Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) - Rat Genome Database
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Gene: Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) Rattus norvegicus
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Symbol: Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
RGD ID: 621526
Description: Exhibits protein phosphatase 1 binding activity. Involved in several processes, including cellular response to nutrient levels; cellular response to organonitrogen compound; and regulation of cellular protein metabolic process. Localizes to cytosol. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gadd34; growth arrest and DNA damage-inducible protein GADD34; Myd116; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116 homolog; Peg-3; progression elevated gene 3 protein; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; RGD1624209
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,000,053 - 96,003,128 (-)NCBI
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Celera190,255,750 - 90,258,825 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dieldrin  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elesclomol  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gliotoxin  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
idarubicin  (ISO)
indometacin  (EXP,ISO)
isoprenaline  (ISO)
lactacystin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
Nodularin  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
rotenone  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
apoptotic process  (IEA)
cellular response to antibiotic  (IEP)
cellular response to calcium ion starvation  (IEP)
cellular response to carbohydrate stimulus  (IEP)
cellular response to cordycepin  (IEP)
cellular response to desipramine  (IEP)
cellular response to drug  (IEP)
cellular response to gold(3+)  (IEP)
cellular response to methamphetamine hydrochloride  (IEP)
cellular response to methyl methanesulfonate  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to oxygen-glucose deprivation  (IEP)
cellular response to UV  (IEP)
endoplasmic reticulum unfolded protein response  (IEP,ISO)
negative regulation of cell death  (IMP)
negative regulation of cell population proliferation  (IDA)
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of phosphoprotein phosphatase activity  (ISO)
negative regulation of protein dephosphorylation  (ISO)
negative regulation of protein processing  (IMP)
negative regulation of response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
peptidyl-serine dephosphorylation  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine dephosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphoprotein phosphatase activity  (IBA,ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of transcription by RNA polymerase I  (ISO)
protein localization to endoplasmic reticulum  (ISO)
regulation of angiogenesis  (IMP)
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
regulation of translational initiation by eIF2 alpha dephosphorylation  (ISO)
response to cocaine  (IEP)
response to endoplasmic reticulum stress  (IBA,IEP,ISO)
response to environmental enrichment  (IEP)
response to immobilization stress  (IEP)
response to organic cyclic compound  (IEP)

Cellular Component

Molecular Function

References

References - curated
1. Amundson SA, etal., Oncogene. 1998 Oct 29;17(17):2149-54.
2. Badiola N, etal., Cell Death Dis. 2011 Apr 28;2:e149. doi: 10.1038/cddis.2011.31.
3. Beauvais G, etal., PLoS One. 2011;6(12):e28946. doi: 10.1371/journal.pone.0028946. Epub 2011 Dec 13.
4. Coustry F, etal., Am J Pathol. 2012 Feb;180(2):738-48. doi: 10.1016/j.ajpath.2011.10.033. Epub 2011 Dec 7.
5. Doutheil J, etal., Brain Res Mol Brain Res. 1999 Jan 8;63(2):225-32.
6. Garcia-Bonilla L, etal., J Neurochem. 2007 Nov;103(4):1368-80. Epub 2007 Aug 30.
7. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Grootjans J, etal., Gastroenterology. 2011 Feb;140(2):529-539.e3. doi: 10.1053/j.gastro.2010.10.040. Epub 2010 Oct 19.
9. Hollander MC, etal., Oncogene. 2003 Jun 19;22(25):3827-32.
10. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
11. Hyrskyluoto A, etal., Exp Cell Res. 2012 Jan 1;318(1):33-42. doi: 10.1016/j.yexcr.2011.08.020. Epub 2011 Sep 7.
12. Jaronen M, etal., Hum Mol Genet. 2013 Feb 15;22(4):646-55. doi: 10.1093/hmg/dds472. Epub 2012 Nov 1.
13. Jayanthi S, etal., PLoS One. 2009 Jun 30;4(6):e6092. doi: 10.1371/journal.pone.0006092.
14. Kitaguchi Y, etal., PLoS One. 2012;7(5):e38038. doi: 10.1371/journal.pone.0038038. Epub 2012 May 31.
15. Kitamura M, etal., Cell Death Differ. 2011 Dec;18(12):1876-88. doi: 10.1038/cdd.2011.63. Epub 2011 May 20.
16. Lelong DC, etal., Stroke. 2007 Dec;38(12):3237-44. Epub 2007 Nov 1.
17. Lin MH, etal., Toxicology. 2014 Jan 6;315:24-37. doi: 10.1016/j.tox.2013.11.007. Epub 2013 Nov 28.
18. Lin W, etal., Am J Pathol. 2008 Nov;173(5):1508-17. doi: 10.2353/ajpath.2008.080449. Epub 2008 Sep 25.
19. Lum CT, etal., Int J Cancer. 2006 Mar 15;118(6):1527-38.
20. Ma J, etal., J Neurooncol. 2011 Jan;101(1):41-8. doi: 10.1007/s11060-010-0237-2. Epub 2010 Jun 12.
21. McCaig D, etal., Brain Res. 2005 Feb 9;1034(1-2):51-61.
22. Mengesdorf T, etal., Biochem J. 2001 Jun 15;356(Pt 3):805-12.
23. Mohammad-Gharibani P, etal., Mol Neurobiol. 2014 Oct;50(2):655-72. doi: 10.1007/s12035-014-8658-0. Epub 2014 Feb 28.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Paschen W, etal., J Neurochem. 2004 Aug;90(3):694-701.
26. Pavlovsky AA, etal., Neuroscience. 2013 Aug 29;246:160-9. doi: 10.1016/j.neuroscience.2013.04.057. Epub 2013 May 2.
27. Penas C, etal., J Neurochem. 2007 Aug;102(4):1242-55. Epub 2007 Jun 19.
28. Pipeline to import KEGG annotations from KEGG into RGD
29. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
31. RGD automated import pipeline for gene-chemical interactions
32. Schug M, etal., Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29.
33. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Su ZZ, etal., Oncogene. 2005 Mar 24;24(13):2247-55.
35. Su ZZ, etal., Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9125-30.
36. Su ZZ, etal., Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15115-20.
37. Szegezdi E, etal., J Cell Mol Med. 2008 Dec;12(6A):2482-96. doi: 10.1111/j.1582-4934.2008.00268.x. Epub 2008 Feb 5.
38. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
Additional References at PubMed
PMID:11381086   PMID:11517336   PMID:11564868   PMID:12556489   PMID:14635196   PMID:15389539   PMID:15601821   PMID:16835242   PMID:19131336   PMID:21518769  


Genomics

Comparative Map Data
Ppp1r15a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,000,053 - 96,003,128 (-)NCBI
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Celera190,255,750 - 90,258,825 (-)NCBICelera
Cytogenetic Map1q22NCBI
PPP1R15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,872,421 - 48,876,058 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,872,421 - 48,876,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,375,649 - 49,379,319 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,067,461 - 54,071,131 (+)NCBINCBI36hg18NCBI36
Build 341954,067,489 - 54,071,126NCBI
Celera1946,243,013 - 46,246,683 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,752,093 - 45,755,763 (+)NCBIHuRef
CHM1_11949,377,516 - 49,381,187 (+)NCBICHM1_1
Ppp1r15a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,172,341 - 45,175,692 (-)NCBIGRCm39mm39
GRCm39 Ensembl745,172,340 - 45,175,692 (-)Ensembl
GRCm38745,522,917 - 45,526,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,522,916 - 45,526,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,778,287 - 52,781,638 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,390,962 - 45,394,255 (-)NCBImm8
Celera740,979,415 - 40,982,766 (-)NCBICelera
Cytogenetic Map7B3NCBI
Ppp1r15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,750,168 - 1,753,629 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,750,227 - 1,753,607 (-)NCBIChiLan1.0ChiLan1.0
PPP1R15A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,880,052 - 54,883,840 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,880,141 - 54,883,003 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,872,596 - 45,876,376 (+)NCBIMhudiblu_PPA_v0panPan3
PPP1R15A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1107,486,438 - 107,489,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11107,486,399 - 107,490,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ppp1r15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366642,910,609 - 2,914,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,172,050 - 54,175,465 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,172,038 - 54,175,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,919,349 - 49,922,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R15A
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Ppp1r15a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,103,251 - 5,107,751 (-)NCBI

Position Markers
RH127458  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01101,511,999 - 101,512,181NCBIRnor6.0
Rnor_5.01102,590,777 - 102,590,959UniSTSRnor5.0
RGSC_v3.4195,994,123 - 95,994,305UniSTSRGSC3.4
Celera190,255,850 - 90,256,032UniSTS
RH 3.4 Map1909.29UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15655769122614963Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123406428108057505Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143579208126240667Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143579208126240667Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143579208126240667Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143579208126240667Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143579208126240667Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143579208126240667Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157761301104391981Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)158209327103209327Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)164588516125875986Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)166113339122614963Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)179134941113593716Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)179689548124689548Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)183656882126240667Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)188634585106002500Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)191093646136093646Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)194225372130917265Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)199983293127203999Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100354344145354344Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:10
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000044788
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 32 22 13 22 7 10 66 27 36 11 7
Low 2 25 19 6 19 1 1 8 8 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044788   ⟹   ENSRNOP00000048451
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079633   ⟹   ENSRNOP00000075192
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,511,907 - 101,514,547 (-)Ensembl
RefSeq Acc Id: NM_133546   ⟹   NP_598230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,000,053 - 96,003,128 (-)NCBI
Rnor_6.01101,511,899 - 101,514,974 (-)NCBI
Rnor_5.01102,590,677 - 102,593,806 (-)NCBI
RGSC_v3.4195,994,023 - 95,997,080 (-)RGD
Celera190,255,750 - 90,258,825 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228974   ⟹   XP_006229036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,511,899 - 101,515,043 (-)NCBI
Rnor_5.01102,590,677 - 102,593,806 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598230   ⟸   NM_133546
- UniProtKB: Q6IN02 (UniProtKB/Swiss-Prot),   A0A0G2JSW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229036   ⟸   XM_006228974
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000075192   ⟸   ENSRNOT00000079633
RefSeq Acc Id: ENSRNOP00000048451   ⟸   ENSRNOT00000044788
Protein Domains
PP1c_bdg

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690045
Promoter ID:EPDNEW_R569
Type:single initiation site
Name:Ppp1r15a_1
Description:protein phosphatase 1, regulatory subunit 15A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,514,984 - 101,515,044EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621526 AgrOrtholog
Ensembl Genes ENSRNOG00000020938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048451 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075192 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044788 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079633 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104357 IMAGE-MGC_LOAD
InterPro Prot_Pase1_reg-su15A/B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91505 IMAGE-MGC_LOAD
NCBI Gene 171071 ENTREZGENE
Pfam PP1c_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r15a PhenoGen
UniProt A0A0G2JSW4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K9Z3_RAT UniProtKB/TrEMBL
  PR15A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88344 UniProtKB/Swiss-Prot
  Q7TQC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r15a  protein phosphatase 1, regulatory subunit 15A  Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Myd116  myeloid differentiation primary response gene 116  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the gadd and Myd family 633491