Crb2 (crumbs cell polarity complex component 2) - Rat Genome Database

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Gene: Crb2 (crumbs cell polarity complex component 2) Chinchilla lanigera
Analyze
Symbol: Crb2
Name: crumbs cell polarity complex component 2
RGD ID: 8991785
Description: ENCODES a protein that exhibits aspartic-type endopeptidase inhibitor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN circulatory system development (ortholog); establishment of cell polarity (ortholog); ingression involved in gastrulation with mouth forming second (ortholog); ASSOCIATED WITH focal segmental glomerulosclerosis (ortholog); focal segmental glomerulosclerosis 9 (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); apicolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: crumbs 2, cell polarity complex component; crumbs family member 2; crumbs homolog 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554194,607,507 - 4,626,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554194,604,883 - 4,626,675 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Crb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554194,607,507 - 4,626,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554194,604,883 - 4,626,675 (-)NCBIChiLan1.0ChiLan1.0
CRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389123,354,065 - 123,380,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9123,356,170 - 123,380,324 (+)EnsemblGRCh38hg38GRCh38
GRCh379126,118,476 - 126,142,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,158,269 - 125,180,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 349123,198,002 - 123,215,932NCBI
Celera996,766,676 - 96,789,262 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef995,733,274 - 95,755,982 (+)NCBIHuRef
CHM1_19126,267,137 - 126,289,699 (+)NCBICHM1_1
T2T-CHM13v2.09135,551,766 - 135,578,059 (+)NCBIT2T-CHM13v2.0
Crb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,666,238 - 37,689,115 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl237,666,261 - 37,689,115 (+)EnsemblGRCm39 Ensembl
GRCm38237,776,225 - 37,799,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,776,249 - 37,799,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv37237,631,769 - 37,654,623 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera237,461,524 - 37,484,418 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
Crb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8341,946,694 - 41,974,629 (+)NCBIGRCr8
mRatBN7.2321,542,138 - 21,564,876 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl321,542,221 - 21,563,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,010,380 - 25,030,705 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0333,595,339 - 33,615,663 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0331,407,370 - 31,427,643 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0322,037,812 - 22,061,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,038,357 - 22,058,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0327,273,846 - 27,296,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,539,288 - 17,559,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1317,436,230 - 17,456,001 (+)NCBI
Celera319,976,389 - 19,996,310 (+)NCBICelera
Cytogenetic Map3q11NCBI
CRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,966,284 - 16,003,414 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1915,968,928 - 16,005,767 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0994,473,423 - 94,511,285 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19123,011,887 - 123,034,544 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,011,968 - 123,032,855 (+)Ensemblpanpan1.1panPan2
CRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1959,427,661 - 59,450,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl959,427,569 - 59,450,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha958,621,652 - 58,645,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0960,346,151 - 60,370,373 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl960,346,149 - 60,370,391 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,104,766 - 59,129,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0959,420,335 - 59,444,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0959,512,745 - 59,536,914 (-)NCBIUU_Cfam_GSD_1.0
Crb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,024,531 - 192,047,256 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648711,793,005 - 11,812,934 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648711,793,078 - 11,813,803 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1264,276,987 - 264,301,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11264,277,549 - 264,301,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21297,886,591 - 297,910,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11214,756,897 - 14,782,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1214,758,618 - 14,779,514 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660791,290,401 - 1,312,970 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476011,579,163 - 11,598,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476011,576,683 - 11,598,354 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000022935   ⟹   ENSCLAP00000022726
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554194,607,507 - 4,626,608 (-)Ensembl
RefSeq Acc Id: XM_005382918   ⟹   XP_005382975
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554194,604,883 - 4,626,675 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382975 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000022726
  ENSCLAP00000022726.1
Reference Protein Sequences
RefSeq Acc Id: XP_005382975   ⟸   XM_005382918
- UniProtKB: A0A8C2W160 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000022726   ⟸   ENSCLAT00000022935
Protein Domains
EGF-like   Laminin G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000015580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000022935 ENTREZGENE
  ENSCLAT00000022935.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
NCBI Gene Crb2 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A8C2W160 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-29 Crb2  crumbs cell polarity complex component 2    crumbs 2, cell polarity complex component  Symbol and/or name change 5135510 APPROVED
2016-08-03 Crb2  crumbs 2, cell polarity complex component    crumbs family member 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Crb2  crumbs family member 2    crumbs homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED