Dab2ip (DAB2 interacting protein) - Rat Genome Database

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Gene: Dab2ip (DAB2 interacting protein) Rattus norvegicus
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Symbol: Dab2ip
Name: DAB2 interacting protein
RGD ID: 621686
Description: Enables GTPase activator activity. Involved in cellular response to epidermal growth factor stimulus; negative regulation of cell growth; and negative regulation of signal transduction. Predicted to be located in axon; endocytic vesicle; and neuronal cell body membrane. Predicted to be part of AIP1-IRE1 complex. Human ortholog(s) of this gene implicated in artery disease (multiple); lung cancer; prostate cancer; and stomach cancer. Orthologous to human DAB2IP (DAB2 interacting protein); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIP-1; ASK-interacting protein 1; DAB2-interacting protein; DIP1/2; disabled homolog 2 (Drosophila) interacting protein; disabled homolog 2 interacting protein; disabled homolog 2-interacting protein; DOC-2/DAB2 interactive protein; DOC2/DAB2 interactive protein; LOC108350356; uncharacterized LOC108350356
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,312,745 - 39,483,730 (+)NCBIGRCr8
mRatBN7.2318,915,290 - 19,086,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,915,290 - 19,086,280 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,993,857 - 22,164,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,578,777 - 30,749,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,824,966 - 28,996,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,889,263 - 15,060,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,889,510 - 15,060,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,200,937 - 20,371,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,667,700 - 14,840,625 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,665,957 - 14,736,995 (+)NCBI
Celera313,627,572 - 13,799,395 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
cell motility involved in cerebral cortex radial glia guided migration  (IEA,ISO,ISS)
cellular response to epidermal growth factor stimulus  (IDA)
cellular response to interleukin-1  (IEA,ISO,ISS)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to tumor necrosis factor  (IEA,ISO,ISS)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO,ISS)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
intracellular signal transduction  (ISO,ISS)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
layer formation in cerebral cortex  (IEA,ISO,ISS)
negative regulation of angiogenesis  (IEA,ISO,ISS)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cell growth  (IDA)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of endothelial cell migration  (IEA,ISO,ISS)
negative regulation of epidermal growth factor receptor signaling pathway  (IDA)
negative regulation of epithelial cell migration  (IEA,ISO,ISS)
negative regulation of epithelial cell proliferation  (IEA,ISO,ISS)
negative regulation of epithelial to mesenchymal transition  (IEA,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO,ISS)
negative regulation of fibroblast proliferation  (IEA,ISO,ISS)
negative regulation of G0 to G1 transition  (IEA,ISO,ISS)
negative regulation of GTPase activity  (ISO,ISS)
negative regulation of MAP kinase activity  (ISO,ISS)
negative regulation of NF-kappaB transcription factor activity  (ISO,ISS)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO,ISS)
negative regulation of protein catabolic process  (IEA,ISO,ISS)
negative regulation of protein serine/threonine kinase activity  (ISO,ISS)
negative regulation of Ras protein signal transduction  (IDA)
negative regulation of toll-like receptor 4 signaling pathway  (IEA,ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (IEA,ISO,ISS)
negative regulation of vascular endothelial growth factor signaling pathway  (IEA,ISO,ISS)
neuron projection morphogenesis  (IEA,ISO,ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of apoptotic signaling pathway  (IEA,ISO,ISS)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of dendrite development  (IEA,ISO,ISS)
positive regulation of epithelial cell proliferation  (ISS)
positive regulation of JNK cascade  (IEA,ISO,ISS)
positive regulation of JUN kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO,ISS)
positive regulation of neuron migration  (IEA,ISO,ISS)
positive regulation of neuron projection development  (ISO,ISS)
positive regulation of proteasomal protein catabolic process  (IEA,ISO,ISS)
positive regulation of protein catabolic process  (ISO,ISS)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of synapse maturation  (IEA,ISO,ISS)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
protein catabolic process  (IEA,ISO,ISS)
regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
regulation of cell cycle  (ISO,ISS)
regulation of p38MAPK cascade  (IEA,ISO,ISS)
regulation of protein-containing complex assembly  (ISO,ISS)
response to unfolded protein  (IEA)
tube formation  (IEA,ISO,ISS)
vascular endothelial growth factor receptor-2 signaling pathway  (IEA,ISO,ISS)

Cellular Component
AIP1-IRE1 complex  (IEA,ISO)
axon  (ISO,ISS)
cerebellar mossy fiber  (IEA,ISO,ISS)
climbing fiber  (IEA,ISO,ISS)
cytoplasm  (ISO,ISS)
dendrite  (IEA)
endocytic vesicle  (IEA,ISO,ISS)
neuronal cell body  (ISO,ISS)
neuronal cell body membrane  (IEA,ISO,ISS)
parallel fiber  (IEA,ISO,ISS)
plasma membrane  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Frequency and association of disabled homolog 2-interacting protein (DAB2IP) variant rs7025486 G>A with coronary artery disease risk in Indian population. Bhanushali AA, etal., Indian Heart J. 2018 Dec;70 Suppl 3(Suppl 3):S480-S482. doi: 10.1016/j.ihj.2018.06.016. Epub 2018 Jun 19.
