Sh2d3c (SH2 domain containing 3C) - Rat Genome Database

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Gene: Sh2d3c (SH2 domain containing 3C) Rattus norvegicus
Analyze
Symbol: Sh2d3c
Name: SH2 domain containing 3C
RGD ID: 1307287
Description: Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in regulation of catalytic activity and small GTPase mediated signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362111; NSP3; SH2 domain-containing protein 3C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)Ensembl
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Celera310,751,515 - 10,786,059 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:29966723  


Genomics

Comparative Map Data
Sh2d3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2316,010,622 - 16,046,491 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)Ensembl
Rnor_6.0311,756,427 - 11,793,547 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,095,296 - 17,130,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,687,031 - 11,731,868 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1311,617,288 - 11,627,810 (+)NCBI
Celera310,751,515 - 10,786,059 (+)NCBICelera
Cytogenetic Map3p11NCBI
SH2D3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,738,317 - 127,778,666 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9127,738,317 - 127,778,710 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,500,596 - 130,540,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,540,419 - 129,580,733 (-)NCBINCBI36hg18NCBI36
Celera9101,151,465 - 101,191,912 (-)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,117,130 - 100,157,604 (-)NCBIHuRef
CHM1_19130,652,151 - 130,692,598 (-)NCBICHM1_1
T2T-CHM13v2.09139,945,763 - 139,986,120 (-)NCBI
Sh2d3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,611,067 - 32,645,019 (+)NCBIGRCm39mm39
GRCm39 Ensembl232,611,067 - 32,645,524 (+)Ensembl
GRCm38232,721,037 - 32,755,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,721,055 - 32,755,512 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,576,592 - 32,610,514 (+)NCBIGRCm37mm9NCBIm37
MGSCv36232,543,081 - 32,577,003 (+)NCBImm8
Celera232,427,779 - 32,461,735 (+)NCBICelera
Cytogenetic Map2BNCBI
Sh2d3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419891,133 - 921,062 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419891,133 - 921,062 (+)NCBIChiLan1.0ChiLan1.0
SH2D3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19127,530,733 - 127,571,016 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,530,733 - 127,571,016 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0998,858,018 - 98,899,661 (-)NCBIMhudiblu_PPA_v0panPan3
SH2D3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,626,379 - 55,656,667 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,626,360 - 55,656,507 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,819,942 - 54,850,176 (+)NCBI
ROS_Cfam_1.0956,547,903 - 56,578,173 (+)NCBI
ROS_Cfam_1.0 Ensembl956,547,816 - 56,578,171 (+)Ensembl
UMICH_Zoey_3.1955,308,165 - 55,338,424 (+)NCBI
UNSW_CanFamBas_1.0955,622,873 - 55,653,134 (+)NCBI
UU_Cfam_GSD_1.0955,714,308 - 55,744,373 (+)NCBI
Sh2d3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,642,351 - 195,671,839 (-)NCBI
SpeTri2.0NW_00493648715,410,878 - 15,440,326 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2D3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,237,679 - 268,270,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,238,967 - 268,270,395 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,129,597 - 302,137,809 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH2D3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,352,947 - 10,395,023 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,354,061 - 10,396,230 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660795,826,055 - 5,867,966 (-)NCBIVero_WHO_p1.0
Sh2d3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,771,456 - 7,800,464 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247607,771,646 - 7,800,487 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH127491  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,046,208 - 16,046,413 (+)MAPPERmRatBN7.2
Rnor_6.0311,793,272 - 11,793,476NCBIRnor6.0
Rnor_5.0317,130,242 - 17,130,446UniSTSRnor5.0
RGSC_v3.4311,731,593 - 11,731,797UniSTSRGSC3.4
Celera310,785,784 - 10,785,988UniSTS
RH 3.4 Map371.1UniSTS
Cytogenetic Map3p11UniSTS
RH138706  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2316,036,423 - 16,036,650 (+)MAPPERmRatBN7.2
Rnor_6.0311,783,487 - 11,783,713NCBIRnor6.0
Rnor_5.0317,120,457 - 17,120,683UniSTSRnor5.0
RGSC_v3.4311,721,808 - 11,722,034UniSTSRGSC3.4
Celera310,775,999 - 10,776,225UniSTS
RH 3.4 Map360.6UniSTS
Cytogenetic Map3p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:129
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000031511, ENSRNOT00000065915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 33 4 2 13 2 66 25 27 11
