QTL 92		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	14090411	48562146	Rat
12879852	Cm93	Cardiac mass QTL 93		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	14090411	48562146	Rat
12879849	Bw180	Body weight QTL 180		0.037	body mass (VT:0001259)	body weight (CMO:0000012)	3	14090411	48562146	Rat
12879853	Am5	Aortic mass QTL 5		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	14090411	48562146	Rat
12879854	Kidm63	Kidney mass QTL 63		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	14090411	48562146	Rat
12879850	Cm91	Cardiac mass QTL 91		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	14090411	48562146	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	75
Count of miRNA genes:	65
Interacting mature miRNAs:	69
Transcripts:	ENSRNOT00000037257
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		6	2	2		2			22	8	6
Low		16	10	8		8			41	27	25	8
Below cutoff	1	17	35	22	18	22	2	2	11		9	3	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07051797	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000037257 ⟹ ENSRNOP00000035420

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	22,038,357 - 22,058,871 (+)	Ensembl

RefSeq Acc Id:

NM_001135761 ⟹ NP_001129233

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	22,038,357 - 22,058,871 (+)	NCBI
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI
RGSC_v3.4	3	17,539,288 - 17,559,629 (+)	RGD
Celera	3	19,976,389 - 19,996,310 (+)	RGD

Sequence:

show sequence

ATGGCGCTGTTGGGGCCTGTGATCTGGGGCTTTAGACGAGATGTCTACCTCCTGTTGCTGCTAC
TGCTGCTGTTGCTGCCGCCCTGGGTCCCGGCTGGGCTGGTTCCTTCAGAGACCCCGAATGTCTG
TGCCTCAGACCCATGTGCTCCAGGGACCAGGTGCCAGGCTACAGAAAGTGGTGGCTTTACCTGT
GAGCCCTTAGAGCTTGGAGGCTGTGCTGCTCAACCGTGCCACCATGGTGCACTGTGTGTGCCCC
AGGGCCCAGATCCTAACGGCTTCCGTTGCTACTGTGTGCCTGGATTCCAGGGACCCCACTGTGA
GCTGGACATCGATGAGTGTGCCTCCCGGCCTTGCCACCATGGGGGCACCTGCCGAAATCTGGCA
GATCACTACGAGTGCCACTGCCCCCTCGGCTATGCAGGCGTGACCTGTGAGGCGGAGGTGGACG
AGTGCTCATCAGCGCCCTGCCTGCACGGAGGCTCGTGCCTGGACGGTGTGGGCTCCTACCGCTG
TGTGTGCGCACCTGGATACGCCGGCGCGAGCTGTCAGCTGGACGTGGACGAGTGCCAGAGCCAG
CCGTGCGAGCACGGTGGCGTGTGTCACGACCTGGTCAACGGTTTCCGGTGCGACTGTGCGGACA
CGGGTTACGAAGGCGCGCGCTGTGAGCAGGAGGTGCTGGAGTGCGCCTCTGCGCCCTGCGTGCA
CAACGCATCCTGCCTCGACGGCTTCCGGAGCTTCCGCTGCCTCTGCTGGCCAGGCTTCAGTGGA
GAGCGGTGCGAAGTGGATGAGGATGAGTGTGCATCGGATCCCTGTCATAATGGGGGCCGGTGCT
CGCAGCGCTCTGACCCGACCTTGTATGGGGGTGTTCAGGCCATCTTCCCCGGAGCCTTCAGCTT
CAGCCAAGCCGCTGGCTTCCTTTGCAGCTGTCCTCCGGGCTTTGCTGGGGATGACTGCAGCGTG
GACGTGAATGAGTGTGCCTCAGAGCCATGTCTCAACGGAGGTAGCTGCCAGGACCTGCCCAATG
GTTTCCAGTGCTACTGTCAGGATGGATACACAGGACTGACATGTCAGGAGGATACGGACGAGTG
CCAGTCGGAACCATGCCTGCACGGTGGGACCTGCAGCGACACTGTAGCAGGCTACATCTGCCAG
TGCCCCGAGGCCTGGGGTGGACATGACTGTTCTGTGCAGCTCACAGGCTGCCAGGGCCACGCCT
GCCCACTGGCTGCCACCTGCATCCCCACCTTCAAGTCTGGTTTCCACAGTTATATCTGCCGTTG
CCTGCCTGGGACCTATGGGTCTTTCTGTGACCAGAATACCACTTTCTCGGTTGTGTCTGGGAGT
TCCGTGTGGGGATTGGTGCCAGCTGGTGCCTCCCTGGCTTTTGCACTGAGATTTCGTACCACCC
TGCTTGCTGGAGCCCTGGCTACTCTTAAGGACTCACGGGACAGCTTGGAGCTGGTTCTGGTGGG
GGCCATGCTCCAAGCCACACTCTGGAGACGTGGCACTGCTGACCTTGTCCTTACACTGCCAGAC
CTAGCCTTAAATGACGGGCATTGGCATCAGGTGGAAGTGACACTCCGCCTGGGAACCCTGGAGC
TGCGGCTCTGGCATGAGGGCTGCCCTGGCCAGCTCTGTGTGGTCTCTGGCACTGTGGCTACAGA
TCCTACAGCCTCGGTGGCTTCTGGGTCTCCGGAGCCCTACTCCATCCATTTGGGCGGCAGGGCC
TTTGCAGGCTGCTTCCAGGATGTGCGTGTGGAAGGGCACCTTCTGCTGCCTGAGGAGCTCAAGG
GAAGTGTGCTCCTGGGTTGTGAGCGCACAGAGCCTTGCCAACCTCTGCCCTGTGCCAATGGAGG
GGCCTGTGTGGACCTGTGGACTGACTTCCGCTGCGACTGCCCGAGACCTTACCATGGGTCCAAG
TGCACTGATGAGGTTCCTGCTGCCACCTTTGGCTTGGGCGGTGTCATGAGCTCAGCCACCTTCC
TGCTCCACCAGATGCTAGGCCCGAACCTCACCGTGTCGTTTTTCCTCCGCACTCGTGAGCCCGC
CAGCCTGTTGCTCCAGTTTGCCAATGATTCAGTTGCTAGCCTAACTGTGTCCCTGAGTGAGGGC
CAGATCCGGGCAGAGGTGCTGGGTCATCCTGCTGTGATCCTCCCTGGGCGCCGGGATGATGGAC
TCCGTCACTTGGTGGTGCTCAGCTTTGGGCCTGACCAGCTCCAGGACCTGGGCCAGTGGCTGTA
TGTGGGTGGGAGGCTCTACCCTGATGATACCCAGCCCTGGGGTGGGCCCTTCCGAGGCTGTCTC
CAGGACCTACAACTCAACGGCATCCACCTCCCCTTCTTCTCTTCTCCCATGGAGAACTCAAGTT
GGCCCAGTGAACTGGAAGCTGGTCAGTCCTCCAACCTCACCCAGGGCTGTGTCTCTGAGGACAC
GTGCAATCCCAATCCCTGTTTCAATGGTGGAACATGCCACATCACCTGGAATGACTTCTACTGC
ACTTGCCCTGACAACTTCACGGGGCCCACCTGTGCCCAGCAGCGATGGTGCCCCAGGCAGCCAT
GCCTGCCGCCTGCCACCTGTGAGGAGGTTCCAGATGGCTTTGTGTGTGTGGCCGAAGCCACGTT
CCGCGAGGGCCCTCCTGCTGTGTTCACAGGCCACAACGTGTCCTCATCGCGCGCGCTCAGCAGG
GTCACCCTGGCCTTCCGCACACGCGACCTGGAGGCTGGGCTGCTGCGCGCTGCCTCTGCCGCGG
GTGCCCACTCCAATATCTGGCTGGCGGTGCGCAATGGCTTGCTGGCAGTAGATGTGGCGGGCTC
GGTGCTGCCGGCGCCCGGGCCGCGCGTGGCTGACGGTGCCTGGCATCGCGTGCGCCTAGCCCGG
GAGTTTCCACAGGCCGCCGCCTCACGCTGGCTGCTGTGGCTGGACGGCGCGGCGACACCCGTGG
CTTTGCACGGCTTGGGCGGCGACCTGGGTTTCCTTCAGGGCCCGGGTGCCGTGCCTCTGCTACT
GGCCGAGAACTTCACGGGCTGCCTGGGCCGGGTGGCGCTCGGCGACCTCCCCTTACCCTTGGCG
CCACCGCGGTCCGGCGCGATGTCTGGGGCACGCGAGCACTTCATGGCTTGGCCTGGGTCTCCGC
CGGCAGTGAGCCTAGGCTGCCGGGGCGGGCCAGTATGCACGCCCTCGCCCTGCCTGCACGGCGG
TGCCTGCCTCGACCTCTTCGACGTCTTTGCTTGTTCCTGCGGCCCCGCCTGGGAAGGACCCCGC
TGCGAGATCCACGCTGATCCATGTCGCTCATCGCCCTGTGTCCGGGGCCAATGCAACACGCGCC
CGGACGGCCGCTTCGAGTGTCGGTGCCCTCCGGGTTTCTCCGGCCCGCGCTGCAGGTTGCCTAC
CTTGCCTCAGGGGTGTAGCCTCAACTCCACCTGCAAGGATGGTGCCCCTTGTGGGGGTGGCCCC
TTAGGCACTAACTGCAGTTGCCAGGAAGGCCTTGCTGGCCTCAGATGTCAGAGTCTTGACCAAC
CCTGTGAAGCCAGTCCTTGCTTGAATGGGGGCACCTGCCGGGTGACCAGTGGCATATTTGAATG
TACTTGCAGTGCAGGATTCTCTGGCCAGTTCTGTGAAGTGGTGAAAACCCTGCCTCTGCCTCTG
CCATTCCCACTGCTGGAGGTAGCAGTGCCTGCAGCCTGTGCCTGCCTCCTCCTCCTCCTCCTGG
GCCTCCTCTCAGGAATTCTGGCTGCCAGAAAGCGCCGCCAGTCTGAGGGCACTTACAGCCCAAG
TCAGCAGGAGGTAGCTGGGGCTCGTCTGGAGATGGACAGTGTCCTCAAGGTGCCACCAGAGGAG
AGACTTATCTAG

