Tsc1 (TSC complex subunit 1) - Rat Genome Database

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Gene: Tsc1 (TSC complex subunit 1) Ictidomys tridecemlineatus
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Symbol: Tsc1
Name: TSC complex subunit 1
RGD ID: 12523843
Description: ENCODES a protein that exhibits ATPase inhibitor activity (inferred); Hsp70 protein binding (inferred); Hsp90 protein binding (inferred); INVOLVED IN activation of GTPase activity (ortholog); adaptive immune response (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; mTOR signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); anterior segment dysgenesis (ortholog); autism spectrum disorder (ortholog); FOUND IN cell projection (ortholog); growth cone (ortholog); lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hamartin; TSC complex subunit 1, transcript variant X1; TSC complex subunit 1, transcript variant X2; TSC complex subunit 1, transcript variant X3; TSC complex subunit 1, transcript variant X4; TSC complex subunit 1, transcript variant X5; TSC complex subunit 1, transcript variant X6; TSC complex subunit 1, transcript variant X7; TSC complex subunit 1, transcript variant X8; tuberous sclerosis 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,562,656 - 199,618,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,331,194 - 19,386,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,331,183 - 19,386,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
adaptive immune response  (IEA,ISO)
adult locomotory behavior  (ISO)
associative learning  (IEA)
cardiac muscle cell differentiation  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell projection organization  (IEA,ISO)
cell-matrix adhesion  (IEA)
cellular response to decreased oxygen levels  (ISO)
cellular response to starvation  (IEA)
cerebral cortex development  (IEA,ISO)
D-glucose import  (IEA,ISO)
hippocampus development  (IEA,ISO)
kidney development  (IEA,ISO)
memory T cell differentiation  (IEA,ISO)
myelination  (IEA,ISO)
negative regulation of ATP-dependent activity  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of cell size  (IEA,ISO)
negative regulation of cellular response to oxidative stress  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of macroautophagy  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of TOR signaling  (IEA)
negative regulation of TORC1 signaling  (IEA)
nervous system development  (IEA,ISO)
neural tube closure  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA)
positive regulation of macroautophagy  (ISO)
positive regulation of stress fiber assembly  (ISO)
potassium ion transport  (IEA,ISO)
protein folding  (IEA)
protein stabilization  (IEA)
regulation of cell cycle  (IEA)
regulation of cell-matrix adhesion  (IEA)
regulation of focal adhesion assembly  (ISO)
regulation of protein kinase activity  (ISO)
regulation of stress fiber assembly  (IEA)
response to insulin  (IEA)
response to nutrient levels  (ISO)
response to peptide  (ISO)
synapse organization  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Tsc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947199,562,656 - 199,618,374 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648719,331,194 - 19,386,892 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648719,331,183 - 19,386,841 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,891,349 - 132,945,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9132,891,348 - 132,946,874 (-)EnsemblGRCh38hg38GRCh38
GRCh379135,766,736 - 135,820,003 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,756,557 - 134,809,841 (-)NCBINCBI36Build 36hg18NCBI36
Build 349132,815,940 - 132,849,574NCBI
Celera9106,308,473 - 106,361,761 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9105,260,658 - 105,313,711 (-)NCBIHuRef
CHM1_19135,917,213 - 135,970,447 (-)NCBICHM1_1
T2T-CHM13v2.09145,103,162 - 145,157,190 (-)NCBIT2T-CHM13v2.0
Tsc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39228,531,005 - 28,581,183 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl228,531,240 - 28,581,179 (+)EnsemblGRCm39 Ensembl
GRCm38228,640,993 - 28,691,172 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl228,641,228 - 28,691,167 (+)EnsemblGRCm38mm10GRCm38
MGSCv37228,496,763 - 28,546,687 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36228,463,252 - 28,513,176 (+)NCBIMGSCv36mm8
Celera228,345,749 - 28,395,673 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.38NCBI
Tsc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8332,367,434 - 32,416,565 (+)NCBIGRCr8
mRatBN7.2311,969,547 - 12,018,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl311,979,729 - 12,015,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx315,059,218 - 15,086,859 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0323,644,177 - 23,671,817 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0321,898,622 - 21,926,266 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.037,219,955 - 7,269,063 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl37,237,192 - 7,265,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0312,570,765 - 12,619,753 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.437,645,313 - 7,672,944 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.137,645,612 - 7,673,244 (+)NCBI
Celera36,767,562 - 6,795,193 (+)NCBICelera
Cytogenetic Map3p12NCBI
Tsc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,197,037 - 2,244,992 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,197,037 - 2,244,992 (-)NCBIChiLan1.0ChiLan1.0
TSC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2116,414,619 - 6,468,611 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan196,415,528 - 6,470,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,007,708 - 104,060,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19132,638,003 - 132,692,264 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9132,638,003 - 132,675,759 (-)Ensemblpanpan1.1panPan2
TSC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1951,409,307 - 51,459,546 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl951,425,937 - 51,454,677 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha950,673,940 - 50,724,548 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0952,304,134 - 52,354,724 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl952,304,753 - 52,354,693 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1951,082,516 - 51,133,112 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0951,407,015 - 51,457,594 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0951,486,514 - 51,537,117 (+)NCBIUU_Cfam_GSD_1.0
TSC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1272,636,532 - 272,685,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11272,636,530 - 272,685,948 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21306,795,196 - 306,819,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,195,604 - 5,249,042 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl125,195,675 - 5,244,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607910,396,791 - 10,450,324 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tsc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247603,498,692 - 3,532,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247603,479,028 - 3,536,612 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003511   ⟹   ENSSTOP00000003143
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648719,331,194 - 19,386,892 (-)Ensembl
RefSeq Acc Id: XM_013356703   ⟹   XP_013212157
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,303 (-)NCBI
SpeTri2.0NW_00493648719,331,183 - 19,386,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723675   ⟹   XP_021579350
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,310 (-)NCBI
SpeTri2.0NW_00493648719,335,948 - 19,386,828 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723676   ⟹   XP_021579351
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,374 (-)NCBI
SpeTri2.0NW_00493648719,335,948 - 19,386,840 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723678   ⟹   XP_021579353
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,352 (-)NCBI
SpeTri2.0NW_00493648719,335,948 - 19,386,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723679   ⟹   XP_021579354
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,311 (-)NCBI
SpeTri2.0NW_00493648719,335,948 - 19,386,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723680   ⟹   XP_021579355
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,368 (-)NCBI
SpeTri2.0NW_00493648719,335,948 - 19,386,838 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040286537   ⟹   XP_040142471
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,091 (-)NCBI
RefSeq Acc Id: XM_040286538   ⟹   XP_040142472
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947199,562,656 - 199,618,303 (-)NCBI
RefSeq Acc Id: XP_013212157   ⟸   XM_013356703
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579353   ⟸   XM_021723678
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579354   ⟸   XM_021723679
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579351   ⟸   XM_021723676
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579355   ⟸   XM_021723680
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021579350   ⟸   XM_021723675
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040142472   ⟸   XM_040286538
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040142471   ⟸   XM_040286537
- Peptide Label: isoform X1
- UniProtKB: I3M2E6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000003143   ⟸   ENSSTOT00000003511


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003477 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003511.3 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Hamartin UniProtKB/TrEMBL
NCBI Gene Tsc1 ENTREZGENE
PANTHER HAMARTIN UniProtKB/TrEMBL
  PTHR15154 UniProtKB/TrEMBL
Pfam Hamartin UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt I3M2E6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-13 Tsc1  TSC complex subunit 1    tuberous sclerosis 1  Symbol and/or name change 5135510 APPROVED