Low 1 10 53 39 6 39 8 11 8 10 14 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000078366   ⟹   ENSRNOP00000072798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,763,706 - 11,793,547 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000087762   ⟹   ENSRNOP00000070659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,010,625 - 16,046,484 (+)Ensembl
Rnor_6.0 Ensembl311,756,384 - 11,793,593 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098941   ⟹   ENSRNOP00000079271
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,034,838 - 16,041,141 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106524   ⟹   ENSRNOP00000084559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,034,838 - 16,046,484 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110408   ⟹   ENSRNOP00000078942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,017,500 - 16,046,484 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113142   ⟹   ENSRNOP00000088575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl316,014,594 - 16,046,484 (+)Ensembl
RefSeq Acc Id: NM_001108579   ⟹   NP_001102049
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,010,625 - 16,046,484 (+)NCBI
Rnor_6.0311,756,427 - 11,793,547 (+)NCBI
Rnor_5.0317,095,296 - 17,130,517 (+)NCBI
RGSC_v3.4311,687,031 - 11,731,868 (+)RGD
Celera310,751,515 - 10,786,059 (+)RGD
Sequence:
RefSeq Acc Id: XM_008761759   ⟹   XP_008759981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,017,336 - 16,046,491 (+)NCBI
Rnor_6.0311,762,339 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761760   ⟹   XP_008759982
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591882   ⟹   XP_017447371
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,030,174 - 16,046,491 (+)NCBI
Rnor_6.0311,777,946 - 11,793,547 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105377   ⟹   XP_038961305
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,010,622 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_039105378   ⟹   XP_038961306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,032,393 - 16,046,491 (+)NCBI
RefSeq Acc Id: XM_039105379   ⟹   XP_038961307
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2316,015,513 - 16,046,491 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001102049   ⟸   NM_001108579
- UniProtKB: A0A0G2JYH7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759981   ⟸   XM_008761759
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008759982   ⟸   XM_008761760
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017447371   ⟸   XM_017591882
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000070659   ⟸   ENSRNOT00000087762
RefSeq Acc Id: ENSRNOP00000072798   ⟸   ENSRNOT00000078366
RefSeq Acc Id: XP_038961305   ⟸   XM_039105377
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961307   ⟸   XM_039105379
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038961306   ⟸   XM_039105378
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000088575   ⟸   ENSRNOT00000113142
RefSeq Acc Id: ENSRNOP00000084559   ⟸   ENSRNOT00000106524
RefSeq Acc Id: ENSRNOP00000078942   ⟸   ENSRNOT00000110408
RefSeq Acc Id: ENSRNOP00000079271   ⟸   ENSRNOT00000098941
Protein Domains
Ras-GEF   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYH7-F1-model_v2 AlphaFold A0A0G2JYH7 1-853 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692001
Promoter ID:EPDNEW_R2517
Type:single initiation site
Name:Sh2d3c_1
Description:SH2 domain containing 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,763,690 - 11,763,750EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307287 AgrOrtholog
BioCyc Gene G2FUF-50125 BioCyc
Ensembl Genes ENSRNOG00000054560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070659 ENTREZGENE
  ENSRNOP00000070659.1 UniProtKB/TrEMBL
  ENSRNOP00000072798.1 UniProtKB/TrEMBL
  ENSRNOP00000078942 ENTREZGENE
  ENSRNOP00000078942.1 UniProtKB/TrEMBL
  ENSRNOP00000079271.1 UniProtKB/TrEMBL
  ENSRNOP00000084559 ENTREZGENE
  ENSRNOP00000084559.1 UniProtKB/TrEMBL
  ENSRNOP00000088575.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078366.2 UniProtKB/TrEMBL
  ENSRNOT00000087762 ENTREZGENE
  ENSRNOT00000087762.2 UniProtKB/TrEMBL
  ENSRNOT00000098941.1 UniProtKB/TrEMBL
  ENSRNOT00000106524 ENTREZGENE
  ENSRNOT00000106524.1 UniProtKB/TrEMBL
  ENSRNOT00000110408 ENTREZGENE
  ENSRNOT00000110408.1 UniProtKB/TrEMBL
  ENSRNOT00000113142.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2_SHEP1/BCAR3/NSP1 UniProtKB/TrEMBL
KEGG Report rno:362111 UniProtKB/TrEMBL
NCBI Gene 362111 ENTREZGENE
Pfam RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PhenoGen Sh2d3c PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE RASGEF_CAT UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2JYH7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2Z5DT54_RAT UniProtKB/TrEMBL
  A0A8I5ZMD8_RAT UniProtKB/TrEMBL
  A0A8I5ZME7_RAT UniProtKB/TrEMBL
  A0A8I6A5D5_RAT UniProtKB/TrEMBL
  A0A8I6GAN0_RAT UniProtKB/TrEMBL
  B0BN10_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Sh2d3c  SH2 domain containing 3C   Sh2d3c_predicted  SH2 domain containing 3C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sh2d3c_predicted  SH2 domain containing 3C (predicted)      Symbol and Name status set to approved 70820 APPROVED