Crb2 (crumbs family member 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Crb2 (crumbs family member 2) Mus musculus
Analyze
Symbol: Crb2
Name: crumbs family member 2
RGD ID: 1551852
MGI Page MGI
Description: Predicted to enable aspartic-type endopeptidase inhibitor activity. Involved in several processes, including embryonic morphogenesis; maintenance of epithelial cell apical/basal polarity; and photoreceptor cell maintenance. Located in several cellular components, including apical plasma membrane; apicolateral plasma membrane; and cell junction. Part of subapical complex. Is active in apical part of cell. Is expressed in early conceptus and embryo. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 9 and ventriculomegaly - cystic kidney disease. Orthologous to human CRB2 (crumbs cell polarity complex component 2); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5930402A21; BC043114; crumbs homolog 2; crumbs-like protein 2; crumbs2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,666,238 - 37,689,115 (+)NCBIGRCm39mm39
GRCm39 Ensembl237,666,261 - 37,689,115 (+)Ensembl
GRCm38237,776,225 - 37,799,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,776,249 - 37,799,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv37237,631,769 - 37,654,623 (+)NCBIGRCm37mm9NCBIm37
Celera237,461,524 - 37,484,418 (+)NCBICelera
Cytogenetic Map2BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior primitive streak morphology  (IAGP)
abnormal chorioallantoic fusion  (IAGP)
abnormal chorion morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal digestive system development  (IAGP)
abnormal electroretinogram waveform feature  (IAGP)
abnormal embryonic epiblast morphology  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal endoderm development  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal eye physiology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal head fold morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal Muller cell morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal ocular fundus morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal retina morphology  (IAGP)
abnormal retina outer limiting membrane morphology  (IAGP)
abnormal retinal bipolar cell morphology  (IAGP)
abnormal retinal blood vessel morphology  (IAGP)
abnormal retinal cone cell morphology  (IAGP)
abnormal retinal cone cell outer segment morphology  (IAGP)
abnormal retinal development  (IAGP)
abnormal retinal ganglion layer morphology  (IAGP)
abnormal retinal layer morphology  (IAGP)
abnormal retinal neuronal layer morphology  (IAGP)
abnormal retinal outer nuclear layer morphology  (IAGP)
abnormal retinal outer plexiform layer morphology  (IAGP)
abnormal retinal photoreceptor layer morphology  (IAGP)
abnormal retinal pigment epithelium morphology  (IAGP)
abnormal retinal progenitor cell morphology  (IAGP)
abnormal retinal rod cell outer segment morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal somite development  (IAGP)
abnormal vibrissa morphology  (IEA)
abnormal visceral yolk sac blood island morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent heart tube  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased circulating glycerol level  (IEA)
decreased retinal apoptosis  (IAGP)
decreased retinal photoreceptor cell number  (IAGP)
decreased total retina thickness  (IAGP)
dilated brain ventricles  (IAGP)
disorganized retinal layers  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
failure of chorioallantoic fusion  (IAGP)
failure of initiation of embryo turning  (IAGP)
hydrocephaly  (IAGP)
increased amacrine cell number  (IAGP)
increased embryo size  (IAGP)
increased retinal apoptosis  (IAGP)
increased retinal rod cell number  (IAGP)
increased total retina thickness  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
retinal degeneration  (IAGP)
retinal neovascularization  (IAGP)
small allantois  (IAGP)
small amniotic cavity  (IAGP)
thin retinal outer nuclear layer  (IAGP)
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:15489334   PMID:15851977   PMID:16075367   PMID:16141072   PMID:16141073   PMID:16885194   PMID:17507402   PMID:17920587  
PMID:18403412   PMID:20399730   PMID:21267068   PMID:21677750   PMID:21732478   PMID:21873635   PMID:22072575   PMID:22398208   PMID:23001562   PMID:23658188   PMID:24164893   PMID:24324803  
PMID:24565864   PMID:25636444   PMID:25742799   PMID:26235047   PMID:26404741   PMID:26496195   PMID:26631503   PMID:26802325   PMID:27616714   PMID:27870829   PMID:29155075   PMID:29539633  
PMID:29893966   PMID:30076417   PMID:30125302   PMID:31145883   PMID:31438467   PMID:31586559   PMID:31718797   PMID:32150534   PMID:32290105  


