Gene: Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Rattus norvegicus
Analyze
Symbol:
Abl1
Name:
ABL proto-oncogene 1, non-receptor tyrosine kinase
Description:
Exhibits delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including glomerular visceral epithelial cell apoptotic process; positive regulation of cellular component organization; and positive regulation of programmed cell death. Localizes to several cellular components, including the growth cone; neuronal cell body; and ruffle. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in acute myeloid leukemia; chronic myeloid leukemia; and precursor B lymphoblastic lymphoma/leukemia. Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase); PARTICIPATES IN p53 signaling pathway; platelet-derived growth factor signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 3,3',5,5'-tetrabromobisphenol A; ammonium chloride.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abl; Abl1_mapped; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) HGNC
OrthoMCL
Alliance orthologs 3
Mus musculus (house mouse):
Abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
abl1 (c-abl oncogene 1, non-receptor tyrosine kinase)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Drosophila melanogaster (fruit fly):
Abl
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoInspector, PANTHER, TreeFam)
Caenorhabditis elegans (roundworm):
abl-1
Alliance
DIOPT (Ensembl Compara, InParanoid, OrthoFinder, OrthoInspector, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 3 10,041,820 - 10,145,076 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 10,041,826 - 10,144,388 (-) Ensembl Rnor_5.0 3 15,401,182 - 15,504,438 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 3 10,804,594 - 10,907,162 NCBI RGSC3.4 rn4 RGSC3.4 Cytogenetic Map 3 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Acute Lymphoblastic Leukemia, with Lymphomatous Features ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features ClinVar PMID:11853795 more ... Acute Lymphoblastic Leukemia, with Lymphomatous Features ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Lymphoblastic leukemia, acute, with lymphomatous features ClinVar PMID:10988075 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12399961 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia, resistant to imatinib ClinVar PMID:11964322 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12399961 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:11569495 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12399961 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12399961 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:14745431 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:11964322 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Leukemia, philadelphia chromosome-positive, resistant to imatinib ClinVar PMID:10988075 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12623848 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12623848 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:11964322 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12623848 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12623848 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Leukemia, philadelphia chromosome-positive, resistant to imatinib ClinVar PMID:11569495 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:21562040 chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:11423618 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Leukemia, philadelphia chromosome-positive, resistant to imatinib ClinVar PMID:11853795 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia ClinVar PMID:12399961 more ... chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Chronic myeloid leukemia, resistant to imatinib ClinVar PMID:12130516 chronic myeloid leukemia ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Leukemia, philadelphia chromosome-positive, resistant to imatinib ClinVar PMID:11853795 congenital heart disease ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Congenital heart disease ClinVar PMID:25741868 , PMID:28288113 Failure to Thrive ISO RGD:1342972 8554872 ClinVar Annotator: match by term: Failure to thrive ClinVar PMID:25741868 , PMID:28288113
Imported Annotations - CTD
adenocarcinoma ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21472143 bone development disease ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28288113 Breast Neoplasms ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20234815 Carcinogenesis ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23968727 chronic myeloid leukemia ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15604220 more ... congenital heart disease ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28288113 Esophageal Neoplasms ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21472143 Experimental Neoplasms ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19878872 Failure to Thrive ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28288113 Liver Neoplasms ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19233941 Musculoskeletal Abnormalities ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28288113 pre-malignant neoplasm ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19233941 precursor lymphoblastic lymphoma/leukemia ISO RGD:1342972 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11984797 , PMID:21898527 Imported Annotations - OMIM
