Uck1 (uridine-cytidine kinase 1) - Rat Genome Database

Name: Uck1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Uck1 (uridine-cytidine kinase 1) Rattus norvegicus

Analyze

Symbol:

Uck1

Name:

uridine-cytidine kinase 1

RGD ID:

1308313

Description:

Predicted to enable cytidine kinase activity and uridine kinase activity. Predicted to be involved in CTP salvage and UMP salvage. Predicted to act upstream of or within UMP biosynthetic process. Predicted to be active in cytoplasm. Biomarker of nerve compression syndrome. Orthologous to human UCK1 (uridine-cytidine kinase 1); PARTICIPATES IN pyrimidine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC311864

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UCK1 (uridine-cytidine kinase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Uck1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Uck1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UCK1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UCK1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Uck1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UCK1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	UCK1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Uck1 (uridine-cytidine kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	UCK2 (uridine-cytidine kinase 2)	HGNC	OrthoDB
Homo sapiens (human):	C10orf67 (chromosome 10 open reading frame 67)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	UCK1 (uridine-cytidine kinase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Uck1 (uridine-cytidine kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	uck1 (uridine-cytidine kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DAS2	Alliance	DIOPT (Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	B0001.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Uck	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	uck1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	35,936,328 - 35,942,213 (-)	NCBI		GRCr8
mRatBN7.2	3	15,538,580 - 15,544,465 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	15,538,591 - 15,544,465 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	18,607,992 - 18,613,850 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	27,192,985 - 27,198,843 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	25,443,461 - 25,449,354 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	11,271,874 - 11,277,757 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	11,271,885 - 11,277,757 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	16,620,744 - 16,626,627 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	11,366,634 - 11,372,517 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	11,264,015 - 11,268,800 (-)	NCBI
Celera	3	10,283,446 - 10,289,273 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive limb-girdle muscular dystrophy (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

genetic disease (ISO)

nerve compression syndrome (IEP)

primary coenzyme Q10 deficiency 7 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4-hydroxyphenyl retinamide (ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

caffeine (ISO)

carbon nanotube (ISO)

celastrol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

dibutyl phthalate (ISO)

dichloroacetic acid (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

leflunomide (ISO)

lithium atom (EXP)

lithium hydride (EXP)

methyl methanesulfonate (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

titanium dioxide (ISO)

trichloroethene (ISO)

triticonazole (EXP)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CMP biosynthetic process (IEA)

CTP salvage (IEA,ISO)

UMP biosynthetic process (ISO)

UMP salvage (IEA,ISO)

Cellular Component

cytoplasm (IBA)

Molecular Function

ATP binding (IEA)

cytidine kinase activity (ISO)

protein binding (ISO)

ribosylnicotinamide kinase activity (IEA)

uridine kinase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Up-regulated uridine kinase gene identified by RLCS in the ventral horn after crush injury to rat sciatic nerves.	Yuh I, etal., Biochem Biophys Res Commun 1999 Dec 9;266(1):104-9.

Additional References at PubMed

PMID:195585	PMID:11306702	PMID:12477932

Genomics

Comparative Map Data

Uck1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	35,936,328 - 35,942,213 (-)	NCBI		GRCr8
mRatBN7.2	3	15,538,580 - 15,544,465 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	15,538,591 - 15,544,465 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	18,607,992 - 18,613,850 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	27,192,985 - 27,198,843 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	25,443,461 - 25,449,354 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	11,271,874 - 11,277,757 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	11,271,885 - 11,277,757 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	16,620,744 - 16,626,627 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	11,366,634 - 11,372,517 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	11,264,015 - 11,268,800 (-)	NCBI
Celera	3	10,283,446 - 10,289,273 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

UCK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	131,523,801 - 131,531,263 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	131,523,801 - 131,531,264 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	134,399,188 - 134,406,650 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	133,389,012 - 133,396,476 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	131,428,744 - 131,436,209	NCBI
Celera	9	104,939,363 - 104,946,841 (-)	NCBI		Celera
Cytogenetic Map	9	q34.13	NCBI
HuRef	9	103,893,800 - 103,901,279 (-)	NCBI		HuRef
CHM1_1	9	134,548,581 - 134,556,053 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	143,736,763 - 143,744,224 (-)	NCBI		T2T-CHM13v2.0

Uck1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	32,145,014 - 32,150,117 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	32,145,014 - 32,150,171 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	32,255,002 - 32,260,105 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	32,255,002 - 32,260,159 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	32,110,522 - 32,115,625 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	32,077,011 - 32,082,070 (-)	NCBI		MGSCv36	mm8
Celera	2	31,959,332 - 31,964,435 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	22.09	NCBI

Uck1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	1,203,934 - 1,208,724 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	1,203,934 - 1,208,720 (-)	NCBI	ChiLan1.0	ChiLan1.0

UCK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	7,823,442 - 7,830,941 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	7,825,808 - 7,832,527 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	102,646,056 - 102,653,525 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	131,285,877 - 131,293,338 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	131,285,877 - 131,293,338 (-)	Ensembl	panpan1.1		panPan2

UCK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	52,609,972 - 52,615,655 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	52,609,313 - 52,614,622 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	51,878,198 - 51,883,925 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	53,513,447 - 53,519,165 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	53,513,484 - 53,519,162 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	52,291,329 - 52,297,027 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	52,610,265 - 52,615,976 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	52,704,647 - 52,710,374 (+)	NCBI		UU_Cfam_GSD_1.0

Uck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	198,499,351 - 198,502,882 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	18,267,885 - 18,271,423 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	18,267,878 - 18,271,406 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UCK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	271,448,365 - 271,453,816 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	271,448,362 - 271,453,811 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	305,456,743 - 305,462,182 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UCK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	6,612,306 - 6,634,326 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	6,612,378 - 6,618,968 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666079	8,922,082 - 8,946,096 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Uck1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	4,490,086 - 4,494,924 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	4,490,118 - 4,494,707 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Uck1
30 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	148
Count of miRNA genes:	116
Interacting mature miRNAs:	128
Transcripts:	ENSRNOT00000015792
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	10778704	30357018	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	10778704	50302886	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	10778704	50302886	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	10778823	30356773	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	10778823	30356773	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10861912	89878372	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	15005422	76927699	Rat

Markers in Region

Umpk

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,542,726 - 15,542,967 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	11,276,019 - 11,276,259	NCBI	Rnor6.0
Rnor_5.0	3	16,624,889 - 16,625,129	UniSTS	Rnor5.0
RGSC_v3.4	3	11,370,779 - 11,371,019	UniSTS	RGSC3.4
Celera	3	10,287,535 - 10,287,775	UniSTS
Cytogenetic Map	3	p11	UniSTS

RH130122

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,538,647 - 15,538,834 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	11,271,942 - 11,272,128	NCBI	Rnor6.0
Rnor_5.0	3	16,620,812 - 16,620,998	UniSTS	Rnor5.0
RGSC_v3.4	3	11,366,702 - 11,366,888	UniSTS	RGSC3.4
Celera	3	10,283,514 - 10,283,700	UniSTS
RH 3.4 Map	3	65.7	UniSTS
Cytogenetic Map	3	p11	UniSTS

RH131674

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,538,229 - 15,538,438 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	11,271,524 - 11,271,732	NCBI	Rnor6.0
Rnor_5.0	3	16,620,394 - 16,620,602	UniSTS	Rnor5.0
RGSC_v3.4	3	11,366,284 - 11,366,492	UniSTS	RGSC3.4
Celera	3	10,283,096 - 10,283,304	UniSTS
RH 3.4 Map	3	65.8	UniSTS
Cytogenetic Map	3	p11	UniSTS

RH138730

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	15,542,078 - 15,542,204 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	11,275,371 - 11,275,496	NCBI	Rnor6.0
Rnor_5.0	3	16,624,241 - 16,624,366	UniSTS	Rnor5.0
RGSC_v3.4	3	11,370,131 - 11,370,256	UniSTS	RGSC3.4
Celera	3	10,286,887 - 10,287,012	UniSTS
RH 3.4 Map	3	71.8	UniSTS
Cytogenetic Map	3	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	34	45	29	19	29	1	1	74	35	41	11	1
Low		9	12	12		12	7	10					7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015792 ⟹ ENSRNOP00000015792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	15,538,591 - 15,544,465 (-)	Ensembl
Rnor_6.0 Ensembl	3	11,271,885 - 11,277,757 (-)	Ensembl

RefSeq Acc Id:

NM_001107831 ⟹ NP_001101301

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	35,936,328 - 35,942,213 (-)	NCBI
mRatBN7.2	3	15,538,580 - 15,544,465 (-)	NCBI
Rnor_6.0	3	11,271,874 - 11,277,757 (-)	NCBI
Rnor_5.0	3	16,620,744 - 16,626,627 (-)	NCBI
RGSC_v3.4	3	11,366,634 - 11,372,517 (-)	RGD
Celera	3	10,283,446 - 10,289,273 (-)	RGD

Sequence:

show sequence

ATGGCCCCGGAAGCGATGCGTACGGCGTCCGCCCCTAGGTCCTGGCGGGAGCAGGCAGAGTCGG
TGGATGTATGTCAGCCGCTCCGGAGATGGCTTCGGCGGGAGGCGGCGGCTCCGAGAGCGCCGCG
CCGGAGGCCGATCGTCCCCAGCCGCGGCCGTTTCTCATCGGCGTGAGCGGTGGCACTGCTAGCG
GCAAGTCAACAGTGTGTGAGAAGATCATGGAGCTGCTGGGGCAGAACGAAGTGGACCGCCGGCA
GCGCAAGTTGGTCATCCTGAGCCAGGACTGCTTCTATAAGGTTCTGACAGCCGAGCAGAAGGCC
AAGGCCTTGAAGGGACAGTACAATTTTGACCATCCAGATGCTTTTGATAATGATCTGATGCACA
AGACCCTGAAAAACATTGTCGAAGGCAAAACTGTCGAGGTCCCCACCTATGATTTTGTGACCCA
CTCAAGGTTACCAGAGACCACTGTGGTCTACCCAGCTGATGTGGTTCTGTTCGAGGGCATCTTG
GTATTCTACACCCAGGAGATCCGGGACATGTTCCACCTGCGCCTCTTTGTGGACACAGACTCCG
ATGTTAGGCTGTCTCGAAGAGTTCTCCGGGATGTGCAGCGAGGAAGGGACCTGGAGCAGATCCT
CACCCAGTACACCGCCTTTGTGAAACCAGCCTTTGAGGAGTTCTGCCTGCCGACCAAGAAATAC
GCTGATGTGATCATCCCTCGAGGGGTTGATAATATGGTGGCCATCAACCTGATCGTGCAGCACA
TCCAGGACATCCTCAATGGTGACCTGTGCAAGCGGCACCGAGGAGGGCCCAACGGGCGCAACTA
CAAGAGGACCTTCCCGGAGCCAGGAGACCACCCTGGGGTGTTGGCCACTGGCAAACGCTCACAC
CTGGAGTCTAGCAGCAGACCCCATTGAGGACCAGCATATGTAGGTTCCCCATAGACCTGACAGA
TAAAGGGTCTGGGCCTGGGGGACAACTACTGGCTCCTAAAAGCACAGTCAGGGATCCCTCTAGT
GTGATCTTGGGTGGCATCAGGACCAAAGCCTTCCTTGCATAAGAGGGCAGACTCATGCTGACCG
AGCATTCTGGTGTCCTCCGCTTCCTCTCGCTGGAGGAGGCCACAGGTCTCTGGGTGGGTCACTG
TCCCAAACAGCATAGTAAGCCTATGGCGCCAGCTTCCCGAGGGATGCAGGACAGACACATGGGG
CAACAGCGGAAACAGCCCAGGCACTGGCTGGCCTGGTGTTAAGACAGTGAACACCAGGGAAGTA
CTTCCCGGTGTGATGTGGTCCGTGTACGTGTTGCAGAAGTTTGCAGAGATGTTCGATATCCTTT
TTGTGTGTGTGTGTGTGTAAGGCTGTTTGTGATCTCTGAACCTAGTTTTACAACCTAACACTGG
GCTATGGTTCAGTCTGAGGAGCCTGAGGCAGGAGCCTACATGACTCTATCTAGGGTCCTGGATC
AGCGTCTCCACAATTCTGCAGGAAGCCTTGAGCCCAAGGGGCTGTCTGTGTACAAGTCACTTAG
GCATAGTTCATGGCTAACATGCAGGGGCAGGCTCTCACCAGGCAGGGGAGCCCTGGAGTGCAGA
GGCAGGCAACCGTGGCTGCCTAAGGCCAGTTAGTCTCCTGCACACCAAACTCAAGCTCCTGGCT
TCACACACTCCCTCCTGTGCTGTCAAGTTTGTCTTCCCTCCCATGGGATGGCGTGTTTTGGAAG
TATCCTTGGCTATTGCCACAAGCTATGGCCCAGGACTCTCATTTCTTGTTAACTACAACTTCAT
TTCTTGTTCAATACAACTGGTTCTCACCACAGCAGCTGAGCTGTGTTGCTCTCAGGAGGTGGTT
TCTGTTAGTGTTGTGCTGATTTTGTTGAACCGAAACCCCTTTTTGGAGGGAGAATCAATAAATA
ACATAAAAAATTA