Genomics

Comparative Map Data
Crb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39237,666,238 - 37,689,115 (+)NCBIGRCm39mm39
GRCm39 Ensembl237,666,261 - 37,689,115 (+)Ensembl
GRCm38237,776,225 - 37,799,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl237,776,249 - 37,799,103 (+)EnsemblGRCm38mm10GRCm38
MGSCv37237,631,769 - 37,654,623 (+)NCBIGRCm37mm9NCBIm37
Celera237,461,524 - 37,484,418 (+)NCBICelera
Cytogenetic Map2BNCBI
CRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9123,356,170 - 123,380,324 (+)EnsemblGRCh38hg38GRCh38
GRCh389123,354,065 - 123,380,326 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379126,118,476 - 126,142,605 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369125,158,269 - 125,180,853 (+)NCBINCBI36hg18NCBI36
Build 349123,198,002 - 123,215,932NCBI
Celera996,766,676 - 96,789,262 (+)NCBI
Cytogenetic Map9q33.3NCBI
HuRef995,733,274 - 95,755,982 (+)NCBIHuRef
CHM1_19126,267,137 - 126,289,699 (+)NCBICHM1_1
Crb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2321,542,138 - 21,564,876 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl322,038,357 - 22,058,871 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0322,037,812 - 22,061,247 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0327,273,846 - 27,296,956 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4317,539,288 - 17,559,629 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1317,436,230 - 17,456,001 (+)NCBI
Celera319,976,389 - 19,996,310 (+)NCBICelera
Cytogenetic Map3q11NCBI
Crb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554194,607,507 - 4,626,608 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554194,604,883 - 4,626,675 (-)NCBIChiLan1.0ChiLan1.0
CRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19123,011,887 - 123,034,544 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9123,011,968 - 123,032,855 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0994,473,423 - 94,511,285 (+)NCBIMhudiblu_PPA_v0panPan3
CRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1959,427,661 - 59,450,436 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl959,427,569 - 59,450,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha958,621,652 - 58,645,938 (-)NCBI
ROS_Cfam_1.0960,346,151 - 60,370,373 (-)NCBI
UMICH_Zoey_3.1959,104,766 - 59,129,041 (-)NCBI
UNSW_CanFamBas_1.0959,420,335 - 59,444,621 (-)NCBI
UU_Cfam_GSD_1.0959,512,745 - 59,536,914 (-)NCBI
Crb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,024,531 - 192,047,256 (+)NCBI
SpeTri2.0NW_00493648711,793,078 - 11,813,803 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1264,276,572 - 264,301,725 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11264,277,549 - 264,301,731 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21297,886,591 - 297,910,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11214,756,897 - 14,782,131 (-)NCBI
ChlSab1.1 Ensembl1214,758,618 - 14,779,514 (-)Ensembl
Vero_WHO_p1.0NW_0236660791,290,401 - 1,312,970 (+)NCBI
Crb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476011,576,683 - 11,598,354 (-)NCBI

Position Markers
48.MMHAP80FLH6.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38237,779,174 - 37,779,326UniSTSGRCm38
MGSCv37237,634,694 - 37,634,846UniSTSGRCm37
Celera237,464,449 - 37,464,601UniSTS
Cytogenetic Map2BUniSTS
Whitehead_YAC2 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2778910341789249Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2834628442346384Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2841803942418228Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2949443443494563Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2949443443494563Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212472666726109Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21432455548324701Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2123971355239859Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22123971355239859Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22379913357799257Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22470000055000000Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22541803957081799Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22713263056506216Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
14746979Manh51_mmandible shape 51 (mouse)22907111763071117Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22907111763071117Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23131302344618192Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3590731269907394Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3590731269907394Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3590731269907394Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23610166771779068Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1469
Count of miRNA genes:696
Interacting mature miRNAs:885
Transcripts:ENSMUST00000050372, ENSMUST00000137693, ENSMUST00000147600
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050372   ⟹   ENSMUSP00000058007
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl237,776,249 - 37,799,103 (+)Ensembl
RefSeq Acc Id: ENSMUST00000137693
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl237,795,169 - 37,796,616 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147600   ⟹   ENSMUSP00000144709
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl237,791,171 - 37,793,523 (+)Ensembl
RefSeq Acc Id: NM_001163566   ⟹   NP_001157038
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39237,666,261 - 37,689,115 (+)NCBI
GRCm38237,776,249 - 37,799,103 (+)NCBI
MGSCv37237,631,769 - 37,654,623 (+)RGD
Celera237,461,524 - 37,484,418 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_374093
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39237,666,238 - 37,683,201 (+)NCBI
GRCm38237,776,225 - 37,793,189 (+)NCBI
Sequence:
RefSeq Acc Id: XR_866013
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39237,666,238 - 37,683,201 (+)NCBI
GRCm38237,776,225 - 37,793,189 (+)NCBI
Sequence:
RefSeq Acc Id: XR_866014
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39237,666,238 - 37,683,535 (+)NCBI
GRCm38237,776,225 - 37,793,523 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH43114 (Get FASTA)   NCBI Sequence Viewer  
  AAH62128 (Get FASTA)   NCBI Sequence Viewer  
  BAC27237 (Get FASTA)   NCBI Sequence Viewer  
  Q80YA8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001157038   ⟸   NM_001163566
- Peptide Label: precursor
- UniProtKB: Q80YA8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000144709   ⟸   ENSMUST00000147600
RefSeq Acc Id: ENSMUSP00000058007   ⟸   ENSMUST00000050372
Protein Domains
EGF-like   LAM_G_DOMAIN   Laminin G-like

Promoters
RGD ID:6877194
Promoter ID:EPDNEW_M2048
Type:initiation region
Name:Crb2_1
Description:Mus musculus crumbs family member 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38237,776,249 - 37,776,309EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2679260 AgrOrtholog
Ensembl Genes ENSMUSG00000035403 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000058007 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000144709 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000147600 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  Laminin_G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:241324 UniProtKB/Swiss-Prot
MGD MGI:2679260 ENTREZGENE
NCBI Gene 241324 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin_G_2 UniProtKB/Swiss-Prot
PhenoGen Crb2 PhenoGen
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot
  LAM_G_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LamG UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot
UniProt A0A0N4SUJ6_MOUSE UniProtKB/TrEMBL
  CRUM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BMI5_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2ALU1 UniProtKB/Swiss-Prot
  Q6P6N1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-14 Crb2  crumbs family member 2    crumbs homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED