Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) - Rat Genome Database

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Gene: Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) Rattus norvegicus
Analyze
Symbol: Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
RGD ID: 621526
Description: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to calcium ion starvation; cellular response to organonitrogen compound; and regulation of protein metabolic process. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gadd34; growth arrest and DNA damage-inducible protein GADD34; Myd116; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116 homolog; Peg-3; progression elevated gene 3 protein; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; RGD1624209
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,000,053 - 96,003,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,385,485 - 101,388,560 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,858,161 - 109,861,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,148,553 - 103,151,628 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Celera190,255,750 - 90,258,825 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
gliotoxin  (EXP)
glycidol  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
idarubicin  (ISO)
indometacin  (EXP,ISO)
isoprenaline  (ISO)
L-glutamine  (EXP)
L-serine  (ISO)
lactacystin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myristicin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
Nodularin  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to antibiotic  (IEP)
cellular response to calcium ion starvation  (IEP)
cellular response to carbohydrate stimulus  (IEP)
cellular response to cordycepin  (IEP)
cellular response to desipramine  (IEP)
cellular response to gold(3+)  (IEP)
cellular response to hypoxia  (IEP)
cellular response to methamphetamine hydrochloride  (IEP)
cellular response to methyl methanesulfonate  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to UV  (IEP)
cellular response to xenobiotic stimulus  (IEP)
endoplasmic reticulum unfolded protein response  (IEP,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of phosphate metabolic process  (IEA)
negative regulation of protein dephosphorylation  (ISO)
negative regulation of protein modification process  (IEA)
negative regulation of protein processing  (IMP)
negative regulation of response to endoplasmic reticulum stress  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine dephosphorylation  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of transcription by RNA polymerase I  (ISO)
protein localization to endoplasmic reticulum  (ISO)
regulation of angiogenesis  (IMP)
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
response to cocaine  (IEP)
response to endoplasmic reticulum stress  (IBA,IEP,ISO)
response to environmental enrichment  (IEP)
response to immobilization stress  (IEP)
response to organic cyclic compound  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Amundson SA, etal., Oncogene. 1998 Oct 29;17(17):2149-54.
2. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Badiola N, etal., Cell Death Dis. 2011 Apr 28;2:e149. doi: 10.1038/cddis.2011.31.
3. Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways. Beauvais G, etal., PLoS One. 2011;6(12):e28946. doi: 10.1371/journal.pone.0028946. Epub 2011 Dec 13.
4. D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis. Coustry F, etal., Am J Pathol. 2012 Feb;180(2):738-48. doi: 10.1016/j.ajpath.2011.10.033. Epub 2011 Dec 7.
5. Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis. Doutheil J, etal., Brain Res Mol Brain Res. 1999 Jan 8;63(2):225-32.
6. Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance. Garcia-Bonilla L, etal., J Neurochem. 2007 Nov;103(4):1368-80. Epub 2007 Aug 30.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Grootjans J, etal., Gastroenterology. 2011 Feb;140(2):529-539.e3. doi: 10.1053/j.gastro.2010.10.040. Epub 2010 Oct 19.
9. Gadd34 functional domains involved in growth suppression and apoptosis. Hollander MC, etal., Oncogene. 2003 Jun 19;22(25):3827-32.
10. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
11. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Hyrskyluoto A, etal., Exp Cell Res. 2012 Jan 1;318(1):33-42. doi: 10.1016/j.yexcr.2011.08.020. Epub 2011 Sep 7.
12. Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production. Jaronen M, etal., Hum Mol Genet. 2013 Feb 15;22(4):646-55. doi: 10.1093/hmg/dds472. Epub 2012 Nov 1.
13. Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. Jayanthi S, etal., PLoS One. 2009 Jun 30;4(6):e6092. doi: 10.1371/journal.pone.0006092.
14. Acrolein induces endoplasmic reticulum stress and causes airspace enlargement. Kitaguchi Y, etal., PLoS One. 2012;7(5):e38038. doi: 10.1371/journal.pone.0038038. Epub 2012 May 31.
15. Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine. Kitamura M, etal., Cell Death Differ. 2011 Dec;18(12):1876-88. doi: 10.1038/cdd.2011.63. Epub 2011 May 20.
16. Novel mouse model of monocular amaurosis fugax. Lelong DC, etal., Stroke. 2007 Dec;38(12):3237-44. Epub 2007 Nov 1.
17. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Lin MH, etal., Toxicology. 2014 Jan 6;315:24-37. doi: 10.1016/j.tox.2013.11.007. Epub 2013 Nov 28.
18. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Lin W, etal., Am J Pathol. 2008 Nov;173(5):1508-17. doi: 10.2353/ajpath.2008.080449. Epub 2008 Sep 25.
19. Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma. Lum CT, etal., Int J Cancer. 2006 Mar 15;118(6):1527-38.
20. Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. Ma J, etal., J Neurooncol. 2011 Jan;101(1):41-8. doi: 10.1007/s11060-010-0237-2. Epub 2010 Jun 12.
21. Evolution of GADD34 expression after focal cerebral ischaemia. McCaig D, etal., Brain Res. 2005 Feb 9;1034(1-2):51-61.
22. Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes. Mengesdorf T, etal., Biochem J. 2001 Jun 15;356(Pt 3):805-12.
23. Mode of action of S-methyl-N, N-diethylthiocarbamate sulfoxide (DETC-MeSO) as a novel therapy for stroke in a rat model. Mohammad-Gharibani P, etal., Mol Neurobiol. 2014 Oct;50(2):655-72. doi: 10.1007/s12035-014-8658-0. Epub 2014 Feb 28.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells. Paschen W, etal., J Neurochem. 2004 Aug;90(3):694-701.
26. Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain. Pavlovsky AA, etal., Neuroscience. 2013 Aug 29;246:160-9. doi: 10.1016/j.neuroscience.2013.04.057. Epub 2013 May 2.
27. Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. Penas C, etal., J Neurochem. 2007 Aug;102(4):1242-55. Epub 2007 Jun 19.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Schug M, etal., Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29.
33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3). Su ZZ, etal., Oncogene. 2005 Mar 24;24(13):2247-55.
35. Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene. Su ZZ, etal., Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9125-30.
36. PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggressiveness and angiogenesis. Su ZZ, etal., Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15115-20.
37. Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim. Szegezdi E, etal., J Cell Mol Med. 2008 Dec;12(6A):2482-96. doi: 10.1111/j.1582-4934.2008.00268.x. Epub 2008 Feb 5.
38. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
Additional References at PubMed
PMID:11381086   PMID:11517336   PMID:11564868   PMID:12556489   PMID:14635196   PMID:15389539   PMID:15601821   PMID:16835242   PMID:19131336   PMID:21518769   PMID:34098025  


Genomics

Comparative Map Data
Ppp1r15a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2196,000,053 - 96,003,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,385,485 - 101,388,560 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,858,161 - 109,861,236 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,148,553 - 103,151,628 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Celera190,255,750 - 90,258,825 (-)NCBICelera
Cytogenetic Map1q22NCBI
PPP1R15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,872,421 - 48,876,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,872,212 - 48,876,059 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,375,678 - 49,379,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,067,461 - 54,071,131 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,067,489 - 54,071,126NCBI
Celera1946,243,013 - 46,246,683 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,752,093 - 45,755,763 (+)NCBIHuRef
CHM1_11949,377,516 - 49,381,187 (+)NCBICHM1_1
T2T-CHM13v2.01951,867,284 - 51,870,921 (+)NCBIT2T-CHM13v2.0
Ppp1r15a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,172,341 - 45,175,692 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,172,340 - 45,175,692 (-)EnsemblGRCm39 Ensembl
GRCm38745,522,917 - 45,526,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,522,916 - 45,526,268 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,778,287 - 52,781,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,390,962 - 45,394,255 (-)NCBIMGSCv36mm8
Celera740,979,415 - 40,982,766 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.34NCBI
Ppp1r15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,750,168 - 1,753,629 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,750,227 - 1,753,607 (-)NCBIChiLan1.0ChiLan1.0
PPP1R15A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11956,902,557 - 56,906,388 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,872,596 - 45,876,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,880,052 - 54,883,840 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,880,141 - 54,883,003 (-)Ensemblpanpan1.1panPan2
PPP1R15A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,486,399 - 107,490,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,486,438 - 107,489,222 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,009,025 - 107,012,774 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,011,176 - 108,014,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,011,176 - 108,014,910 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,678,133 - 107,681,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,324,992 - 107,328,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,160,618 - 108,164,367 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,292,394 - 21,296,016 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366642,910,609 - 2,914,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,172,050 - 54,175,463 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,172,038 - 54,175,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,919,349 - 49,922,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R15A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366607321,992,307 - 21,996,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r15a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,103,072 - 5,107,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,103,251 - 5,107,751 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r15a
7 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:10
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000044788
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)190532338123479925Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)194494440117601394Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat

Markers in Region
RH127458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,000,152 - 96,000,335 (+)MAPPERmRatBN7.2
Rnor_6.01101,511,999 - 101,512,181NCBIRnor6.0
Rnor_5.01102,590,777 - 102,590,959UniSTSRnor5.0
RGSC_v3.4195,994,123 - 95,994,305UniSTSRGSC3.4
Celera190,255,850 - 90,256,032UniSTS
RH 3.4 Map1909.29UniSTS
Cytogenetic Map1q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 32 22 13 22 7 10 66 27 36 11 7
Low 2 25 19 6 19 1 1 8 8 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000044788   ⟹   ENSRNOP00000048451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)Ensembl
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079633   ⟹   ENSRNOP00000075192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,511,907 - 101,514,547 (-)Ensembl
RefSeq Acc Id: NM_133546   ⟹   NP_598230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2196,000,053 - 96,003,128 (-)NCBI
Rnor_6.01101,511,899 - 101,514,974 (-)NCBI
Rnor_5.01102,590,677 - 102,593,806 (-)NCBI
RGSC_v3.4195,994,023 - 95,997,080 (-)RGD
Celera190,255,750 - 90,258,825 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_598230   ⟸   NM_133546
- UniProtKB: Q7TQC2 (UniProtKB/Swiss-Prot),   O88344 (UniProtKB/Swiss-Prot),   Q6IN02 (UniProtKB/Swiss-Prot),   A0A0G2JSW4 (UniProtKB/TrEMBL),   A6JB49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075192   ⟸   ENSRNOT00000079633
RefSeq Acc Id: ENSRNOP00000048451   ⟸   ENSRNOT00000044788
Protein Domains
Protein phosphatase 1 regulatory subunit 15A/B C-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IN02-F1-model_v2 AlphaFold Q6IN02 1-578 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621526 AgrOrtholog
BioCyc Gene G2FUF-59678 BioCyc
Ensembl Genes ENSRNOG00000020938 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000048451 ENTREZGENE
  ENSRNOP00000048451.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044788 ENTREZGENE
  ENSRNOT00000044788.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7104357 IMAGE-MGC_LOAD
InterPro Prot_Pase1_reg-su15A/B_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:171071 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91505 IMAGE-MGC_LOAD
NCBI Gene 171071 ENTREZGENE
PANTHER GH11727P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PP1c_bdg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r15a PhenoGen
UniProt A0A0G2JSW4 ENTREZGENE, UniProtKB/TrEMBL
  A6JB49 ENTREZGENE, UniProtKB/TrEMBL
  O88344 ENTREZGENE
  PR15A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TQC2 ENTREZGENE
UniProt Secondary O88344 UniProtKB/Swiss-Prot
  Q7TQC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r15a  protein phosphatase 1, regulatory subunit 15A  Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Myd116  myeloid differentiation primary response gene 116  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the gadd and Myd family 633491