Tsc1 (TSC complex subunit 1) - Rat Genome Database

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Gene: Tsc1 (TSC complex subunit 1) Rattus norvegicus
Analyze
Symbol: Tsc1
Name: TSC complex subunit 1
RGD ID: 620124
Description: Predicted to enable ATPase inhibitor activity; heat shock protein binding activity; and protein folding chaperone. Involved in several processes, including negative regulation of GTPase activity; positive regulation of stress fiber assembly; and regulation of macroautophagy. Located in growth cone; nucleus; and perinuclear region of cytoplasm. Used to study obesity. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; mTOR signaling pathway; insulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hamartin; tuberous sclerosis 1; tuberous sclerosis 1 protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,367,434 - 32,416,565 (+)NCBIGRCr8
mRatBN7.2311,969,547 - 12,018,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,979,729 - 12,015,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx315,059,218 - 15,086,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,644,177 - 23,671,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,898,622 - 21,926,266 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,219,955 - 7,269,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,237,192 - 7,265,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,570,765 - 12,619,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,645,313 - 7,672,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.137,645,612 - 7,673,244 (+)NCBI
Celera36,767,562 - 6,795,193 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Tsc1Ratbreast cancer disease_progressionISOTSC1 (Homo sapiens)11568707mRNA:decreased expression:breastRGD 
Tsc1RatInsulin Resistance  ISOTsc1 (Mus musculus)1624197 RGD 
Tsc1Ratintellectual disability  ISOTSC1 (Homo sapiens)11535605associated with Tuberous Sclerosis and DNA:frameshift mutationsRGD 
Tsc1RatKidney Neoplasms  ISOTsc1 (Mus musculus)11570508 RGD 
Tsc1RatLung Neoplasms  ISOTsc1 (Mus musculus)11568678 RGD 
Tsc1Ratobesity  IDA 11570513DNA:hypermethylation:promoterRGD 
Tsc1Ratpancreatic carcinoma  ISOTsc1 (Mus musculus)11570510 RGD 
Tsc1Ratpleomorphic xanthoastrocytoma  ISOTSC1 (Homo sapiens)11570509mRNA:decreased expression:brainRGD 
Tsc1Rattuberous sclerosis  ISOTSC1 (Homo sapiens)1624196DNA:nonsense mutations and deletion: :multipleRGD 
Tsc1Rattuberous sclerosis susceptibilityISOTSC1 (Homo sapiens)9068941DNA:nonsense mutations and deletion: :multipleRGDPMID:9242607 and REF_RGD_ID:1624196
Tsc1Rattuberous sclerosis  ISOTSC1 (Homo sapiens)11073512DNA:nonsense mutation:exon:p.R509X (c.1525C>T) (human)RGD 
Tsc1Rattuberous sclerosis  ISOTSC1 (Homo sapiens)11062248DNA:deletions more ...RGD 
Tsc1Rattuberous sclerosis  ISOTsc1 (Mus musculus)11570511 RGD 
Tsc1Rattuberous sclerosis 1 treatmentISOTSC1 (Homo sapiens)11570507 RGD 
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Tsc1Ratacute myeloid leukemia  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Acute myeloid leukemiaClinVarPMID:25741868 more ...
Tsc1Ratautism spectrum disorder  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disordersClinVarPMID:21309039 more ...
Tsc1Ratautosomal dominant nocturnal frontal lobe epilepsy  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant epilepsyClinVar 
Tsc1Ratbreast cancer  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10353610 more ...
Tsc1Ratcraniopharyngioma  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:22161988 more ...
Tsc1Ratdevelopmental and epileptic encephalopathy  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Tsc1Ratdevelopmental and epileptic encephalopathy 14  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 14ClinVarPMID:28492532
Tsc1Ratearly infantile epileptic encephalopathy  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
Tsc1RatEhlers-Danlos syndrome classic type 1  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and classic typeClinVarPMID:28492532
Tsc1Ratepilepsy  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVarPMID:10227394 more ...
Tsc1RatFocal Cortical Dysplasia of Taylor  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10205261 more ...
Tsc1RatFocal Cortical Dysplasia of Taylor, Type IIB  ISOTSC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cortical dysplasia of Taylor with balloon cellsClinVarPMID:10227394 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227394 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227394 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227394 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10090883 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227394 more ...
Tsc1RatHereditary Neoplastic Syndromes  ISOTSC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227394 more ...
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Original Reference(s)
Tsc1Ratautistic disorder  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18067135
Tsc1Ratbrain disease  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21062901
Tsc1Ratcognitive disorder  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18067135
Tsc1Ratepilepsy  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12112044 and PMID:21062901
Tsc1RatFocal Cortical Dysplasia of Taylor  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12112044 and PMID:28215400
Tsc1Rathepatocellular carcinoma  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21499249
Tsc1Ratlymphangioleiomyomatosis  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32078667
Tsc1RatMouth Neoplasms  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18538015
Tsc1Ratprogressive myoclonus epilepsy  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17484760
Tsc1Ratrenal cell carcinoma  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22138691
Tsc1Ratsquamous cell carcinoma  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18538015
Tsc1Rattuberous sclerosis  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18345974 more ...
Tsc1Rattuberous sclerosis 1  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Tsc1RatWest syndrome  ISOTSC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18345974
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Tsc1RatFocal Cortical Dysplasia of Taylor  ISOTSC1 (Homo sapiens)7240710 OMIM 
Tsc1Ratlymphangioleiomyomatosis  ISOTSC1 (Homo sapiens)7240710 OMIM 
Tsc1Rattuberous sclerosis 1  ISOTSC1 (Homo sapiens)7240710 OMIM 

