H2AX (H2A.X variant histone) - Rat Genome Database
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Gene: H2AX (H2A.X variant histone) Homo sapiens
Analyze
Symbol: H2AX
Name: H2A.X variant histone
RGD ID: 1346464
HGNC Page HGNC
Description: Exhibits enzyme binding activity and histone binding activity. Involved in DNA damage checkpoint. Localizes to centrosome; nuclear speck; and site of double-strand break. Colocalizes with chromosome, telomeric region.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: H2A histone family member X; H2A histone family, member X; H2A.X; H2A/X; H2AFX; H2AX histone; histone H2A.x; histone H2AX
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11119,093,854 - 119,095,467 (-)EnsemblGRCh38hg38GRCh38
GRCh3811119,093,874 - 119,095,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,964,580 - 118,966,177 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,469,794 - 118,471,387 (-)NCBINCBI36hg18NCBI36
Build 3411118,469,796 - 118,471,387NCBI
Celera11116,121,998 - 116,123,592 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,904,032 - 114,905,625 (-)NCBIHuRef
CHM1_111118,850,886 - 118,852,479 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-ephedrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (EXP)
1,10-phenanthroline  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1,4-benzoquinone  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
1H-pyrazole  (ISO)
2,2'-bipyridine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4,6-trinitrotoluene  (ISO)
2,4-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-Amino-3-methyl-9H-pyrido[2,3-b]indole  (EXP)
2-Amino-9H-pyrido[2,3-b]indole  (EXP)
2-deoxy-D-glucose  (EXP)
2-methoxy-17beta-estradiol  (EXP)
2-nitroanisole  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
680C91  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9-aminoacridine  (EXP)
[6]-Shogaol  (EXP)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (EXP)
all-trans-retinoic acid  (EXP)
alternariol  (EXP)
alvocidib  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aphidicolin  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
azathioprine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
benzo[e]pyrene  (EXP)
berberine  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
bortezomib  (EXP,ISO)
busulfan  (EXP)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP,ISO)
calciol  (EXP)
calcitriol  (EXP)
camptothecin  (EXP,ISO)
capsaicin  (EXP)
carbamate ester  (EXP)
carbon nanotube  (ISO)
carboplatin  (EXP)
carmustine  (EXP)
celecoxib  (EXP)
chlorambucil  (EXP)
chlordecone  (ISO)
chlorite  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
chromone  (EXP)
cisplatin  (EXP,ISO)
clofarabine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
CU-O LINKAGE  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
cyhalothrin  (EXP)
cylindrospermopsin  (EXP)
cyprodinil  (EXP)
cytarabine  (EXP)
daunorubicin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (EXP)
elemental selenium  (EXP)
ellipticine  (EXP)
emodin  (EXP)
Enterolactone  (EXP)
epothilone A  (EXP)
erdosteine  (ISO)
erlotinib hydrochloride  (EXP)
Estragole  (ISO)
ethanol  (EXP,ISO)
etoposide  (EXP,ISO)
ferric oxide  (EXP)
flavanones  (EXP)
fludioxonil  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fomepizole  (EXP)
fotemustine  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
furan  (ISO)
genistein  (EXP)
Glu-P-1  (EXP)
Glu-P-2  (EXP)
glutathione  (ISO)
glycerol 2-phosphate  (EXP)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxyurea  (EXP,ISO)
imiquimod  (ISO)
iprodione  (EXP)
irinotecan  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
isocyanates  (EXP,ISO)
isoflavones  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
kaempferol  (EXP,ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
leptomycin B  (EXP)
Longikaurin A  (EXP)
lovastatin  (EXP,ISO)