hide sequence

RefSeq Acc Id:

XM_006234103 ⟹ XP_006234165

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	22,037,812 - 22,061,247 (+)	NCBI
Rnor_5.0	3	27,273,846 - 27,296,956 (+)	NCBI

Sequence:

show sequence

ACCTTACTGATAGCCTCAAGGACAGGATCTGTGTGGTAGGGTGGGACCCAGGAGGGCAGCAGGG
ACAGGAACCCCTGTGAGAGGAGGGGAGGGGCCTTGATATCTCAGGTGTGGAAGGAGCAGGTTAA
GTAAGGACAGATGGGAGCGCTGAACTAGGAGCACCGAACTGAGGCCAGGCGGGAGGACCAAGGC
CTGAAACTGCCGGGTAGCTGAGCTCTTGCGGGAAATCGGACTAGCCCCAGGCATCCTGGCCCGC
CCCATGGACCGGACTGCCTGGCAAGAGGGCTTGTGCACTGAGACCCAGGGTCAGGCCCAGGGCC
TTGTCTGGAGCTGAGGCCTCCGAAGGGGCTGGAGTCTGTGAAGTGCGGTGGGTCAGACCCTCCG
CGAGGATCCTGCTCCGGGAGGAGCAGTGGGAGGCGGGGCGGAGGGGGAGGGCTGGAGGAGGGGC
CGGGCCTCTGTCCACCTCGTCAGTGCTGGTTGGAGGGACGAAGGGGCGCGGAGCCCGCCGAGCA
GAGGGTTCCCATAGGCAAGCAGAGCCGGCTGCCATGGCGCTGTTGGGGCCTGTGATCTGGGGCT
TTAGACGAGATGTCTACCTCCTGTTGCTGCTACTGCTGCTGTTGCTGCCGCCCTGGGTCCCGGC
TGGGCTGGTTCCTTCAGAGACCCCGAATGTCTGTGCCTCAGACCCATGTGCTCCAGGGACCAGG
TGCCAGGCTACAGAAAGTGGTGGCTTTACCTGTGAGCCCTTAGAGCTTGGAGGCTGTGCTGCTC
AACCGTGCCACCATGGTGCACTGTGTGTGCCCCAGGGCCCAGATCCTAACGGCTTCCGTTGCTA
CTGTGTGCCTGGATTCCAGGGACCCCACTGTGAGCTGGACATCGATGAGTGTGCCTCCCGGCCT
TGCCACCATGGGGGCACCTGCCGAAATCTGGCAGATCACTACGAGTGCCACTGCCCCCTCGGCT
ATGCAGGCGTGACCTGTGAGGCGGAGGTGGACGAGTGCTCATCAGCGCCCTGCCTGCACGGAGG
CTCGTGCCTGGACGGTGTGGGCTCCTACCGCTGTGTGTGCGCACCTGGATACGCCGGCGCGAGC
TGTCAGCTGGACGTGGACGAGTGCCAGAGCCAGCCGTGCGAGCACGGTGGCGTGTGTCACGACC
TGGTCAACGGTTTCCGGTGCGACTGTGCGGACACGGGTTACGAAGGCGCGCGCTGTGAGCAGGA
GGTGCTGGAGTGCGCCTCTGCGCCCTGCGTGCACAACGCATCCTGCCTCGACGGCTTCCGGAGC
TTCCGCTGCCTCTGCTGGCCAGGCTTCAGTGGAGAGCGGTGCGAAGTGGATGAGGATGAGTGTG
CATCGGATCCCTGTCATAATGGGGGCCGGTGCTCGCAGCGCTCTGACCCGACCTTGTATGGGGG
TGTTCAGGCCATCTTCCCCGGAGCCTTCAGCTTCAGCCAAGCCGCTGGCTTCCTTTGCAGCTGT
CCTCCGGGCTTTGCTGGACTGACATGTCAGGAGGATACGGACGAGTGCCAGTCGGAACCATGCC
TGCACGGTGGGACCTGCAGCGACACTGTAGCAGGCTACATCTGCCAGTGCCCCGAGGCCTGGGG
TGGACATGACTGTTCTGTGCAGCTCACAGGCTGCCAGGGCCACGCCTGCCCACTGGCTGCCACC
TGCATCCCCACCTTCAAGTCTGGTTTCCACAGTTATATCTGCCGTTGCCTGCCTGGGACCTATG
GGTCTTTCTGTGACCAGAATACCACTTTCTCGGTTGTGTCTGGGAGTTCCGTGTGGGGATTGGT
GCCAGCTGGTGCCTCCCTGGCTTTTGCACTGAGATTTCGTACCACCCTGCTTGCTGGAGCCCTG
GCTACTCTTAAGGACTCACGGGACAGCTTGGAGCTGGTTCTGGTGGGGGCCATGCTCCAAGCCA
CACTCTGGAGACGTGGCACTGCTGACCTTGTCCTTACACTGCCAGACCTAGCCTTAAATGACGG
GCATTGGCATCAGGTGGAAGTGACACTCCGCCTGGGAACCCTGGAGCTGCGGCTCTGGCATGAG
GGCTGCCCTGGCCAGCTCTGTGTGGTCTCTGGCACTGTGGCTACAGATCCTACAGCCTCGGTGG
CTTCTGGGTCTCCGGAGCCCTACTCCATCCATTTGGGCGGCAGGGCCTTTGCAGGCTGCTTCCA
GGATGTGCGTGTGGAAGGGCACCTTCTGCTGCCTGAGGAGCTCAAGGGAAGTGTGCTCCTGGGT
TGTGAGCGCACAGAGCCTTGCCAACCTCTGCCCTGTGCCAATGGAGGGGCCTGTGTGGACCTGT
GGACTGACTTCCGCTGCGACTGCCCGAGACCTTACCATGGGTCCAAGTGCACTGATGAGGTTCC
TGCTGCCACCTTTGGCTTGGGCGGTGTCATGAGCTCAGCCACCTTCCTGCTCCACCAGATGCTA
GGCCCGAACCTCACCGTGTCGTTTTTCCTCCGCACTCGTGAGCCCGCCAGCCTGTTGCTCCAGT
TTGCCAATGATTCAGTTGCTAGCCTAACTGTGTCCCTGAGTGAGGGCCAGATCCGGGCAGAGGT
GCTGGGTCATCCTGCTGTGATCCTCCCTGGGCGCCGGGATGATGGACTCCGTCACTTGGTGGTG
CTCAGCTTTGGGCCTGACCAGCTCCAGGACCTGGGCCAGTGGCTGTATGTGGGTGGGAGGCTCT
ACCCTGATGATACCCAGCCCTGGGGTGGGCCCTTCCGAGGCTGTCTCCAGGACCTACAACTCAA
CGGCATCCACCTCCCCTTCTTCTCTTCTCCCATGGAGAACTCAAGTTGGCCCAGTGAACTGGAA
GCTGGTCAGTCCTCCAACCTCACCCAGGGCTGTGTCTCTGAGGACACGTGCAATCCCAATCCCT
GTTTCAATGGTGGAACATGCCACATCACCTGGAATGACTTCTACTGCACTTGCCCTGACAACTT
CACGGGGCCCACCTGTGCCCAGCAGCGATGGTGCCCCAGGCAGCCATGCCTGCCGCCTGCCACC
TGTGAGGAGGTTCCAGATGGCTTTGTGTGTGTGGCCGAAGCCACGTTCCGCGAGGGCCCTCCTG
CTGTGTTCACAGGCCACAACGTGTCCTCATCGCGCGCGCTCAGCAGGGTCACCCTGGCCTTCCG
CACACGCGACCTGGAGGCTGGGCTGCTGCGCGCTGCCTCTGCCGCGGGTGCCCACTCCAATATC
TGGCTGGCGGTGCGCAATGGCTTGCTGGCAGTAGATGTGGCGGGCTCGGTGCTGCCGGCGCCCG
GGCCGCGCGTGGCTGACGGTGCCTGGCATCGCGTGCGCCTAGCCCGGGAGTTTCCACAGGCCGC
CGCCTCACGCTGGCTGCTGTGGCTGGACGGCGCGGCGACACCCGTGGCTTTGCACGGCTTGGGC
GGCGACCTGGGTTTCCTTCAGGGCCCGGGTGCCGTGCCTCTGCTACTGGCCGAGAACTTCACGG
GCTGCCTGGGCCGGGTGGCGCTCGGCGACCTCCCCTTACCCTTGGCGCCACCGCGGTCCGGCGC
GATGTCTGGGGCACGCGAGCACTTCATGGCTTGGCCTGGGTCTCCGCCGGCAGTGAGCCTAGGC
TGCCGGGGCGGGCCAGTATGCACGCCCTCGCCCTGCCTGCACGGCGGTGCCTGCCTCGACCTCT
TCGACGTCTTTGCTTGTTCCTGCGGCCCCGCCTGGGAAGGACCCCGCTGCGAGATCCACGCTGA
TCCATGTCGCTCATCGCCCTGTGTCCGGGGCCAATGCAACACGCGCCCGGACGGCCGCTTCGAG
TGTCGGTGCCCTCCGGGTTTCTCCGGCCCGCGCTGCAGGTTGCCTACCTTGCCTCAGGGGTGTA
GCCTCAACTCCACCTGCAAGGATGGTGCCCCTTGTGGGGGTGGCCCCTTAGGCACTAACTGCAG
TTGCCAGGAAGGCCTTGCTGGCCTCAGATGTCAGAGTCTTGACCAACCCTGTGAAGCCAGTCCT
TGCTTGAATGGGGGCACCTGCCGGGTGACCAGTGGCATATTTGAATGTACTTGCAGTGCAGGAT
TCTCTGGCCAGTTCTGTGAAGTGGTGAAAACCCTGCCTCTGCCTCTGCCATTCCCACTGCTGGA
GGTAGCAGTGCCTGCAGCCTGTGCCTGCCTCCTCCTCCTCCTCCTGGGCCTCCTCTCAGGAATT
CTGGCTGCCAGAAAGCGCCGCCAGTCTGAGGGCACTTACAGCCCAAGTCAGCAGGAGGTAGCTG
GGGCTCGTCTGGAGATGGACAGTGTCCTCAAGGTGCCACCAGAGGAGAGACTTATCTAGGCTTG
GCTGGCTGCTATGTCCTGAAGGCCCCACAGGGTCACCACAGAACTTCTACCTGGAGACCCAAGG
AGACTGTTTCCAGAGATGGGACATCCACAGGATGTGCCCCGGTGGCTGGCAGCCCTTGCCCTGT
CCATCCATGGACTCAGGAAGTGGGAAACGACTCAGGGAAGCAGAGAAGGCTGTGAGGGAATGCA
CCTCTCTGACCTGCTGGGCTGTATACAGGGCACACGTGGGTGTCCATGGTATGACAGGGTGTGT
GCGTGTGTGTTTGTGTGCATCTTTCTGTTTGGGGAAGAAAGGAGAGGAAGAAAGAGAATATACA
TGGGGATGTGTTGGTCAGCAGATTGTAATGTGTTATGACTGTGGTAAGAGCTTCATGTCTGGGG
ACAACCCAGATGGATACCTCTGAGACAGGGGCAGCCCAAGGCTGCACGTTCTCTCACACTGAAC
TGGCCACAGCTTACCCAAGCACCTAGACTTTGGTCTTGACATCTTGTTCTCCAAGGACAGCCCT
TATCCTGGGGAAGCTGGGAAATAGAGGAGTATCCTTGGTTTCCAGAACAAAAGCCCTTTGGGGT
AGATCTGACTTGACAGTGCTATGGCCATGGCTGTAGGGCAGGTCTGCAGGAACCATGGAGCAGC
TGCCCTGGGCTGTCCTGCCTGCTGTGGGCACTTGCTGGAGTGGAGCAACCTGTCTGCCTACCTC
ACGAGGGAGGCTATTCTGAGGATCCGAGAGACAAACAGGCAGAAAACTTCAGAAGTCATTAAAA
TTCCATTCTGATGGAAAGAACTGGTGCCCTTTTGGGTGTTGGAAAGTGGCTCACCTGCCTAGAG
TTGAAAGGACTTCTTGGGACCTTGGAAAGGAGGCAGAAGGATGGAGATGTCTTTCTCCCCTGTC
CCTGGCCCCTGCAGACTCACCATCTTGTGGTTCTCCAGCGCAGGCTACCCCTTTGCCTGCAGTT
CTGTTGCCAAGGAAGACCTCTGTTGTGTGCCAAACAGCAGTACCCGGCAGATGGACCGCAGGCA
GCTTCTGCACTGGTGCTCGTCCTGTGACTACTCAGTGTGCTTGACTTCTGATACCCCCTGCCCC
AAGCACTGGCCTGCAGGTTTAGCCTCCCTGAAACCTCCCAGAGCCCTCTGACTTGGAGAGGTGT
CCTTTGTCTTCCTTGTTTACCAGGAGTTTCCACGTGCAAATGCCAAGTGACTTTTACACATGGA
AGCTGGCTGTTTCAAGGTTTCAGCCGGCTCAGAAGGCAGACGTGGGCTTTGATATGAGACCCTG
GATGCTAAGCTAGGAGGCCTGCTTGGTTCTTACCCTGTAGTGGTGGGACCACTTCGCCATCAGC
TGTCTCCATGTCCCTTGGGAGAGGGAAGAGGAAACAGGCTCCTGTGTGAACTGTTGCAGTTGCC
AGCTCCCAAGATGTTTCCTGTGGAATGCCAACTCGATGAAACATTCCAGTTCCACGTCAGTGTC
ACCAATGTGGCCTACACAAGTACTCACTTGGGGTAGATGCTGTTCTTGCTGAGATATGGCGGAG
GGGTGGAACTTGTTCGTTCGTATAGTCCTGCCCCCTGCTCATCTATAATCCCTCACTGGGAGGG
ATGGTGGCTCAGAGCCTCAGGTATGCATAGGCTGGAGTGCAGTGGCCTCTACTTCTGCAGGATG
GCTGGTGGAGATGAGTACCTGCTCAGGCTCCCCATGCCCAGAGCTCCTTGAAGGACTCGGGACT
ACAGTCCTCTGCCCAGTTTCAGTGACCACATCTAGAGTTCATCATTGGGACTGCAGCTTCTACC
CGGTGAGATGGACAGGTGACAACAAACATGTGCAGTGGGCCACAGGTGTCTGCTGCTTCCTAGG
CTGCCCCACACCTCGTCACCCTACTGCCCACTGCTTCATCTTGTGTGGAGCCCAGAGTTTGCTG
GGGTGGAGGAAGTGGAGCTGAGACCTGTCCTGAAACACCAGGATGCCAGGAGGCTTTCCATGAC
CCAGGAGAGACTGCTGTCTAGTGGCTGAGCACACCAAGACAGAGCCCTGGGCGGGATGGGGGGG
CTCTGGCCTAGGCCTCAGGGACCCATAAACCTCTCAGACACAGAGAGGGTCCCTAAAGTGATAG
GGACCTCTGATGACTCCACCCCCGTGTTCCCAACCCCCAGAAACCCTGGGGTTGGCTGTCTGAC
CATTTACACATAGGAAATGAGAAATCAGGTCAAATGTGCACAATTTCCTGCATGTCTCTGTGGA
TGTTTTCTTAAATGGTTAGTCTGTGTTTTACCTTGGTTTATTGAAAGGAATCAATTTTCAAGAT
TCATCAAATCAATAAGGTAAAAAGGAAAAGCAAGATCAAAGAAACAATAACAAACATTTCATTA
TAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001129233	(Get FASTA)	NCBI Sequence Viewer
	XP_006234165	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00520	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001129233 ⟸ NM_001135761
- Peptide Label:	precursor
- UniProtKB:	D4A3W2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALLGPVIWGFRRDVYLLLLLLLLLLPPWVPAGLVPSETPNVCASDPCAPGTRCQATESGGFTC EPLELGGCAAQPCHHGALCVPQGPDPNGFRCYCVPGFQGPHCELDIDECASRPCHHGGTCRNLA DHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGASCQLDVDECQSQ PCEHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCVHNASCLDGFRSFRCLCWPGFSG ERCEVDEDECASDPCHNGGRCSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPGFAGDDCSV DVNECASEPCLNGGSCQDLPNGFQCYCQDGYTGLTCQEDTDECQSEPCLHGGTCSDTVAGYICQ CPEAWGGHDCSVQLTGCQGHACPLAATCIPTFKSGFHSYICRCLPGTYGSFCDQNTTFSVVSGS SVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLELVLVGAMLQATLWRRGTADLVLTLPD LALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSGTVATDPTASVASGSPEPYSIHLGGRA FAGCFQDVRVEGHLLLPEELKGSVLLGCERTEPCQPLPCANGGACVDLWTDFRCDCPRPYHGSK CTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLRTREPASLLLQFANDSVASLTVSLSEG QIRAEVLGHPAVILPGRRDDGLRHLVVLSFGPDQLQDLGQWLYVGGRLYPDDTQPWGGPFRGCL QDLQLNGIHLPFFSSPMENSSWPSELEAGQSSNLTQGCVSEDTCNPNPCFNGGTCHITWNDFYC TCPDNFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCVAEATFREGPPAVFTGHNVSSSRALSR VTLAFRTRDLEAGLLRAASAAGAHSNIWLAVRNGLLAVDVAGSVLPAPGPRVADGAWHRVRLAR EFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGAVPLLLAENFTGCLGRVALGDLPLPLA PPRSGAMSGAREHFMAWPGSPPAVSLGCRGGPVCTPSPCLHGGACLDLFDVFACSCGPAWEGPR CEIHADPCRSSPCVRGQCNTRPDGRFECRCPPGFSGPRCRLPTLPQGCSLNSTCKDGAPCGGGP LGTNCSCQEGLAGLRCQSLDQPCEASPCLNGGTCRVTSGIFECTCSAGFSGQFCEVVKTLPLPL PFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEE RLI hide sequence