chronic myeloid leukemia ISO RGD:1342972 7240710 OMIM
1,2-dimethylhydrazine increases expression EXP 6480464 1, 2-Dimethylhydrazine results in increased expression of ABL1 mRNA CTD PMID:27840820 17alpha-ethynylestradiol affects expression ISO RGD:1332211 6480464 Ethinyl Estradiol affects the expression of ABL1 mRNA CTD PMID:17555576 17alpha-ethynylestradiol multiple interactions ISO RGD:1332211 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABL1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:1332211 6480464 Ethinyl Estradiol results in increased expression of ABL1 mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:1342972 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of ABL1 mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1332211 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABL1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1332211 6480464 Tetrachlorodibenzodioxin results in decreased expression of ABL1 mRNA CTD PMID:26290441 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1332211 6480464 Tetrachlorodibenzodioxin results in increased expression of ABL1 mRNA CTD PMID:17942748 2-methylcholine affects expression ISO RGD:1342972 6480464 beta-methylcholine affects the expression of ABL1 mRNA CTD PMID:21179406 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of ABL1 mRNA CTD PMID:28970181 4-hydroperoxycyclophosphamide increases expression ISO RGD:1332211 6480464 perfosfamide results in increased expression of ABL1 mRNA CTD PMID:19429390 4-nitroquinoline N-oxide increases expression ISO RGD:1332211 6480464 4-Nitroquinoline-1-oxide results in increased expression of ABL1 mRNA CTD PMID:22561872 4-nitroquinoline N-oxide decreases expression ISO RGD:1332211 6480464 4-Nitroquinoline-1-oxide results in decreased expression of ABL1 mRNA CTD PMID:22561872 4-phenylcoumarin increases expression ISO RGD:1332211 6480464 4-phenylcoumarin analog results in increased expression of ABL1 mRNA CTD PMID:27773722 acetaldehyde multiple interactions ISO RGD:1342972 6480464 ABL1 protein promotes the reaction [Acetaldehyde results in increased phosphorylation of and results in decreased activity of PPARG protein], Imatinib Mesylate inhibits the reaction [Acetaldehyde results in increased activity of ABL1 protein] CTD PMID:17030193 acetaldehyde increases activity ISO RGD:1342972 6480464 Acetaldehyde results in increased activity of ABL1 protein CTD PMID:17030193 all-trans-retinoic acid increases expression ISO RGD:1332211 6480464 Tretinoin results in increased expression of ABL1 mRNA CTD PMID:16788091 all-trans-retinoic acid multiple interactions ISO RGD:1342972 6480464 [Tretinoin co-treated with arsenic trioxide] results in increased expression of ABL1 mRNA CTD PMID:15894607 alvocidib multiple interactions ISO RGD:1342972 6480464 [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein more ... CTD PMID:15039284 amiodarone increases expression ISO RGD:1342972 6480464 Amiodarone results in increased expression of ABL1 mRNA CTD PMID:19774075 ammonium chloride increases expression EXP 6480464 Ammonium Chloride results in increased expression of ABL1 protein CTD PMID:16483693 arsenous acid decreases expression ISO RGD:1342972 6480464 Arsenic Trioxide results in decreased expression of ABL1 mRNA more ... CTD PMID:10648417 more ... arsenous acid affects response to substance ISO RGD:1342972 6480464 ABL1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:10648417 arsenous acid multiple interactions ISO RGD:1342972 6480464 [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide co-treated with Arsenic Trioxide] results in decreased phosphorylation of ABL1 protein more ... CTD PMID:15894607 more ... ATP multiple interactions ISO RGD:1342972 6480464 [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein, sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 atropine multiple interactions ISO RGD:1342972 6480464 [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 belinostat decreases expression ISO RGD:1342972 6480464 belinostat results in decreased expression of ABL1 mRNA CTD PMID:19606018 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1342972 6480464 7 more ... CTD PMID:19150397 bisphenol A increases expression ISO RGD:1332211 6480464 bisphenol A results in increased expression of ABL1 mRNA CTD PMID:23704952 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of ABL1 mRNA CTD PMID:25181051 bortezomib multiple interactions ISO RGD:1342972 6480464 [alvocidib co-treated with Bortezomib co-treated with ABL1 protein] results in decreased phosphorylation of LYN protein more ... CTD PMID:15039284 more ... bosutinib decreases activity ISO RGD:1342972 6480464 bosutinib results in decreased activity of ABL1 protein CTD PMID:17114238 butanal decreases expression ISO RGD:1342972 6480464 butyraldehyde results in decreased expression of ABL1 mRNA CTD PMID:26079696 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of ABL1 mRNA CTD PMID:19167457 cadmium dichloride multiple interactions ISO RGD:1332211 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA CTD PMID:19840844 calcitriol increases expression ISO