Nr5a1 (nuclear receptor subfamily 5, group A, member 1) - Rat Genome Database

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Gene: Nr5a1 (nuclear receptor subfamily 5, group A, member 1) Rattus norvegicus
Analyze
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
RGD ID: 68350
Description: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including calcineurin-mediated signaling; positive regulation of male gonad development; and response to gonadotropin-releasing hormone. Located in nucleus. Used to study gonadal dysgenesis. Human ortholog(s) of this gene implicated in Zellweger syndrome; adrenal cortical hypofunction; gonadal dysgenesis (multiple); primary ovarian insufficiency 7; and spermatogenic failure 8. Orthologous to human NR5A1 (nuclear receptor subfamily 5 group A member 1); INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ad4bp; Ad4BP/SF-1; adrenal 4-binding protein; Ftzf1; fushi tarazu factor homolog 1; nuclear receptor subfamily 5 group A member 1; Sf-1; steroid hormone receptor Ad4BP; steroidogenic factor 1; STF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2322,464,786 - 22,486,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,933,801 - 25,954,690 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0334,518,798 - 34,539,688 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0332,331,170 - 32,351,980 (-)NCBIRnor_WKY
Rnor_6.0322,998,900 - 23,020,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,223,427 - 28,244,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,498,913 - 18,519,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,395,933 - 18,412,441 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
20-hydroxycholesterol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (EXP,ISO)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
atrazine  (EXP,ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bucladesine  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
daidzein  (EXP)
daidzein 7-O-beta-D-glucoside  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP)
diethyl phthalate  (EXP)
diethylstilbestrol  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenitrothion  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
gentamycin  (EXP)
glycitein  (EXP)
glycitin  (EXP)
icariin  (ISO)
imidacloprid  (EXP)
iprodione  (EXP)
L-ascorbic acid  (EXP)
methapyrilene  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotine  (EXP,ISO)
paracetamol  (EXP)
perfluoroundecanoic acid  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
proanthocyanidin  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
pyruvic acid  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
simazine  (ISO)
sirolimus  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
Tetrachlorobisphenol A  (ISO)
triadimefon  (EXP)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimethyltin  (EXP)
triphenylstannane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zearalenone  (EXP)
zinc oxide  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Gonadal determination and adrenal development are regulated by the orphan nuclear receptor steroidogenic factor-1, in a dose-dependent manner. Achermann JC, etal., J Clin Endocrinol Metab. 2002 Apr;87(4):1829-33.
2. Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Falender AE, etal., Endocrinology. 2003 Aug;144(8):3598-610.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Transgenic rescue of SF-1-null mice. Karpova T, etal., Ann N Y Acad Sci. 2005 Dec;1061:55-64.
6. Calcineurin and CRTC2 mediate FSH and TGFß1 upregulation of Cyp19a1 and Nr5a in ovary granulosa cells. Lai WA, etal., J Mol Endocrinol. 2014 Oct;53(2):259-70. doi: 10.1530/JME-14-0048. Epub 2014 Jul 23.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. Nomura M, etal., J Biol Chem 1995 Mar 31;270(13):7453-61.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Genetic and clinical aspects of Zellweger spectrum patients with PEX1 mutations. Rosewich H, etal., J Med Genet. 2005 Sep;42(9):e58.
15. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Shen JH and Ingraham HA, Mol Endocrinol 2002 Mar;16(3):529-40.
16. Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian granulosa cells. Yazawa T, etal., Endocrinology. 2003 May;144(5):1920-30.
17. Anterior pituitary gene expression with reproductive aging in the female rat. Zheng W, etal., Biol Reprod. 2007 Jun;76(6):1091-102. Epub 2007 Mar 7.
Additional References at PubMed
PMID:8395654   PMID:10369247   PMID:10446902   PMID:10567391   PMID:10848616   PMID:11071856   PMID:11796523   PMID:12610109   PMID:12651892   PMID:12730328   PMID:12732652   PMID:12861022  
PMID:14726490   PMID:14988433   PMID:15118069   PMID:15146959   PMID:15590666   PMID:15829514   PMID:16109736   PMID:16176945   PMID:16469813   PMID:17526944   PMID:17664281   PMID:17804753  
PMID:18004794   PMID:18992787   PMID:19301398   PMID:19389484   PMID:19457926   PMID:19814654   PMID:20026603   PMID:20924043   PMID:21412441   PMID:21734262   PMID:21757499   PMID:21820362  
PMID:22447829   PMID:23610160   PMID:23637637   PMID:24405868   PMID:27378692   PMID:27490115   PMID:27610946   PMID:27855412   PMID:28964809   PMID:30342431   PMID:31041823  