2. Low Expression of ASK1-Interacting Protein-1 Is Significantly Correlated with Tumor Angiogenesis and Poor Survival in Patients with Early Stage Non-Small Cell Lung Cancer. Chen C, etal., Onco Targets Ther. 2019 Dec 10;12:10739-10747. doi: 10.2147/OTT.S222332. eCollection 2019.
3. miR-1307-3p promotes tumor growth and metastasis of hepatocellular carcinoma by repressing DAB2 interacting protein. Chen S, etal., Biomed Pharmacother. 2019 Sep;117:109055. doi: 10.1016/j.biopha.2019.109055. Epub 2019 Jun 5.
4. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Gretarsdottir S, etal., Nat Genet. 2010 Aug;42(8):692-7. doi: 10.1038/ng.622. Epub 2010 Jul 11.
5. Association of a sequence variant in DAB2IP with coronary heart disease. Harrison SC, etal., Eur Heart J. 2012 Apr;33(7):881-8. doi: 10.1093/eurheartj/ehr075. Epub 2011 Mar 28.
6. Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin. Lai CH, etal., Oncotarget. 2014 Jul 30;5(14):5523-34. doi: 10.18632/oncotarget.2133.
7. DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. Legaki E, etal., In Vivo. 2019 May-Jun;33(3):737-742. doi: 10.21873/invivo.11533.
8. miR-182 contributes to cell proliferation, invasion and tumor growth in colorectal cancer by targeting DAB2IP. Li X, etal., Int J Biochem Cell Biol. 2019 Jun;111:27-36. doi: 10.1016/j.biocel.2019.04.002. Epub 2019 Apr 8.
9. Short AIP1 (ASK1-Interacting Protein-1) Isoform Localizes to the Mitochondria and Promotes Vascular Dysfunction. Li Z, etal., Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):112-127. doi: 10.1161/ATVBAHA.119.312976. Epub 2019 Oct 17.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Absence of DAB2IP promotes cancer stem cell like signatures and indicates poor survival outcome in colorectal cancer. Min J, etal., Sci Rep. 2015 Nov 13;5:16578. doi: 10.1038/srep16578.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. miR-92b promotes gastric cancer growth by activating the DAB2IP-mediated PI3K/AKT signalling pathway. Ni QF, etal., Cell Prolif. 2020 Jan;53(1):e12630. doi: 10.1111/cpr.12630. Epub 2019 Nov 12.
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses. Rhodin K, etal., J Dent Res. 2014 Sep;93(9):882-90. doi: 10.1177/0022034514544506. Epub 2014 Jul 23.
18. Expression of DAB2IP in human trophoblast and its role in trophoblast invasion. Shan N, etal., J Matern Fetal Neonatal Med. 2016;29(3):393-9. doi: 10.3109/14767058.2014.1001974. Epub 2015 Jan 21.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Low expression level of ASK1-interacting protein-1 correlated with tumor angiogenesis and poor survival in patients with esophageal squamous cell cancer. Sun D, etal., Onco Targets Ther. 2018 Nov 1;11:7699-7707. doi: 10.2147/OTT.S178131. eCollection 2018.
21. DOC-2/DAB2 interactive protein regulates proliferation and mobility of nasopharyngeal carcinoma cells by targeting PI3K/Akt pathway. Wang B, etal., Oncol Rep. 2017 Jul;38(1):317-324. doi: 10.3892/or.2017.5704. Epub 2017 Jun 6.