RGD:1342972 6480464 Calcitriol results in increased expression of ABL1 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1342972 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ABL1 mRNA CTD PMID:21592394 capsaicin increases expression ISO RGD:1342972 6480464 Capsaicin results in increased expression of ABL1 mRNA CTD PMID:19502594 cisplatin multiple interactions ISO RGD:1342972 6480464 [[[Cisplatin co-treated with 2 more ... CTD PMID:21214929 more ... cisplatin decreases expression ISO RGD:1342972 6480464 Cisplatin results in decreased expression of ABL1 mRNA CTD PMID:27392435 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of ABL1 protein CTD PMID:22023808 cisplatin increases response to substance ISO RGD:1342972 6480464 ABL1 protein results in increased susceptibility to Cisplatin CTD PMID:21324906 cocaine affects expression ISO RGD:1332211 6480464 Cocaine affects the expression of ABL1 mRNA CTD PMID:15681117 copper atom multiple interactions ISO RGD:1342972 6480464 [Thiosemicarbazones binds to Copper] which results in increased expression of ABL1 protein CTD PMID:20931265 copper(0) multiple interactions ISO RGD:1342972 6480464 [Thiosemicarbazones binds to Copper] which results in increased expression of ABL1 protein CTD PMID:20931265 crizotinib decreases activity ISO RGD:1332211 6480464 crizotinib results in decreased activity of ABL1 protein CTD PMID:21812414 cyproconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of ABL1 mRNA CTD PMID:29038839 cytochalasin D multiple interactions ISO RGD:1332211 6480464 EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 cytochalasin D increases phosphorylation ISO RGD:1332211 6480464 Cytochalasin D results in increased phosphorylation of ABL1 protein CTD PMID:21900236 daunorubicin decreases response to substance ISO RGD:1342972 6480464 ABL1 results in decreased susceptibility to Daunorubicin CTD PMID:12410571 diarsenic trioxide decreases expression ISO RGD:1342972 6480464 Arsenic Trioxide results in decreased expression of ABL1 mRNA more ... CTD PMID:10648417 more ... diarsenic trioxide multiple interactions ISO RGD:1342972 6480464 [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide co-treated with Arsenic Trioxide] results in decreased phosphorylation of ABL1 protein more ... CTD PMID:15894607 more ... diarsenic trioxide affects response to substance ISO RGD:1342972 6480464 ABL1 protein affects the susceptibility to Arsenic Trioxide CTD PMID:10648417 dicrotophos increases expression ISO RGD:1342972 6480464 dicrotophos results in increased expression of ABL1 mRNA CTD PMID:28302478 doxorubicin multiple interactions ISO RGD:1342972 6480464 [[[Doxorubicin co-treated with 2 more ... CTD PMID:21214929 epoxiconazole multiple interactions EXP 6480464 [cyproconazole co-treated with epoxiconazole] results in increased expression of ABL1 mRNA CTD PMID:29038839 gallic acid multiple interactions ISO RGD:1342972 6480464 Gallic Acid promotes the reaction [Imatinib Mesylate results in decreased phosphorylation of [BCR protein mutant form binds to ABL1 protein mutant form]] more ... CTD PMID:22245431 gold atom multiple interactions ISO RGD:1342972 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA CTD PMID:28433809 gold(0) multiple interactions ISO RGD:1342972 6480464 [Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA CTD PMID:28433809 histamine multiple interactions ISO RGD:1342972 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] more ... CTD PMID:16849647 hydrogen peroxide increases activity ISO RGD:1342972 6480464 Hydrogen Peroxide results in increased activity of ABL1 protein CTD PMID:17030193 hydrogen peroxide affects expression ISO RGD:1342972 6480464 Hydrogen Peroxide affects the expression of ABL1 protein CTD PMID:21179406 hydrogen peroxide multiple interactions ISO RGD:1342972 6480464 Imatinib Mesylate inhibits the reaction [Hydrogen Peroxide results in increased activity of ABL1 protein] CTD PMID:17030193 lipopolysaccharide increases expression ISO RGD:1332211 6480464 Lipopolysaccharides results in increased expression of ABL1 mRNA CTD PMID:12057914 LY294002 multiple interactions ISO RGD:1342972 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA] CTD PMID:16849647 mangiferin decreases expression ISO RGD:1342972 6480464 mangiferin results in decreased expression of ABL1 mRNA CTD PMID:15498116 mercury atom increases expression ISO RGD:1342972 6480464 Mercury results in increased expression of ABL1 mRNA CTD PMID:19937285 mercury(0) increases expression ISO RGD:1342972 6480464 Mercury results in increased expression of ABL1 mRNA CTD PMID:19937285 metformin multiple interactions ISO RGD:1342972 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA CTD PMID:29309887 methamphetamine increases expression ISO RGD:1332211 6480464 Methamphetamine results in increased expression of ABL1 mRNA CTD PMID:26307267 methylmercury chloride increases expression ISO RGD:1332211 6480464 methylmercuric chloride results in increased expression of ABL1 mRNA CTD PMID:20061341 myristicin decreases expression ISO RGD:1342972 6480464 myristicin results in decreased expression of ABL1 mRNA CTD PMID:24792648 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine decreases expression ISO RGD:1342972 6480464 N more ... CTD PMID:12756304 N,N-dimethylsphingosine multiple interactions ISO RGD:1342972 6480464 [Bortezomib co-treated with N, N-dimethylsphingosine] results in decreased expression of ABL1 protein CTD PMID:21195056 N-acetyl-L-cysteine multiple interactions ISO RGD:1332211 6480464 Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein] CTD PMID:16481037 N-methyl-4-phenylpyridinium multiple interactions ISO RGD:1332211 6480464 1-Methyl-4-phenylpyridinium promotes the reaction [ABL1 protein binds to and results in increased phosphorylation of and results in increased activity of GSK3B protein], 1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in increased activity of ABL1 protein CTD PMID:30165626 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:1332211 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of ABL1 mRNA more ... CTD PMID:19840844 nilotinib decreases phosphorylation ISO RGD:1342972 6480464 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased phosphorylation of ABL1 protein, 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in decreased phosphorylation of ABL1 protein mutant form CTD PMID:19878872 , PMID:23883479 nilotinib multiple interactions ISO RGD:1342972 6480464 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine] more ... CTD PMID:16849647 more ... okadaic acid multiple interactions ISO RGD:1332211 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of ABL1 mRNA CTD PMID:19840844 paclitaxel multiple interactions ISO RGD:1342972 6480464 [Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA CTD PMID:29309887 panobinostat multiple interactions ISO RGD:1342972 6480464 [Cisplatin co-treated with panobinostat] affects the expression of ABL1 mRNA CTD PMID:21791302 paracetamol affects expression ISO RGD:1332211 6480464 Acetaminophen affects the expression of ABL1 mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1342972 6480464 Acetaminophen results in increased expression of ABL1 mRNA CTD PMID:29067470 paraquat increases expression ISO RGD:1342972 6480464 Paraquat results in increased expression of ABL1 mRNA CTD PMID:18836921 parathion multiple interactions ISO RGD:1342972 6480464 [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 parathion increases expression ISO RGD:1342972 6480464 Parathion results in increased expression of ABL1 mRNA CTD PMID:17390078 phenobarbital decreases methylation ISO RGD:1332211 6480464 Phenobarbital results in decreased methylation of ABL1 gene, Phenobarbital results in decreased methylation of ABL1 promoter CTD PMID:19233941 , PMID:19482888 phenobarbital increases expression ISO RGD:1332211 6480464 Phenobarbital results in increased expression of ABL1 mRNA CTD PMID:19482888 phenylephrine multiple interactions EXP 6480464 ABL1 protein affects the reaction [Phenylephrine promotes the reaction [BCAR1 protein binds to CRK protein]] more ... CTD PMID:17615370 phenylephrine increases phosphorylation EXP 6480464 Phenylephrine results in increased phosphorylation of ABL1 protein CTD PMID:17615370 phenylephrine affects response to substance EXP 6480464 ABL1 protein affects the susceptibility to Phenylephrine CTD PMID:17615370 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1332211 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ABL1 mRNA CTD PMID:19840844 platycodin D multiple interactions ISO RGD:1342972 6480464 [platycodin D co-treated with Imatinib Mesylate] results in decreased expression of ABL1 protein CTD PMID:29552859 ponatinib multiple interactions ISO RGD:1342972 6480464 ponatinib inhibits the reaction [ABL1 protein mutant form results in increased phosphorylation of ABL1 protein mutant form] more ... CTD PMID:19878872 ponatinib decreases phosphorylation ISO RGD:1342972 6480464 ponatinib results in decreased phosphorylation of ABL1 protein, ponatinib results in decreased phosphorylation of ABL1 protein mutant form CTD PMID:19878872 , PMID:25304212 ponatinib decreases activity ISO RGD:1342972 6480464 ponatinib analog results in decreased activity of ABL1 protein more ... CTD PMID:19878872 more ... potassium chloride multiple interactions EXP 6480464 ABL1 protein affects the reaction [Potassium Chloride results in increased phosphorylation of BCAR1 protein] CTD PMID:17615370 potassium chloride increases phosphorylation EXP 6480464 Potassium Chloride results in increased phosphorylation of ABL1 protein CTD PMID:17615370 potassium chloride affects response to substance EXP 6480464 ABL1 protein affects the susceptibility to Potassium Chloride CTD PMID:17615370 purmorphamine multiple interactions ISO RGD:1342972 6480464 purmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]] CTD PMID:22397755 quercetin decreases expression ISO RGD:1342972 6480464 Quercetin results in decreased expression of ABL1 protein CTD PMID:19207037 resveratrol multiple interactions ISO RGD:1342972 6480464 purmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]], resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form] CTD PMID:22397755 rottlerin multiple interactions ISO RGD:1342972 6480464 rottlerin inhibits the reaction [[ABL1 protein results in increased phosphorylation of and results in decreased activity of PPARG protein] which results in increased expression of COL1A1 protein] CTD PMID:17030193 sodium arsenite increases expression ISO RGD:1342972 6480464 