Genomics

Comparative Map Data
Nr5a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2322,464,786 - 22,486,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx325,933,801 - 25,954,690 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0334,518,798 - 34,539,688 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0332,331,170 - 32,351,980 (-)NCBIRnor_WKY
Rnor_6.0322,998,900 - 23,020,441 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,223,427 - 28,244,968 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,498,913 - 18,519,738 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,395,933 - 18,412,441 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBICelera
Cytogenetic Map3q12NCBI
NR5A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,481,236 - 124,507,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9124,481,236 - 124,507,420 (-)EnsemblGRCh38hg38GRCh38
GRCh379127,243,515 - 127,269,678 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,283,336 - 126,309,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 349124,323,069 - 124,349,253NCBI
Celera997,890,732 - 97,916,915 (-)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef996,856,059 - 96,882,213 (-)NCBIHuRef
CHM1_19127,392,508 - 127,418,653 (-)NCBICHM1_1
T2T-CHM13v2.09136,679,465 - 136,705,624 (-)NCBIT2T-CHM13v2.0
Nr5a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,582,668 - 38,604,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,582,668 - 38,604,554 (-)EnsemblGRCm39 Ensembl
GRCm38238,692,656 - 38,714,542 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl238,692,656 - 38,714,542 (-)EnsemblGRCm38mm10GRCm38
MGSCv37238,548,180 - 38,570,062 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,514,636 - 38,536,512 (-)NCBIMGSCv36mm8
Celera240,416,849 - 40,438,726 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.42NCBI
Nr5a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,632,220 - 3,654,375 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,632,248 - 3,654,367 (+)NCBIChiLan1.0ChiLan1.0
NR5A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19124,122,968 - 124,149,292 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,122,968 - 124,149,292 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0995,605,282 - 95,628,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Nr5a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947192,970,909 - 193,007,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648712,739,439 - 12,763,734 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648712,739,445 - 12,763,729 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR5A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,284,493 - 265,311,417 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,284,491 - 265,311,547 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,123,683 - 299,135,326 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q210-q211NCBI
NR5A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11213,640,453 - 13,666,748 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1213,640,473 - 13,666,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660792,411,630 - 2,438,042 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr5a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476010,605,877 - 10,626,386 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476010,603,504 - 10,626,259 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr5a1
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:182
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000017651
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1558657Cm43Cardiac mass QTL 436.60.0000000293heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)heart rate (CMO:0000002)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat

Markers in Region
PMC140651P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,480,005 - 22,480,126 (+)MAPPERmRatBN7.2
Rnor_6.0323,014,119 - 23,014,239NCBIRnor6.0
Rnor_5.0328,238,646 - 28,238,766UniSTSRnor5.0
RGSC_v3.4318,513,416 - 18,513,536UniSTSRGSC3.4
Celera320,913,229 - 20,913,349UniSTS
Cytogenetic Map3q11UniSTS
RH132410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,464,929 - 22,465,134 (+)MAPPERmRatBN7.2
Rnor_6.0322,999,044 - 22,999,248NCBIRnor6.0
Rnor_5.0328,223,571 - 28,223,775UniSTSRnor5.0
RGSC_v3.4318,498,341 - 18,498,545UniSTSRGSC3.4
Celera320,898,154 - 20,898,358UniSTS
RH 3.4 Map3213.12UniSTS
Cytogenetic Map3q11UniSTS
UniSTS:464684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2322,466,078 - 22,466,196 (+)MAPPERmRatBN7.2
Rnor_6.0323,000,192 - 23,000,309NCBIRnor6.0
Rnor_5.0328,224,719 - 28,224,836UniSTSRnor5.0
RGSC_v3.4318,499,489 - 18,499,606UniSTSRGSC3.4
Celera320,899,302 - 20,899,419UniSTS
Cytogenetic Map3q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 7 1 30
Low 1 5 8 10 15 9 8
Below cutoff 7 11 6 5 6 46 14 1 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017651   ⟹   ENSRNOP00000017651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl322,465,502 - 22,486,328 (-)Ensembl
Rnor_6.0 Ensembl322,999,616 - 23,020,441 (-)Ensembl
RefSeq Acc Id: NM_001191099   ⟹   NP_001178028
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2322,465,502 - 22,486,328 (-)NCBI
Rnor_6.0322,999,616 - 23,020,441 (-)NCBI
Rnor_5.0328,223,427 - 28,244,968 (-)NCBI
Celera320,898,726 - 20,919,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234106   ⟹   XP_006234168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2322,464,786 - 22,481,269 (-)NCBI
Rnor_6.0322,998,900 - 23,016,310 (-)NCBI
Rnor_5.0328,223,427 - 28,244,968 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001178028   ⟸   NM_001191099
- UniProtKB: P50569 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006234168   ⟸   XM_006234106
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000017651   ⟸   ENSRNOT00000017651
Protein Domains
NR LBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50569-F1-model_v2 AlphaFold P50569 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68350 AgrOrtholog
BioCyc Gene G2FUF-49906 BioCyc
Ensembl Genes ENSRNOG00000012682 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000017651 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017651 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot
  NR5_fam UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:83826 UniProtKB/Swiss-Prot
NCBI Gene 83826 ENTREZGENE
PANTHER PTHR24086 UniProtKB/Swiss-Prot
Pfam Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PhenoGen Nr5a1 PhenoGen
PIRSF Nuc_orph_FTZ-F1 UniProtKB/Swiss-Prot
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48508 UniProtKB/Swiss-Prot
UniProt P50569 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr5a1  nuclear receptor subfamily 5, group A, member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation expression is transcriptionally regulated through an E box element 68249