hide sequence

RefSeq Acc Id:

XM_063283964 ⟹ XP_063140034

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	35,937,978 - 35,942,205 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101301	(Get FASTA)	NCBI Sequence Viewer
	XP_063140034	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68897	(Get FASTA)	NCBI Sequence Viewer
	EDL93251	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015792
	ENSRNOP00000015792.5

RefSeq Acc Id:

NP_001101301 ⟸ NM_001107831

- UniProtKB:

B5DF24 (UniProtKB/TrEMBL), A6JU46 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSAAPEMASAGGGGSESAAPEADRPQPRPFLIGVSGGTASGKSTVCEKIMELLGQNEVDRRQRK
LVILSQDCFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHKTLKNIVEGKTVEVPTYDFVTHSR
LPETTVVYPADVVLFEGILVFYTQEIRDMFHLRLFVDTDSDVRLSRRVLRDVQRGRDLEQILTQ
YTAFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDLCKRHRGGPNGRNYKR
TFPEPGDHPGVLATGKRSHLESSSRPH

hide sequence

RefSeq Acc Id:

ENSRNOP00000015792 ⟸ ENSRNOT00000015792

RefSeq Acc Id:	XP_063140034 ⟸ XM_063283964
- Peptide Label:	isoform X1

Protein Domains

Phosphoribulokinase/uridine kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DF24-F1-model_v2	AlphaFold	B5DF24	1-283	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691979

Promoter ID:

EPDNEW_R2504

Type:

multiple initiation site

Name:

Uck1_1

Description:

uridine-cytidine kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	11,277,721 - 11,277,781	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308313	AgrOrtholog
BioCyc Gene	G2FUF-50150	BioCyc
BioCyc Pathway	PWY-7193 [pyrimidine ribonucleosides salvage I]	BioCyc
BioCyc Pathway Image	PWY-7193	BioCyc
Ensembl Genes	ENSRNOG00000011467	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015792	ENTREZGENE
	ENSRNOT00000015792.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	PRK/URK	UniProtKB/TrEMBL
	Uridine_kinase	UniProtKB/TrEMBL
KEGG Report	rno:311864	UniProtKB/TrEMBL
NCBI Gene	311864	ENTREZGENE
PANTHER	PTHR10285:SF66	UniProtKB/TrEMBL
	URIDINE KINASE	UniProtKB/TrEMBL
Pfam	PRK	UniProtKB/TrEMBL
PhenoGen	Uck1	PhenoGen
PRINTS	URIDINKINASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011467	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A6JU46	ENTREZGENE, UniProtKB/TrEMBL
	B5DF24	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Uck1	uridine-cytidine kinase 1	Uck1_predicted	uridine-cytidine kinase 1 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Uck1_predicted	uridine-cytidine kinase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

BioCyc Pathways