sodium arsenite results in increased expression of ABL1 mRNA CTD PMID:12016162 sodium arsenite decreases expression ISO RGD:1332211 6480464 sodium arsenite results in decreased expression of ABL1 mRNA CTD PMID:16014739 sorafenib multiple interactions ISO RGD:1342972 6480464 sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] CTD PMID:19366808 sorafenib decreases activity ISO RGD:1342972 6480464 sorafenib results in decreased activity of ABL1 protein mutant form CTD PMID:19366808 sorafenib decreases phosphorylation ISO RGD:1342972 6480464 sorafenib results in decreased phosphorylation of ABL1 protein mutant form CTD PMID:19366808 tamoxifen affects expression ISO RGD:1332211 6480464 Tamoxifen affects the expression of ABL1 mRNA CTD PMID:17555576 tamoxifen decreases response to substance ISO RGD:1342972 6480464 ABL1 protein results in decreased susceptibility to Tamoxifen CTD PMID:20234815 testosterone increases expression ISO RGD:1342972 6480464 Testosterone results in increased expression of ABL1 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1342972 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of ABL1 mRNA CTD PMID:21592394 tetrachloromethane increases phosphorylation ISO RGD:1342972 6480464 Carbon Tetrachloride results in increased phosphorylation of ABL1 protein CTD PMID:17030193 tetrachloromethane multiple interactions ISO RGD:1342972 6480464 Imatinib Mesylate inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of ABL1 protein] CTD PMID:17030193 trichostatin A decreases expression ISO RGD:1342972 6480464 trichostatin A results in decreased expression of ABL1 mRNA CTD PMID:19606018 , PMID:23770000 tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate multiple interactions ISO RGD:1342972 6480464 [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA CTD PMID:17390078 tungsten decreases expression ISO RGD:1332211 6480464 Tungsten results in decreased expression of ABL1 mRNA CTD PMID:30912803 valproic acid increases expression ISO RGD:1332211 6480464 Valproic Acid results in increased expression of ABL1 mRNA CTD PMID:21427059 valproic acid affects expression ISO RGD:1342972 6480464 Valproic Acid affects the expression of ABL1 mRNA CTD PMID:25979313 vanadium atom increases expression ISO RGD:1342972 6480464 Vanadium results in increased expression of ABL1 mRNA CTD PMID:19000753 vanadium(0) increases expression ISO RGD:1342972 6480464 Vanadium results in increased expression of ABL1 mRNA CTD PMID:19000753 vorinostat multiple interactions ISO RGD:1342972 6480464 [Dasatinib co-treated with vorinostat] results in decreased expression of ABL1 protein mutant form more ... CTD PMID:12446442 more ... vorinostat decreases expression ISO RGD:1342972 6480464 vorinostat results in decreased expression of ABL1 mRNA mutant form, vorinostat results in decreased expression of ABL1 protein mutant form CTD PMID:12446442 zinc atom affects expression ISO RGD:1342972 6480464 Zinc affects the expression of ABL1 protein CTD PMID:16636310 zinc(0) affects expression ISO RGD:1342972 6480464 Zinc affects the expression of ABL1 protein CTD PMID:16636310
Biological Process actin cytoskeleton organization ISO RGD:1332211 1624291 (MGI:MGI:3694142, PMID:11279004) RGD MGI:MGI:3694142 , PMID:11279004 actin filament branching ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 actin filament polymerization IMP 8693596 RGD activated T cell proliferation ISO RGD:1332211 1624291 MGI:MGI:3525886 (MGI:MGI:4399009 , PMID:18025176) RGD MGI:MGI:4399009 , PMID:18025176 activation of protein kinase C activity ISO RGD:1342972 1624291 (PMID:10713049) RGD PMID:10713049 alpha-beta T cell differentiation ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4399009 , PMID:18025176) RGD MGI:MGI:4399009 , PMID:18025176 associative learning IEP 8693396 RGD B cell proliferation ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:3839222 , PMID:19228876) RGD MGI:MGI:3839222 , PMID:19228876 B cell proliferation involved in immune response ISO RGD:1332211 1624291 MGI:MGI:1856663 more ... RGD MGI:MGI:1927957 more ... B cell receptor signaling pathway ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:1927957 more ... RGD MGI:MGI:1927957 more ... B-1 B cell homeostasis ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:3839222 , PMID:19228876) RGD MGI:MGI:3839222 , PMID:19228876 Bergmann glial cell differentiation ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4840122 , PMID:20980600) RGD MGI:MGI:4840122 , PMID:20980600 cardiovascular system development ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:1327082 , PMID:9883720) RGD MGI:MGI:1327082 , PMID:9883720 cellular response to DNA damage stimulus ISO RGD:1342972 1624291 (PMID:15657060) RGD PMID:15657060 cellular response to hydrogen peroxide ISO RGD:1342972 1624291 (PMID:10713049) RGD PMID:10713049 cellular response to lipopolysaccharide ISO RGD:1332211 1624291 MGI:MGI:1856663 (MGI:MGI:82358 , PMID:8806812) RGD MGI:MGI:82358 , PMID:8806812 cellular response to oxidative stress IEP 8693571 protein:increased expression:cerebellum: RGD cellular response to transforming growth factor beta stimulus IEP 8693572 RGD cerebellum morphogenesis ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4840122 , PMID:20980600) RGD MGI:MGI:4840122 , PMID:20980600 collateral sprouting ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 DNA conformation change ISO RGD:1342972 1624291 (PMID:9558345) RGD PMID:9558345 DNA damage induced protein phosphorylation ISO RGD:1342972 1624291 (PMID:18280240) RGD PMID:18280240 endothelial cell migration ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 epidermal growth factor receptor signaling pathway ISO RGD:1332211 1624291 MGI:MGI:95290 more ... RGD MGI:MGI:3814963 , PMID:18827006 establishment of protein localization ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 glomerular visceral epithelial cell apoptotic process IMP 8693403 RGD integrin-mediated signaling pathway ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 learning or memory IMP 8693418 RGD microspike assembly ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 negative regulation of BMP signaling pathway ISO RGD:1332211 1624291 MGI:MGI:104738 (MGI:MGI:5449665 , PMID:22729085) RGD MGI:MGI:5449665 , PMID:22729085 negative regulation of cell-cell adhesion ISO RGD:1332211 1624291 MGI:MGI:103178 more ... RGD MGI:MGI:5574138 , PMID:24367707 negative regulation of cellular senescence ISO RGD:1332211 1624291 MGI:MGI:104738 (MGI:MGI:5449665 , PMID:22729085) RGD MGI:MGI:5449665 , PMID:22729085 negative regulation of endothelial cell apoptotic process ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:5499228 , PMID:23840065) RGD MGI:MGI:5499228 , PMID:23840065 negative regulation of ERK1 and ERK2 cascade ISO RGD:1332211 1624291 MGI:MGI:104738 (MGI:MGI:5449665 , PMID:22729085) RGD MGI:MGI:5449665 , PMID:22729085 negative regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1332211 1624291 MGI:MGI:108086 (MGI:MGI:4366111 , PMID:19805123) RGD MGI:MGI:4366111 , PMID:19805123 negative regulation of long-term synaptic potentiation ISO RGD:1332211 1624291 ComplexPortal:CPX-1134 more ... RGD MGI:MGI:5588508 , PMID:24658113 negative regulation of mitotic cell cycle ISO RGD:1332211 1624291 MGI:MGI:97874 more ... RGD MGI:MGI:80031 , PMID:8612582 negative regulation of phospholipase C activity ISO RGD:1342972 1624291 (PMID:24367707) RGD PMID:24367707 negative regulation of protein serine/threonine kinase activity ISO RGD:1342972 1624291 (PMID:11121037) RGD PMID:11121037 negative regulation of ubiquitin-protein transferase activity ISO RGD:1342972 1624291 (PMID:20823226) RGD PMID:20823226 neural tube closure ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:1327082 , PMID:9883720) RGD MGI:MGI:1327082 , PMID:9883720 neuroepithelial cell differentiation ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:1327082 , PMID:9883720) RGD MGI:MGI:1327082 , PMID:9883720 neuromuscular process controlling balance ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4840122 , PMID:20980600) RGD MGI:MGI:4840122 , PMID:20980600 neuron differentiation ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:1327082 , PMID:9883720) RGD MGI:MGI:1327082 , PMID:9883720 neuropilin signaling pathway ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 peptidyl-tyrosine autophosphorylation ISO RGD:1342972 1624291 (PMID:10518561), (PMID:24520051) RGD PMID:10518561 , PMID:24520051 peptidyl-tyrosine phosphorylation ISO RGD:1332211 1624291 (MGI:MGI:3694185 more ... RGD MGI:MGI:3694185 more ... peptidyl-tyrosine phosphorylation ISO RGD:1342972 1624291 (PMID:10713049), (PMID:11121037), (PMID:24520051), (PMID:28428613), (PMID:7590236), (PMID:9144171) RGD PMID:10713049 more ... phagocytosis ISO RGD:1332211 1624291 MGI:MGI:2153718 more ... RGD MGI:MGI:5432825 more ... platelet-derived growth factor receptor signaling pathway ISO RGD:1332211 1624291 (MGI:MGI:3814963 more ... RGD MGI:MGI:3814963 more ... platelet-derived growth factor receptor-beta signaling pathway ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 positive regulation blood vessel branching ISO RGD:1332211 1624291 (MGI:MGI:5588737, PMID:24863063) RGD MGI:MGI:5588737 , PMID:24863063 positive regulation of actin cytoskeleton reorganization ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 positive regulation of actin filament binding ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 positive regulation of apoptotic process IMP 1598672 RGD positive regulation of apoptotic process ISO RGD:1342972 1624291 (PMID:9037071) RGD PMID:9037071 positive regulation of apoptotic process ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:4366111 , PMID:19805123) RGD MGI:MGI:4366111 , PMID:19805123 positive regulation of cell migration involved in sprouting angiogenesis ISO RGD:1332211 1624291 (MGI:MGI:5588737, PMID:24863063) RGD MGI:MGI:5588737 , PMID:24863063 positive regulation of cytosolic calcium ion concentration ISO RGD:1342972 1624291 (PMID:24367707) RGD PMID:24367707 positive regulation of dendrite development IMP 8693421 RGD positive regulation of endothelial cell migration ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 positive regulation of ERK1 and ERK2 cascade ISO RGD:1332211 1624291 (MGI:MGI:3814963, PMID:18827006) RGD MGI:MGI:3814963 , PMID:18827006 positive regulation of extracellular matrix organization IMP 8693597 RGD positive regulation of fibroblast proliferation IMP 8693597 RGD positive regulation of focal adhesion assembly ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 positive regulation of hydrogen peroxide-mediated programmed cell death IMP 8693407 RGD positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4399009 , PMID:18025176) RGD MGI:MGI:4399009 , PMID:18025176 positive regulation of interferon-gamma secretion ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4399009 , PMID:18025176) RGD MGI:MGI:4399009 , PMID:18025176 positive regulation of interleukin-2 secretion ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4399009 , PMID:18025176) RGD MGI:MGI:4399009 , PMID:18025176 positive regulation of microtubule binding ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 positive regulation of mitotic cell cycle ISO RGD:1332211 1624291 MGI:MGI:97528 more ... RGD MGI:MGI:3814963 , PMID:18827006 positive regulation of neuron apoptotic process IMP 8693418 RGD positive regulation of neuron death ISO RGD:1332211 1624291 MGI:MGI:2176222 more ... RGD MGI:MGI:4833709 , PMID:20823226 positive regulation of neuron death IMP 8693407 RGD positive regulation of osteoblast proliferation ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:5449665 , PMID:22729085) RGD MGI:MGI:5449665 , PMID:22729085 positive regulation of oxidoreductase activity ISO RGD:1342972 1624291 (PMID:12893824) RGD PMID:12893824 positive regulation of peptidyl-tyrosine phosphorylation ISO RGD:1342972 1624291 (PMID:15657060) RGD PMID:15657060 positive regulation of protein phosphorylation ISO RGD:1342972 1624291 (PMID:24700464) RGD PMID:24700464 positive regulation of release of sequestered calcium ion into cytosol ISO RGD:1332211 1624291 MGI:MGI:88319 (MGI:MGI:3839222 , PMID:19228876) RGD MGI:MGI:3839222 , PMID:19228876 positive regulation of stress fiber assembly ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 positive regulation of substrate adhesion-dependent cell spreading ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 positive regulation of vasoconstriction IMP 8693596 RGD positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4834959 , PMID:20837657) RGD MGI:MGI:4834959 , PMID:20837657 post-embryonic development ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:1327082 , PMID:9883720) RGD MGI:MGI:1327082 , PMID:9883720 protein autophosphorylation ISO RGD:1342972 1624291 (PMID:10713049) RGD PMID:10713049 protein autophosphorylation IDA 8693575 RGD protein phosphorylation ISO RGD:1332211 1624291 (MGI:MGI:5142352 more ... RGD MGI:MGI:5142352 more ... protein phosphorylation ISO RGD:1342972 1624291 (PMID:24863063) RGD PMID:24863063 regulation of actin cytoskeleton organization ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 regulation of actin cytoskeleton organization ISO RGD:1332211 1624291 MGI:MGI:108091 more ... RGD MGI:MGI:1327082 more ... regulation of apoptotic process IBA MGI:MGI:87859 more ... 13792537 PMID:21873635 GO_Central regulation of axon extension ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 regulation of Cdc42 protein signal transduction ISO RGD:1342972 1624291 (PMID:26051942) RGD PMID:26051942 regulation of cell cycle ISO RGD:1332211 1624291 (MGI:MGI:2157287, PMID:11809706) RGD MGI:MGI:2157287 , PMID:11809706 regulation of cell population proliferation ISO RGD:1332211 1624291 MGI:MGI:98834 (MGI:MGI:1858587 , PMID:10805805) RGD MGI:MGI:1858587 , PMID:10805805 regulation of cellular senescence ISO RGD:1332211 1624291 MGI:MGI:1338938 (MGI:MGI:5449665 , PMID:22729085) RGD MGI:MGI:5449665 , PMID:22729085 regulation of extracellular matrix organization ISO RGD:1332211 1624291 MGI:MGI:87860 (MGI:MGI:4840122 , PMID:20980600) RGD MGI:MGI:4840122 , PMID:20980600 regulation of microtubule polymerization ISO RGD:1342972 1624291 (PMID:24520051) RGD PMID:24520051 regulation of modification of synaptic structure IGI ComplexPortal:CPX-1134 12911004 PMID:24658113 ARUK-UCL regulation of modification of synaptic structure ISO RGD:1332211 1624291 ComplexPortal:CPX-1134 more ... RGD MGI:MGI:5588508 , PMID:24658113 regulation of response to DNA damage stimulus ISO RGD:1342972 1624291 (PMID:9461559) RGD PMID:9461559 regulation of T cell differentiation ISO RGD:1332211 1624291 (MGI:MGI:5142352, PMID:21690296) RGD MGI:MGI:5142352 , PMID:21690296 response to drug IEP 8693585 RGD response to endoplasmic reticulum stress IDA 8693588 RGD response to epinephrine IEP 8693414 RGD response to oxidative stress ISO RGD:1332211 1624291 (MGI:MGI:5004801, PMID:17626041) RGD MGI:MGI:5004801 , PMID:17626041 response to oxidative stress ISO RGD:1342972 1624291 UniProtKB:Q03468 (PMID:17626041) RGD PMID:17626041 signal transduction in response to DNA damage ISO RGD:1342972 1624291 (PMID:15657060), (PMID:9037071) RGD PMID:15657060 , PMID:9037071 spleen development ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:2153797 , PMID:2065352) RGD MGI:MGI:2153797 , PMID:2065352 substrate adhesion-dependent cell spreading ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 T cell receptor signaling pathway ISO RGD:1332211 1624291 (MGI:MGI:3798766, PMID:18305217) RGD MGI:MGI:3798766 , PMID:18305217 thymus development ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:2153797 , PMID:2065352) RGD MGI:MGI:2153797 , PMID:2065352 transitional one stage B cell differentiation ISO RGD:1332211 1624291 MGI:MGI:2153718 (MGI:MGI:3839222 , PMID:19228876) RGD MGI:MGI:3839222 , PMID:19228876 Cellular Component actin cytoskeleton ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 cell IEA GO:0007204 1600115 GO_REF:0000108 GOC GO_REF:0000108 cell IEA GO:0051281 1600115 GO_REF:0000108 GOC GO_REF:0000108 cell leading edge ISO RGD:1332211 1624291 (MGI:MGI:4462113, PMID:20417104) RGD MGI:MGI:4462113 , PMID:20417104 cytoplasm ISO RGD:1342972 1624291 (PMID:17515907) RGD PMID:17515907 cytoplasm ISO RGD:1332211 1624291 (MGI:MGI:2175933 more ... RGD MGI:MGI:2175933 more ... cytoplasm IDA 8693403 RGD cytosol ISO RGD:1342972 1624291 (PMID:11120811) RGD PMID:11120811 dendrite IDA 12911004 PMID:24658113 ARUK-UCL endoplasmic reticulum IDA 8693588 RGD growth cone IDA 8693599 RGD mitochondrion IDA 8693588 RGD neuron projection IDA 8693579 RGD neuronal cell body IDA 8693592 RGD neuronal cell body IDA 12911004 PMID:24658113 ARUK-UCL nuclear body ISO RGD:1342972 1624291 RGD GO_REF:0000052 nucleolus ISO RGD:1342972 1624291 (PMID:12944467), (PMID:17626041) RGD PMID:12944467 , PMID:17626041 nucleoplasm ISO RGD:1342972 1624291 RGD GO_REF:0000052 nucleus ISO RGD:1332211 1624291 (MGI:MGI:3694152 more ... RGD MGI:MGI:3694152 more ... nucleus ISO RGD:1342972 1624291 (PMID:17626041), (PMID:17888034), (PMID:9168116) RGD PMID:17626041 more ... nucleus IDA 12911004 PMID:24658113 ARUK-UCL nucleus IDA 8693403 RGD perinuclear region of cytoplasm ISO RGD:1342972 1624291 (PMID:17888034) RGD PMID:17888034 protein-containing complex ISO RGD:1342972 1624291 UniProtKB:P46108 (PMID:12384576) RGD PMID:12384576 ruffle IDA 1598670 RGD synapse IDA 8693579 RGD Molecular Function actin filament binding ISO RGD:1332211 1624291 (MGI:MGI:2175933, PMID:11864995) RGD MGI:MGI:2175933 , PMID:11864995 ATP binding ISO RGD:1342972 1624291 (PMID:9144171) RGD PMID:9144171 ATP binding ISO RGD:1332211 1624291 (MGI:MGI:3694185, PMID:9109492) RGD MGI:MGI:3694185 , PMID:9109492 bubble DNA binding ISO RGD:1342972 1624291 (PMID:9558345) RGD PMID:9558345 delta-catenin binding IDA 8693599 RGD ephrin receptor binding ISO RGD:1332211 1624291 UniProtKB:D3ZZK3 (MGI:MGI:5588508 , PMID:24658113) RGD MGI:MGI:5588508 , PMID:24658113 four-way junction DNA binding ISO RGD:1342972 1624291 (PMID:9558345) RGD PMID:9558345 kinase activity ISO RGD:1332211 1624291 (MGI:MGI:2446961, PMID:12379650) RGD MGI:MGI:2446961 , PMID:12379650 kinase activity ISO RGD:1342972 1624291 (PMID:28288113) RGD PMID:28288113 magnesium ion binding ISO RGD:1342972 1624291 (PMID:9144171) RGD PMID:9144171 magnesium ion binding ISO RGD:1332211 1624291 (MGI:MGI:3694185, PMID:9109492) RGD MGI:MGI:3694185 , PMID:9109492 manganese ion binding ISO RGD:1342972 1624291 (PMID:9144171) RGD PMID:9144171 manganese ion binding ISO RGD:1332211 1624291 (MGI:MGI:3694185, PMID:9109492) RGD MGI:MGI:3694185 , PMID:9109492 mitogen-activated protein kinase binding ISO RGD:1342972 1624291 UniProtKB:Q13177 (PMID:11121037) RGD PMID:11121037 neuropilin binding ISO RGD:1332211 1624291 UniProtKB:P97333 (MGI:MGI:5588737 , PMID:24863063) RGD MGI:MGI:5588737 , PMID:24863063 neuropilin binding ISO RGD:1342972 1624291 UniProtKB:O14786 (PMID:24863063) RGD PMID:24863063 non-membrane spanning protein tyrosine kinase activity ISO RGD:1342972 1624291 (PMID:28428613), (PMID:9461559) RGD PMID:28428613 , PMID:9461559 phosphotyrosine residue binding ISO RGD:1342972 1624291 UniProtKB:O84462 , UniProtKB:Q6GX35 (PMID:20624904) RGD PMID:20624904 proline-rich region binding ISO RGD:1342972 1624291 UniProtKB:Q9NYB9 (PMID:15657060), (PMID:7590236) RGD PMID:15657060 , PMID:7590236 protein binding IPI RGD:2070 1598671 RGD protein binding ISO RGD:1342972 1624291 UniProtKB:O35158 more ... RGD PMID:11374898 more ... protein binding ISO RGD:1332211 1624291 UniProtKB:P28693 more ... RGD MGI:MGI:1099567 more ... protein binding IPI RGD:68424 8693579 RGD protein binding IPI RGD:620144 8693411 RGD protein C-terminus binding ISO RGD:1342972 1624291 UniProtKB:Q99638 (PMID:11971963) RGD PMID:11971963 protein domain specific binding ISO RGD:1332211 1624291 UniProtKB:P55194 more ... RGD MGI:MGI:1344938 , PMID:8438166 protein kinase activity ISO RGD:1332211 1624291 (MGI:MGI:2175933 more ... RGD MGI:MGI:2175933 more ... protein kinase activity ISO RGD:1342972 1624291 (PMID:11120811), (PMID:24863063) RGD PMID:11120811 , PMID:24863063 protein kinase activity IMP 8693572 RGD protein kinase binding IPI RGD:70514 8693570 RGD protein kinase C binding ISO RGD:1342972 1624291 UniProtKB:Q05655 (PMID:10713049) RGD PMID:10713049 protein tyrosine kinase activity ISO RGD:1342972 1624291 (PMID:11121037), (PMID:12944467), (PMID:15657060), (PMID:15657136), (PMID:17888034), (PMID:20823226), (PMID:24520051), (PMID:7590236), (PMID:9144171) RGD PMID:11121037 more ... protein tyrosine kinase activity ISO RGD:1332211 1624291 MGI:MGI:104738 more ... RGD MGI:MGI:2384444 more ... sequence-specific double-stranded DNA binding ISO RGD:1342972 1624291 (PMID:9558345) RGD PMID:9558345 SH2 domain binding ISO RGD:1342972 1624291 UniProtKB:P46108 (PMID:12384576) RGD PMID:12384576 SH3 domain binding ISO RGD:1342972 1624291 UniProtKB:Q9NYB9 (PMID:7590236) RGD PMID:7590236 supercoiled DNA binding NOT ISO RGD:1342972 1624291 (PMID:9558345) RGD PMID:9558345 syntaxin binding ISO RGD:1342972 1624291 UniProtKB:Q9Z158 (PMID:23006999) RGD PMID:23006999
Gene-Chemical Interaction Annotations