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Tsc1Rat(1->4)-beta-D-glucan multiple interactionsISOTsc1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TSC1 mRNACTDPMID:36331819
Tsc1Rat(S)-naringenin multiple interactionsISOTSC1 (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of TSC1 mRNACTDPMID:36235125
Tsc1Rat1,2-dimethylhydrazine multiple interactionsISOTsc1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of TSC1 mRNACTDPMID:22206623
Tsc1Rat1,2-dimethylhydrazine affects expressionISOTsc1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of TSC1 mRNACTDPMID:22206623
Tsc1Rat17alpha-ethynylestradiol affects expressionISOTsc1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of TSC1 mRNACTDPMID:17555576
Tsc1Rat17beta-estradiol decreases expressionISOTsc1 (Mus musculus)6480464Estradiol results in decreased expression of TSC1 mRNACTDPMID:39298647
Tsc1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOTsc1 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Tsc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of TSC1 mRNACTDPMID:22298810
Tsc1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOTsc1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of TSC1 mRNACTDPMID:26290441
Tsc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOTsc1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of TSC1 mRNACTDPMID:21570461
Tsc1Rat4,4'-sulfonyldiphenol decreases expressionISOTsc1 (Mus musculus)6480464bisphenol S results in decreased expression of TSC1 mRNACTDPMID:39298647
Tsc1Rat4,4'-sulfonyldiphenol decreases methylationISOTsc1 (Mus musculus)6480464bisphenol S results in decreased methylation of TSC1 exonCTDPMID:33297965
Tsc1Rat4-hydroxynon-2-enal decreases expressionISOTsc1 (Mus musculus)64804644-hydroxy-2-nonenal results in decreased expression of TSC1 mRNACTDPMID:19191707
Tsc1Rat5-aza-2'-deoxycytidine affects expressionISOTSC1 (Homo sapiens)6480464Decitabine affects the expression of TSC1 mRNACTDPMID:23300844
Tsc1Rat5-azacytidine multiple interactionsISOTSC1 (Homo sapiens)6480464[Azacitidine affects the methylation of TSC1 promoter] which affects the expression of TSC1 mRNACTDPMID:18538015
Tsc1Ratacrolein multiple interactionsISOTSC1 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of TSC1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of TSC1 mRNACTDPMID:32699268
Tsc1Ratacrylamide increases expressionISOTSC1 (Homo sapiens)6480464Acrylamide results in increased expression of TSC1 mRNACTDPMID:32763439
Tsc1Rataflatoxin B1 increases expressionISOTsc1 (Mus musculus)6480464Aflatoxin B1 results in increased expression of TSC1 mRNACTDPMID:19770486
Tsc1Rataflatoxin B1 decreases expressionEXP 6480464Aflatoxin B1 results in decreased expression of TSC1 mRNACTDPMID:33354967
Tsc1Ratall-trans-retinoic acid decreases expressionISOTSC1 (Homo sapiens)6480464Tretinoin results in decreased expression of TSC1 mRNACTDPMID:33167477

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Biological Process
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Tsc1Ratactivation of GTPase activity involved_inISOTSC1 (Homo sapiens)1624291 PMID:10806479RGDPMID:10806479
Tsc1Ratadaptive immune response acts_upstream_of_or_withinISOTsc1 (Mus musculus)1624291MGI:2656240 PMID:25271321RGDPMID:25271321
Tsc1Ratadaptive immune response acts_upstream_of_or_withinIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratadult locomotory behavior involved_inIMP 10448950PMID:23435171ParkinsonsUK-UCL 
Tsc1Ratassociative learning involved_inIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratassociative learning involved_inISOTsc1 (Mus musculus)1624291MGI:2656240 PMID:26158416RGDPMID:26158416
Tsc1Ratcardiac muscle cell differentiation acts_upstream_of_or_withinISOTsc1 (Mus musculus)1624291MGI:2183146 PMID:11438694RGDPMID:11438694
Tsc1Ratcardiac muscle cell differentiation acts_upstream_of_or_withinIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcell population proliferation acts_upstream_ofISOTsc1 (Mus musculus)1624291MGI:2183146 PMID:11438694RGDPMID:11438694
Tsc1Ratcell population proliferation acts_upstream_ofIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcell projection organization acts_upstream_of_or_withinISOTsc1 (Mus musculus)1624291MGI:2656240 PMID:16286931RGDPMID:16286931
Tsc1Ratcell projection organization acts_upstream_of_or_withinIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcell-matrix adhesion involved_inISOTSC1 (Homo sapiens)1624291 PMID:10806479RGDPMID:10806479
Tsc1Ratcell-matrix adhesion involved_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcellular response to decreased oxygen levels involved_inIMP 10448950PMID:23435171ParkinsonsUK-UCL 
Tsc1Ratcellular response to starvation involved_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcellular response to starvation involved_inISSUniProtKB:Q925741600115GO_REF:0000024UniProtGO_REF:0000024
Tsc1Ratcellular response to starvation involved_inISOTSC1 (Homo sapiens)1624291 PMID:24529379RGDPMID:24529379
Tsc1Ratcerebral cortex development acts_upstream_of_or_withinISOTsc1 (Mus musculus)1624291MGI:2176055 more ...RGDPMID:17522300
Tsc1Ratcerebral cortex development acts_upstream_of_or_withinIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Tsc1Ratactin filament located_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratactin filament located_inISOTSC1 (Homo sapiens)1624291 PMID:10806479RGDPMID:10806479
Tsc1Ratcell cortex located_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcell cortex located_inISOTSC1 (Homo sapiens)1624291 PMID:10806479RGDPMID:10806479
Tsc1Ratcell projection  IDA 11568689 RGD 
Tsc1Ratciliary basal body located_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratciliary basal body located_inIEAUniProtKB:X5D9D2 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratciliary basal body located_inISOTSC1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Tsc1Ratcytoplasm located_inISOTSC1 (Homo sapiens)1624291 PMID:9580671RGDPMID:9580671
Tsc1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Tsc1Ratcytoplasm located_inIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcytoplasm located_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcytoplasm located_inISOTsc1 (Mus musculus)1624291 PMID:11741832 and PMID:16286931RGDPMID:11741832 and PMID:16286931
Tsc1Ratcytosol located_inISOTSC1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Tsc1Ratcytosol located_inIEAUniProtKB:X5D9D2 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Tsc1Ratcytosol located_inIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratcytosol located_inISOTSC1 (Homo sapiens)1624291 PMID:10585443 and PMID:24529379RGDPMID:10585443 and PMID:24529379
Tsc1Ratcytosol located_inISSUniProtKB:Q925741600115GO_REF:0000024UniProtGO_REF:0000024
Tsc1Ratgrowth cone  IDA 633519 RGD 
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Molecular Function
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Tsc1RatATPase inhibitor activity enablesISOTsc1 (Mus musculus)1624291 PMID:29127155RGDPMID:29127155
Tsc1RatATPase inhibitor activity enablesIEAUniProtKB:Q9EP53 and ensembl:ENSMUSP000000281551600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1RatATPase inhibitor activity enablesISOTSC1 (Homo sapiens)1624291 PMID:29127155RGDPMID:29127155
Tsc1RatATPase inhibitor activity enablesIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1RatHsp70 protein binding enablesIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1RatHsp70 protein binding enablesISOTSC1 (Homo sapiens)1624291 PMID:29127155RGDPMID:29127155
Tsc1RatHsp90 protein binding enablesIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1RatHsp90 protein binding enablesISOTSC1 (Homo sapiens)1624291UniProtKB:P07900 more ...RGDPMID:29127155
Tsc1Ratprotein binding  IPIPpp1r15a (Rattus norvegicus)9999170 RGD 
Tsc1Ratprotein binding enablesISOTSC1 (Homo sapiens)1624291UniProtKB:A2RU56 more ...RGDPMID:10585443 more ...
Tsc1Ratprotein binding enablesISOTsc1 (Mus musculus)1624291UniProtKB:D3YZU1 more ...RGDPMID:10806479 more ...
Tsc1Ratprotein binding  IPIBex3 (Rattus norvegicus)11570512 RGD 
Tsc1Ratprotein folding chaperone enablesISOTSC1 (Homo sapiens)1624291 PMID:10585443RGDPMID:10585443
Tsc1Ratprotein folding chaperone enablesIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
Tsc1Ratprotein-folding chaperone binding enablesISOTSC1 (Homo sapiens)1624291UniProtKB:P49815 and PMID:10585443RGDPMID:10585443
Tsc1Ratprotein-folding chaperone binding enablesIEAUniProtKB:Q92574 and ensembl:ENSP000002985521600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Tsc1Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Tsc1RatmTOR signaling pathway   IEA 6907045 KEGGrno:04150

Imported Annotations - PID (archival)

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Tsc1RatmTOR signaling pathway   ISOTSC1 (Homo sapiens)6484113 PIDPID:200096

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Reference Title
Reference Citation
1. Regulation of mTORC1 by PI3K signaling. Dibble CC and Cantley LC, Trends Cell Biol. 2015 Sep;25(9):545-55. doi: 10.1016/j.tcb.2015.06.002. Epub 2015 Jul 6.
2. Neurogenin 3-directed cre deletion of Tsc1 gene causes pancreatic acinar carcinoma. Ding L, etal., Neoplasia. 2014 Nov 20;16(11):909-17. doi: 10.1016/j.neo.2014.08.010. eCollection 2014 Nov.
3. Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. Feliciano DM, etal., J Clin Invest. 2011 Apr;121(4):1596-607. doi: 10.1172/JCI44909. Epub 2011 Mar 14.
4. Antisense suppression of TSC1 gene product, hamartin, enhances neurite outgrowth in NGF-treated PC12h cells. Floricel F, etal., Brain Dev. 2007 Sep;29(8):502-9. Epub 2007 Mar 21.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. Goncharova E, etal., J Cell Biol. 2004 Dec 20;167(6):1171-82.
8. The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. Haddad LA, etal., J Biol Chem 2002 Nov 15;277(46):44180-6.
9. The preventive effect of liraglutide on the lipotoxic liver injury via increasing autophagy. He Y, etal., Ann Hepatol. 2020 Jan - Feb;19(1):44-52. doi: 10.1016/j.aohep.2019.06.023. Epub 2019 Sep 24.
10. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Hyrskyluoto A, etal., Exp Cell Res. 2012 Jan 1;318(1):33-42. doi: 10.1016/j.yexcr.2011.08.020. Epub 2011 Sep 7.
11. Tuberin and hamartin are aberrantly expressed and linked to clinical outcome in human breast cancer: the role of promoter methylation of TSC genes. Jiang WG, etal., Eur J Cancer. 2005 Jul;41(11):1628-36.
12. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Kobayashi T, etal., Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8762-7. Epub 2001 Jul 3.
13. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. Liang MC, etal., Oncogene. 2010 Mar 18;29(11):1588-97. doi: 10.1038/onc.2009.452. Epub 2009 Dec 7.
14. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
15. The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. Mak BC, etal., J Biol Chem 2003 Feb 21;278(8):5947-51. Epub 2003 Jan 02.
16. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
17. N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo. Momose S, etal., Biochem Biophys Res Commun. 2007 May 11;356(3):693-8. Epub 2007 Mar 13.
18. Pam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complex. Murthy V, etal., J Biol Chem 2004 Jan 9;279(2):1351-8. Epub 2003 Oct 14.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
1 to 20 of 36 rows
PMID:9580671   PMID:9809973   PMID:10029074   PMID:10585443   PMID:10806479   PMID:10807585   PMID:10915759   PMID:11175345   PMID:11741832   PMID:15185396   PMID:15664737   PMID:15851513  
PMID:15888477   PMID:16286931   PMID:16393152   PMID:16636147   PMID:16996505   PMID:17308101   PMID:17522300   PMID:18511518   PMID:19348060   PMID:19420259   PMID:19897899   PMID:25211037  
PMID:25271321   PMID:28215400   PMID:29127155   PMID:32739207   PMID:37020385   PMID:39169069  



Tsc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,367,434 - 32,416,565 (+)NCBIGRCr8
mRatBN7.2311,969,547 - 12,018,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,979,729 - 12,015,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx315,059,218 - 15,086,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,644,177 - 23,671,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,898,622 - 21,926,266 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,219,955 - 7,269,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,237,192 - 7,265,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,570,765 - 12,619,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,645,313 - 7,672,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.137,645,612 - 7,673,244 (+)NCBI
Celera36,767,562 - 6,795,193 (+)NCBICelera
Cytogenetic Map3p12NCBI
TSC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,891,349 - 132,945,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9132,891,348 - 132,946,874 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,766,736 - 135,820,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,756,557 - 134,809,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 349132,815,940 - 132,849,574NCBI
Celera9106,308,473 - 106,361,761 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9105,260,658 - 105,313,711 (-)NCBIHuRef
CHM1_19135,917,213 - 135,970,447 (-)NCBICHM1_1
T2T-CHM13v2.09145,103,162 - 145,157,190 (-)NCBIT2T-CHM13v2.0
Tsc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,531,005 - 28,581,183 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,531,240 - 28,581,179 (+)EnsemblGRCm39 Ensembl
GRCm38228,640,993 - 28,691,172 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,641,228 - 28,691,167 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,496,763 - 28,546,687 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,463,252 - 28,513,176 (+)NCBIMGSCv36mm8
Celera228,345,749 - 28,395,673 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Tsc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,197,037 - 2,244,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,197,037 - 2,244,992 (-)NCBIChiLan1.0ChiLan1.0
TSC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,414,619 - 6,468,611 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,415,528 - 6,470,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,007,708 - 104,060,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,638,003 - 132,692,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,638,003 - 132,675,759 (-)Ensemblpanpan1.1panPan2
TSC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,409,307 - 51,459,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,425,937 - 51,454,677 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,673,940 - 50,724,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,304,134 - 52,354,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,304,753 - 52,354,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,082,516 - 51,133,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,407,015 - 51,457,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,486,514 - 51,537,117 (+)NCBIUU_Cfam_GSD_1.0
Tsc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,562,656 - 199,618,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,331,194 - 19,386,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,331,183 - 19,386,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,636,532 - 272,685,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,636,530 - 272,685,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,795,196 - 306,819,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,195,604 - 5,249,042 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,195,675 - 5,244,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607910,396,791 - 10,450,324 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,498,692 - 3,532,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,479,028 - 3,536,612 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Tsc1
246 total Variants

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:41
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000016904
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

1 to 10 of 22 rows
PMC18172P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2311,991,703 - 11,992,226 (+)MAPPERmRatBN7.2
Rnor_6.037,242,180 - 7,242,702NCBIRnor6.0
Rnor_5.0312,592,870 - 12,593,392UniSTSRnor5.0
RGSC_v3.437,650,177 - 7,650,699UniSTSRGSC3.4
Celera36,772,426 - 6,772,948UniSTS
Cytogenetic Map3p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 22 of 22 rows
RefSeq Transcripts NM_021854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB011821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB016165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 22 of 22 rows

Ensembl Acc Id: ENSRNOT00000016904   ⟹   ENSRNOP00000016904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl311,979,729 - 12,015,674 (+)Ensembl
Rnor_6.0 Ensembl37,237,192 - 7,265,145 (+)Ensembl
RefSeq Acc Id: NM_021854   ⟹   NP_068626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,697 - 32,416,562 (+)NCBI
mRatBN7.2311,969,725 - 12,018,588 (+)NCBI
Rnor_6.037,237,316 - 7,264,947 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
RGSC_v3.437,645,313 - 7,672,944 (+)RGD
Celera36,767,562 - 6,795,193 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233844   ⟹   XP_006233906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,434 - 32,416,565 (+)NCBI
mRatBN7.2311,969,549 - 12,018,591 (+)NCBI
Rnor_6.037,219,955 - 7,269,063 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233845   ⟹   XP_006233907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,760 - 32,416,565 (+)NCBI
mRatBN7.2311,970,129 - 12,018,591 (+)NCBI
Rnor_6.037,220,597 - 7,269,063 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233846   ⟹   XP_006233908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,375,074 - 32,416,565 (+)NCBI
mRatBN7.2311,978,921 - 12,018,591 (+)NCBI
Rnor_6.037,227,084 - 7,269,063 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233847   ⟹   XP_006233909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,374,514 - 32,416,565 (+)NCBI
mRatBN7.2311,976,537 - 12,018,591 (+)NCBI
Rnor_6.037,227,013 - 7,269,063 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233849   ⟹   XP_006233911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,522 - 32,416,565 (+)NCBI
mRatBN7.2311,969,547 - 12,018,591 (+)NCBI
Rnor_6.037,219,955 - 7,269,063 (+)NCBI
Rnor_5.0312,570,765 - 12,619,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105772   ⟹   XP_038961700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,374,633 - 32,416,565 (+)NCBI
mRatBN7.2311,976,662 - 12,018,591 (+)NCBI
RefSeq Acc Id: XM_063284467   ⟹   XP_063140537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,518 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284468   ⟹   XP_063140538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,518 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284469   ⟹   XP_063140539
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,374,512 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284470   ⟹   XP_063140540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,368,138 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284471   ⟹   XP_063140541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,375,070 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284472   ⟹   XP_063140542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,806 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284474   ⟹   XP_063140544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,516 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284475   ⟹   XP_063140545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,792 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284476   ⟹   XP_063140546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,367,522 - 32,416,565 (+)NCBI
RefSeq Acc Id: XM_063284477   ⟹   XP_063140547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8332,387,250 - 32,416,565 (+)NCBI
1 to 5 of 18 rows
1 to 5 of 18 rows
RefSeq Acc Id: NP_068626   ⟸   NM_021854
- UniProtKB: Q9Z136 (UniProtKB/Swiss-Prot),   A6JTP4 (UniProtKB/TrEMBL),   A0A8L2Q989 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233911   ⟸   XM_006233849
- Peptide Label: isoform X4
- UniProtKB: A0A8L2Q989 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233906   ⟸   XM_006233844
- Peptide Label: isoform X3
- UniProtKB: Q9Z136 (UniProtKB/Swiss-Prot),   A6JTP4 (UniProtKB/TrEMBL),   A0A8L2Q989 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233907   ⟸   XM_006233845
- Peptide Label: isoform X3
- UniProtKB: Q9Z136 (UniProtKB/Swiss-Prot),   A6JTP4 (UniProtKB/TrEMBL),   A0A8L2Q989 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233909   ⟸   XM_006233847
- Peptide Label: isoform X3
- UniProtKB: Q9Z136 (UniProtKB/Swiss-Prot),   A6JTP4 (UniProtKB/TrEMBL),   A0A8L2Q989 (UniProtKB/TrEMBL)
- Sequence:

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z136-F1-model_v2 AlphaFold Q9Z136 1-1163 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50273 BioCyc
Ensembl Genes ENSRNOG00000011470 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016904 ENTREZGENE
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  Hamartin UniProtKB/Swiss-Prot
KEGG Report rno:60445 UniProtKB/Swiss-Prot
NCBI Gene 60445 ENTREZGENE
PANTHER HAMARTIN UniProtKB/Swiss-Prot
  PTHR15154 UniProtKB/Swiss-Prot
Pfam Hamartin UniProtKB/Swiss-Prot
PhenoGen Tsc1 PhenoGen
RatGTEx ENSRNOG00000011470 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
UniProt A0A8L2Q989 ENTREZGENE, UniProtKB/TrEMBL
  A6JTP4 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z136 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-05 Tsc1  TSC complex subunit 1  Tsc1  tuberous sclerosis 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Tsc1  tuberous sclerosis 1      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Tsc1        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_function binds to neurofilament light chain 633519
gene_function associates with Pam, an interactor of Myc 1304444