Aif1l (allograft inflammatory factor 1-like) - Rat Genome Database

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Gene: Aif1l (allograft inflammatory factor 1-like) Rattus norvegicus
Analyze
Symbol: Aif1l
Name: allograft inflammatory factor 1-like
RGD ID: 1305081
Description: Predicted to enable actin filament binding activity and calcium ion binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Part of protein-containing complex. Orthologous to human AIF1L (allograft inflammatory factor 1 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC362107; RGD1305081; similar to ionized calcium binding adapter molecule 2 (Iba2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,627,239 - 35,651,793 (+)NCBIGRCr8
mRatBN7.2315,229,476 - 15,254,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,229,524 - 15,254,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,302,434 - 18,326,985 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,887,419 - 26,911,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,134,603 - 25,159,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,237,944 - 9,262,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,237,944 - 9,262,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0314,598,261 - 14,622,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,053,196 - 11,078,079 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,945,778 - 10,972,062 (+)NCBI
Celera39,976,750 - 10,001,583 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Absence of AIF1L contributes to cell migration and a poor prognosis of breast cancer. Liu P, etal., Onco Targets Ther. 2018 Sep 5;11:5485-5498. doi: 10.2147/OTT.S165874. eCollection 2018.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Noda Y, etal., Biochem Biophys Res Commun. 2005 May 20;330(4):1041-7.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18699778   PMID:19056867   PMID:23376485  


Genomics

Comparative Map Data
Aif1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,627,239 - 35,651,793 (+)NCBIGRCr8
mRatBN7.2315,229,476 - 15,254,033 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,229,524 - 15,254,023 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,302,434 - 18,326,985 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,887,419 - 26,911,975 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,134,603 - 25,159,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.039,237,944 - 9,262,628 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,237,944 - 9,262,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0314,598,261 - 14,622,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,053,196 - 11,078,079 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1310,945,778 - 10,972,062 (+)NCBI
Celera39,976,750 - 10,001,583 (+)NCBICelera
Cytogenetic Map3p12NCBI
AIF1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389131,096,531 - 131,123,144 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9131,096,476 - 131,123,152 (+)EnsemblGRCh38hg38GRCh38
GRCh379133,971,918 - 133,998,531 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,961,733 - 132,988,360 (+)NCBINCBI36Build 36hg18NCBI36
Build 349131,001,465 - 131,028,093NCBI
Celera9104,510,955 - 104,537,611 (+)NCBICelera
Cytogenetic Map9q34.12-q34.13NCBI
HuRef9103,462,597 - 103,489,133 (+)NCBIHuRef
CHM1_19134,121,047 - 134,147,670 (+)NCBICHM1_1
T2T-CHM13v2.09143,304,798 - 143,331,382 (+)NCBIT2T-CHM13v2.0
Aif1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,840,315 - 31,863,454 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,840,151 - 31,863,454 (+)EnsemblGRCm39 Ensembl
GRCm38231,950,303 - 31,973,442 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,950,139 - 31,973,442 (+)EnsemblGRCm38mm10GRCm38
MGSCv37231,805,823 - 31,828,962 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,772,312 - 31,795,451 (+)NCBIMGSCv36mm8
Celera231,653,266 - 31,676,512 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.95NCBI
Aif1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513936,889 - 954,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955513936,889 - 954,667 (+)NCBIChiLan1.0ChiLan1.0
AIF1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,228,896 - 8,255,509 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan198,231,238 - 8,257,851 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09102,218,242 - 102,244,846 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19130,865,394 - 130,891,744 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,863,031 - 130,891,744 (+)Ensemblpanpan1.1panPan2
AIF1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1952,944,925 - 52,966,953 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl952,947,570 - 52,966,894 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,145,653 - 52,167,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0953,846,023 - 53,868,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl953,846,023 - 53,868,071 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,623,528 - 52,645,555 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0952,944,014 - 52,966,040 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,037,079 - 53,059,133 (-)NCBIUU_Cfam_GSD_1.0
Aif1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947198,193,397 - 198,211,193 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648717,961,854 - 17,979,749 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648717,961,922 - 17,979,721 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIF1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1271,072,734 - 271,102,803 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11271,075,376 - 271,099,984 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21305,102,354 - 305,127,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AIF1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,016,619 - 7,043,663 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl127,016,398 - 7,043,575 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,457,744 - 8,484,869 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aif1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,739,793 - 4,757,280 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,739,886 - 4,757,291 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aif1l
161 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:356
Count of miRNA genes:217
Interacting mature miRNAs:249
Transcripts:ENSRNOT00000013286
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat

Markers in Region
D3Kyo2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,246,796 - 15,246,941 (-)MAPPERmRatBN7.2
Rnor_6.039,245,037 - 9,245,181NCBIRnor6.0
Rnor_5.0314,605,354 - 14,605,498UniSTSRnor5.0
RGSC_v3.4311,070,842 - 11,070,986UniSTSRGSC3.4
RGSC_v3.4311,070,841 - 11,070,986RGDRGSC3.4
Celera39,994,339 - 9,994,490UniSTS
RH 3.4 Map358.9UniSTS
RH 3.4 Map358.9RGD
Cytogenetic Map3p11UniSTS
AI013738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,253,581 - 15,253,676 (-)MAPPERmRatBN7.2
Rnor_6.039,238,301 - 9,238,395NCBIRnor6.0
Rnor_5.0314,598,618 - 14,598,712UniSTSRnor5.0
RGSC_v3.4311,077,628 - 11,077,722UniSTSRGSC3.4
Celera310,001,132 - 10,001,226UniSTS
RH 3.4 Map359.0UniSTS
Cytogenetic Map3p11UniSTS
BE119659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,240,446 - 15,240,596 (-)MAPPERmRatBN7.2
Rnor_6.039,251,382 - 9,251,531NCBIRnor6.0
Rnor_5.0314,611,699 - 14,611,848UniSTSRnor5.0
RGSC_v3.4311,064,480 - 11,064,629UniSTSRGSC3.4
Celera39,987,983 - 9,988,132UniSTS
RH 3.4 Map358.5UniSTS
Cytogenetic Map3p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 35 12 4 8 4 1 1 58 35 34 1
Low 3 8 34 26 11 26 7 10 16 7 11 7
Below cutoff 11 11 11

Sequence


RefSeq Acc Id: ENSRNOT00000013286   ⟹   ENSRNOP00000013286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,229,524 - 15,254,023 (+)Ensembl
Rnor_6.0 Ensembl39,237,944 - 9,262,628 (-)Ensembl
RefSeq Acc Id: NM_001108578   ⟹   NP_001102048
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,627,239 - 35,651,793 (+)NCBI
mRatBN7.2315,229,476 - 15,254,033 (+)NCBI
Rnor_6.039,237,944 - 9,262,628 (-)NCBI
Rnor_5.0314,598,261 - 14,622,945 (-)NCBI
RGSC_v3.4311,053,196 - 11,078,079 (+)RGD
Celera39,976,750 - 10,001,583 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102048 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93259 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013286.5
RefSeq Acc Id: NP_001102048   ⟸   NM_001108578
- UniProtKB: A6JU37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013286   ⟸   ENSRNOT00000013286
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZRD9-F1-model_v2 AlphaFold D3ZRD9 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691962
Promoter ID:EPDNEW_R2487
Type:initiation region
Name:Aif1l_1
Description:allograft inflammatory factor 1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.039,262,577 - 9,262,637EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305081 AgrOrtholog
BioCyc Gene G2FUF-50166 BioCyc
Ensembl Genes ENSRNOG00000009951 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013286.6 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro AIF-1_EF_pair UniProtKB/TrEMBL
  AIF1/AIF1L UniProtKB/TrEMBL
  EF-hand-like_dom UniProtKB/TrEMBL
  EF_hand_Ca-bd UniProtKB/TrEMBL
KEGG Report rno:362107 UniProtKB/TrEMBL
NCBI Gene 362107 ENTREZGENE
PANTHER PTHR10356 UniProtKB/TrEMBL
  PTHR10356:SF5 UniProtKB/TrEMBL
Pfam AIF-1 UniProtKB/TrEMBL
PhenoGen Aif1l PhenoGen
PROSITE EF_HAND_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009951 RatGTEx
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A6JU37 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRD9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-06-12 Aif1l  allograft inflammatory factor 1-like  RGD1305081  similar to ionized calcium binding adapter molecule 2 (Iba2)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1305081  similar to ionized calcium binding adapter molecule 2 (Iba2)   RGD1305081_predicted  similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305081_predicted  similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)  LOC362107_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC362107_predicted  similar to ionized calcium binding adapter molecule 2 (Iba2) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL