RGD Reference Report - DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators. - Rat Genome Database

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DAB2IP Expression in Abdominal Aortic Aneurysm: EZH2 and mir-363-3p as Potential Mediators.

Authors: Legaki, Evangelia  Klonaris, Christos  Athanasiadis, Dimitrios  Patelis, Nikolaos  Sioziou, Anna  Liakakos, Theodoros  Gazouli, Maria 
Citation: Legaki E, etal., In Vivo. 2019 May-Jun;33(3):737-742. doi: 10.21873/invivo.11533.
RGD ID: 401938604
Pubmed: PMID:31028191   (View Abstract at PubMed)
PMCID: PMC6559911   (View Article at PubMed Central)
DOI: DOI:10.21873/invivo.11533   (Journal Full-text)


BACKGROUND/AIM: Nine genetic loci have been associated with abdominal aortic aneurysm (AAA) susceptibility, including DAB2IP. This gene is playing a role in apoptosis, cell proliferation and epithelial-to-mesenchymal transition in cancers. This study aimed to elucidate the differential expression levels of DAB2IP in AAA tissues and investigate whether mir-363-3p and EZH2 can be considered as potential mediators of its expression.
MATERIALS AND METHODS: 18 AAA samples and 15 non-aneurysmatic controls were collected. Relative mRNA expression levels of DAB2IP, EZH2 and mir-363-3p were measured using qPCR.
RESULTS: DAB2IP was significant up-regulated (~2.29 fold) in AAA tissues, while EZH2 and mir-363-3p were down-regulated (3.28 and 3.62-fold, respectively). A limited negative correlation was found between the DAB2IP and EZH2 expression and between DAB2IP and the mir-363-3p.
CONCLUSION: An increased expression of DAB2IP in AAA tissues was shown. We suggest 2 potential mediators of DAB2IP expression in abdominal aortic aneurysm, EZH2 and mir-363-3p.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abdominal aortic aneurysm  IEP 401938604mRNA:increased expression:aorta (human)RGD 
abdominal aortic aneurysm  ISODAB2IP (Homo sapiens)401938604; 401938604mRNA:increased expression:aorta (human)RGD 
abdominal aortic aneurysm  IEP 401938604; 401938604mRNA:decreased expression:aorta (human)RGD 
abdominal aortic aneurysm  ISOEZH2 (Homo sapiens)401938604; 401938604mRNA:decreased expression:aorta (human)RGD 
abdominal aortic aneurysm  ISOMIR363 (Homo sapiens)401938604; 401938604mRNA:decreased expression:aorta (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dab2ip  (DAB2 interacting protein)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Mir363  (microRNA 363)

Genes (Mus musculus)
Dab2ip  (disabled 2 interacting protein)
Ezh2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)
Mir363  (microRNA 363)

Genes (Homo sapiens)
DAB2IP  (DAB2 interacting protein)
EZH2  (enhancer of zeste 2 polycomb repressive complex 2 subunit)
MIR363  (microRNA 363)


Additional Information