Manumycin A  (EXP)
mechlorethamine  (ISO)
MeIQ  (EXP)
MeIQx  (EXP)
menadione  (EXP)
menaquinone  (EXP)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methotrexate  (EXP)
methoxsalen  (EXP)
miconazole  (ISO)
mitomycin C  (EXP)
mitoxantrone  (EXP,ISO)
N,N-dimethylformamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
n-propyl gallate  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
nimustine  (EXP)
nitrogen mustard  (EXP)
nocodazole  (EXP)
norethisterone  (EXP)
NS-398  (EXP)
NSC 23766  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
olaparib  (EXP)
oxaliplatin  (EXP,ISO)
oxybenzone  (EXP,ISO)
paclitaxel  (EXP)
palbociclib  (EXP)
palmatine  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
pentamidine  (EXP)
phenanthridone  (EXP)
phenobarbital  (EXP,ISO)
phenol  (EXP)
PhIP  (EXP)
phosphoramide mustard  (ISO)
phthalic acid  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(vinylpyrrolidone)  (EXP)
potassium bromate  (ISO)
potassium dichromate  (EXP)
procymidone  (EXP)
promethazine  (ISO)
propiconazole  (ISO)
propylparaben  (EXP)
protein kinase inhibitor  (EXP)
pterostilbene  (EXP)
pyrimethamine  (EXP)
quercetin  (EXP,ISO)
rac-1,2-dichloropropane  (EXP,ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
resorcinol  (EXP)
resveratrol  (EXP)
ribavirin  (EXP)
romidepsin  (EXP)
rotenone  (ISO)
Satratoxin H  (ISO)
selenium atom  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Sodium salicylate  (EXP)
sterigmatocystin  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
T-2 toxin  (EXP)
temozolomide  (EXP,ISO)
TEMPO  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
toxaphene  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
trichostatin A  (EXP,ISO)
triciribine  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP,ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
veliparib  (EXP)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)
Xanthatin  (EXP)
zearalenone  (ISO)
zebularine  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2587254   PMID:7769017   PMID:7929075   PMID:8076949   PMID:9488723   PMID:9566873   PMID:10477747   PMID:10734083   PMID:10959836   PMID:11080476   PMID:11110662   PMID:11331621  
PMID:11571274   PMID:11673449   PMID:11689053   PMID:11893489   PMID:11927591   PMID:12033261   PMID:12220643   PMID:12372432   PMID:12419185   PMID:12447390   PMID:12475977   PMID:12477932  
PMID:12485996   PMID:12551934   PMID:12556884   PMID:12607005   PMID:12660252   PMID:12689589   PMID:12697768   PMID:12792649   PMID:12915485   PMID:12926989   PMID:14519663   PMID:14627815  
PMID:14657027   PMID:15059890   PMID:15064416   PMID:15149599   PMID:15201865   PMID:15279782   PMID:15364958   PMID:15389585   PMID:15485898   PMID:15489221   PMID:15489334   PMID:15574327  
PMID:15604234   PMID:15613478   PMID:15655354   PMID:15707990   PMID:15723802   PMID:15733840   PMID:15816840   PMID:15870294   PMID:15905198   PMID:16046194   PMID:16153602   PMID:16169070  
PMID:16240122   PMID:16306615   PMID:16310392   PMID:16319397   PMID:16322227   PMID:16377563   PMID:16382446   PMID:16426422   PMID:16494514   PMID:16494516   PMID:16522924   PMID:16622419  
PMID:16628006   PMID:16678501   PMID:16788066   PMID:16820410   PMID:16820894   PMID:16872365   PMID:16909103   PMID:16927366   PMID:16932743   PMID:16953663   PMID:17024177   PMID:17064697  
PMID:17106266   PMID:17110439   PMID:17145805   PMID:17203247   PMID:17227291   PMID:17276133   PMID:17304220   PMID:17327276   PMID:17372987   PMID:17498979   PMID:17548670   PMID:17594478  
PMID:17620599   PMID:17634426   PMID:17668632   PMID:17709392   PMID:17851762   PMID:17874213   PMID:17904670   PMID:17925396   PMID:17957241   PMID:17974976   PMID:18001824   PMID:18001825  
PMID:18206537   PMID:18285460   PMID:18328813   PMID:18344987   PMID:18397884   PMID:18406329   PMID:18457664   PMID:18536151   PMID:18583988   PMID:18614045   PMID:18616816   PMID:18622584  
PMID:18638378   PMID:18656236   PMID:18727058   PMID:18758438   PMID:18829552   PMID:18955500   PMID:19005492   PMID:19020308   PMID:19064695   PMID:19092802   PMID:19107196   PMID:19146767  
PMID:19180575   PMID:19202324   PMID:19234442   PMID:19265496   PMID:19273588   PMID:19305155   PMID:19338747   PMID:19351884   PMID:19377482   PMID:19377486   PMID:19397442   PMID:19401347  
PMID:19446503   PMID:19477424   PMID:19500350   PMID:19513550   PMID:19536649   PMID:19638463   PMID:19651821   PMID:19657269   PMID:19666485   PMID:19707781   PMID:19734146   PMID:19766185  
PMID:19805520   PMID:19845771   PMID:19859659   PMID:19861731   PMID:19895790   PMID:19903578   PMID:19910469   PMID:19952118   PMID:19996277   PMID:20000738   PMID:20023412   PMID:20023697  
PMID:20028875   PMID:20046100   PMID:20051134   PMID:20053681   PMID:20062073   PMID:20075863   PMID:20089662   PMID:20101220   PMID:20118229   PMID:20150765   PMID:20157507   PMID:20159462  
PMID:20173316   PMID:20224553   PMID:20351298   PMID:20356835   PMID:20360682   PMID:20360685   PMID:20372780   PMID:20394854   PMID:20448412   PMID:20460517   PMID:20461094   PMID:20488183  
PMID:20506293   PMID:20512932   PMID:20569192   PMID:20573551   PMID:20618440   PMID:20681785   PMID:20681793   PMID:20802463   PMID:20811699   PMID:20823146   PMID:20921231   PMID:20936109  
PMID:21044950   PMID:21068397   PMID:21116096   PMID:21124906   PMID:21131828   PMID:21142613   PMID:21182205   PMID:21184737   PMID:21199394   PMID:21224359   PMID:21270334   PMID:21293379  
PMID:21317870   PMID:21383063   PMID:21463514   PMID:21505975   PMID:21512825   PMID:21566283   PMID:21566653   PMID:21596504   PMID:21622030   PMID:21623170   PMID:21630459   PMID:21631283  
PMID:21676867   PMID:21679440   PMID:21690091   PMID:21704408   PMID:21704409   PMID:21824286   PMID:21840613   PMID:21873635   PMID:21900206   PMID:21938931   PMID:21979596   PMID:22064073  
PMID:22154951   PMID:22157895   PMID:22170789   PMID:22184063   PMID:22193777   PMID:22404984   PMID:22442661   PMID:22467212   PMID:22565321   PMID:22586326   PMID:22655027   PMID:22730535  
PMID:22754379   PMID:22787276   PMID:22941933   PMID:22946062   PMID:22972498   PMID:22980979   PMID:22986342   PMID:23045526   PMID:23109425   PMID:23145133   PMID:23235539   PMID:23306199  
PMID:23319141   PMID:23413139   PMID:23449797   PMID:23518201   PMID:23533145   PMID:23536437   PMID:23545587   PMID:23617930   PMID:23658700   PMID:23703345   PMID:23726848   PMID:23739328  
PMID:23739334   PMID:23777805   PMID:23793869   PMID:23803252   PMID:23946494   PMID:24009179   PMID:24021642   PMID:24054861   PMID:24064905   PMID:24158819   PMID:24163101   PMID:24196443  
PMID:24321564   PMID:24352470   PMID:24363165   PMID:24429368   PMID:24507776   PMID:24603765   PMID:24606682   PMID:24682951   PMID:24704006   PMID:24781148   PMID:24830786   PMID:24871368  
PMID:24981860   PMID:25043086   PMID:25202016   PMID:25252977   PMID:25288669   PMID:25293814   PMID:25299772   PMID:25459351   PMID:25483710   PMID:25487737   PMID:25512560   PMID:25533843  
PMID:25537504   PMID:25619392   PMID:25651738   PMID:25665578   PMID:25695757   PMID:25699650   PMID:25712102   PMID:25731851   PMID:25733871   PMID:25738604   PMID:25772433   PMID:25794041  
PMID:25798074   PMID:25808442   PMID:25815686   PMID:25847270   PMID:25852190   PMID:25862913   PMID:25889915   PMID:25894690   PMID:25921070   PMID:25923214   PMID:25948554   PMID:25963833  
PMID:26026585   PMID:26045162   PMID:26067661   PMID:26073471   PMID:26095369   PMID:26116906   PMID:26121674   PMID:26158906   PMID:26186194   PMID:26191270   PMID:26209609   PMID:26237645  
PMID:26243567   PMID:26314960   PMID:26317799   PMID:26318153   PMID:26344197   PMID:26482424   PMID:26496610   PMID:26507658   PMID:26541290   PMID:26628370   PMID:26711340   PMID:26717153  
PMID:26734725   PMID:26791933   PMID:26820970   PMID:26852132   PMID:26854228   PMID:26876487   PMID:26884865   PMID:26936624   PMID:26949251   PMID:26976643   PMID:27084940   PMID:27108688  
PMID:27113385   PMID:27146073   PMID:27166270   PMID:27177470   PMID:27226232   PMID:27247425   PMID:27248496   PMID:27262441   PMID:27315462   PMID:27345151   PMID:27365048   PMID:27389782  
PMID:27391338   PMID:27462463   PMID:27643881   PMID:27715493   PMID:27773672   PMID:27780918   PMID:27795300   PMID:27813335   PMID:27907109   PMID:27918549   PMID:27922110   PMID:27926873  
PMID:28065597   PMID:28190324   PMID:28240985   PMID:28242625   PMID:28351323   PMID:28359030   PMID:28386126   PMID:28388353   PMID:28514442   PMID:28536406   PMID:28543539   PMID:28661481  
PMID:28714367   PMID:28796254   PMID:28983621   PMID:29104064   PMID:29165316   PMID:29187454   PMID:29207178   PMID:29229926   PMID:29275316   PMID:29298432   PMID:29309426   PMID:29378905  
PMID:29462394   PMID:29478914   PMID:29499138   PMID:29509190   PMID:29523790   PMID:29581234   PMID:29662616   PMID:29678143   PMID:29684114   PMID:29704994   PMID:29845934   PMID:29937341  
PMID:29985131   PMID:30006243   PMID:30013081   PMID:30021884   PMID:30072594   PMID:30096372   PMID:30110629   PMID:30126387   PMID:30165463   PMID:30185813   PMID:30196744   PMID:30275188  
PMID:30344095   PMID:30349055   PMID:30425250   PMID:30462294   PMID:30463901   PMID:30560944   PMID:30582855   PMID:30598506   PMID:30664650   PMID:30920061   PMID:30952868   PMID:30979931  
PMID:31009828   PMID:31043422   PMID:31045206   PMID:31101118   PMID:31127894   PMID:31176019   PMID:31180492   PMID:31217297   PMID:31445935   PMID:31504778   PMID:31533041   PMID:31552812  
PMID:31586073   PMID:31616951   PMID:31729360   PMID:31736361   PMID:31753913   PMID:31757956   PMID:31848352   PMID:31980649   PMID:32041954   PMID:32203168   PMID:32236595   PMID:32778572  
PMID:32780723   PMID:32928367   PMID:33001583  


Genomics

Comparative Map Data
H2AX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11119,093,854 - 119,095,467 (-)EnsemblGRCh38hg38GRCh38
GRCh3811119,093,874 - 119,095,465 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,964,580 - 118,966,177 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,469,794 - 118,471,387 (-)NCBINCBI36hg18NCBI36
Build 3411118,469,796 - 118,471,387NCBI
Celera11116,121,998 - 116,123,592 (-)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,904,032 - 114,905,625 (-)NCBIHuRef
CHM1_111118,850,886 - 118,852,479 (-)NCBICHM1_1
H2ax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39944,246,012 - 44,247,374 (+)NCBIGRCm39mm39
GRCm38944,334,715 - 44,336,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl944,334,694 - 44,336,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv37944,142,798 - 44,144,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv36944,085,710 - 44,087,072 (+)NCBImm8
Celera941,589,440 - 41,590,802 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
cM Map924.84NCBI
H2ax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0848,665,652 - 48,666,981 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl848,665,652 - 48,666,981 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0847,284,623 - 47,285,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4847,312,609 - 47,313,938 (+)NCBIRGSC3.4rn4RGSC3.4
Celera844,258,161 - 44,259,490 (+)NCBICelera
Cytogenetic Map8q22NCBI
LOC102025775
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541220,203,772 - 20,204,203 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541220,203,173 - 20,204,714 (-)NCBIChiLan1.0ChiLan1.0
LOC100994157
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111117,862,383 - 117,862,841 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v011113,932,078 - 113,933,679 (-)NCBIMhudiblu_PPA_v0panPan3
H2AX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl514,766,126 - 14,766,557 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1514,765,625 - 14,766,590 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101966907
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365424,046,930 - 4,049,017 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522201
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl946,309,653 - 46,310,084 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1946,308,824 - 46,310,494 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2951,343,962 - 51,345,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
H2AFX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1110,467,775 - 110,468,206 (-)Ensembl
ChlSab1.11110,466,692 - 110,468,776 (-)NCBI
LOC101701891
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478414,475,813 - 14,477,269 (-)NCBI

Position Markers
STS-M95623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,964,406 - 118,964,654UniSTSGRCh37
Build 3611118,469,616 - 118,469,864RGDNCBI36
Celera11116,121,820 - 116,122,068RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,903,854 - 114,904,102UniSTS
GeneMap99-GB4 RH Map11385.48UniSTS
D11S4378  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,964,823 - 118,964,944UniSTSGRCh37
Build 3611118,470,033 - 118,470,154RGDNCBI36
Celera11116,122,237 - 116,122,358RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,904,271 - 114,904,392UniSTS
GeneMap99-GB4 RH Map11385.17UniSTS
Whitehead-RH Map11538.9UniSTS
RH70756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,965,160 - 118,965,250UniSTSGRCh37
Build 3611118,470,370 - 118,470,460RGDNCBI36
Celera11116,122,574 - 116,122,664RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,904,608 - 114,904,698UniSTS
RH80367  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,965,975 - 118,966,092UniSTSGRCh37
Build 3611118,471,185 - 118,471,302RGDNCBI36
Celera11116,123,390 - 116,123,507RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,905,423 - 114,905,540UniSTS
GeneMap99-GB4 RH Map11385.69UniSTS
G15876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,965,403 - 118,965,631UniSTSGRCh37
Build 3611118,470,613 - 118,470,841RGDNCBI36
Celera11116,122,817 - 116,123,047RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,904,851 - 114,905,079UniSTS
H2AFX_1240  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,964,443 - 118,965,250UniSTSGRCh37
Build 3611118,469,653 - 118,470,460RGDNCBI36
Celera11116,121,857 - 116,122,664RGD
HuRef11114,903,891 - 114,904,698UniSTS
DPAGT1_8310  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,967,063 - 118,967,720UniSTSGRCh37
Build 3611118,472,273 - 118,472,930RGDNCBI36
Celera11116,124,478 - 116,125,135RGD
HuRef11114,906,512 - 114,907,169UniSTS
STS-R55620  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,967,314 - 118,967,516UniSTSGRCh37
Build 3611118,472,524 - 118,472,726RGDNCBI36
Celera11116,124,729 - 116,124,931RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,906,763 - 114,906,965UniSTS
GeneMap99-GB4 RH Map11386.42UniSTS
A004Z11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,964,835 - 118,964,988UniSTSGRCh37
Build 3611118,470,045 - 118,470,198RGDNCBI36
Celera11116,122,249 - 116,122,402RGD
Cytogenetic Map11q23.3UniSTS
HuRef11114,904,283 - 114,904,436UniSTS
GeneMap99-GB4 RH Map11383.6UniSTS
Whitehead-RH Map11535.4UniSTS
H2AFX  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711118,965,733 - 118,965,885UniSTSGRCh37
Build 3611118,470,943 - 118,471,095RGDNCBI36
Celera11116,123,148 - 116,123,300RGD
HuRef11114,905,181 - 114,905,333UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR328hsa-miR-328-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19377482
MIR24-2hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19377482
MIR138-2hsa-miR-138-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21693595
MIR138-1hsa-miR-138-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21693595
MIR138-2hsa-miR-138-5pOncomiRDBexternal_infoNANA21693595
MIR138-1hsa-miR-138-5pOncomiRDBexternal_infoNANA21693595
MIR24-1hsa-miR-24-3pMirtarbaseexternal_infoReporter assay;Western blot;qRT-PCRFunctional MTI19377482

Predicted Target Of
Summary Value
Count of predictions:1192
Count of miRNA genes:437
Interacting mature miRNAs:484
Transcripts:ENST00000375167, ENST00000530167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 4
Medium 2371 2070 1497 380 1664 244 3700 1384 3708 338 1453 1602 153 1 1054 2265 6 2
Low 68 921 229 244 285 221 657 813 25 81 3 11 22 150 523
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000375167   ⟹   ENSP00000364310
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11119,093,879 - 119,095,449 (-)Ensembl
RefSeq Acc Id: ENST00000530167   ⟹   ENSP00000434024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl11119,093,854 - 119,095,467 (-)Ensembl
RefSeq Acc Id: NM_002105   ⟹   NP_002096
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811119,093,874 - 119,095,465 (-)NCBI
GRCh3711118,964,580 - 118,966,177 (-)NCBI
Build 3611118,469,794 - 118,471,387 (-)NCBI Archive
HuRef11114,904,032 - 114,905,625 (-)ENTREZGENE
CHM1_111118,850,886 - 118,852,479 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002096   ⟸   NM_002105
- UniProtKB: P16104 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000434024   ⟸   ENST00000530167
RefSeq Acc Id: ENSP00000364310   ⟸   ENST00000375167

Promoters
RGD ID:6788977
Promoter ID:HG_KWN:14363
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000375167
Position:
Human AssemblyChrPosition (strand)Source
Build 3611118,470,381 - 118,471,367 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000050331] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.2-23.3(chr11:113444446-120648921)x3 copy number gain See cases [RCV000050627] Chr11:113444446..120648921 [GRCh38]
Chr11:113315168..120519630 [GRCh37]
Chr11:112820378..120024840 [NCBI36]
Chr11:11q23.2-23.3
pathogenic
GRCh38/hg38 11q23.3-25(chr11:118789765-134998513)x3 copy number gain See cases [RCV000051213] Chr11:118789765..134998513 [GRCh38]
Chr11:118660474..134868407 [GRCh37]
Chr11:118165684..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851372-134998526)x3 copy number gain See cases [RCV000134064] Chr11:116851372..134998526 [GRCh38]
Chr11:116722088..134868420 [GRCh37]
Chr11:116227298..134373630 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.2-25(chr11:112864326-131189315)x3 copy number gain See cases [RCV000137582] Chr11:112864326..131189315 [GRCh38]
Chr11:112832130..131059210 [GRCh37]
Chr11:112240259..130564420 [NCBI36]
Chr11:11q23.2-25
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116868935-135075271)x3 copy number gain See cases [RCV000137453] Chr11:116868935..135075271 [GRCh38]
Chr11:116739651..134945165 [GRCh37]
Chr11:116244861..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic|conflicting data from submitters
GRCh38/hg38 11q23.3(chr11:118933083-119215291)x3 copy number gain See cases [RCV000137489] Chr11:118933083..119215291 [GRCh38]
Chr11:118803792..119086001 [GRCh37]
Chr11:118309002..118591211 [NCBI36]
Chr11:11q23.3
likely benign
GRCh38/hg38 11q23.3-25(chr11:116806268-135075271)x3 copy number gain See cases [RCV000138307] Chr11:116806268..135075271 [GRCh38]
Chr11:116676984..134945165 [GRCh37]
Chr11:116182194..134450377 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh38/hg38 11q23.3-24.2(chr11:117333952-127709156)x3 copy number gain See cases [RCV000139362] Chr11:117333952..127709156 [GRCh38]
Chr11:117204668..127579051 [GRCh37]
Chr11:116709878..127084261 [NCBI36]
Chr11:11q23.3-24.2
pathogenic
GRCh38/hg38 11q23.3-25(chr11:116851395-134998513)x3 copy number gain See cases [RCV000148276] Chr11:116851395..134998513 [GRCh38]
Chr11:116722111..134868407 [GRCh37]
Chr11:116227321..134373617 [NCBI36]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3(chr11:115215434-120559928)x3 copy number gain See cases [RCV000240308] Chr11:115215434..120559928 [GRCh37]
Chr11:11q23.3
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116700253-134904063) copy number gain not provided [RCV000767816] Chr11:116700253..134904063 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000449449] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116684163-134938470)x3 copy number gain See cases [RCV000447848] Chr11:116684163..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain See cases [RCV000512291] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3-25(chr11:116681007-134938470)x3 copy number gain not provided [RCV000683373] Chr11:116681007..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3(chr11:116669751-120979377)x3 copy number gain not provided [RCV000683365] Chr11:116669751..120979377 [GRCh37]
Chr11:11q23.3
likely pathogenic
Single allele deletion Short stature [RCV001003892] Chr11:114433313..131230466 [GRCh37]
Chr11:11q23.2-25
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
Single allele duplication Schizophrenia [RCV000754124] Chr11:118989374..135076622 [GRCh38]
Chr11:11q23.3-25
likely pathogenic
GRCh37/hg19 11q23.3-25(chr11:116697066-134934063)x3 copy number gain not provided [RCV000737686] Chr11:116697066..134934063 [GRCh37]
Chr11:11q23.3-25
pathogenic
NC_000011.9:g.(?_117856768)_(118972385_?)del deletion Immunodeficiency 19 [RCV001031688] Chr11:117856768..118972385 [GRCh37]
Chr11:11q23.3
pathogenic
NC_000011.9:g.(?_117856768)_(118972385_?)dup duplication Glucose-6-phosphate transport defect [RCV001031254] Chr11:117856768..118972385 [GRCh37]
Chr11:11q23.3
uncertain significance
GRCh37/hg19 11q23.3-25(chr11:116691675-134889485) copy number gain not provided [RCV000767667] Chr11:116691675..134889485 [GRCh37]
Chr11:11q23.3-25
pathogenic
NC_000011.9:g.(?_118007722)_(119170511_?)del deletion Long QT syndrome 10 [RCV000816632] Chr11:118007722..119170511 [GRCh37]
Chr11:11q23.3
uncertain significance
GRCh37/hg19 11q23.3-25(chr11:117830263-134938470)x3 copy number gain not provided [RCV000848151] Chr11:117830263..134938470 [GRCh37]
Chr11:11q23.3-25
pathogenic
GRCh37/hg19 11q23.3(chr11:118280670-119650105)x3 copy number gain not provided [RCV001006451] Chr11:118280670..119650105 [GRCh37]
Chr11:11q23.3
uncertain significance
NC_000011.9:g.(?_118895600)_(118972385_?)dup duplication Glucose-6-phosphate transport defect [RCV001031316] Chr11:118895600..118972385 [GRCh37]
Chr11:11q23.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4739 AgrOrtholog
COSMIC H2AX COSMIC
Ensembl Genes ENSG00000188486 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000364310 UniProtKB/Swiss-Prot
  ENSP00000434024 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000375167 UniProtKB/Swiss-Prot
  ENST00000530167 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot
GTEx ENSG00000188486 GTEx
HGNC ID HGNC:4739 ENTREZGENE
Human Proteome Map H2AX Human Proteome Map
InterPro Histone-fold UniProtKB/Swiss-Prot
  Histone_H2A UniProtKB/Swiss-Prot
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
  Histone_H2A_CS UniProtKB/Swiss-Prot
KEGG Report hsa:3014 UniProtKB/Swiss-Prot
NCBI Gene 3014 ENTREZGENE
OMIM 601772 OMIM
Pfam Histone UniProtKB/Swiss-Prot
  Histone_H2A_C UniProtKB/Swiss-Prot
PharmGKB PA29116 PharmGKB
PRINTS HISTONEH2A UniProtKB/Swiss-Prot
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot
SMART H2A UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot
UniGene Hs.477879 ENTREZGENE
UniProt H2AX_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4ZGJ7 UniProtKB/Swiss-Prot
  Q6IAS5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-30 H2AX  H2A.X variant histone  H2AFX  H2A histone family member X  Symbol and/or name change 5135510 APPROVED
2015-11-24 H2AFX  H2A histone family member X  H2AFX  H2A histone family, member X  Symbol and/or name change 5135510 APPROVED