Scl71 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Scl71 (Serum cholesterol level QTL 71) Rattus norvegicus

Symbol: Scl71
Name: Serum cholesterol level QTL 71
RGD ID: 10450806
Previously known as: f8-C (large LDL)
Trait: blood LDL cholesterol amount   (VT:0000181)    
Measurement Type: blood low density lipoprotein cholesterol level   (CMO:0000053)    
LOD Score: 5.8
P Value: 0.001
Variance: 39.0
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2324,192,455 - 27,494,778RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0324,772,984 - 28,136,884RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0329,989,957 - 33,340,453RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4320,341,140 - 23,762,628RGD_MAPPER_PIPELINERGSC3.4
Cross Type: Not Available
Strains Crossed: SHR.BN-(D8Mit5-D8Mgh6)/Ipcv BXH2/Cub 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain

References

References - curated
# Reference Title Reference Citation
1. Genomic determinants of triglyceride and cholesterol distribution into lipoprotein fractions in the rat. Hodulova M, etal., PLoS One. 2014 Oct 8;9(10):e109983. doi: 10.1371/journal.pone.0109983. eCollection 2014.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
11496785LOC10835055160S ribosomal protein L12 pseudogene32424981424250522Rat
41069797LOC120102003small nucleolar RNA SNORA7032455500324555138Rat
1561736Rpl10l3ribosomal protein L10A like 332455508024555585Rat
1306160Lrp1bLDL receptor related protein 1B32459430226715037Rat
41034676Actg1-ps7actin, gamma 1, pseudogene 732528326925290132Rat
41092566LOC120101541uncharacterized LOC12010154132689036826909301Rat
41393928LOC120102048small nucleolar RNA SNORA1732689649926896629Rat
41260220LOC120101542MLV-related proviral Env polyprotein-like32733382827335839Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
37010D3Rat4916032749462127494778Ratregion
60385D3Got17521932419245524192674Ratregion
66449D3Mco1623632501365025013911Ratregion
5031023BE12111215132616782126167972Ratregion
5075148RH13842619032519428725194478Ratregion
5074814RH13823318832634165826341846Ratregion
8693334rs106929875032451200424512004Ratregion
5504044px-43d224632447248124472727Ratregion
5499587At-9B-134114132445043524451577Ratregion
Position Markers

Flank 1: (D3Got175)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2324,192,455 - 24,192,674 (+)MAPPER
Rnor_6.0324,772,984 - 24,773,202NCBI
Rnor_5.0329,989,957 - 29,990,175UniSTS
RGSC_v3.4320,341,140 - 20,341,358UniSTS
RGSC_v3.4320,341,140 - 20,341,358RGD
RGSC_v3.1320,237,512 - 20,237,730RGD
Celera322,606,209 - 22,606,427UniSTS
RH 3.4 Map3257.6UniSTS
RH 3.4 Map3257.6RGD
Cytogenetic Map3q11UniSTS
Flank 2: (D3Rat49)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2327,494,621 - 27,494,778 (+)MAPPER
Rnor_6.0328,136,728 - 28,136,884NCBI
Rnor_5.0333,340,297 - 33,340,453UniSTS
RGSC_v3.4323,762,471 - 23,762,628RGD
RGSC_v3.4323,762,472 - 23,762,628UniSTS
RGSC_v3.1323,658,844 - 23,659,000RGD
Celera325,815,457 - 25,815,613UniSTS
RH 3.4 Map3295.7UniSTS
RH 3.4 Map3295.7RGD
SHRSP x BN Map312.0598UniSTS
SHRSP x BN Map312.0598RGD


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32419245527494778Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat


Additional Information

RGD Curation Notes
Note Type Note Reference
qtl_general number of animals used: 8-13 males, 4 month old from 15 PXO recombinant inbred strains 10402111
qtl_general software used: STATISTICA 10 CZ; ANOVA 10402111
qtl_general measurement method: 4 month old male rats were fed high-sucrose diet for 1 week; blood samples were taken from the tail vein after overnight fasting, lipoprotein fractions were determined by HPLC 10402111
qtl_general confidence interval: 20,496-22,532 Kbp 10402111
qtl_general 1 gene is present in this region 10402111
qtl_general 8th fraction of large LDL 10402111