22. The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer. Wang J, etal., Oncotarget. 2015 Sep 29;6(29):27427-39. doi: 10.18632/oncotarget.4861.
23. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. Wang Z, etal., J Biol Chem 2002 Apr 12;277(15):12622-31.
24. MicroRNA-889 promotes cell proliferation in colorectal cancer by targeting DAB2IP. Xiao Y, etal., Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3326-3334. doi: 10.26355/eurrev_201904_17695.
25. Association of the variant rs2243421 of human DOC-2/DAB2 interactive protein gene (hDAB2IP) with gastric cancer in the Chinese Han population. Xu S, etal., Gene. 2013 Feb 15;515(1):200-4. doi: 10.1016/j.gene.2012.11.043. Epub 2012 Dec 14.
26. A common genetic variant (97906C>A) of DAB2IP/AIP1 is associated with an increased risk and early onset of lung cancer in Chinese males. Yang L, etal., PLoS One. 2011;6(10):e26944. doi: 10.1371/journal.pone.0026944. Epub 2011 Oct 26.
27. A DAB2IP genotype: sex interaction is associated with abdominal aortic aneurysm expansion. Ye Z, etal., J Investig Med. 2017 Oct;65(7):1077-1082. doi: 10.1136/jim-2016-000404. Epub 2017 Jul 11.
28. Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma. Zhang X, etal., J Gastroenterol Hepatol. 2012 Jun;27(6):1117-25. doi: 10.1111/j.1440-1746.2011.07049.x.
Additional References at PubMed
PMID:8889548   PMID:12813029   PMID:15310755   PMID:17389591   PMID:18281285   PMID:19033661   PMID:19903888   PMID:19948740   PMID:20080667   PMID:20154697   PMID:21890121   PMID:23056358  
PMID:23326475   PMID:23376485   PMID:25468996   PMID:30361391  


Genomics

Comparative Map Data
Dab2ip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8339,312,745 - 39,483,730 (+)NCBIGRCr8
mRatBN7.2318,915,290 - 19,086,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl318,915,290 - 19,086,280 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx321,993,857 - 22,164,973 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0330,578,777 - 30,749,893 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0328,824,966 - 28,996,227 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0314,889,263 - 15,060,286 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,889,510 - 15,060,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0320,200,937 - 20,371,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4314,667,700 - 14,840,625 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1314,665,957 - 14,736,995 (+)NCBI
Celera313,627,572 - 13,799,395 (+)NCBICelera
Cytogenetic Map3p11NCBI
DAB2IP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389121,567,074 - 121,785,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9121,567,057 - 121,785,530 (+)EnsemblGRCh38hg38GRCh38
GRCh379124,329,353 - 124,547,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369123,369,220 - 123,587,630 (+)NCBINCBI36Build 36hg18NCBI36
Build 349121,584,617 - 121,624,486NCBI
Celera994,977,959 - 95,196,365 (+)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef993,947,187 - 94,165,205 (+)NCBIHuRef
CHM1_19124,476,692 - 124,695,048 (+)NCBICHM1_1
T2T-CHM13v2.09133,763,089 - 133,981,519 (+)NCBIT2T-CHM13v2.0
Dab2ip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39235,448,285 - 35,621,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl235,448,278 - 35,621,006 (+)EnsemblGRCm39 Ensembl
GRCm38235,558,446 - 35,730,994 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl235,558,266 - 35,730,994 (+)EnsemblGRCm38mm10GRCm38
MGSCv37235,413,978 - 35,586,514 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36235,514,003 - 35,553,001 (+)NCBIMGSCv36mm8
Celera235,262,708 - 35,435,145 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map223.74NCBI
Dab2ip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554196,228,591 - 6,416,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554196,229,437 - 6,416,619 (-)NCBIChiLan1.0ChiLan1.0
DAB2IP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,559,459 - 17,775,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1917,561,808 - 17,777,742 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0992,696,798 - 92,912,425 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19121,206,211 - 121,254,336 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9121,143,457 - 121,254,336 (+)Ensemblpanpan1.1panPan2
DAB2IP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,725,887 - 60,918,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,726,809 - 60,918,139 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,923,807 - 60,112,921 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,652,013 - 61,841,403 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,649,556 - 61,841,557 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1960,418,457 - 60,607,676 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,735,047 - 60,780,893 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,826,819 - 60,947,231 (-)NCBIUU_Cfam_GSD_1.0
Dab2ip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947190,288,527 - 190,474,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648710,145,278 - 10,243,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648710,056,809 - 10,243,021 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAB2IP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1261,659,785 - 261,859,830 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11261,732,280 - 261,859,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21293,998,983 - 294,126,953 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAB2IP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11217,802,030 - 18,017,648 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1217,801,831 - 17,830,890 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603525,028,520 - 25,243,744 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dab2ip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476013,472,672 - 13,657,930 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476013,472,500 - 13,658,070 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dab2ip
686 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1218
Count of miRNA genes:284
Interacting mature miRNAs:377
Transcripts:ENSRNOT00000059993, ENSRNOT00000066877
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
11528620Bss113Bone structure and strength QTL 1139.752e-10femur morphology trait (VT:0000559)femoral neck width (CMO:0001695)31649064819241681Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
BE116388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,986,510 - 18,986,665 (+)MAPPERmRatBN7.2
Rnor_6.0314,960,470 - 14,960,624NCBIRnor6.0
Rnor_5.0320,271,797 - 20,271,951UniSTSRnor5.0
RGSC_v3.4314,739,451 - 14,739,605UniSTSRGSC3.4
Celera313,698,787 - 13,698,941UniSTS
RH 3.4 Map3168.5UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF236130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF565256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU759383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000080760   ⟹   ENSRNOP00000068688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,915,290 - 19,085,441 (+)Ensembl
Rnor_6.0 Ensembl314,889,510 - 15,057,557 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083134   ⟹   ENSRNOP00000072901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl319,047,262 - 19,086,280 (+)Ensembl
Rnor_6.0 Ensembl315,038,267 - 15,060,284 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090735   ⟹   ENSRNOP00000068818
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl319,016,347 - 19,085,441 (+)Ensembl
Rnor_6.0 Ensembl314,990,652 - 15,060,286 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094494   ⟹   ENSRNOP00000091180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,915,290 - 19,086,280 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103632   ⟹   ENSRNOP00000086079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,978,237 - 19,086,280 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106017   ⟹   ENSRNOP00000096499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,978,237 - 19,086,280 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108040   ⟹   ENSRNOP00000077217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl318,998,376 - 19,086,280 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112672   ⟹   ENSRNOP00000083416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl319,058,363 - 19,086,280 (+)Ensembl
RefSeq Acc Id: NM_138710   ⟹   NP_619724
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,312,745 - 39,483,730 (+)NCBI
mRatBN7.2318,915,290 - 19,086,282 (+)NCBI
Rnor_6.0314,889,263 - 15,060,286 (+)NCBI
Rnor_5.0320,200,937 - 20,371,268 (+)NCBI
RGSC_v3.4314,667,700 - 14,840,625 (+)RGD
Celera313,627,572 - 13,799,395 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104216   ⟹   XP_038960144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,375,752 - 39,483,730 (+)NCBI
mRatBN7.2318,978,302 - 19,086,282 (+)NCBI
RefSeq Acc Id: XM_039104222   ⟹   XP_038960150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,444,164 - 39,483,730 (+)NCBI
mRatBN7.2319,046,941 - 19,086,282 (+)NCBI
RefSeq Acc Id: XM_063283045   ⟹   XP_063139115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,336,372 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283046   ⟹   XP_063139116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,375,754 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283047   ⟹   XP_063139117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,375,754 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283048   ⟹   XP_063139118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,312,897 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283049   ⟹   XP_063139119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,312,897 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283050   ⟹   XP_063139120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,375,753 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283051   ⟹   XP_063139121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,312,897 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283052   ⟹   XP_063139122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,337,610 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283053   ⟹   XP_063139123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,396,647 - 39,483,730 (+)NCBI
RefSeq Acc Id: XM_063283054   ⟹   XP_063139124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8339,444,911 - 39,483,730 (+)NCBI