RefSeq Acc Id:

XP_006234165 ⟸ XM_006234103

- Peptide Label:

isoform X1

- Sequence:

show sequence

MALLGPVIWGFRRDVYLLLLLLLLLLPPWVPAGLVPSETPNVCASDPCAPGTRCQATESGGFTC
EPLELGGCAAQPCHHGALCVPQGPDPNGFRCYCVPGFQGPHCELDIDECASRPCHHGGTCRNLA
DHYECHCPLGYAGVTCEAEVDECSSAPCLHGGSCLDGVGSYRCVCAPGYAGASCQLDVDECQSQ
PCEHGGVCHDLVNGFRCDCADTGYEGARCEQEVLECASAPCVHNASCLDGFRSFRCLCWPGFSG
ERCEVDEDECASDPCHNGGRCSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPGFAGLTCQE
DTDECQSEPCLHGGTCSDTVAGYICQCPEAWGGHDCSVQLTGCQGHACPLAATCIPTFKSGFHS
YICRCLPGTYGSFCDQNTTFSVVSGSSVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLE
LVLVGAMLQATLWRRGTADLVLTLPDLALNDGHWHQVEVTLRLGTLELRLWHEGCPGQLCVVSG
TVATDPTASVASGSPEPYSIHLGGRAFAGCFQDVRVEGHLLLPEELKGSVLLGCERTEPCQPLP
CANGGACVDLWTDFRCDCPRPYHGSKCTDEVPAATFGLGGVMSSATFLLHQMLGPNLTVSFFLR
TREPASLLLQFANDSVASLTVSLSEGQIRAEVLGHPAVILPGRRDDGLRHLVVLSFGPDQLQDL
GQWLYVGGRLYPDDTQPWGGPFRGCLQDLQLNGIHLPFFSSPMENSSWPSELEAGQSSNLTQGC
VSEDTCNPNPCFNGGTCHITWNDFYCTCPDNFTGPTCAQQRWCPRQPCLPPATCEEVPDGFVCV
AEATFREGPPAVFTGHNVSSSRALSRVTLAFRTRDLEAGLLRAASAAGAHSNIWLAVRNGLLAV
DVAGSVLPAPGPRVADGAWHRVRLAREFPQAAASRWLLWLDGAATPVALHGLGGDLGFLQGPGA
VPLLLAENFTGCLGRVALGDLPLPLAPPRSGAMSGAREHFMAWPGSPPAVSLGCRGGPVCTPSP
CLHGGACLDLFDVFACSCGPAWEGPRCEIHADPCRSSPCVRGQCNTRPDGRFECRCPPGFSGPR
CRLPTLPQGCSLNSTCKDGAPCGGGPLGTNCSCQEGLAGLRCQSLDQPCEASPCLNGGTCRVTS
GIFECTCSAGFSGQFCEVVKTLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEG
TYSPSQQEVAGARLEMDSVLKVPPEERLI

hide sequence

RefSeq Acc Id:

ENSRNOP00000035420 ⟸ ENSRNOT00000037257

Protein Domains

EGF-like LAM_G_DOMAIN

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	27288387	27288388	C	T	snv	ACI/EurMcwi (MCW), ZFDM (KyushuU), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), ACI/N (KNAW), ACI/EurMcwi (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), SHR/NCrlPrin (KNAW), SHR/NHsd (KNAW), SHR/OlaIpcv (KNAW), SHR/OlaIpcvPrin (KNAW), SHRSP/Gcrc (KNAW), F344/NRrrc (Illumina) (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), GK/Ox (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), MNS/Gib (KNAW), WN/N (KNAW), SDLEF7/Barth (UDEL), LE/OrlBarth (UDEL), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), COP/CrCrl (MCW & UW)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	22052678	22052679	C	T	snv	ACI/EurMcwi (MCW), WAG/Rij (RGD), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDR, CDS, ACI/N (MCW), Buf/N (MCW), F344/NRrrc (MCW), MR/N (MCW), WN/N (MCW), ACI/EurMcwi (RGD), BBDP/Wor (RGD), F344/NCrl (RGD), GK/Ox (RGD), LE/Stm (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LH/MavRrrc (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SHR/NHsd (RGD), SHRSP/Gcrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), COP/CrCrl (MCW & UW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	17553436	17553437	C	T	snv	SHR/OlaIpcv (ICL), DA/BklArbNsi (ICAHN), SS/JrHsdMcwi (MDC), ACI/N (KNAW), BUF/N (KNAW), F344/NRrrc (KNAW), LE/Stm (KNAW), MR/N (KNAW), WN/N (KNAW), SHR/OlaIpcv (KNAW), ACI/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), COP/CrCrl (MCW & UW), GH/OmrMcwi (MCW), ACI/EurMcwi (ICL), BBDP/WorN (ICL), F344/NCrl (ICL), LE/Stm (ICL), GK/Ox (ICL), LEW/Crl (ICL), LEW/NCrl (ICL), LH/MavRrrc (ICL), MHS/Gib (ICL), MNS/Gib (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), SHR/OlaIpcv (ICL), SHR/NHsd (ICL), SHRSP/Gcrc (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WAG/Rij (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), F344/NHsd (ICAHN), SHRSP/Gcrc (MDC)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309368	AgrOrtholog
Ensembl Genes	ENSRNOG00000025498	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000035420	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000037257	ENTREZGENE, UniProtKB/TrEMBL
InterPro	ConA-like_subgrp	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_Ca-bd	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Laminin_G	UniProtKB/TrEMBL
KEGG Report	rno:366031	UniProtKB/TrEMBL
NCBI Gene	366031	ENTREZGENE
Pfam	EGF	UniProtKB/TrEMBL
	Laminin_G_2	UniProtKB/TrEMBL
PhenoGen	Crb2	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LAM_G_DOMAIN	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	LamG	UniProtKB/TrEMBL
Superfamily-SCOP	ConA_like_lec_gl	UniProtKB/TrEMBL
UniGene	Rn.195474	ENTREZGENE
UniProt	D4A3W2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-12-04	Crb2	crumbs cell polarity complex component 2	Crb2	crumbs 2, cell polarity complex component	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-01	Crb2	crumbs 2, cell polarity complex component	Crb2	crumbs family member 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-02-13	Crb2	crumbs family member 2	Crb2	crumbs homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-01	Crb2	crumbs homolog 2 (Drosophila)	RGD1309368	similar to 5930402A21 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	RGD1309368	similar to 5930402A21 protein	RGD1309368_predicted	similar to 5930402A21 protein (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-20	RGD1309368_predicted	similar to 5930402A21 protein (predicted)	LOC366031_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC366031_predicted	similar to 5930402A21 protein (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM