Rapgef1 (Rap guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Rapgef1 (Rap guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Rapgef1
Name: Rap guanine nucleotide exchange factor 1
RGD ID: 619793
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of neuron projection development; and regulation of MAPK cascade. Located in perinuclear region of cytoplasm and phagocytic vesicle membrane. Part of protein-containing complex. Biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C3G; C3G-1; C3G-1, C3G-2; C3G-2; Grf2; Rap guanine nucleotide exchange factor (GEF) 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Rapgef1_v2   Rapgef1_v1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2312,898,349 - 13,016,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. Chung J, etal., J Immunol. 2008 Oct 15;181(8):5501-9.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The Ras-mitogen-activated protein kinase pathway is critical for the activation of matrix metalloproteinase secretion and the invasiveness in v-crk-transformed 3Y1. Liu E, etal., Cancer Res. 2000 May 1;60(9):2361-4.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells. Rufanova VA, etal., Can J Physiol Pharmacol. 2010 Aug;88(8):808-16. doi: 10.1139/Y10-056.
10. C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis. Rufanova VA, etal., Kidney Int. 2009 Jan;75(1):31-40. doi: 10.1038/ki.2008.448. Epub 2008 Sep 10.
11. Rho GTPases in insulin-stimulated glucose uptake. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
12. Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Schonherr C, etal., Oncogene. 2010 May 13;29(19):2817-30. doi: 10.1038/onc.2010.27. Epub 2010 Mar 1.
13. Identification of a novel splice variant of C3G which shows tissue-specific expression. Shivakrupa, etal., DNA Cell Biol 1999 Sep;18(9):701-8.
14. Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation. Wang Z, etal., Mol Cell Biol. 2006 Mar;26(6):2130-45.
Additional References at PubMed
PMID:9560161   PMID:10548487   PMID:12466202   PMID:12671687   PMID:14551197   PMID:14712229   PMID:16858399   PMID:17515907   PMID:17724123   PMID:21840392   PMID:23291598   PMID:23686869  
PMID:25621495   PMID:30152875  


Genomics

Comparative Map Data
Rapgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2312,898,349 - 13,016,234 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
RAPGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389131,576,775 - 131,740,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9131,576,770 - 131,740,076 (-)EnsemblGRCh38hg38GRCh38
GRCh379134,452,162 - 134,615,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369133,441,978 - 133,602,746 (-)NCBINCBI36Build 36hg18NCBI36
Celera9104,992,289 - 105,153,075 (-)NCBICelera
Cytogenetic Map9q34.13NCBI
HuRef9103,946,113 - 104,106,918 (-)NCBIHuRef
CHM1_19134,601,537 - 134,762,344 (-)NCBICHM1_1
T2T-CHM13v2.09143,789,743 - 143,952,984 (-)NCBIT2T-CHM13v2.0
Rapgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,509,732 - 29,630,376 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,509,732 - 29,630,990 (+)EnsemblGRCm39 Ensembl
GRCm38229,619,720 - 29,740,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,619,720 - 29,740,978 (+)EnsemblGRCm38mm10GRCm38
MGSCv37229,475,240 - 29,595,883 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,441,729 - 29,562,372 (+)NCBIMGSCv36mm8
Celera229,325,793 - 29,447,456 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.32NCBI
Rapgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555131,226,205 - 1,315,922 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555131,224,418 - 1,328,176 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19131,337,001 - 131,468,336 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9131,337,001 - 131,495,664 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09102,698,970 - 102,861,482 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RAPGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1952,429,204 - 52,566,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl952,450,597 - 52,563,778 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha951,696,813 - 51,835,167 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0953,332,127 - 53,471,097 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl953,332,194 - 53,469,116 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,105,371 - 52,243,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0952,430,365 - 52,567,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0952,522,579 - 52,661,232 (+)NCBIUU_Cfam_GSD_1.0
Rapgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947198,537,011 - 198,642,163 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648718,305,488 - 18,410,952 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648718,305,537 - 18,411,170 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1271,494,248 - 271,600,920 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11271,494,243 - 271,624,609 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21305,502,204 - 305,633,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1126,407,030 - 6,566,200 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,437,454 - 6,567,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,999,335 - 9,158,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,376,713 - 4,474,837 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,376,733 - 4,474,834 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rapgef1
371 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:279
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000019220, ENSRNOT00000060977, ENSRNOT00000074424
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat

Markers in Region
RH129681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,015,971 - 13,016,175 (+)MAPPERmRatBN7.2
Rnor_6.038,306,815 - 8,307,018NCBIRnor6.0
Rnor_5.0313,650,164 - 13,650,367UniSTSRnor5.0
Celera37,794,181 - 7,794,384UniSTS
RH 3.4 Map335.3UniSTS
Cytogenetic Map3p12UniSTS
BF386172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,994,988 - 12,995,157 (+)MAPPERmRatBN7.2
Rnor_6.038,285,833 - 8,286,001NCBIRnor6.0
Rnor_5.0313,629,182 - 13,629,350UniSTSRnor5.0
Celera37,773,187 - 7,773,355UniSTS
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS
UniSTS:234364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,015,379 - 13,015,561 (+)MAPPERmRatBN7.2
Rnor_6.038,306,223 - 8,306,404NCBIRnor6.0
Rnor_5.0313,649,572 - 13,649,753UniSTSRnor5.0
Celera37,793,589 - 7,793,770UniSTS
Cytogenetic Map3p12UniSTS
UniSTS:224268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2312,972,261 - 12,972,447 (+)MAPPERmRatBN7.2
Rnor_6.038,251,757 - 8,251,942NCBIRnor6.0
Rnor_5.0313,596,245 - 13,596,430UniSTSRnor5.0
RGSC_v3.438,660,842 - 8,661,027UniSTSRGSC3.4
Celera37,750,720 - 7,750,905UniSTS
Cytogenetic Map3p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 34 19 19 19 8 11 74 35 41 11 8
Low 1 23 22 22
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_006224337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ249986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000060977   ⟹   ENSRNOP00000057696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,921,409 - 13,013,984 (+)Ensembl
Rnor_6.0 Ensembl38,192,575 - 8,304,976 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093970   ⟹   ENSRNOP00000081072
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095571   ⟹   ENSRNOP00000082703
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,953,944 - 13,013,984 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099738   ⟹   ENSRNOP00000080887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,955,327 - 13,013,984 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108449   ⟹   ENSRNOP00000088594
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl312,898,266 - 13,013,984 (+)Ensembl
RefSeq Acc Id: XM_006233902   ⟹   XP_006233964
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,579 - 13,016,234 (+)NCBI
Rnor_6.038,189,596 - 8,307,077 (+)NCBI
Rnor_5.0313,534,547 - 13,650,426 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761683   ⟹   XP_008759905
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761684   ⟹   XP_008759906
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,568 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761685   ⟹   XP_008759907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761686   ⟹   XP_008759908
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,569 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592102   ⟹   XP_017447591
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,561 - 13,016,234 (+)NCBI
Rnor_6.038,189,594 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592108   ⟹   XP_017447597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,573 - 13,016,234 (+)NCBI
Rnor_6.038,189,595 - 8,307,077 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106157   ⟹   XP_038962085
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,553 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106158   ⟹   XP_038962086
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,555 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106159   ⟹   XP_038962087
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,561 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106160   ⟹   XP_038962088
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,898,349 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106161   ⟹   XP_038962089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,566 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106162   ⟹   XP_038962090
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,559 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106163   ⟹   XP_038962091
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,553 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106164   ⟹   XP_038962092
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,898,349 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106165   ⟹   XP_038962093
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,559 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106166   ⟹   XP_038962094
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,898,349 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106167   ⟹   XP_038962095
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,563 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106168   ⟹   XP_038962096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,568 - 13,016,234 (+)NCBI
RefSeq Acc Id: XM_039106169   ⟹   XP_038962097
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2312,918,579 - 13,016,234 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_006233964   ⟸   XM_006233902
- Peptide Label: isoform X19
- Sequence:
RefSeq Acc Id: XP_008759905   ⟸   XM_008761683
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008759906   ⟸   XM_008761684
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_008759907   ⟸   XM_008761685
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_008759908   ⟸   XM_008761686
- Peptide Label: isoform X14
- Sequence:
RefSeq Acc Id: XP_017447591   ⟸   XM_017592102
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017447597   ⟸   XM_017592108
- Peptide Label: isoform X17
- Sequence:
RefSeq Acc Id: ENSRNOP00000057696   ⟸   ENSRNOT00000060977
RefSeq Acc Id: XP_038962094   ⟸   XM_039106166
- Peptide Label: isoform X15
RefSeq Acc Id: XP_038962088   ⟸   XM_039106160
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038962092   ⟸   XM_039106164
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038962085   ⟸   XM_039106157
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962091   ⟸   XM_039106163
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038962086   ⟸   XM_039106158
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962090   ⟸   XM_039106162
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038962093   ⟸   XM_039106165
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038962087   ⟸   XM_039106159
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038962095   ⟸   XM_039106167
- Peptide Label: isoform X16
RefSeq Acc Id: XP_038962089   ⟸   XM_039106161
- Peptide Label: isoform X7
- UniProtKB: F1M8L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962096   ⟸   XM_039106168
- Peptide Label: isoform X18
RefSeq Acc Id: XP_038962097   ⟸   XM_039106169
- Peptide Label: isoform X20
RefSeq Acc Id: ENSRNOP00000088594   ⟸   ENSRNOT00000108449
RefSeq Acc Id: ENSRNOP00000081072   ⟸   ENSRNOT00000093970
RefSeq Acc Id: ENSRNOP00000080887   ⟸   ENSRNOT00000099738
RefSeq Acc Id: ENSRNOP00000082703   ⟸   ENSRNOT00000095571
Protein Domains
N-terminal Ras-GEF   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8L9-F1-model_v2 AlphaFold F1M8L9 1-1253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619793 AgrOrtholog
BioCyc Gene G2FUF-50258 BioCyc
Ensembl Genes ENSRNOG00000014316 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057696 ENTREZGENE
  ENSRNOP00000057696.5 UniProtKB/TrEMBL
  ENSRNOP00000080887 ENTREZGENE
  ENSRNOP00000080887.1 UniProtKB/TrEMBL
  ENSRNOP00000081072.1 UniProtKB/TrEMBL
  ENSRNOP00000082703 ENTREZGENE
  ENSRNOP00000082703.1 UniProtKB/TrEMBL
  ENSRNOP00000088594 ENTREZGENE
  ENSRNOP00000088594.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060977 ENTREZGENE
  ENSRNOT00000060977.6 UniProtKB/TrEMBL
  ENSRNOT00000093970.1 UniProtKB/TrEMBL
  ENSRNOT00000095571 ENTREZGENE
  ENSRNOT00000095571.1 UniProtKB/TrEMBL
  ENSRNOT00000099738 ENTREZGENE
  ENSRNOT00000099738.1 UniProtKB/TrEMBL
  ENSRNOT00000108449 ENTREZGENE
  ENSRNOT00000108449.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
NCBI Gene 63881 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PhenoGen Rapgef1 PhenoGen
PROSITE RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
UniProt A0A8I5ZQV4_RAT UniProtKB/TrEMBL
  A0A8I5ZRV1_RAT UniProtKB/TrEMBL
  A0A8I5ZUL6_RAT UniProtKB/TrEMBL
  A0A8I6A6H6_RAT UniProtKB/TrEMBL
  F1M8L9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef1  Rap guanine nucleotide exchange factor 1  Rapgef1  Rap guanine nucleotide exchange factor (GEF) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rapgef1  Rap guanine nucleotide exchange factor (GEF) 1  Grf2  C3G protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Grf2  C3G protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein variant C3G-2 contains a 51 amino acid insertion 632980
gene_transcript variant C3G-2 is expressed at high levels in testis while variant C3G-1 is present in most other tissues 632980