RefSeq Acc Id: NP_619724   ⟸   NM_138710
- UniProtKB: A0A8I6AD88 (UniProtKB/TrEMBL),   A0A8I5YBP5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068688   ⟸   ENSRNOT00000080760
Ensembl Acc Id: ENSRNOP00000068818   ⟸   ENSRNOT00000090735
Ensembl Acc Id: ENSRNOP00000072901   ⟸   ENSRNOT00000083134
RefSeq Acc Id: XP_038960144   ⟸   XM_039104216
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A0J3 (UniProtKB/TrEMBL),   A0A8I6GLM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960150   ⟸   XM_039104222
- Peptide Label: isoform X10
- UniProtKB: A0A8L2R6L0 (UniProtKB/TrEMBL),   A6JUF8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091180   ⟸   ENSRNOT00000094494
Ensembl Acc Id: ENSRNOP00000077217   ⟸   ENSRNOT00000108040
Ensembl Acc Id: ENSRNOP00000086079   ⟸   ENSRNOT00000103632
Ensembl Acc Id: ENSRNOP00000083416   ⟸   ENSRNOT00000112672
Ensembl Acc Id: ENSRNOP00000096499   ⟸   ENSRNOT00000106017
RefSeq Acc Id: XP_063139118   ⟸   XM_063283048
- Peptide Label: isoform X5
- UniProtKB: A6JUF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139121   ⟸   XM_063283051
- Peptide Label: isoform X8
- UniProtKB: A0A0G2JTF2 (UniProtKB/TrEMBL),   A0A8I5YBP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139119   ⟸   XM_063283049
- Peptide Label: isoform X6
- UniProtKB: A0A8I5YBP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139115   ⟸   XM_063283045
- Peptide Label: isoform X2
- UniProtKB: A0A8I5YBP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139122   ⟸   XM_063283052
- Peptide Label: isoform X9
- UniProtKB: A0A8I5YBP5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139120   ⟸   XM_063283050
- Peptide Label: isoform X7
- UniProtKB: A0A0G2JTS0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139117   ⟸   XM_063283047
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GLM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139116   ⟸   XM_063283046
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GLM2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139123   ⟸   XM_063283053
- Peptide Label: isoform X11
- UniProtKB: A6JUF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139124   ⟸   XM_063283054
- Peptide Label: isoform X11
- UniProtKB: A6JUF9 (UniProtKB/TrEMBL)
Protein Domains
C2   Disabled homolog 2-interacting protein C-terminal   PH   Ras-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P730-F1-model_v2 AlphaFold Q6P730 1-996 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692023
Promoter ID:EPDNEW_R2545
Type:single initiation site
Name:Dab2ip_1
Description:DAB2 interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0314,990,695 - 14,990,755EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621686 AgrOrtholog
BioCyc Gene G2FUF-50028 BioCyc
Ensembl Genes ENSRNOG00000055226 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080760.2 UniProtKB/TrEMBL
  ENSRNOT00000083134.2 UniProtKB/TrEMBL
  ENSRNOT00000090735.2 UniProtKB/TrEMBL
  ENSRNOT00000094494.1 UniProtKB/TrEMBL
  ENSRNOT00000103632.1 UniProtKB/TrEMBL
  ENSRNOT00000106017.1 UniProtKB/TrEMBL
  ENSRNOT00000108040.1 UniProtKB/TrEMBL
  ENSRNOT00000112672.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598046 IMAGE-MGC_LOAD
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF3498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192126 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72307 IMAGE-MGC_LOAD
NCBI Gene 192126 ENTREZGENE
PANTHER PTHR10194 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10194:SF26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF3498 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dab2ip PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055226 RatGTEx
SMART RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JTF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JTS0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YBP5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWZ0_RAT UniProtKB/TrEMBL
  A0A8I6A0J3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AD88 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLM2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R6L0 ENTREZGENE, UniProtKB/TrEMBL
  A6JUF8 ENTREZGENE, UniProtKB/TrEMBL
  A6JUF9 ENTREZGENE, UniProtKB/TrEMBL
  A6JUG0_RAT UniProtKB/TrEMBL
  A6JUG1_RAT UniProtKB/TrEMBL
  DAB2P_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q924M9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Dab2ip  DAB2 interacting protein  LOC108350356  uncharacterized LOC108350356  Data merged from RGD:11512228 737654 PROVISIONAL
2016-08-02 LOC108350356  uncharacterized LOC108350356      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-26 Dab2ip  DAB2 interacting protein  Dab2ip  disabled homolog 2 (Drosophila) interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-10 Dab2ip  disabled homolog 2 (Drosophila) interacting protein  DIP1/2  DOC2/DAB2 interactive protein  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED
2002-08-07 DIP1/2  DOC2/DAB2 interactive protein      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Ras GTPase-activating protein homology domain (N terminus), 10 proline repeats and a leucine zipper domain 632628