RGD Reference Report - Molecular mechanisms of mTOR-mediated translational control. - Rat Genome Database

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Molecular mechanisms of mTOR-mediated translational control.

Authors: Ma, XM  Blenis, J 
Citation: Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
RGD ID: 2308795
Pubmed: PMID:19339977   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm2672   (Journal Full-text)

The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis. Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AKT1S1HumanmTOR signaling pathway   TAS  RGD 
Akt1s1RatmTOR signaling pathway   ISOAKT1S1 (Homo sapiens) RGD 
Akt1s1MousemTOR signaling pathway   ISOAKT1S1 (Homo sapiens) RGD 
EIF4EBP1HumanmTOR signaling pathway   TAS  RGD 
Eif4ebp1RatmTOR signaling pathway   ISOEIF4EBP1 (Homo sapiens) RGD 
Eif4ebp1MousemTOR signaling pathway   ISOEIF4EBP1 (Homo sapiens) RGD 
MAPKAP1HumanmTOR signaling pathway   TAS  RGD 
MLST8HumanmTOR signaling pathway   TAS  RGD 
MTORHumanmTOR signaling pathway   TAS  RGD 
Mapkap1RatmTOR signaling pathway   ISOMAPKAP1 (Homo sapiens) RGD 
Mapkap1MousemTOR signaling pathway   ISOMAPKAP1 (Homo sapiens) RGD 
Mlst8RatmTOR signaling pathway   ISOMLST8 (Homo sapiens) RGD 
Mlst8MousemTOR signaling pathway   ISOMLST8 (Homo sapiens) RGD 
MtorRatmTOR signaling pathway   ISOMTOR (Homo sapiens) RGD 
MtorMousemTOR signaling pathway   ISOMTOR (Homo sapiens) RGD 
RHEBHumanmTOR signaling pathway   TAS  RGD 
RICTORHumanmTOR signaling pathway   TAS  RGD 
RPS6KB1HumanmTOR signaling pathway   TAS  RGD 
RPS6KB2HumanmTOR signaling pathway   TAS  RGD 
RPTORHumanmTOR signaling pathway   TAS  RGD 
RRAGAHumanmTOR signaling pathway   TAS  RGD 
RRAGBHumanmTOR signaling pathway   TAS  RGD 
RRAGCHumanmTOR signaling pathway   TAS  RGD 
RRAGDHumanmTOR signaling pathway   TAS  RGD 
RhebRatmTOR signaling pathway   ISORHEB (Homo sapiens) RGD 
RhebMousemTOR signaling pathway   ISORHEB (Homo sapiens) RGD 
RictorRatmTOR signaling pathway   ISORICTOR (Homo sapiens) RGD 
RictorMousemTOR signaling pathway   ISORICTOR (Homo sapiens) RGD 
Rps6kb1RatmTOR signaling pathway   ISORPS6KB1 (Homo sapiens) RGD 
Rps6kb1MousemTOR signaling pathway   ISORPS6KB1 (Homo sapiens) RGD 
Rps6kb2RatmTOR signaling pathway   ISORPS6KB2 (Homo sapiens) RGD 
Rps6kb2MousemTOR signaling pathway   ISORPS6KB2 (Homo sapiens) RGD 
RptorRatmTOR signaling pathway   ISORPTOR (Homo sapiens) RGD 
RptorMousemTOR signaling pathway   ISORPTOR (Homo sapiens) RGD 
RragaRatmTOR signaling pathway   ISORRAGA (Homo sapiens) RGD 
RragaMousemTOR signaling pathway   ISORRAGA (Homo sapiens) RGD 
RragbRatmTOR signaling pathway   ISORRAGB (Homo sapiens) RGD 
RragbMousemTOR signaling pathway   ISORRAGB (Homo sapiens) RGD 
Rragb_v1RatmTOR signaling pathway   ISORRAGB (Homo sapiens) RGD 
RragcRatmTOR signaling pathway   ISORRAGC (Homo sapiens) RGD 
RragcMousemTOR signaling pathway   ISORRAGC (Homo sapiens) RGD 
RragdRatmTOR signaling pathway   ISORRAGD (Homo sapiens) RGD 
RragdMousemTOR signaling pathway   ISORRAGD (Homo sapiens) RGD 
TSC1HumanmTOR signaling pathway   TAS  RGD 
TSC2HumanmTOR signaling pathway   TAS  RGD 
Tsc1RatmTOR signaling pathway   ISOTSC1 (Homo sapiens) RGD 
Tsc1MousemTOR signaling pathway   ISOTSC1 (Homo sapiens) RGD 
Tsc2RatmTOR signaling pathway   ISOPsmb8 (Mus musculus) RGD 
Tsc2MousemTOR signaling pathway   ISOPsmb8 (Mus musculus) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akt1s1  (AKT1 substrate 1)
Eif4ebp1  (eukaryotic translation initiation factor 4E binding protein 1)
Mapkap1  (MAPK associated protein 1)
Mlst8  (MTOR associated protein, LST8 homolog)
Mtor  (mechanistic target of rapamycin kinase)
Rheb  (Ras homolog, mTORC1 binding)
Rictor  (RPTOR independent companion of MTOR, complex 2)
Rps6kb1  (ribosomal protein S6 kinase B1)
Rps6kb2  (ribosomal protein S6 kinase B2)
Rptor  (regulatory associated protein of MTOR, complex 1)
Rraga  (Ras-related GTP binding A)
Rragb  (Ras-related GTP binding B)
Rragb_v1  (Ras-related GTP binding B, variant 1)
Rragc  (Ras-related GTP binding C)
Rragd  (Ras-related GTP binding D)
Tsc1  (TSC complex subunit 1)
Tsc2  (TSC complex subunit 2)

Genes (Mus musculus)
Akt1s1  (AKT1 substrate 1)
Eif4ebp1  (eukaryotic translation initiation factor 4E binding protein 1)
Mapkap1  (mitogen-activated protein kinase associated protein 1)
Mlst8  (MTOR associated protein, LST8 homolog (S. cerevisiae))
Mtor  (mechanistic target of rapamycin kinase)
Rheb  (Ras homolog enriched in brain)
Rictor  (RPTOR independent companion of MTOR, complex 2)
Rps6kb1  (ribosomal protein S6 kinase, polypeptide 1)
Rps6kb2  (ribosomal protein S6 kinase, polypeptide 2)
Rptor  (regulatory associated protein of MTOR, complex 1)
Rraga  (Ras-related GTP binding A)
Rragb  (Ras-related GTP binding B)
Rragc  (Ras-related GTP binding C)
Rragd  (Ras-related GTP binding D)
Tsc1  (TSC complex subunit 1)
Tsc2  (TSC complex subunit 2)

Genes (Homo sapiens)
AKT1S1  (AKT1 substrate 1)
EIF4EBP1  (eukaryotic translation initiation factor 4E binding protein 1)
MAPKAP1  (MAPK associated protein 1)
MLST8  (MTOR associated protein, LST8 homolog)
MTOR  (mechanistic target of rapamycin kinase)
RHEB  (Ras homolog, mTORC1 binding)
RICTOR  (RPTOR independent companion of MTOR complex 2)
RPS6KB1  (ribosomal protein S6 kinase B1)
RPS6KB2  (ribosomal protein S6 kinase B2)
RPTOR  (regulatory associated protein of MTOR complex 1)
RRAGA  (Ras related GTP binding A)
RRAGB  (Ras related GTP binding B)
RRAGC  (Ras related GTP binding C)
RRAGD  (Ras related GTP binding D)
TSC1  (TSC complex subunit 1)
TSC2  (TSC complex subunit 2)


Additional Information